http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_645bd5c7c983695f685c121707d165d3
Outgoing Links
Predicate | Object |
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family-name | Yang Yang Yang |
name | Yang Yang |
given-name | Yang |
organization-name | State Key Laboratory of Physical Chemistry of Solid Surfaces; iChEM; Department of Chemical and Biochemical Engineering; College of Chemistry and Chemical Engineering; Xiamen University Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University Shanghai 200433 P. R. China College of Marine Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361000, China; College of Environment and Public Health, Xiamen Huaxia University, Xiamen, Fujian 361000, China Department of Intensive Care Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China Department of Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine No 507 Zhengmin Road Shanghai 200433 China; School of Materials Science and Engineering Tongji University Shanghai 201804 China Department of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing 210000, China). Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science & Engineering Fudan University Shanghai 200433 China Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua University Beijing 100084 China Advanced Nanofabrication Imaging and Characterization Lab, King Abdullah University of Science and Technology, Thuwal 4700, Makkah, Kingdom of Saudi Arabia Key Laboratory for Plant Diversity and Biogeography of East Asia, Kunming Institute of Botany, Chinese Academy of Sciences, Lanhei Road 132, Kunming, Yunnan 650204, PR China Department of Physics Free University Berlin Berlin Germany Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, 100044, PR China; Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, 100044, PR China State Key Laboratory of Physical Chemistry of Solid Surfaces; iChEM; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen University of Texas Health Science Center at Houston Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi’an, China; Department of Biomedical Engineering, The Fourth Military Medical University, Xi’an, China School of Pharmacy; Shenyang Pharmaceutical University; Shenyang 110016; China The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing 210008, Jiangsu, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry and Materials Science, Northwest University, Xi’an, Shaanxi 710069, P. R. China College of Veterinary Medicine Gansu Agriculture University Lanzhou China Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University, School of Medicine, New Haven, CT 06510, USA The Bone Marrow Transplantation Center and Multiple Myeloma Treatment Center The First Affiliated Hospital of Medical College, Zhejiang University Hangzhou China Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana-Champaign, Ill., and Center for Taiji Studies, Champaign, Ill., USA. School of Science; Beijing Jiaotong University; Beijing; China Jinling Hospital Institute of Clinical Laboratory Science, School of Medicine, Nanjing University Nanjing Jiangsu China Department of Pharmaceutics, China Pharmaceutical University, Nanjing, China School of Materials Science and Engineering Tongji University Shanghai 201804 China; Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 P. R. China; Central Laboratory Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China Institute of Microscale Optoelectronics, Shenzhen University, Shenzhen 518060, China The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, China Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106, United States Center of Super-Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, People’s Republic of China Department of Ultrasound, The Second Clinical Medical College , Jinan University, Shenzhen People’s Hospital, Shenzhen, Guangdong 518020 , China These authors contributed equally to this work; Department of Biostatistics, University of Florida, Gainesville, FL, United States Key Laboratory of Environment and Health, Ministry of Education and Ministry of Environmental Protection, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China National-Local Joint Engineering Laboratory of New Energy Photoelectric Devices, College of Physics Science and Technology, Hebei University, Baoding 071002, China National Center for Nanoscience and Technology, Beijing 100190, China Department of Clinical Psychology Yangzhou University Affiliated Northern Jiangsu People's Hospital Yangzhou China Department of Radiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Pharmacodynamics, College of Pharmacy University of Florida Gainesville Florida USA; Department of Biochemistry and Structural Biology University of Texas Health Science Center at San Antonio San Antonio Texas USA 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China Institute of Life Sciences Jiangsu University Zhenjiang 212013 China Infertility Center, Qilu Hospital, Shandong University School of Medicine Shandong 250012 People's Republic of China College of Physical Education Yangzhou University Yangzhou China; Institute of Sports, Exercise and Brain Yangzhou University Yangzhou China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences, Shaanxi Normal University, Xi'an, China. State Key Lab of Physical Chemistry of Solid Surfaces Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, Fujian, People’ s Republic of China The key of Laboratory Precision Medicine for Severe Autoimmune Diseases of Anhui Province Anhui Institute of Innovative Drugs Anhui Medical University Hefei China; The Key Laboratory of Anti‐inflammatory and Immune Medicines Ministry of Education Hefei China; Institute for Liver Diseases of Anhui Medical University Hefei China College of Furniture and Art Design, Central South University of Forestry and Technology, Changsha 410000, China; Green Furniture Engineering Technology Research Center, National Forestry & Grassland Administration, Changsha 410004, China; Green Home Engineering Technology Research Center, Changsha 410004, China Department of Gastroenterological Surgery, Surgical Oncology Laboratory, Peking University People's Hospital, Xicheng District, Beijing, China Department of Pathogenic Biology Qingdao University Medical College Qingdao China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 500 Dongchuan Road, Shanghai 200241, China Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China National Center for Nanoscicence and Technology, No. 11, Bei Yi Tiao, Zhong guan cun, Beijing 100190, China Wood Technology and Wood Chemistry, Department of Wood Technology and Wood-based Composites, Georg-August-University of Göttingen, Büsgenweg 4, D-37077 Göttingen, Germany; State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou, 510640, People’s Republic of China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention Department of Environmental Science and Engineering Fudan University Shanghai 200433 P. R. China Northwest A&F University, 12469, Yangling, Shaanxi, China; Institute of Laboratory Medicine, Nanjing Jinling Hospital, Clinical School of Medical College, Nanjing University, Nanjing 210002, Jiangsu, China National Engineering Research Center for Urban Pollution Control, College of Environmental Science and Engineering, Tongji University, Shanghai, China Department of the Eighth Healthcare, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China Changchun University of Science and Technology Institute of Applied Biology, Shanxi University Taiyuan China; Section of Animal Genetics Interfaculty Institute of Cell Biology, University of Tübingen Tübingen Germany School of Materials Science and Engineering, Tianjin University, Tianjin 300072, P. R. China Department of Orthopedics, Tianjin Hospital, Tianjin 300211, P.R. China School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510640, China Chongqing Academy of Chinese Materia Medica, Chongqing, China Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, Northeast Agricultural University, Harbin, PR China Department of Radiology Children's Hospital of Soochow University Suzhou China Institute of Entomology, College of Agriculture, Yangtze University, Jingzhou 434025, Hubei, China; Hubei Engineering Research Center for Pest Forewarning and Management, Yangtze University, Jingzhou 434025, Hubei, China Department of Orthopaedics, General Hospital of Tianjin Medical University, Tianjin, 300052, P.R. China. yangyang-8686@163.com Department of Otorhinolaryngology, Shengjing Hospital, China Medical University, Shenyang 110004, China. Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China The College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai 200233, China Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China The Institute of Seawater Desalination and Multipurpose Utilization Ministry of Natural Resources (Tianjin) Tianjin 300192 P. R. China Department of Intensive Care Medicine, Western Health, Melbourne, Victoria, Australia; Department of Surgery, University of Melbourne, Melbourne, Victoria, Australia Department of Microbiology, College of Life Science, Nankai University, Tianjin 300071, China 2Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.; 4O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama. Purdue University College of Pharmacy & Purdue Institute for Integrative Neuroscience (PIIN). Department of Nosocomial Infection Management, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China. College of Chinese Medicinal Materials, Jilin Agricultural University, Changchun 130118, China Hefei National Laboratory for Physical Science at Microscale Department of Materials Science & Engineering National Synchrotron Radiation Laboratory, and Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China Hefei 230026 P. R. China Department of Animal Science, Center for Reproductive Biology and Health, College of Agricultural Sciences and State Key Laboratory of Oncogenes and Related Genes, Department of Biliary-Pancreatic Surgery, Renji Hospital Affliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, Jiangsu 210023, P. R. China School of Biomedical and Pharmaceutical Sciences, Guangdong University of Technology, Guangzhou 510006, Guangdong, China. Department of Cardiovascular Medicine, Affiliated Hospital of Jining Medical University, Jining, Shandong 272000, P.R. China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Xuzhou Medical University, Xuzhou, Jiangsu 221004, P.R. China Center for Single Molecule Biophysics, the Biodesign Institute and ‡Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, United States Department of Pediatrics, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China (WX,YZ,BZ,YY,YW,CL); Department of Ophthalmology, The Affiliated People’s Hospital of Jiangsu University, Zhenjiang, People’s Republic of China (BX) Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering & Pen‐Tung Sah Institute of Micro‐Nano Science and Technology Xiamen University Xiamen 361005 China Department of Chemistry; Shanghai University; Shanghai 200444 P. R. China; Nano-Bionics Division and i -Lab; Suzhou Institute of Nano-Tech and Nano-Bionics; Chinese Academy of Sciences; Suzhou 215123 P. R. China Key Laboratory of Green and Precise Synthetic Chemistry and applications, Ministry of Education, College of Chemistry and Materials Science, Huaibei Normal University, Huaibei, Anhui 235000, P. R. China Beijing Advanced Innovation Center for Soft Matter Science and Engineering & Beijing Engineering Research Center for the Synthesis and Applications of Waterborne Polymers Beijing University of Chemical Technology Beijing 100029 China Department of Prosthodontics Peking University School and Hospital of Stomatology National Clinical Research Center for Oral Diseases National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology Beijing China Epstein Department of Industrial and Systems Engineering University of Southern California 3715 McClintock Ave Los Angeles CA 90089‐01932 USA Solarmer Energy, Inc., El Monte, California 91731, Department of Materials Science and Engineering, University of California Los Angeles, Los Angeles, California 90095 Jiangsu Chia Tai Fenghai Pharmaceutical Co. Ltd. State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle, College of Chemistry and Chemical Engineering Xiamen University Xiamen Fujian P. R. China Center of Super‐Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science City University of Hong Kong Hong Kong SAR P.R. China Organ Transplantation Center, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Peoples Republic of China College of Food Science and Nutritional Engineering, China Agricultural University, 17 Qinghua East Road, Haidian District, Beijing 100083, China Department of Medical Genetics and Key Laboratory for Experimental Teratology of the Ministry of Education Shandong University School of Medicine Jinan China School of Pharmacy, Anhui Medical University, Hefei, Anhui 230032, P.R. China School of Statistics and Mathematics, Nanjing Audit University, Nanjing, People's Republic of China College of Environment and Public Health, Xiamen Huaxia University, Xiamen, Fujian 361024, People’s Republic of China Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE) School of Physics Beijing Institute of Technology Beijing 100081 China School of Agriculture, Yunnan University, Kunming, China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan 650500, China Department of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao‐tong University School of Medicine Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolism Shanghai China State Key Laboratory of Chemical Resource Engineering, School of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China; Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China Ministry of Education Key Laboratory of Low-Grade Energy Utilization Technologies and Systems, Chongqing University, Chongqing 400030, China Jiangsu Key Laboratory of Electrochemical Energy Storage Technologies, College of Material Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, People's Republic of China School of Life Sciences, Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan 430079, China Department of Cardiology, The First Bethune Hospital of Jilin University, Changchun, 130021, China Department of Biomedical Engineering The Fourth Military Medical University Xi'an China; Department of General Surgery Beidaihe Sanatorium Beijing Military Area Command Qinhuangdao China Hainan Institute of Zhejiang University Sanya 572025 China; Laboratory of Cell and Molecular Biology Institute of Vegetable Science Zhejiang University Hangzhou China; Key Laboratory of Horticultural Plant Growth Development and Quality Improvement Ministry of Agriculture – Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Hangzhou China Department of Neurosurgery, Southwest Hospital, Third Military Medical University, Chongqing, China MOE Joint International Research Laboratory of Animal Health & Food Safety Nanjing Agricultural University Nanjing 210095 P. R. China; Key Laboratory of Animal Physiology & Biochemistry College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 P. R. China School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China Department of Radiology, Tongde Hospital of Zhejiang Province, Hangzhou, China; Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, China Department of Neurosurgery, Sanbo Brain Hospital Capital Medical University, Beijing, China Central Laboratory of Yan’an Hospital Affiliated to Kunming Medical University Kunming China; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province Kunming China; Kunming Medical University Kunming China Second Hospital Affiliated to Southern University of Science and Technology(Shenzhen Third People's Hospital)Shenzhen, Chinaand Department of Agronomy, Iowa State University, Ames, Iowa 50011 Department of Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China, and Department of Materials Science and Engineering, University of California, Los Angeles, California 90095 Freie Universität Berlin, Experimentelle Physik, Arnimallee 14, D-14195 Berlin, Germany National Clinical Research Center for Infectious Diseases, State Key Discipline of Infectious Diseases, Shenzhen Third People's Hospital, Second Hospital Affiliated with the Southern University of Science and Technology, Shenzhen, China. Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China Department of Orthopedics, Taizhou Hospital of Zhejiang Province, Zhejiang, China State Key Laboratory of Fine Chemicals, Zhang Dayu College of Chemistry Dalian University of Technology Dalian 116024 P. R. China Department of Cardiovascular Medicine, Second Xiangya Hospital, Central South University, Changsha, China First Affiliated Hospital, Xi'an Medical University, Xi'an 710077, China. Department of Chemistry, University of Massachusetts−Amherst, 240 Thatcher Road, Amherst, Massachusetts 01003, United States Dermatology Department The First Affiliated Hospital of Yunnan University of Traditional Chinese Medicine Kunming China Key Laboratory of Resource Biology and Biotechnology in Western China; Ministry of Education; Faculty of Life Sciences; Northwest University; Xi'an 710069 School of Mechanical and Automotive Engineering South China University of Technology Guangzhou 510640 China Department of Respiratory, The Second People’s Hospital of Lianyungang , Lianyungang 222023 , Jiangsu , China Laboratory of Ichthyology, Shanghai Ocean University, Shanghai, China;; Shanghai Key Laboratory of Marine Animal Taxonomy and Evolution, Shanghai, China Department of Reproduction, The Second Hospital of Hebei Medical University, Shijiazhuang, China School of Life Sciences, Zhengzhou University Australian Institute for Bioengineering and Nanotechnology; The University of Queensland; Brisbane; Australia Department of Neurosurgery, The 451st Hospital of Chinese People's Liberation Army, Xi'an, Shaanxi 710054, P.R. China Class 1, Grade 2019, Department of Stomatology, Bengbu Medical College, China Advanced Nanofabrication, Imaging and Characterization Core lab, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Kingdom of Saudi Arabia Department of Biological Sciences, University at Buffalo, State University of New York, Buffalo, New York; Department of Urology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai Institute of Andrology, Shanghai 200001, China. oliveryang100100@sina.com Department of Materials Science and Engineering University of California Los Angeles CA 90095‐9000 USA Department of Neurology The Second Hospital of Hebei Medical University Shijiazhuang China; Hebei Key Laboratory of Vascular Homeostasis and Hebei Collaborative Innovation Center for Cardio‐cerebrovascular Disease Shijiazhuang China School of Electrical and Data Engineering, University of Technology, Ultimo, Sydney 2007, Australia Information Management Department, Guangdong Provincial People's Hospital, Guangzhou 510080, P. R. China. Department of Chemistry and Biochemistry, and Center for Molecular Design and Biomimicry, Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, 210028, Jiangsu, China; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, 210028, Jiangsu, China School of Life Sciences, East China Normal University, 200062 Shanghai, China (Y.S., Y.Y., C.Y., Y.X., X.S., X.L.); Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Science, 200032 Shanghai, China (Z.Y., H.H.); Department of Biology, Technische Universität Dresden, D–01062 Dresden, Germany (J.L.M.); Plant Biotechnology, Faculty of Biology, and Centre for Biological Signallin Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-sen University/Institute of Organ Transplantation, Sun Yat-sen University, Guangzhou 510630, China. yysysu@163.com Department of Pharmacology School of Basic Medical Sciences & Center of Medical Research and Innovation Shanghai Pudong Hospital & State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200032 China Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Langenbeckstraße 1, 55131 Mainz, Germany, +49 6131 17-7371 College of Computer Science and Technology, Nanjing University of Aeronautics and Astronautics, Nanjing, Jiangsu 210016, China; Department of Information Technology, Nanjing Radio and TV University, Nanjing City Vocational College, Nanjing, Jiangsu 210002, China Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China; The Cooperative Innovation Center for Sustainable Pig Production, Wuhan 430070, China Department of Computer Science and Engineering, Center for Brain‐Like Computing and Machine Intelligence Shanghai Jiao Tong University Shanghai China Department of Materials Science and Engineering California Nano Systems Institute University of California Los Angeles CA 90095 USA National Center for Nanoscience and Technology, Beijing 100190, P. R. China College of Animal Science and Technology Key Laboratory of Applied Technology on Green‐Eco‐Healthy Animal Husbandry of Zhejiang Province Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology Zhejiang A&F University Hangzhou China State Key Laboratory of Molecular Reaction Dynamics; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian 116023; People's Republic of China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China Department of Therapeutic Center of Anemia Institute of Hematology and Blood Diseases Hospital Chinese Academy of Medical Science & Peking Union Medical College (CAMS & PUMC) Tianjin China School of Dentistry, Lanzhou University, Lanzhou, P.R. China. Department of Materials Science and Engineering, UCLA School of Engineering and Applied Science, Los Angeles, California, USA Department of Material Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States Neurology, The First Affiliated Hospital of Sun Yat-Sen University; and Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou School of Mechanical and Automotive Engineering; South China University of Technology; Guangzhou 510640; China Key Laboratory of Condition Monitoring and Control for Power Plant Equipment of Ministry of Education, School of Energy, Power and Mechanical Engineering, North China Electric Power University, Beijing 102206, China College of Chemistry and Materials science; Sichuan Normal University; Chengdu 610066; China Department of Chemistry and Biochemistry 201 Mullica Hill Road Rowan University Glassboro New Jersey 08028 College of Chemistry and Chemical Engineering, Shannxi University of Science & Technology, Xi’an 710021, China School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 P. R. China Department of Urology, Peking University First Hospital, Xicheng, Beijing, China; Institute of Urology, Peking University, National Urological Cancer Center, Beijing, China Department of Rheumatology Xiangya Hospital Central South University Changsha City Hunan Province China; Department of Pathophysiology Xiangya School of Medicine Central South University Hunan Province Changsha City China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China NHC Key Laboratory of Hormones and Development (Tianjin Medical University), Tianjin Key Laboratory of Metabolic Diseases Tianjin Medical University Metabolic Diseases Hospital and Tianjin Institute of Endocrinology Tianjin China Department of Pediatric Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China. jiamusi101@126.com Department of Otorhinolaryngology, Head and Neck Surgery National Center for Children’s Health Beijing Children’s Hospital Capital Medical University Beijing China School of Chemistry and Chemical Engineering, Shanghai Electrochemical Energy Devices Research Center, Shanghai Jiao Tong University, Shanghai 200240, P. R. China National Institute for Viral Disease Control and Prevention, China CDC, Beijing 102206, China. yy860225@163.com 1Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.; 3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama. Zhuhai Interventional Medical Centre, Zhuhai People’s Hospital (Zhuhai hospital affiliated with Jinan University); Department of Radiology, Zhuhai People’s Hospital (Zhuhai Hospital affiliated with Jinan University) Zhuhai, China China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science and Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, Anhui, China Beijing Institute of Radiation Medicine Beijing China Key Laboratory of Environmental Health of Ministry of Education, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, PR China Neurosurgery, Jinzhou Central Hospital, Jinzhou, Liaoning, China College of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400030; China Department of Integrated Traditional and Western Medicine, West China Hospital, Sichuan University Chengdu 610041, Sichuan, China. Department of Interventional Radiology, Southern Medical University, Guangzhou, China. yang1023yang@yahoo.com.cn Frazer Institute, Faculty of Medicine, University of Queensland From the Departments of Cardiology (F.F., L.Q., J.J., Y.Y., J.L., Y.Z., Y.H.) and Clinical Laboratory (H.L.), Peking University First Hospital, Beijing, China; State Key Laboratory for Organ Failure Research, Renal Division, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China (X.X., X.Q.); and Department of Emergency, Tsinghua University, YuQuan Hospital, Beijing, China (Y.L.). *Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, MD Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China; Department of Pharmacology Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology Chongqing Medical University Chongqing 400016 China Department of Engineering Science, Institute of Biomedical Engineering Department of Orthopedics The Third Affiliated Hospital Academy of Orthopedics Southern Medical University Guangzhou China Engineering Research Centre of Fujian‐Taiwan Special Marine Food Processing and Nutrition Ministry of Education Fuzhou China School of Acupuncture–Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China. Intensive Care Unit Western Health Melbourne Victoria Australia State Key Laboratory of Coordination Chemistry Chemistry and Biomedicine Innovation Center (ChemBIC) School of Chemistry and Chemical Engineering Nanjing University 163 Xianlin Avenue 210023 Nanjing Jiangsu China Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education Sun Yat‐sen University Guangzhou China Department of General Surgery, Xinqiao Hospital, Third Military Medical University Chongqing, China. Nanjing Xianlin Drum Tower Hospital Nanjing China Department of Otorhinolaryngology Head and Neck Surgery, National Center for Children’s Health, Beijing Children’s Hospital, Capital Medical University, Beijing, China Department of Chemistry; University at Albany; State University of New York; Albany; USA Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, 229 Taibai North Road, Xi’an 710069, China Beijing StoneWise Technology Co Ltd., Haidian Street #15, Haidian District, Beijing 100080, China School of Automotive Engineering, Chongqing University , Chongqing 400044, People's Republic of China Department of Chemistry; School of Science; Beijing Jiaotong University; Beijing 100044; People's Republic of China The Key Laboratory of Plant Resources Conservation and Germplasm Innovation in Mountainous Region (Ministry of Education)/Guizhou Key Lab of Agro-Bioengineering, Institute of Agro-Bioengineering and College of Life Sciences, Guizhou University, Guiyang, China; Chongqing Academy of Chinese Materia Medica, No. 34 Nanshan Road, Nan’an District, Chongqing 400065, China School of Electro-mechanical Engineering, Guangdong University of Technology, Guangzhou, China, 510006 Department of Respiratory, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of Child development and Critical Disorders Chongqing Key Laboratory of Pediatrics Chongqing China Key Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy Sichuan University Chengdu P. R. China School of Life Sciences and Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P. R. China Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China School of Pharmacology Binzhou Medical University Yantai 264003 China; Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment Yantai 264003 China Department of Respiratory Medicine, Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, Jiangsu 211100, China Department of Pediatric Transplantation, Organ Transplantation Center, Tianjin First Central Hospital, Tianjin, China State Key Laboratory of Chemical Resource Engineering, Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China; Quzhou Institute for Innovation in Resource Chemical Engineering, Quzhou 324000, Zhejiang Province, China Nursing Department, Vocational College, Shanghai Jian Qiao University; and Bone Marrow Transplantation Center, Institute of Hematology, The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310004 China Department of Pathology and Cancer Research Center Yanbian University Medical College Yanji China; Key Laboratory of the Science and Technology Department of Jilin Province Yanji China Department of Stomatology, North China University of Science and Technology Affiliated Hospital, Tangshan, 063000 Hebei, China Department of Chemistry and the Tsinghua Center for Frontier Polymer Research Tsinghua University Beijing 100084 P. R. China Department of Pharmaceutics, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450052, Henan, P. R. China Department of Rehabilitation, The First Hospital of China Medical University, No. 155 Nanjing North Road, Shenyang 110001, China Department of Kinesiology and Community Health, University of Illinois Urbana-Champaign, Urbana, IL 61801, USA. yyang5@uiuc.edu State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, First Affiliated Hospital of Chongqing Medical University , Chongqing, China Center of Biotechnology R&D, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China; University of Chinese Academy of Sciences, Beijing 100049, China Institute of Chinese Materia Medica China Academy of Chinese Medical Science Beijing China School of Public Health, Xi’an Jiaotong University, Xi’an, P.R. China Institute of Pediatrics, Nanjing Medical University, Nanjing 210029, P.R. China. MOE Key Laboratory of Advanced Textile Materials & Manufacturing Technology, Zhejiang Sci-Tech University, Hangzhou, 310018, China Department of Pharmaceutical Sciences, College of Pharmacy, South Dakota State University, Brookings, South Dakota 57007, United States Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 P. R. China Department of Biology Georgia State University 50 Decatur Street Atlanta Georgia Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China Pen-Tung Sah Institute of Micro-Nano Science and Technology State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering,iChEM Xiamen University Xiamen 361005 China Department of Mechanical Engineering San Diego State University San Diego CA 92182 USA Department of Chemistry, ‡Smalley Institute for Nanoscale Science and Technology, and §Department of Material Science and NanoEngineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States Department of Gastrointestinal Surgery, Third Affiliated Hospital of Sun Yat-sen University, Guangdong, PR China State Key Laboratory of Oral Diseases, Sichuan University, Sichuan, P.R. China and Department of Oral Implantology, West China College of Stomatology, Sichuan University, Sichuan, P.R. China National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Umezono, Tsukuba 305-8568, Japan Genetic Diagnosis Center, Yunnan Provincial Key Laboratory for Birth Defects and Genetic Diseases The First People’s Hospital of Yunnan Province Kunming China; Affiliated Hospital of Kunming University of Science and Technology Kunming China Institute for Infectious Diseases and Endemic Diseases Prevention and Control Beijing Center for Diseases Prevention and Control Beijing China Central Laboratory of Yan’an Hospital Affiliated to Kunming Medical University, Kunming, Yunnan Province, China; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan Province, China; Kunming Medical University, Kunming, Yunnan Province, China Department of Radiation Oncology, the Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, Erqi District, China Institute of Animal Nutrition, Northeast Agricultural University, Harbin, Heilongjiang 150030, P. R. China Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China; Center of Systems Biology and Human Health, School of Science and Institute for Advanced Study, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, Wuhan 430030, China Department of Biomedical Engineering Fourth Military Medical University Xi'an China College of Mathematics & Information Science, Guiyang University, Guiyang, China; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China; State Key Laboratory of Applied Optics, Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130012, P. R. China Divison of Cardiology, Nanjing Jinling Hostpital, Nanjing, China Biostatics, and Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California Department of Critical Care Medicine, The Sixth Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong, P. R. China Department of Genetics and Immunology Program Stanford University School of Medicine Stanford California State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People’s Republic of China Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University, Shanghai 200433, People’s Republic of China State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, China Department of Urology, Haiyang People's Hospital, Yantai, Shandong 264001, P.R. China The Comprehensive Cancer Centre Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University Nanjing China Department of Veterinary and Biomedical Sciences, University of Minnesota, Saint Paul, Minnesota, USA Department of Palliative Management, Jiangsu Cancer Hospital and Research Institute, The Affiliated Jiangsu Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford, Oxford, OX3 7DQ, UK; Oxford-Suzhou Centre for Advanced Research, Suzhou, 215123, China Department of Electrical and Computer Engineering University of Toronto 10 King's College Road Toronto ON M5S 3G4 Canada Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China; Savid Medical School University of Chinese Academy of Sciences Beijing China Department of Pharmacy, Changzheng Hospital, The Second Military Medical University of CPLA, Shanghai 200003, China; Department of Pharmacy, The 71st Group Army Hospital of CPLA Army, The Affiliated Huaihai Hospital of Xuzhou Medical University, Xuzhou 221004, China; Department of Laboratory Diagnostics, Changzheng Hospital, The Second Military Medical University of CPLA, Shanghai 200003, China School of Science, Harbin Institute of Technology (Shenzhen), Shenzhen 518055, China Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy, Sichuan University, Chengdu 610041, China Department of Obstetrics and Gynecology, Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou, Zhejiang, P.R. China Jiangsu Provincial Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), 400038 Chongqing, China. Department of Materials Science and Engineering and California NanoSystems Institute, University of California, Los Angeles, CA 90095 School of Nursing, Nanjing Medical University, Nanjing, China State Key Laboratory of Precision Measuring Technology & Instruments Tianjin University Tianjin 300072 China Department of Cardiac Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People’s Hospital, Sichuan, P.R. China Translational Research Program, Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, University of Maryland School of Medicine, Baltimore, Maryland; Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel HillChapel Hill, NC, USA Department of Chemistry and Applied Biosciences, ETH Zurich, CH-8093 Zurich, Switzerland School of Kinesiology, Shanghai University of Sport, Shanghai 200438, China Department of Radiology and BioMedical Engineering and Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Public Health of the Ministry of Agriculture, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China Technical Centre for Soil, Agriculture and Rural Ecology and Environment, Ministry of Ecology and Environment, Beijing 100012, PR China Department of Pharmacy, Huaihai Hospital affiliated with Xuzhou Medical University, Xuzhou, China; Xi'an Center for Disease Control and Prevention Xi'an China Shanghai Key Laboratory of Functional Materials Chemistry and Laboratory of Organometallic Chemistry; East China University of Science and Technology; Shanghai 200237; People's Republic of China Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai, 200438, China College of Food Science Southwest University Chongqing China; National Teaching Demonstration Center of Food Science and Engineering Southwest University Chongqing China Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China (mainland) Shenzhen Key Laboratory of Gene Regulation and Systems Biology , School of Life Sciences, , Shenzhen 518055, China; Southern University of Science and Technology , School of Life Sciences, , Shenzhen 518055, China; Department of Systems Biology , School of Life Sciences, , Shenzhen 518055, China; Southern University of Science and Technology , School of Life Sciences, , Shenzhen 518055, China CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences and Medical Center University of Science & Technology of China Hefei Anhui China Department of Biochemistry and Biophysics Peking University Health Science Center Beijing China Department of Neurovascular Surgery, The Third Medical Centre, Chinese PLA (People's Liberation Army) General Hospital, Beijing 100039, P.R. China Intelligent Agricultural Equipment Laboratory, Anhui Agricultural University, HeFei, China; College of Engineering, Anhui Agricultural University, HeFei, China School of Food Engineering, Harbin University of Commerce, Harbin 150076, China Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China Department of Biostatistics, University of Florida, College of Public Health and Health Professions & Emerging Pathogens Institute, Gainesville, Florida, USA Department of Otolaryngology, Head and Neck Surgery, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health, Beijing, China; Department of Kinesiology and Community Health, University of Illinois at Urbana, Center for Taiji Studies Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University , Ames , IA 50011 , USA The Hospital of Shunyi District Beijing China Innovation Experimental College, Northwest A&F University, Yangling 712100, Shaanxi, China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-environmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, People’s Republic of China College of Computer Science and Technology, Northeastern University, Shenyang, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China Department of Dermatology The First Hospital of China Medical University Heping District Shenyang P.R. China; NHC Key Laboratory of Immunodermatology, China Medical University Heping District Shenyang P.R. China; Key Laboratory of Immunodermatology, China Medical University Ministry of Education Heping District Shenyang P.R. China; National and Local Joint Engineering Research Center of Immunodermatological Theranostics Heping District Shenyang P.R. China Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing Department of Gastroenterology Nanjing University Medical School Affiliated Drum Tower Hospital Nanjing China; Jiangsu Clinical Medical Center of Digestive Disease Nanjing China Department of Anesthesiology, Wujiang Hospital Affiliated to Nantong University, Suzhou, Jiangsu 215200, P.R. China Department of Bioinformatics and Computational Biology, University of Texas MD Anderson Cancer Center, Houston, Texas, USA;Division of Biostatistics, University of Texas Health Science Center at Houston, School of Public Health, Houston, Texas, USA Department of Chemistry and Theoretical Chemistry Institute, University of Wisconsin, Madison, 1101 University Avenue, Madison, Wisconsin 53706, Department of Chemistry, University of Minnesota, 207 Pleasant St. SE, Minneapolis, Minnesota 55455, and Department of Physical and Theoretical Chemistry, TU Braunschweig, Hans-Sommer-Strasse 10, D-38106 Braunschweig, Germany 2Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama.; 3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama. Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane 4001, Australia Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Institute of New Energy iChEM (Collaborative Innovation Center of Chemistry for Energy Materials) Fudan University Shanghai 200433 P. R. China Department of Radiology Suining Central Hospital Suining China Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery, Guangzhou, China; Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery, Guangzhou, China Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1; Julia McFarlane Diabetes Research Centre, Faculty of Medicine, University of Calgary, 3330 Hospital Drive N.W., Calgary, Alberta, Canada T2N 4N1 Department of Animal Nutrition and Feed Science College of Animal Science and Technology Huazhong Agricultural University Wuhan 430070 China; The Cooperative Innovation Center for Sustainable Pig Production Wuhan 430070 China School of New Energy, North China Electric Power University, Beijing 102206, P. R. China Department of Urology, Southwest Hospital, Army Medical University, Chongqing, China. Research Center of Modernization of Traditional Chinese Medicine, College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, China Department of Pathology, University of Alabama at Birmingham, Birmingham, AL, USA; Comprehensive Cancer Center and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, AL, USA State Key Laboratory of Oral Diseases, Sichuan University Chengdu 610041, China Department of Prosthodontics, Peking University School and Hospital of Stomatology, Beijing 100081, China. School of Material Science and Engineering, University of Jinan, Jinan 250022, Shandong, China Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Department of General Surgery, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China Beijing United Imaging Research Institute of Intelligent Imaging United Imaging Healthcare Group Beijing China College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, People’s Republic of China.; Jiangsu Co-Innovation Center for Important Animal Infectious Diseases and Zoonoses, Yangzhou 225009, People’s Republic of China. School of Earth and Space Science; Peking University; Beijing 100871; PR China Beijing United Imaging Research Institute of Intelligent Imaging Beijing China Department of Otolaryngology, Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children's Health (NCCH) Beijing China Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA. Department of Neonatology, Nanjing Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China. xiaoguangzhou@163.com. Wood Technology and Wood Chemistry University of Goettingen Büsgenweg 4 D‐37077 Göttingen Germany Department of Gastrointestinal Surgery, Department of General Surgery, the First Affiliated Hospital of Anhui Medical University Department of Chemistry and Alberta Glycomics Centre; University of Alberta; Edmonton; Canada Department of Dermatology, The First Hospital of China Medical University, Shenyang, China; National joint Engineering Research Center for Theranostics of Immunological Skin Diseases, The First Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, Shenyang, China Key Laboratory of Artificial Micro‐ and Nano‐Structures of Ministry of Education School of Physics and Technology Wuhan University Wuhan 430072 China Department of Bioengineering, Zunyi Medical University, Zhuhai Campus, Zhuhai, Guangdong 519041, China Department of Pharmacology School of Basic Medical Sciences and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200032 P. R. China Department of Materials Science and NanoEngineering, Rice University, Houston, Texas 77005, United States Department of Dermatology The 6th Medical Center of General Hospital of PLA Beijing P.R. China The First Hospital of Jilin University Changchun Jilin Province China Department of Anesthesia, Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences, Stomatology Hospital of Chongqing Medical University, No. 426 Songshibeilu, Yubei District, Chongqing 401146, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing; Guangdong Provincial Key Laboratory of Immune Regulation and Immunotherapy, School of Laboratory Medicine and Biotechnology, Southern Medical University , Guangzhou , China Central Mindanao University Musuan Bukidnon The Philippines; School of Pharmaceutical Sciences Hunan University of Medicine Huaihua China Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China; School of Materials Science and Engineering, Tongji University, Shanghai 201804, China State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education) Breast Cancer Center Peking University Cancer Hospital and Institute Beijing 100142 P. R. China Department of Urology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, People's Republic of China; Shanghai Institute of Andrology, Shanghai, People's Republic of China Oncology Department, Nanjing Drum Tower Hospital (Gaochun Branch), Nanjing City, China School of Chemistry and Chemical Engineering; Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering; Hefei University of Technology; Hefei; P. R. China Department of Otolaryngology, Head and Neck Surgery Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China The Comprehensive Cancer Center of Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School Nanjing University Nanjing China; Clinical Cancer Institute of Nanjing University Nanjing China; State Key Laboratory of Analytical Chemistry for Life Sciences, School of Chemistry and Chemical Engineering Nanjing University Nanjing China Key Laboratory of Drug-Targeting and Drug Delivery System of, the Ministry of Education Sichuan Research Center for, Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University Chengdu 610041 P. R. China National Laboratory of Medical Molecular BiologyInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, People's Republic of China Health Science Center Hebei University Baoding People's Republic of China Shanghai Pulmonary Hospital Shanghai China Division of Rheumatology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian 361021, China 2State Key Laboratory of Cancer Biology, Department of Medical Genetics and Developmental Biology, Fourth Military Medical University, Xi'an, China. Department of Radiology, Chongqing Prevention and Treatment Center forOccupational Diseases, China Department of Chemistry Haverford College Haverford PA 19041 USA 1Department of Biology, School of Pharmaceutical Sciences, Tsinghua University, Beijing, China 1State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment & Health (Ministry of Education), Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Thoracic Radiotherapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China School of Pharmacy,Anhui Medical University,Hefei,China; Institute for Liver Diseases,Anhui Medical University,Hefei,China Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering, Beijing Advanced Innovation Centre for Biomedical Engineering, Beihang University, Beijing, China State Key Laboratory of Agro-Biotechnology, China Agricultural University, Beijing, China; Division of Infectious Diseases, Cincinnati Children's Hospital Medical Center Key Laboratory of Applied Marine Biotechnology, Ningbo University, Ministry of Education, Ningbo, China; Key Laboratory of Marine Biotechnology of Zhejiang Province, Ningbo University, Ningbo, China; College of Marine Sciences, Ningbo University, Ningbo, China State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China Department of Cardiothoracic Surgery, Xinhua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, P. R. China. School of New Energy, North China Electric Power University, Beijing 102206, People's Republic of China Department of Dermatology The First Hospital of China Medical University Shenyang China; Key Laboratory of Immunodermatology National Health Commission/Ministry of Education Shenyang China Hangzhou Center for Disease Control and Prevention, Hangzhou, People’s Republic of China State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China Sichuan Yizhichun Tea Industry Co., Ltd, , Leshan 614503, Sichuan, China Department of Neurosurgery, Zhumadian Central Hospital, Zhumadian 463000, Henan, People's Republic of China Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji 133002, China Department of Cardiovascular Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, 410011, China Hunan Agricultural University, China Beijing Urban Road Maintenance and Management Center,Beijing 100053, People’s Republic of China Department of Materials Science and Engineering, University of Florida , Gainesville, FL , USA Department of Nephrology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou China; Research Institute of Nephrology, Zhengzhou University, Zhengzhou China; Key laboratory of precision diagnosis and treatment for chronic kidney disease in Henan province, Zhengzhou China; Core unit of national clinical medical research center of kidney disease, Zhengzhou China *Julia McFarlane Diabetes Research Centre, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada; and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China NanoScience Technology Center Department of Materials Science and Engineering Renewable Energy and Chemical Transformation Cluster Department of Chemistry University of Central Florida Orlando FL 32826 USA Department of Neonates, Children’s Hospital of Nanjing Medical University, Nanjing, China; The Third Department of Orthopedics, the Affiliated Hospital of Chengde Medical College, China Department of Animal Sciences, Shanxi Agricultural University, Taigu, China Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan) and School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Radiation Oncology, Zhejiang Key Lab of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China Department of Cell Biology and Genetics, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi, P.R. China Institute of Neuroscience Zhejiang University School of Medicine Hangzhou China Department of Computer Science and Engineering, Information Engineering College, Shanghai Maritime University, 1550 Haigang Avenue, Shanghai 201306, China Otorhinolaryngology Head and Neck Surgery, Baoshan People’s Hospital, Baoshang, Yunnan, China Center for Big Data Research in Health and Medicine The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China Department of Oncology, The Affiliated Taikang Xianlin Drum Tower Hospital of Medical School of Nanjing University, Nanjing, Jiangsu 210046, P.R. China Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing, China School of New Energy, North China Electric Power University, Beijing 102206, People’s Republic of China Duke University 1 Department of Chemistry, , Durham, North Carolina 27708, USA Key Laboratory of Microelectronics Devices & Integrated Technology; Institute of Microelectronics; Chinese Academy of Sciences; Beijing 100029; P. R. China Chongqing Key Laboratory of Plant Disease Biology, College of Plant Protection, Southwest University, Chongqing 400715, P.R. China MOE Joint International Research Laboratory of Animal Health & Food Safety Nanjing Agricultural University Nanjing P. R. China; Key Laboratory of Animal Physiology & Biochemistry Nanjing Agricultural University Nanjing P. R. China National Centre for Nanoscience and Technology, Beijing 100080, China, and Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Department of General Surgery Xuanwu Hospital Capital Medical University Beijing China Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, China Department of Pathology; The First Affiliated Hospital of Sun Yat-Sen University; Guangzhou 510080; People's Republic of China Ministry of Education Key Laboratory of Low‐grade Energy Utilization Technologies and Systems Chongqing University Chongqing P. R. China Jiangsu Laboratory of Advanced Functional Material; School of Chemistry and Materials Engineering; Changshu Institute of Technology; Changshu 215500; P.R. China Department of Respiratory and Critical Care Medicine, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, P. R. China Texas Christian University, USA Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 P. R. China Institute of Medical and Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China; Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science and Technology of China, Hefei 230026, China State Key Laboratory of NBC Protection for Civilian, Beijing, 102205, China Sanmenxia Central Hospital of Henan Province, Henan 472000, China State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, School of Chemistry and Chemical Engineering, Ningxia University, Yinchuan, Ningxia 750021, PR China Department of Pulmonary and Critical Care Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology, Chengdu 610032, China Laboratory for Neuroscience Research in Neurosurgery, F.M. Kirby Neurobiology Program,; Departments of bSurgery and Institute of Nuclear and New Energy Technology Tsinghua University Beijing 100084 China Department of Hematology, Chinese PLA General Hospital, Beijing 100853, China. Department of Orthopedic Surgery Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Key Lab of Polyoxometalate Science of Ministry of Education, National & Local United Engineering Laboratory for Power Battery, Northeast Normal University, Changchun 130024, People’s Republic of China College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China; College of Environment and Public Health, Xiamen Huaxia University, 288 Tianma Road, Xiamen, Fujian 361024, China Department of Computer Science, Shanghai Jiao Tong University, and Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering, Shanghai, China Department of Gastroenterology, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China. School of Tea and Food Science & Technology, Anhui Agricultural University, Hefei 230036, China; State Key Laboratory of Tea Plant Biology and Utilization, Anhui Agricultural University, Hefei 230036, China Department of Radiology and Functional and Molecular Imaging Key Lab of Shaanxi Province, Tangdu Hospital, Fourth Military Medical University , 569 Xinsi Road, Xi'an 710038, Shaanxi , China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Clinical Laboratory, Peking University Cancer Hospital and Institute, Beijing 100142, P.R. China Department of Plastic and Reconstructive Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an, 710032, China; Medical Insurance and New Rural Cooperative Medical Insurance Administration Center, The 252nd Hospital of PLA, Baoding, 071000, China Harbin University of Commerce College of Pharmacy Harbin China MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences Lanzhou University Lanzhou 730000 China *Julia McFarlane Diabetes Research Centre, Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Calgary, Calgary, Canada; and College of Biotechnology, Tianjin University of Science & Technology, No. 29, 13th Avenue, TEDA, Tianjin, 300457, China Department of Chemistry; Bohai University; Jinzhou; P. R. China Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine No.507 Zhengmin Road Shanghai 200433 China; School of Materials Science and Engineering Tongji University Shanghai 201804 China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi’an, China (T.L., Y.Y.).; Department of Biomedical Engineering (T.L., Y.Y.) Footscray Hospital 160 Gordon St Footscray Victoria 3011 Australia Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA, USA Tianjin Cardiovascular Institute, Tianjin Chest Hospital, Tianjin 300051, P.R. China College of Bioinformatics Science and Technology Harbin Medical University China School of Materials Science and Engineering; Hefei University of Technology; Hefei; P. R. China Roy J. Carver Department of Biochemistry, Biophysics and Molecular Biology, Iowa State University, Ames, IA 50011, USA Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences, Sanya, Hainan 572000, P. R. China Beijing Institute of Pharmacology and Toxicology, Beijing, People’s Republic of China State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources; School of Chemistry and Pharmacy; Guangxi Normal University; Guilin 541004; China Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. School of Mechanical Engineering and Automation, Beihang University, Beijing, China Department of Immunology, Guizhou Medical University, Guiyang, China. Beijing National Research Center for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco‐environmental Sciences, Chinese Academy of Sciences Beijing 100085 China Sichuan University of Science and Engineering, Zigong, China Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, China School of Pharmacology, Binzhou Medical University, Yantai, Shandong 264003, P.R. China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Zhong Guan Cun, Bei Yi Tiao 11 Beijing 100190 China Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China. Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing, China. Medical Oncology, Harbin Medical University Cancer Hospital Harbin Heilongjiang China Department of Thoracic Surgery, Dongtai People’s Hospital, Dongtai 224299, China Shanghai Key Lab. of D&A for Metal‐Functional Materials School of Materials Science & Engineering Tongji University Shanghai 201804 P.R. China Laboratory of Neuro-Oncology, Tianjin Neurological Institute;; Department of Neurosurgery, Tianjin Medical University General Hospital;; Key Laboratory of Neurotrauma, Variation, and Regeneration, Ministry of Education and Tianjin Municipal Government; Department of Pharmacology, Chongqing Medical University, The Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 400016, China Artemisinin Research Center, and Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, China Department of Medical Oncology, Cancer Center, West China Hospital, Sichuan University; West China Biomedical Big Data Center, Sichuan University Department of Urology, Peking University First Hospital and Institute of Urology Peking University Beijing China; National Research Center for Genitourinary Oncology Beijing China; Beijing Key Laboratory of Urogenital Diseases (Male) Molecular Diagnosis and Treatment Center Beijing China Department of Cardiac Surgery, Peking University First Hospital, Beijing 100034, China. Department of Endocrinology, the Second Affiliated Hospital, Kunming Medical University, Kunming, Yunnan, China Shanghai Lanhui Medical Technology Co., Ltd, Shanghai, China Department of Biostatistics, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, U. S. A. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong 999077, China Department of Biomedical Engineering The Fourth Military Medical University Xi'an China Institute of Environmental Research at Greater Bay; Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou, Guangdong 510006, PR China Department of Critical Care Medicine Affiliated Hospital of Zunyi Medical University, Guizhou Zunyi China Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, China. chengrui351@163.com. Chongqing Key Laboratory of Ultrasound Molecular Imaging Institute of Ultrasound Imaging Chongqing Medical University Chongqing 400016 P. R. China Key Laboratory of Tropical Biological Resources Ministry of Education Key Laboratory for Marine Drugs of Haikou Hainan University Haikou China; College of Agriculture Hainan University Haikou China International Joint Research Center of Aerospace Biotechnology and Medical Engineering of Ministry of Science and Technology of China, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100191, P.R. ChinaP.R. China Department of Biochemistry and Molecular Biology State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China; Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China Anhui Medical University, Hefei, China; Yang Yang and Fanfan Li are Co-corresponding author in the manuscript. Department of Mechanical and Industrial Engineering, Northeastern University, Boston, Massachusetts 02115, United States Department of Hematology, Zhongshan Hospital, Fudan University, Shanghai, China Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China Department of Biomedical Engineering; University of Virginia; Charlottesville Virginia USA Department of Obstetrics and Gynecology, The Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China The Second Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050001, China Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, California 90095 College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, China Department of Cardiology, The First Affiliated Hospital, Cardiovascular Institute, Harbin Medical University, 23 Youzheng Street, Harbin, PR China Research Institute of Applied Biology Shanxi University Taiyuan 030006 Shanxi China School of Pharmaceutical Sciences Hunan University of Medicine Huaihua Hunan China Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China.; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission, Shanghai, China. State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan Province, China Shanghai Skin Disease and STD Hospital, 196 Wu Yi Road, Shanghai, China 200050 Department of Surgery University of Melbourne Melbourne Victoria Australia; Intensive Care Unit Western Hospital Footscray Victoria Australia COVID‐19 Research Center, Institute of Laboratory Medicine, Jinling Hospital Nanjing University School of Medicine Nanjing Jiangsu China; School of Medicine Jiangsu University Zhenjiang Jiangsu China Department of Genetics Stanford University School of Medicine Stanford CA USA Department of Chemistry, Tsinghua University, Beijing, 100084, People’s Republic of China Department of Thoracic Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, P. R. China Department of Biopharmaceutical Sciences, University of Illinois, Chicago, Illinois 60612, United States State Key Laboratory of Natural and Biomimetic Drugs, Ministry of Education Key Laboratory of Cell Proliferation and Differentiation, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Center for Life Sciences, Institute of Molecular Medicine, College of Future Technology, Peking University, Beijing, China (J.W., H.Z., Y.T., C.Y., Y.Y., Y.Z.). Department of Biomedical Engineering, Fourth Military Medical University, Xi’an 710032, China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Xi’an 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, Xi’an 710032, China Hubei Key Laboratory on Organic and Polymeric Opto-Electronic Materials, College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China Department of Obstetrics And Gynaecology The First Affiliated Hospital of Ningbo University Ningbo China Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Lishui Hospital, School of Medicine, Zhejiaing University, Lishui 323000, Zhejiang, China Department of Oral and Maxillofacial & Head and Neck Oncology, Beijing Stomatological Hospital, Capital Medical University, Beijing, China Chinese Academy of Tropical Agricultural Sciences, Environment and Plant Protection Institute, Haikou, Hainan, China Department of Pathlology, Hunan Cancer Hospital, Changsha, 410013 Hunan Province, China The Institute of Seawater Desalination and Multipurpose Utilization, Ministry of Natural Resources (Tianjin), Tianjin 300192, P. R. China Endoscopy Center, Shengjing Hospital of China Medical University, Shenyang, China Department of Mechanical and Aerospace Engineering and Hong Kong University of Science and Technology, Kowloon, Hong Kong. Hefei National Laboratory for Physical Sciences at the Microscale School of Life Sciences University of Science and Technology of China Hefei China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education); State Key Laboratory of Natural and Biomimetic Drugs; Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function; Department of Biochemistry and Molecular Biology; Peking University Health Science Center; Beijing, China Department of Cardiovascular Surgery Xijing Hospital The Fourth Military Medical University Xi'an China; Department of Biomedical Engineering The Fourth Military Medical University Xi'an China School of Life Sciences, Jilin University, 2699 Qianjin Street, Changchun 130012, China; National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, China CAS Key Laboratory of Soft Matter Chemistry, CAS High Magnetic Field Laboratory, Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 100049, China. Shanghai Key Laboratory of Regulatory Biology, The Institute of Biomedical Sciences & School of Life Sciences, East China Normal University, Shanghai, 200241, China Key Laboratory for Power Machinery and Engineering of Ministry of Education, School of Mechanical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Wood Technology and Wood Chemistry University of Goettingen Büsgenweg 4 Göttingen 37077 Germany; State Key Laboratory of Pulp and Paper Engineering South China University of Technology Wushan Road 381 Guangzhou 510640 P. R. China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, China Department of Liver Surgery and Liver Transplantation, Guangzhou Clinical Research and Translation Center for Liver Disease, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Chengdu, P.R. China Department of Obstetrics and Gynecology, Center for Reproductive Medicine, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, PR China Functional Thin Films Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China State Key Laboratory of Molecular Engineering of Polymers; Department of Macromolecular Science; Fudan University; Shanghai 200433; China Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Utrecht, The Netherlands; Netherlands Proteomics Center, Utrecht, The Netherlands Department of Cell Biology, Key Lab of Medical Cell Biology, Ministry of Education, China Medical University, Shenyang The State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, Inner Mongolia University, Hohhot, Inner Mongolia, China (mainland) CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, 100190 Beijing, China First Hospital, Jilin University, Changchun, Jilin Province, China Department of Otorhinolaryngology Head and Neck Surgery, Baoshan People’s Hospital , Baoshan 678000 , Yunnan Province , China Department of Pharmacology School of Basic Medical Sciences & Department of Pharmacy Shanghai Pudong Hospital Fudan University Shanghai 200032 P. R. China College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, China. doubleyang360@gmail.com Emerging Pathogens Institute, University of Florida , Gainesville, Florida , USA; Department of Biostatistics, College of Public Health and Health Professions, University of Florida , Gainesville, Florida , USA Department of Cardiology, The Third Affiliated Hospital of Anhui Medical University, Hefei 230061, Anhui, China Department of Hepatology, The Fourth Hospital of Huai’an, Huai’an, Jiangsu, China Department of Radiotherapy & Oncology, Xi 'an International Medical Center Hospital, Xi’an, Shaanxi, 710000, China Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States; California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Department of Respiratory Medicine, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China Department of Laboratory Diagnostics, Changzheng Hospital, Second Military Medical University of CPLA, Shanghai, China;; Department of Pharmacy, Changzheng Hospital, Second Military Medical University of CPLA, Shanghai, China;; Affiliated Huaihai Hospital of Xuzhou Medical University (The 97th Hospital of CPLA), Xuzhou, China State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China The First Hospital of Jilin University Changchun China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 China Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, China; Key Laboratory of Clinical Pharmacology of Antibiotics, National Health Commission of People’s Republic of China, Shanghai, China Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai, China College of Chemistry and Materials Science; Jinan University; Guangzhou 510632; China Beijing Key Laboratory for Forest Pest Control College of Forestry Beijing Forestry University Beijing P. R. China Beijing Institute of Pharmacology and Toxicology, Beijing, PR China and School of Environmental Science and Engineering State Key Lab of Metal Matrix Composites Shanghai Jiao Tong University 800 Dongchuan Road Shanghai 200240 China Guangzhou Institute of Chemistry, Chinese Academy of Sciences, Guangzhou 510650, P. R .China; Key Laboratory of Cellulose Lignocellulosics Chemistry, Chinese Academy of Sciences, Guangzhou 510650, P. R .China Hunan University of Chinese Medicine Changsha, 410007, China. California NanoSystems Institute and Department of Chemistry and Biochemistry, Department of Mechanical and Aerospace Engineering, and Department of Materials Science and Engineering, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, CA 90095-1569 and Department of Chemical Engineering, and School of Chemistry, The University of Birmingham, Edgbaston, Birmingham, B15 2TT, U.K Department of Rheumatology, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China; Sepsis Translational Medicine Key Laboratory of Hunan, Central South University, Changsha, Hunan, China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 P. R. China Department of Urology, Peking University First Hospital and Institute of Urology, Peking University, Beijing 100034, China Department of Liver Transplantation and Hepatobiliary Surgery, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong Province, China College of Life Sciences, Zaozhuang University, Zaozhuang 277160, China. State Key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Key Laboratory of Low-grade Energy Utilization Technologies and Systems (Chongqing University), Ministry of Education, Chongqing 400030, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400030, China Department of Obstetrics, ShuLan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College, Hangzhou City, Zhejiang, China Mendoza College of Business, University of Notre Dame, Notre Dame, IN 46556 Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China School of Life Sciences, Yunnan University, Kunming, P.R. China and Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P.R. China From the Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College. Department of Pharmacology and Toxicology Shanghai Institute of Planned Parenthood Research 2140 Xie Tu Road Shanghai 200032 People's Republic of China School of Life Science and Engineering, Foshan University, Foshan, China. Department of Materials Science and Engineering and California NanoSystems Institute University of California Los Angeles CA 90095 USA Centre for Quantum Physics Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE) School of Physics Beijing Institute of Technology Beijing 10081 China Beijing National Laboratory for Molecular Sciences CAS Key Laboratories of Organic Solids and Analytical Chemistry for Living Biosystems CAS Research/Education Center of Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; School of Chemistry University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, People's Republic of China; Department of Histology and Embryology, Anhui Medical University, Hefei, People's Republic of China Science and Technology on Monolithic Integrated Circuits and Modules Laboratory, Nanjing Electronic Device Institute, Nanjing 210016, China Department of Gastroenterology and Endoscopy, The Fifth Affiliated Zhuhai Hospital of Zunyi Medical University, Zhuhai, China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agroenvironmental Pollution Control and Management, Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China State Key Laboratory of Physical Chemistry of Solid Surfaces Pen‐Tung Sah Institute of Micro‐Nano Science and Technology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China; Institute of Artificial Intelligence Xiamen University Xiamen 361005 China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China College of Information, Mechanical and Electrical Engineering, Shanghai Normal University, Shanghai 200234, China Department of Emergency, Fuzhou General Hospital, Fuzhou, Fujian 350025, China 3Internal Medicine and Ministry of Education Key Laboratory of Experimental Teratology and Institute of Molecular Medicine and Genetics, Shandong University School of Medicine, Jinan, Shandong 250012, China 1 Centre for Nanoscale Science and Technology Collaborative Innovation Center of ChemicalScience and Engineering (Tianjin) School of Materials Science and Engineering Nankai University Tianjin 300071 China; State Key Laboratory and Institute of Elemento‐Organic Chemistry Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300071 China Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China §Julia McFarlane Diabetes Research Centre, University of Calgary, Calgary, Alberta T2N 4N1, Canada;; ¶Department of Microbiology, Immunology, and Infectious Diseases, Faculty of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada; Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA CAS Key Laboratory of Standardization and Measurement for Nanotechnology; CAS Key Laboratory of Biological Effects of Nanomaterials and Nanosafety; CAS Center for Excellence in Nanoscience; National Center for Nanoscience and Technology; Beijing 100190 China Department of Neurology, Yale University School of Medicine, New Haven, Connecticut.; Center for Neuroscience and Regeneration Research, Yale University School of Medicine, New Haven, Connecticut.; Rehabilitation Research Center, VA Connecticut Healthcare System, West Haven, Connecticut.; Department of Biology, Georgia State University, Atlanta, Georgia. Department of Laboratory Medicine, the First People's Hospital of Leshan Central Research Institute of Shanghai Pharmaceutical (Group) Co., Ltd., Shanghai 201203, China Department of Neurology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China; Both the authors contributed equally as co-authors. Upstream Development, Bioprocess Development Shire Lexington Massachusetts Australian Institute for Bioengineering and Nanotechnology UQ-JLU Joint Research Centre for Future Materials The University of Queensland St Lucia Brisbane QLD 4072 Australia The University of the Chinese Academy of Science, Beijing, PR China 100039 Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, P. R. China Department of Nephrology, The Second Affiliated Hospital of Nanchang University , Nanchang , PR China Department of Urology Peking University First Hospital and Institute of Urology, Peking University Beijing China; National Research Center for Genitourinary Oncology Beijing China; Beijing Key Laboratory of Urogenital Diseases (male) Molecular Diagnosis and Treatment Center Beijing China 1 Center for Systems Biology,; 2 School of Computer Science and Technology, Soochow University, Suzhou 215006, China and; 3 Department of Experimental Medical Science, Lund University, Lund SE 221 84, Sweden College of Optical Science and Engineering State Key Laboratory of Modern Optical Instrumentation Zhejiang University Hangzhou 310027 China; International Research Center for Advanced Photonics Hangzhou Zhejiang 310027 China College of Physics and Information Engineering Institute of Micro‐Nano Devices and Solar Cells Fuzhou University Fuzhou 350108 China Department of Building and Real Estate, The Hong Kong Polytechnic University, PR China School of Investigation, People's Public Security University of China Beijing China Energy Materials & Physics Group, Department of Physics, Shanghai University, Shanghai 200444, China Center of Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China, National Center for Nanoscience and Nanotechnology, Beijing 100190, People’s Republic of China, and State Key Laboratory of Nuclear Physics and Technology, Peking University, Beijing 100871, People’s Republic of China State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL 60208;; Kellogg School of Management, Northwestern University, Evanston, IL 60208; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an 710069, China. *Corresponding author, E-mail: yang200214yy@nwu.edu.cn. Department of Chemistry, University of Illinois at Urbana−Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, United States Department of Ultrasound, Second Xiangya Hospital Central South University Changsha China The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu 730000, PR China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, Hubei, China; Department of Infectious Diseases, University of Georgia College of Veterinary Medicine, Athens, Georgia, USA Department of Neurology, Nanjing First Hospital Nanjing Medical University, Nanjing, PR China Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, 450008, PR China Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University, Chongqing 400038, China * Biochemistry and Molecular Biology and Sichuan Provincial Branch of China National Tobacco Corporation; Chengdu; China Laboratory of Cardiovascular and Aging Research, Department of Endocrinology, Metabolism, and Cardiovascular System, Faculty of Science and Medicine University of Fribourg Fribourg Switzerland Institute for Photon Science and Synchrotron Radiation (IPS) Karlsruhe Institute of Technology (KIT) Eggenstein‐Leopoldshafen Germany Key Laboratory of Biodiversity and Biogeography Kunming Institute of Botany, Chinese Academy of Sciences 132 Lanhei Road Kunming Yunnan 650201 China Department of Otolaryngology, Ministry of Education Key Laboratory of Child Development and Disorders, National Clinical Research Center for Child Health and Disorders (Chongqing), China International Science and Technology Cooperation base of Child development and Critical Disorders, Chongqing Key Laboratory of Child Infection and Immunity, Children's Hospital of Chongqing Medical University, Chongqing 400014, P.R. China The Second Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China. Sichuan Energy Construction Engineering Group Co., Ltd, Chengdu 610021, China Hefei National Laboratory for Physical Sciences at the Microscale Department of Materials Science and Engineering CAS Key Laboratory of Materials for Energy Conversion University of Science and Technology of China Hefei Anhui 230026 China Key Laboratory for Ultrafine Materials of Ministry of Education, The State Key Laboratory of Bioreactor Engineering, and Engineering Research Center for Biomedical Materials of Ministry of Education, East China University of Science and Technology, Shanghai 200237, People’s Republic of China National Clinical Research Center for Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Animal Science, Center for Reproductive Biology and Health, College of Agricultural Sciences, The Pennsylvania State University, University Park, PA 16802 Department of Chemistry, ‡Richard E. Smalley Institute for Nanoscale Science and Technology, and §Department of Materials Science and NanoEngineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States Department of Otolaryngology‑Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi'an, Shaanxi 710032, P.R. China Intelligent Polymer Research Institute, ARC Centre of Excellence for Electromaterials Science, University of Wollongong, Wollongong 2522, Australia Key Laboratory of Low-grade Energy Utilization Technologies and Systems, Chongqing University, Ministry of Education, Chongqing 400030, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400030, China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis, Faculty of Chemistry, Northeast Normal University, Changchun 130024, China Department of Pharmaceutical Sciences, College of Pharmacy South Dakota State University, Brookings, South Dakota 57007, United States Department of Organ Transplantation, Tongji Hospital, Huazhong University of Science and Technology, Wuhan 430030, China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology Beijing 100190 China School of Physics and Electronic Information, Weifang University, Weifang 261061, China Department of Tumor Department of Hematology China–Japan Union Hospital of Jilin University Changchun China Department of Oral Implantology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat‑sen University, Guangzhou, Guangdong 510055, P.R. China From the Department of Cardiovascular Surgery, Xijing Hospital, The Fourth Military Medical University, Xi’an, China (Y.Y., W.D., Z.J., S.Y., D.Y.); Team 10, School of Stomatology, The Fourth Military Medical University, Xi’an, China (Y.L.); and Department of Prosthodontics, School of Stomatology, The Fourth Military Medical University, Xi’an, China (J.Y.). Key Laboratory for Renewable Energy, Beijing Key Laboratory for New Energy Materials and Devices, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China; Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210093, China; Jiangsu Provincial Key Laboratory of Photonic and Electronic Materials Sciences and Technology, Nanjing University, Nanjing 210093, China Eye center of Xiangya Hospital, Central South University, Changsha, Hunan Province, China; Department of Ophthalmology, the First People’s Hospital of Yueyang, Yueyang, Hunan, China State Key Laboratory of Crop Stress Biology for Arid Areas, Key Laboratory of Northwest Loess Plateau Crop Pest Management of Ministry of Agriculture, College of Plant Protection Northwest A&F University Yangling China Laboratory of Pharmacognosy and Natural Medicine Chemistry, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. yyabc1007@126.com Department of Liver Transplantation, The Third Affiliated Hospital, Sun Yat-Sen University, 600 Tianhe Road, Guangzhou 510630, China Faculty of Life Science and Technology Kunming University of Science and Technology Yunnan China Department of Genetics, Stanford School of Medicine, Stanford University, Stanford, CA 94305-5318 The Clinical Hospital of Chengdu Brain Science Institute , School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 611731, PR China Department of Anatomy, Histology and Embryology, Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou, Liaoning, China Atmospheric Sciences and Global Change Division Pacific Northwest National Laboratory Richland WA USA Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin 150086, Heilongjiang, China. MOE Key Laboratory of Laser Life Science and Institute of Laser Life Science South China Normal University Guangzhou China; College of Biophotonics South China Normal University Guangzhou China Department of Physics Freie Universitat Berlin Arnimallee 14 14195 Berlin Germany Department of Otolaryngology, Union Hospital of Hua Zhong Technology&Science University, Wuhan 430022, China. College of Textile and Clothing Engineering, Soochow University, Suzhou 215021, China Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650500, China; Yunnan Key Laboratory of Disaster Reduction in Civil Engineering, Kunming 650500, China; International Joint Laboratory for Green Construction and Intelligent Maintenance of Yunnan Province, Kunming 650500, China Department of Anesthesiology Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China State Key Lab of Physical Chemistry of Solid Surfaces State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing, China Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Shenzhen, China Department of Biochemistry and Molecular Biology, University of Calgary, Calgary, Alberta, CANADA Beijing Key Laboratory for Forest Pest Control, Beijing Forestry University, No. 35 Qinghua East Road, Haidian District, Beijing, 100083, China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China; Songshan Lake Materials Laboratory Dongguan 523808 China Department of Materials Science and NanoEngineering and Department of Chemistry, Rice University, Houston, Texas 77005, United States College of clinical medicine; Panzhihua University; Panzhihua 617000; China College of Life Sciences, Nankai University Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Digital Medicine and Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, 510515, China Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China. yangyang97@mails.tsinghua.edu.cn Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China. Georgia Cancer Center and Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, U.S.A. Department of Hematology Zhongshan Hospital Fudan University Shanghai China Department of Gastroenterology, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing City, China; Department of Mechanical and Industrial Engineering, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, United States From the Departments of Pathology and Orthopaedic Surgery, the Myeloma Institute for Research and Therapy, Center for Orthopaedic Research, Arkansas Cancer Research Center, University of Arkansas for Medical Sciences, Little Rock; ImClone Systems Incorporated, New York, NY. School of Acupuncture–Moxibustion and Tuina, Beijing University of Chinese Medicine, Chaoyang District, Beijing, China.; Beijing Yan Shan Hospital, Fang Shan District, Beijing, China. Department of Neurology, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou 350004, Fujian Province, China. State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300000, China Department of Biology, Indiana University, Bloomington, IN, USA State Grid Chongqing Electric Power Company, Chongqing 400015, China Infertility Center, Qilu Hospital, Shandong University School of Medicine, Jinan, Shandong, People's Republic of China. State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen; P. R. China 1Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, China Medical University, Shenyang, Liaoning, People’s Republic of China Department of Clinical Psychology, Clinical Medical College of Yangzhou University, Yangzhou, China Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials(MoE); State Key Laboratory of Polymer Materials Engineering; National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan); College of Chemistry; Sichuan University State Key Laboratory of Power System Department of Electrical Engineering Tsinghua University Beijing 100084 China Biomechanics Labs of Orthopedic Research Institute, Tianjin Hospital, Tianjin, China Department of Nuclear Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, 450000, China Department of Pathology St. Luke's International Hospital Tokyo; Department of Pathology Tohoku University Hospital Sendai Department of Urology, Kunming Yan'an Hospital, Kunming, Yunnan, China (mainland) Departments of Diagnostic and Interventional Radiology State Key Laboratory of Chemical Resource Engineering, Institute of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China Yunnan Key Laboratory of Biomass Big Data, Yunnan Agricultural University, Kunming, China; College of Science, Yunnan Agricultural University, Kunming, China Key Laboratory of Environmental Medicine and Engineering, Ministry of Education, Jiangsu Key Laboratory for Biomaterials and Devices, School of Public Health, Southeast University, Nanjing, China Department of Laboratory of Pathology, Hebei Cancer Institute The Fourth Hospital of Hebei Medical University Shijiazhuang Hebei China Department of Biology, University of Wisconsin-Stevens Point, Stevens Point, WI 54481, USA. Gansu Provincial Hospital, Lanzhou, 730000 Gansu, China Department of Gastroenterological Surgery; Peking University People's Hospital; Beijing, PR China Department of Neurosurgery, University Hospital of Zurich, University of Zurich, CH‑8091 Zurich, Switzerland Department of Neurobiology, Yale University School of Medicine, New Haven, CT 06520; and Department of General Surgery, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing - China Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China Graduate School of Global Environmental Studies Kyoto University Kyoto Japan Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People's Republic of China Departments of Gastroenterological Surgery and Surgical Oncology Peking University People's Hospital Beijing China Research Center for Environment and Female Reproductive Health The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 China School of Environment, Beijing Key Laboratory for Emerging Organic Contaminants Control, State Key Joint Laboratory of Environment Simulation and Pollution Control (SKLESPC), Tsinghua University, Beijing 100084, China Department of Chemistry University of Waterloo Waterloo Ontario Canada Department of Genetics Stanford University School of Medicine Stanford CA Key Laboratory of Neurotrauma, Department of Neurosurgery Southwest Hospital Third Military Medical University (Army Medical University) Chongqing China School of Life Science East China Normal University Shanghai China Beijing Golden Feather New Energy Technology Co., Ltd, Beijing 100080, China Department of Health Policy and Management, West China School of Public Health and West China Fourth Hospital,Sichuan University,Chengdu 610041,China. MOE Joint International Research Laboratory of Animal Health & Food Safety, Institute of Immunology, Nanjing Agricultural University , Nanjing 210095 , P. R. China; Key Laboratory of Animal Physiology and Biochemistry, College of Veterinary Medicine, Nanjing Agricultural University , Nanjing 210095 , P. R. China Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment & Health (Ministry of Education), Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Histology and Embryology, College of Basic Medicine, Binzhou Medical University, Yantai, Shandong 264003, P.R. China Department of Radiology, Huashan Hospital, Fudan University , No. 12 Middle Wulumuqi Road, Shanghai 200040, China Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610,United States Technical Centre for Soil, Agriculture and Rural Ecology and Environment, Ministry of Ecology and Environment, Beijing 100012, China Authors' Affiliation: State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China College of Animal Science and Technology, Zhejiang A&F University, Lin'an 311300, China Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA. Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Nanjing, People's Republic of China School of Pharmaceutical Sciences, Hunan University of Medicine, Huaihua, China Department of Biomedical Engineering The Fourth Military Medical University Xi'an China; Department of Thoracic and Cardiovascular Surgery Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu China Tsinghua University School of Medicine, Haidian District, Beijing, China Department of Genetics, Stanford University, Stanford, CA 94305-5318 Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University , Shanghai, People’s Republic of China Department of Gastrointestinal Surgery, Affiliated Cancer Hospital of Guangxi Medical University Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital, Shenzhen Shanghai Municipal Center for Students' Physical Fitness and Health Surveillance Department of Medicinal Chemistry and Molecular Pharmacology Purdue University College of Pharmacy West Lafayette Indiana USA; Purdue Institute for Integrative Neuroscience West Lafayette Indiana USA Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China Department of Cardiology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Key Laboratory of Agro-Food Processing and Quality Control, Institute of Food Science and Technology, Chinese Academy of Agricultural Science, Beijing 100193, People’s Republic of China Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, Guangdong, P. R. China. Authors' Affiliations: 1State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School; and 2Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China Key Laboratory of Food Science and Engineering of Heilongjiang Province, College of Food Engineering Harbin University of Commerce Harbin China Ardelyx, Fremont, California, USA. Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 1 , Dalian 116023, China; University of Chinese Academy of Sciences 2 , Beijing 100049, China Department of Biological Sciences Purdue University 915 W. State Street West Lafayette IN 47907‐2054 USA Chongqing Key Laboratory of Ultrasound Molecular Imaging; Institute of Ultrasound Imaging; The Second Affiliated Hospital; Chongqing Medical University; Chongqing 400010 Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, MOE Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, China College of Animal Science Shanxi Agricultural University Taigu China Anhui Geological Museum, Hefei, Anhui, China Suzhou Key Laboratory of Functional Ceramic Materials, Changshu Institute of Technology, Changshu 215500, PR China Department of Chemistry and Biochemistry; University of Maryland; College Park; USA College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Suzhou, China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development; School of Chemistry and Molecular Engineering; East China Normal University; 3663 North Zhongshan Rd; Shanghai Department of Breast Center, Peking University People’s Hospital, Beijing, People’s Republic of China Department of Engineering Science, Institute of Biomedical Engineering, University of Oxford, Oxford, UK Department of Computational Mathematics, Science and Engineering, Michigan State University, East Lansing, MI 48824 USA. DOE-Plant Research Laboratory, Michigan State University , East Lansing, MI 48824 Department of Thoracic and Cardiovascular Surgery Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China; Department of Biomedical Engineering The Fourth Military Medical University Xi'an China Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine Nanjing University of Chinese Medicine Nanjing Jiangsu 210028 China Department of Pharmacy, Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China Information and Statistics Center, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong, China State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, NO1 Xujiaping, Yanchangbu, Lanzhou 730046, China State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China Department of Hepatic Surgery and Liver transplantation Center of The Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University; Organ Transplantation Research Center of Guangdong Province, Guangzhou, Guangdong, China (mainland) Department of Urology, Kunming Yan’an Hospital, The Yan’an Affiliated Hospital of Kunming Medical University, Kunming 650233, China Jilin University, Changchun, China COVID-19 Research Center, Institute of laboratory medicine, Jinling Hospital, Nanjing University School of medicine, the first school of clinical medicine, Southern Medical University, China Department of Pathology, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, P. R. China. Department of Molecular and Cellular PathologyUniversity of Alabama at BirminghamBirminghamALUSA Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China Pharmacology and Toxicology Research Laboratory, Shanghai Institute of Planned Parenthood Research, National Evaluation Centre for The Toxicology of Fertility Regulating Drugs, Shanghai 200032, P.R. China BMW-Brilliance Automotive Ltd., Shenyang 100044, China State Key Laboratory of Rice Biology China National Rice Research Institute Hangzhou 310006 China; College of Life and Environmental Sciences Hangzhou Normal University Hangzhou 310036 China Department of Cardiac Surgery Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai 200025 P. R. China Department of Urology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China *Department of Biochemistry and Molecular Biology, From the Chinese Center for Disease Control and Prevention, Beijing (Q.L., X.W., L.Z., R.R., N.X., C.L., D.L., J.Z., W.T., L.J., Q.W., R.W., Y.Z., G. Shi, G.F.G., Z.F.), the Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei (X.G., Y.T., X.X., Y.W., Q.C., M.L., C.C., R.Y., S.Z., Y. Luo, B.Y.), the World Health Organization Collaborating Centre for Infectious Disease Epidemiology and Control, School of Public Health, University of Hong Kong, Hong Kong (P.W., K.S.M.L., E.H.Y.L., J.Y.W... Department of Biology, Georgia State University, Atlanta, Georgia; and From Shenzhen Bao’an Traditional Chinese Medicine Hospital, Guangzhou University of Chinese Medicine; Department of Plastic and Reconstructive Surgery, Zhongshan Hospital of Fudan University; College of Clinical Medicine and Department of Plastic Surgery, Zhujiang Hospital, Southern Medical University; and Department of Plastic Surgery, General Hospital of Southern Theater Command. Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai 200031 China Department of Chemistry, ‡Smalley Institute for Nanoscale Science and Technology, and §Department of Materials Science and NanoEngineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States Optometry Teaching & Research Office, Xi'an Medical University, Xi'an 710021, Shaanxi Province, China. Beijing Center for Disease Prevention and Control, Beijing Research Center for Preventive Medicine, Beijing, China Department of Surgery, The University of Melbourne, Parkville, VIC, Australia; Department of Intensive Care, Western Hospital, Melbourne, VIC, Australia State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering; Pen-Tung Sah Institute of Micro-Nano Science and Technology; Graphene Industry and Engineering Research Institute; iChEM State Key Laboratory of Biotherapy, West China Hospital and West China Medical School, Sichuan University, Chengdu, Sichuan, The People's Republic of China. Department of Spine Surgery, Tongde Hospital of Zhejiang Province , No. 234 Gucui Road , Hangzhou 310012 , Zhejiang Province , China Animal Experimental Center, West China Hospital Sichuan University Chengdu China Institute of Oncology, Third Inpatient Building of Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China Shanghai Educational Development Co. Ltd Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, 650500, China Department of Dermatology, The First Affiliated Hospital of Jinan University, Guangzhou, Guangdong, China; Institute of Mycology, Jinan University, Guangzhou, Guangdong, China Key Laboratory of Green Chemical Engineering Process of Ministry of Education/Hubei Key Laboratory of Novel Reactor and Green Chemical Technology Institution Wuhan Institute of Technology Wuhan China Shanghai Skin Disease Hospital, Shanghai, China State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, Hong Kong Polytechnic University, Hong Kong SAR 999077, China Department of Biostatistics, School of Public Health and Health Professions; University at Buffalo; Buffalo New York From the Department of Spine Surgery, Institute of Drug Clinical Trial for Orthopedic Diseases, The Third Affiliated Hospital of Sun Yat-sen University; Guangdong Provincial Center for Engineering and Technology Research of Minimally Invasive Spine Surgery; and Guangdong Provincial Center for Quality Control of Minimally Invasive Spine Surgery, Guangzhou, China. International School of Information Science and Engineering, Dalian University of Technology, Dalian, China 1Department of Internal Medicine, Kochi Medical School, Nankoku, Kochi, Japan and Department of Chemistry and the Materials Research Center, Northwestern University, 2145 Sheridan Road, Evanston, Illinois 60208, United States Department of Ultrasound, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China College of Food and Biological Engineering, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources Jimei University Xiamen Fujian China Tianjin First Central Hospital, Tianjin, P.R. China Institute for Infectious Disease and Endemic Disease Control, Beijing Center for Disease Prevention and Control, Beijing, People’s Republic of China The Institute of Seawater Desalination and Multipurpose Utilization Ministry of Natural Resources (Tianjin) Tianjin 300192 China School of Public Health Fudan University Shanghai China; SKLORG, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204 Yunnan, China; University of Shanghai for Science and Technology Medical office, The Affiliated Hospital of Guizhou Medical University, Guiyang 550001, China. Faculty of Pharmaceutical Engineering, School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou People's Republic of China Key Laboratory of Green Chemistry & Technology of Ministry of Education; College of Chemistry; Sichuan University; Chengdu 610064; P. R. China Key Laboratory of Food Safety Research, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Department of Cardiology Fourth Affiliated Hospital of China Medical University Shenyang China Department of Cardiovascular Surgery, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of Materials Science and Engineering, California NanoSystems Institute (CNSI), University of California, Los Angeles, California 90095, United States Department of Environmental Science and Engineering, Tsinghua University, Beijing 100084, China. Institute of Modern Physics, Department of Nuclear Science and Technology, Fudan University 4 , Shanghai 200433, China; Key Laboratory of Nuclear Physics and Ion-Beam Application (MOE), Fudan University 5 , Shanghai 200433, China Yan'an Hospital of Kunming City, Kunming, China Department of Hematology, General Hospital of the Chinese PLA, Beijing 100853, China. Department of Chemistry and Biochemistry and Department of Materials Science and Engineering, University of Maryland, College Park, Maryland 20742, United States College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals Zhejiang University of Technology Hangzhou 310014 P. R. China 1Key Laboratory for Environment and Health (Ministry of Education), Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing, China Department of Dermatology, Affiliated Hospital of Southwest Medical University, Luzhou, People’s Republic of China †Tianjin Key Laboratory of Medical Epigenetics, Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin 300070, China; Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices Shaanxi Engineering Lab for Advanced Energy Technology School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 China Institute of Translational Medicine, Jilin University , Changchun, Jilin, China Faculty of Environment and Life Beijing University of Technology Beijing China College of Chemistry and Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling, Shaanxi 712100, PR China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853 Institute for Viral Hepatitis, Key Laboratory of Molecular Biology of Infectious Diseases of the Ministry of Education, Chongqing University of Medical Sciences, Chongqing, China. School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, People’s Republic of China; Key Laboratory of Green and Precise Synthetic Chemistry and Applications, College of Chemistry and Material Science, Huaibei Normal University, Huaibei 235000, People’s Republic of China Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100144, China CAS Key Laboratory of Behavioral Science, Center for Brain Science and Learning Difficulties Institute of Psychology, Chinese Academy of Sciences Beijing China; Department of Psychology University of Chinese Academy of Sciences Beijing China Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, People’s Republic of China Department of Chemistry Rice University 6100 Main Street Houston TX 77005 USA; Smalley Institute for Nanoscale Science and Technology Rice University 6100 Main Street Houston TX 77005 USA CAS Key Laboratory of Soft Matter Chemistry; Department of Chemistry; University of Science and Technology of China; Hefei; China College of Chemistry and Chemical Engineering Inner Mongolia University for the Nationalities Tongliao 028000 P. R. China Department of Materials Science and Engineering and California Nano Systems Institute University of California Los Angeles CA 90095 USA Guilin Medical University; Guilin 541004; P. R. China State Key Laboratory of Fine Chemicals; Zhang Dayu College of Chemistry; Dalian University of Technology; P. R. China Department of Pediatric, Xi’An NO.3 Hospital, Xi’an, Shaanxi Province, China School of Public Health, Sun Yat-sen University, Guangzhou, China Institute of Industrial Catalysis; School of Chemical Engineering and Technology; Xi'an Jiaotong University; Xi'an; China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China; Beijing Institute of Pharmacology and Toxicology, Beijing, China, School of Medicine, The Chinese University of HongKong, Shenzhen, China Department of Social Medicine School of Public Health Central South University Changsha Hunan China Department of Chemistry and Biochemistry; Rowan University; Glassboro; USA; Department of Chemistry State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China; Laboratory of Analytical Chemistry, Research Institute of Chemical Defence, Beijing 102205, China Diagnostic, Molecular and Interventional Radiology Icahn School of Medicine at Mount Sinai New York New York USA School of Biology, Yunnan University, Kunming 650500, China Department of Chemistry and Biochemistry, and Center for Single Molecule Biophysics, Biodesign Institute at Arizona State University, 1001 South McAllister Avenue, Tempe, Arizona 85287-5601, United States Authors' Affiliations: 1Department of Hematology, Xijing Hospital, Fourth Military Medical University; and 2Department of Bioengineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, Shaanxi, PR China Laboratory of Immunology and Virology, Shanghai University of Traditional Chinese Medicine, Shanghai, P. R. China Tongji Hospital Tongji University Shanghai China State Key Laboratory of Earth Surface Processes and Resource Ecology, and Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering, College of Life Sciences, Beijing Normal University , Beijing , China Department of Neurology and Suzhou Clinical Research Center of Neurological Disease, The Second Affiliated Hospital of Soochow University, Suzhou 215004, China; Institute of Neuroscience, Soochow University, 199 Renai Road, Suzhou, Jiangsu 215123, China Shanghai Key Laboratory of Bio-Energy Crops , School of Life Sciences, Shanghai University, Shanghai 200444, China; Shanghai Key Laboratory of Bio-Energy Crops , School of Life Sciences, Shanghai University, Shanghai 200444, China Department of Pharmacology, Guilin Medical University, Guilin, Guangxi 541000, P.R. China Key Laboratory for Stem Cells and Tissue Engineering, Ministry of Education, Sun Yat-sen University, Guangzhou 510080, China Key Laboratory for Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology, Meilong Road, 130, Shanghai 200237, P. R. China Pingshan General Hospital, Southern Medical University, Shenzhen 518118, China; Pingshan District Peoples’ Hospital of Shenzhen, Shenzhen 518118, China Shanghai Institute of Pharmceutical Industry No. 1320, Beijing West Rd. Shanghai 201203 China Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China; Shanghai Key Laboratory of Radiation Oncology, Shanghai 200032, China Department of Radiology at Tongji Hospital, Tongji Medical College, HUST, Wuhan, China Department of Biochemistry and Molecular Biology Augusta University Augusta GA USA Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing College of Chemistry Sichuan University Chengdu 610064 China School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, P. R. China State Key Laboratory of Pulp & Paper Engineering School of Light industry Science and Engineering South China University of Technology Guangzhou 510640 China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan 430072, China.; Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China. Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital, People’s Republic of China University of New South Wales Sydney NSW Australia Department of Mechanical Engineering, The University of Hong Kong, Hong Kong, China. Authors' Affiliations: 1Department of Cardiovascular Surgery, Xijing Hospital; Center for Infectious Disease Research, School of Medicine, Tsinghua University, Beijing 10084, China College of Geographic Science, Harbin Normal University, Harbin 150025, China. Department of Orthopaedics, Beijing Rehabilitation Hospital, Capital University of Medical Sciences, Beijing 100144, China Department of Epidemiology and Biostatistics School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Key Laboratory of Environment and Health Tongji Medical College Huazhong University of Science and Technology Ministry of Education & Ministry of Environmental Protection Wuhan China Clinical Laboratory, Huanghua Boai Hospital, Cangzhou, Hebei, China Third Department of Breast Surgery, The Third Affiliated Hospital of Kunming Medical University and Yunnan Cancer Hospital, Kunming, Yunnan 650118, P.R. China Department of Respiratory Medicine Zhejiang Provincial People's Hospital Hangzhou Zhejiang 310014 P.R. China; People's Hospital of Hangzhou Medical College Hangzhou Zhejiang 310014 P.R. China Department of Radiology, Tangdu Hospital, The Fourth Military Medical University, Xi’an 710038, Shaanxi, P.R. China Yang Yang, Manyu Li, and Hung-Chu Lin, Department of Psychology, University of Louisiana at Lafayette, Lafayette, LA;, Email: yang.yang@louisiana.edu Department of Cardiology First Hospital of Jilin University Changchun Jilin China School of Life Sciences Jilin University Changchun China Department of Gastroenterology, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing, China State Key Laboratory of Urban and Regional Ecology, Research Center for Eco‐Environmental Sciences, Chinese Academy of Sciences Beijing 100085 China Institute of Deep-Sea Science and Engineering, Chinese Academy of Science, Guangzhou 572000, China School of Mechanical Engineering and Automation, Beihang University, Beijing, China. Beijing Municipal Commission of Health and Family Planning, Beijing, China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine and State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200120 P. R. China Department of Genetics, School of Medicine, Stanford University , Stanford, California, USA College of Pharmacy, Harbin University of Commerce, Harbin, China Department of Spine Surgery, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 0086-510630, China European Synchrotron Radiation Facility, 38000 Grenoble, France; State Key Laboratory of Molecular Reaction Dynamics Dalian Institute of Chemical Physics Chinese Academy of Science Dalian 116023 P. R. China Key laboratory of Bio-resources and Eco-environment of the Ministry of Education, College of Life Sciences Sichuan University Chengdu Sichuan China Key Laboratory for Plant Diversity and Biogeography of East Asia Kunming Institute of Botany Chinese Academy of Sciences Kunming 650201 China Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei, China Organ Transplantation Center,Tianjin First Central Hospital,Tianjin,People’s Republic of China; Tianjin Key Laboratory for Organ Transplantation,Tianjin,People’s Republic of China Department of Mechanical Engineering San Diego State University Campanile Drive San Diego CA 92182 USA Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, The Third Military Medical University (Army Military Medical University), Chongqing, China Univ. Bordeaux, CNRS, Bordeaux INP, IMS, UMR 5218, F33400, Talence, France Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering University of Science and Technology of China Hefei 230026 China Department of Neurology, General Hospital of PLA, Beijing 100853, China. College of Pharmaceutical Science & Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals; Zhejiang University of Technology; Hangzhou 310014; China Department of Radiology, Affiliated Zhongshan Hospital of Dalian University, No. 6 Jiefang St, Zhongshan District, Dalian Liaoning 116001, China. Institute of Pharmacology and Toxicology, Medical Faculty, Rheinisch-Westfälische Technische Hochschule Aachen University, Aachen, Germany Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 China; Songshan Lake Materials Laboratory Dongguan Guangdong 523808 China School of Electrical and Energy Power Engineering, Yangzhou University, Yangzhou 225002, China School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA 98109, USA. Department of Urology The First Affiliated Hospital of Zhengzhou University Zhengzhou People's Republic of China Department of Orthopedics Tianjin Hospital Tianjin PR China Computational Biology Department School of Computer Science Carnegie Mellon University Pittsburgh PA 15213 USA State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China Advanced Catalysis Research Group, RIKEN Center for Sustainable Resource Science, 2-1 Hirosawa, Wako, Saitama 351-0198, Japan NIHR Applied Research Collaboration Greater Manchester, School of Health Sciences; The University of Manchester, and Manchester Academic Health Science Centre; Manchester UK Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University); Ministry of Education; College of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715 Department of Clinical Medicine, Guangdong Medical University, Zhanjiang 524023, P.R. China Department of Pharmacy, The Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou, China Laboratory of Fishes, Shanghai Ocean University, Shanghai, China;; Shanghai Key Laboratory of Marine Animal Taxonomy and Evolution, Shanghai, China Department of Chemistry, University of Massachusetts-Amherst, 240 Thatcher Way, Amherst, Massachusetts 01003, United States Division of NanoMedicine, Department of Medicine, ‡California NanoSystems Institute, §Department of Chemistry & Biochemisty, and ⊥Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States School of Computer Science and Technology, Soochow University, No1. Shizi Street, Suzhou, 215006 Jiangsu, China; Provincial Key Laboratory for Computer Information Processing Technology, No1. Shizi Street, Soochow University, Suzhou, 215006 Jiangsu, China Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China7Department of Hepatic Surgery, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, China National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, The Third People's Hospital of Shenzhen, Second Hospital Affiliated to Southern University of Science and Technology , Shenzhen 518112 , China Department of Physics, Freie Universität Berlin, Arnimallee 14, 14195 Berlin, Germany; Center for Supramolecular Interactions, Takustr. 3, 14195 Berlin, Germany Key Laboratory of Carbohydrate Chemistry and Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, Wuxi 214122, China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Institute of New Energy, Fudan University, Shanghai 200433, China China Zhongguancun Pharmaceutical Productivity Centre Beijing 101111, China. Key Laboratory of Drug Targeting and Drug Delivery System of Education Ministry, Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, Chengdu, P.R. China College of Veterinary Medicine, Institute of Traditional Chinese Veterinary Medicine, Nanjing, Jiangsu 210095, P. R. China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, P. R. China Fourth Affiliated Hospital of China Medical University, Huanggu, Shenyang 110032, Liaoning, China Department of Network Medicine, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, P.R. China Wood Technology and Wood Chemistry, Department of Wood Technology and Wood-based Composites, University of Goettingen, Büsgenweg 4, 37077 Göttingen, Germany Department of Prosthodontics, Peking University School and Hospital of Stomatology School of Computer Science and Engineering, Beihang University, Beijing, China Department of Health Education, West China School of Public Health, Sichuan University, Chengdu, China †Diabetes and Endocrine Research Group, and East China Normal University 3 Department of Physics, , Shanghai 200062, China; University of California 4 Department of Chemical Engineering and Materials Science, , Davis, California 95616, USA Hefei National Laboratory for Physical Sciences at Microscale Department of Materials Science & Engineering University of Science and Technology of China Hefei 230026 P. R. China; The Anhui Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field Laboratory Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei 230026 P. R. China Department of Pediatric Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang 330006, P.R. China Department of Civil and Environmental Engineering and California NanoSystems Institute; Department of Materials Science and Engineering; University of California, Los Angeles (UCLA), Los Angeles, California Department of Materials Science and Engineering, ‡California NanoSystems Institute, University of California, Los Angeles, California 90095, United States CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Chinese Academy of Sciences, Beijing 100190, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China; Department of General Dentistry West China Hospital of Stomatology Sichuan University Chengdu China Key Laboratory of TCM Clinical Pharmacy Shenzhen Bao'an Authentic TCM Therapy Hospital Shenzhen P. R. China Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230601, P.R. China. Department of Hepatic Surgery and Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, P.R. China State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Key Laboratory of Preparation and Application Environmentally Friendly Materials of Ministry of Education; Jilin Normal University; Siping 136000; P. R. China Authors' Affiliations: 1Department of Pathology, 2Center for Metabolic Bone Disease, and 3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama; 4G. Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy; 5sigma-tau Industrie Farmaceutiche Riunite S.p.A., Pomezia, Italy; 6sigma-tau Research, Mendrisio, Switzerland; 7National Cancer Institute, Foundation IRCCS, Milan, Italy; and 8Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel; Authors' Affiliations: 1Department of Pathology, 2Center for Metabolic Bone Disease, and 3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama; 4G. Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy; 5sigma-tau Industrie Farmaceutiche Riunite S.p.A., Pomezia, Italy; 6sigma-tau Research, Mendrisio, Switzerland; 7National Cancer Institute, Foundation IRCCS, Milan, Italy; and 8Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel; Authors' Affiliations: 1Department of Pathology, 2Center for Metabolic Bone Disease, and 3Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama; 4G. Ronzoni Institute for Chemical and Biochemical Research, Milan, Italy; 5sigma-tau Industrie Farmaceutiche Riunite S.p.A., Pomezia, Italy; 6sigma-tau Research, Mendrisio, Switzerland; 7National Cancer Institute, Foundation IRCCS, Milan, Italy; and 8Cancer and Vascular Biology Research Center, The Bruce Rappaport Faculty of Medicine, Technion, Haifa, Israel State Key Laboratory of Oncogenes and Related Genes, Center for Single‐Cell Omics, School of Public Health Shanghai Jiao Tong University School of Medicine Shanghai China; CAS Key Laboratory of Nutrition, Metabolism and Food Safety Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai China Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang Jiangxi China Department of Neurosurgery, Shengjing Hospital of China Medical University, Shenyang, China; Liaoning Clinical Medical Research Center in Nervous System Disease, Shenyang, China; Key Laboratory of Neuro-oncology in Liaoning Province, Shenyang, China Department of Neonates, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, P.R. China; Department of Child Healthcare, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, Jiangsu, P.R. China Department of Radiation Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450002, China. College of Pharmacy, Dalian Medical University, Dalian, Liaoning, China Department of Colorectal and Anal Surgery, Baoji People's Hospital, Baoji, China. Department of General Surgery, Hebei Medical University Fourth Affiliated Hospital and Hebei Provincial Tumor Hospital, Shijiazhuang 050000, Hebei, P.R. China Department of Laboratory Medicine and the Center for Stem Cell and Developmental Biology, and; Multiple Myeloma Treatment Center and Department of Hematology, The First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, Zhejiang, China; Key Laboratory of UV-Emitting Materials and Technology, Ministry of Education, Northeast Normal University, Changchun, Jilin 130024, China Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province, School of Life Sciences, Yunnan University, Kunming, Yunnan 650091, P.R. China Lab of Biorefinery Chinese Academy of Sciences Shanghai Advanced Research Institute Pudong Shanghai People's Republic of China Department of Respiratory Medicine, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou, Zhejiang, P.R. China; Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan, China. Research Institute of Social Development Southwestern University of Finance and Economics Chengdu China Department of Hematology Zhongshan Hospital, Fudan University Shanghai China Institute of Immunology, PLA, Third Military Medical University, Chongqing, China Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 China; School of Materials Science and Engineering Tongji University Shanghai 201804 China Department of Materials Science and Engineering University of California Los Angeles Los Angeles CA 90095 USA State Key Laboratory of Materials Processing and Die & Mould Technology, and School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan, Hubei 430074, People’s Republic of China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan China Department of Anesthesia, Affiliated Hospital of Zunyi Medical University, Zunyi 563000, China. Zunyi Medical University, Guizhou Provincial Key Laboratory of Fundamental Research on Anesthesiology and Organ Protection, Zunyi 563000, China. Center for Molecular Design and Biomimetics, The Biodesign Institute, Department of Chemistry and Biochemistry, Arizona State University, Tempe, Arizona 85287, United States State Key Laboratory of High-efficiency Utilization of Coal and Green Chemical Engineering, School of chemistry and Chemical Engineering, Ningxia University, Yinchuan, Ningxia 750021, PR China Faculty of Vehicle Engineering, Chongqing Industry Polytechnic College , Chongqing 401120, People's Republic of China yangyang911127@cqu.edu.cn State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005; China Department of Chemistry University of Cincinnati Cincinnati OH 45221 USA Department of Engineering Science, University of Oxford, Oxford, U.K. Clinical Medical College of Acupuncture and Rehabilitation, Guangzhou University of Chinese Medicine, Guangzhou State Key Laboratory of Common Mechanism Research for Major Diseases Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College Beijing 100005 China; Department of Biochemistry and Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College Beijing 100005 China Key Laboratory of Artificial Micro- and Nano-Structures of the Ministry of Education, Hubei Nuclear Solid Physics Key Laboratory, School of Physics and Technology, Wuhan University, Wuhan 430072, China; School of Science, Hubei University of Technology, Wuhan 430068, China Department of Gynaecology and Obstetrics, The First Affiliated Hospital of Xi’an Medical University, Xi’an 710077, Shaanxi, China Key Laboratory of TCM Clinical Pharmacy Shenzhen Bao'an Authentic TCM Therapy Hospital Shenzhen Guangdong China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),; Department of Biochemistry and Molecular Biology, and Department of Polymer Science & Engineering, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China School of Petrochemical Engineering, Changzhou University, Changzhou 213164, People’s Republic of China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine Nanjing 210028, China Jiangsu Province Academy of Traditional Chinese Medicine Nanjing 210028, China. Laboratory Department, People's Hospital of Leshan, Leshan, Sichuan Province, China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan, P. R. China COVID‐19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, The First School of Clinical Medicine Southern Medical University Nanjing China College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, 100083, China Department of Thoracic and Cardiovascular Surgery Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School Nanjing China; Department of Biomedical Engineering The Fourth Military Medical University Xi'an China Interfaculty Institute for Cell Biology Animal Genetics, Universität Tübingen Tübingen Germany College of Civil Engineering, Zhejiang University of Technology, Hangzhou 310023, China; Key Laboratory of Civil Engineering Structures & Disaster Prevention and Mitigation Technology of Zhejiang Province, Hangzhou 310023, China Drug Discovery and Design Center; Shanghai Institute of Materia Medica (SIMM); Chinese Academy of Sciences; Shanghai 201203; China Cancer Center; West China Hospital; West China Medical School; Sichuan University; Chengdu National Center for Nanoscience and Technology Zhong Guan Cun Bei Yi Tiao 11 Beijing 100190 P. R. China Department of Cardiology, The Third Hospital of Hebei Medical University, 050051 Shijiazhuang City, Hebei Province, China The Key Laboratory of Hematology of Jiangxi Province, The Department of Hematology, The Second Affiliated Hospital of Nanchang University, 1 Minde Road, Nanchang, 330006 Jiangxi, China; Graduate School of Medicine, Nanchang University, 465 Bayi Road, Nanchang, 330006 Jiangxi, China The National Engineering Research Centre for Wheat, Henan Agricultural University, Zhengzhou, 450002, China Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302 United States 1 Department of Respiratory and Infectious Disease of Geriatrics, The First Hospital of China Medical University , Shenyang , Liaoning Province , China ; Department of Respiratory Medicine Jiangning Hospital Nanjing Medical University Nanjing China Guangzhou Institute of Chemistry Chinese Academy of Sciences Xingke Road 368 510675 Guangzhou P. R. China; Key Laboratory of Cellulose and Lignocellulosics Chemistry Chinese Academy of Sciences 510650 Guangzhou P. R. China; Guangdong Provincial Key Laboratory of Organic Polymer Materials for Electronics 510650 Guangzhou P. R. China Zhang Dayu College of Chemistry, State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China Department of Psychiatry, Beijing Anding Hospital, Beijing 100029, China Department of Urological Surgery, China Three Gorges University Affiliated Yichang City First People's Hospital, Yichang, Hubei 443000, P.R. China The University of Manchester School of Health Sciences, Faculty of Biology, Medicine and Health, , Manchester M13 9PL , UK; Manchester Academic Health Science Centre , Manchester M13 9NQ , UK; The University of Manchester NIHR Applied Research Collaboration Greater Manchester, , Manchester M13 9PL , UK Department of Cardiology The First Affiliated Hospital of Anhui Medical University Hefei Anhui China Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. ESRF, The European Synchrotron, 38000 Grenoble, France Department of Experimental Hematology, Beijing Institute of Radiation Medicine, Beijing, China. College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021 Fujian, P.R. China Department of Food Nutrition, College of Food Science and Technology Huazhong Agricultural University Wuhan China Fudan University 1 EBIT Laboratory, Institute of Modern Physics, , Shanghai 200433, People's Republic of China; Fudan University 2 The Key Laboratory of Applied Ion Beam Physics (Ministry of Education), , Shanghai 200433, People's Republic of China Beijing National Laboratory for Molecular Science, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing, 100871, People's Republic of China Department of Ophthalmology Affiliated Hospital of Weifang Medical University Weifang Shandong China Georgetown University Medical Center, Washington, D.C. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, School of Life Sciences and Medicine, Northwest University , Xi'an , China; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, School of Life Sciences and Medicine, Northwest University , Xi'an , China School of Chemistry Dalian University of Technology Dalian 116024 China Department of Geriatrics and Secret Service, First Affiliated Hospital, Army Medical University, Chongqing, China National Key Discipline of Human Anatomy School of Basic Medical Sciences Southern Medical University Guangzhou China; Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangzhou China School of Physics and Electronic Information Engineering, Henan Polytechnic University, Jiaozuo 454003, China Department of Translational Medicine Center The First Affiliated Hospital of Zhengzhou University Zhengzhou China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Department of Ophthalmology, Yan'an Hospital, Kunming 650051, China. cnynyy@163.com State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology, Sichuan University Chengdu China; Department of General Dentistry West China Hospital of Stomatology, Sichuan University Chengdu China Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States Key Laboratory of Low‐Grade Energy Utilization Technologies and Systems Institute of Engineering Thermophysics Chongqing University Chongqing 400030 P.R. China; Department of Chemistry and Biochemistry University of California ‐ Santa Cruz Santa Cruz CA 95064 USA Department of Medicinal Chemistry and Molecular Pharmacology College of Pharmacy, Purdue University West Lafayette Indiana USA; Purdue Institute for Integrative Neuroscience Purdue University West Lafayette Indiana USA Key Laboratory of Environmental Pollution Monitoring and Disease Control , Ministry of Education & School of Public Health, , Dongqing Road 2, Guiyang 550025 , China; Guizhou Medical University , Ministry of Education & School of Public Health, , Dongqing Road 2, Guiyang 550025 , China Cardiology Department The First Affiliated Hospital of Anhui Medical University Hefei Anhui China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University Xi’an China MOE Key Laboratory of Advanced Micro-Structured Materials, Institute of Precision Optical Engineering, School of Physics Science and Engineering, Tongji University, Shanghai 200092, China Department of Neurosurgery Tangdu Hospital The Fourth Military Medical University Xi'an China Institute of Deep-Sea Science and Engineering, Chinese Academy of Sciences, Sanya, Hainan, 572000, P. R. China Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, China. CMC Analytical Department, Frontage Lab Inc, Exton, PA Key Laboratory of Applied Technology on Green‐Eco‐Healthy Animal Husbandry of Zhejiang Province Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology College of Animal Science and Technology College of Veterinary Medicine Zhejiang A&F University Lin'an Zhejiang China School of Chemical Science and Engineering; School of Life Science and Technology; Shanghai Key Laboratory of Chemical Assessment and Sustainability; Tongji University; Shanghai 200092 Department of Orthopedics, the First Affiliated Hospital of Zhejiang University, Hangzhou 310006, China. School of Life Sciences Yunnan University Kunming P. R. China; Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P. R. China Department of Hip Traumatology Tianjin Hospital Tianjin China International Medicine Center, Tianjin Hospital, 406 Jiefang South Road, Hexi District, Tianjin 300211, China Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy Northwest A&F University Yangling 712100 China Department of Radiology, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China. Department of Traumatic Orthopedics, Beijing Jishuitan Hospital Guizhou Hospital, Guiyang, Guizhou, China (mainland) Department of Radiation Oncology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China Department of Chemistry, ‡Smalley Institute for Nanoscale Science and Technology, §Department of Materials Science and NanoEngineering, and ∥Department of Computer Science, Rice University, 6100 Main Street, Houston, Texas 77005, United States Breast Disease Center Peking University People’s Hospital Beijing China Department of Orthopaedics, Gansu Provincial Hospital, Lanzhou 730000, Gansu, China Department of Chemical and Materials Engineering University of Alberta Edmonton Alberta T6G 1H9 Canada Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China; Xihua University, School of Energy and Environment, Chengdu 610039, China Department of Pathology, Cancer Research Center, Yanbian University Medical College, Yanji 133002, China College of Animal Science, Shanxi Agricultural University, Taigu, Jinzhong 030801, China Department of Neurology, Shanghai Second People’s Hospital, Shanghai 200011, P. R. China Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong 226001, China Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry; College of Chemistry and Chemical Engineering; Lanzhou University; Lanzhou 730000; P. R. China Nanjing University of Science and Technology, Nanjing, China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy, Jiangxi Science & Technology Normal University, 605 Fenglin Road, Nanchang 330013, China Office of Biostatistics Research, National Heart, Lung, and Blood Institute, Bethesda, Maryland; Departments of Thoracic Surgery, Yan'an University Affiliated Hospital, Yan'an, PR China Liver Transplantation Center and Department of Hepatic Surgery Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Oral and Maxillofacial & Head and Neck Oncology Beijing Stomatological Hospital Capital Medical University Beijing China Key Laboratory of Pollinating Insect Biology, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing, China Clinical Systems Biology Laboratories, Translation Medicine Center The First Affiliated Hospital of Zhengzhou University, Zhengzhou University Zhengzhou Henan China School of Kinesiology, Shanghai University of Sport, Shanghai, China. College of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China Department of Oral Implantology; Guanghua School of Stomatology; Hospital of Stomatology; Sun Yat-Sen University; Guangzhou Paediatric Cardiac Surgery Centre, Fuwai Hospital, National Centre for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Tumor Immunology and Gene Therapy center, Shanghai Eastern Hepatobiliary Surgery Hospital, Shanghai, China State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China Center for MRI Research, Academy for Advanced Interdisciplinary Studies Peking University Beijing China; Beijing City Key Lab for Medical Physics and Engineering Institution of Heavy Ion Physics, School of Physics, Peking University Beijing China Faculty of Physics Bielefeld University Universitätsstraße 25 33615 Bielefeld Germany Yunnan Baiyao Group Shanghai Science & Technology Co., Ltd., Shanghai 201100, China; East Asia Skin Health Research Center, Beijing 100037, China Department of Neurology, Chinese PLA General Hospital, Beijing 100853, China. Nanshan College, Guangzhou Medical University, Guangzhou, Guangdong, China. Zhejiang Key Laboratory of Organ Development and Regeneration College of Life and Environmental Sciences, Hangzhou Normal University Hangzhou China Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305-5318 Shenzhen University; Key Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong Province Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children′s Hospital, National Center for Children′s Health, Capital Medical University, Beijing, China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing, China Wuhan National Laboratory for Optoelectronics (WNLO) and School of Optical and Electronic Information, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan 430074, P. R. China; School of Integrated Circuits and Wuhan National Laboratory for Optoelectronics (WNLO), Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Chemistry and Theoretical Chemistry Institute, University of Wisconsin, Madison, 1101 University Avenue, Madison, Wisconsin 53706 Department of Neurosurgery, Qilu Hospital, Shandong University, Jinan, China Department of Neurosurgery and Key Laboratory of Neurotrauma, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing 400038, China;Department of Neurosurgery, The 904th Hospital of PLA, School of Medicine of Anhui Medical University, Wuxi 214044, Jiangsu, China. Department of Pathology, The Second Affiliated Hospital of Guilin Medical University, Guilin, Guangxi, China (mainland) Department of Thoracic Surgery Huadong Hospital Affiliated to FuDan University Shanghai China; Department of Thoracic Surgery Shanghai Chest Hospital, Shanghai Jiao Tong University Shanghai China Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin, People's Republic of China. Department of Pediatric Transplantation, Tianjin First Central Hospital, Tianjin, China.; Tianjin Key Laboratory for Organ Transplantation, Tianjin, China. Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Guangzhou, China Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan, China Department of Plant Biosecurity and MARA Key Laboratory of Surveillance and Management for Plant Quarantine Pests College of Plant Protection China Agricultural University Beijing China The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, 321 Zhongshan Road, Nanjing 210008, China Department of Hepatic Surgery and Liver Transplantation Center the Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China; Organ Transplantation Research Center of Guangdong Province Guangzhou China; Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes the Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Basic Medical College The Third Department of Urology (Renal Transplant), Dalian Friendship Hospital, Dalian, Liaoning, China Department of Hepatology Qilu Hospital of Shandong University Jinan China Department of Oncology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China 1Department of Hematology and Respiratory Medicine, Kochi Medical School, Kochi University, Kochi, Japan and National Center for Nanoscience and TechnologyBeiyitiao 11, Zhongguancun Beijing 100190 China State Key Laboratory of Power Transmission Equipment Technology, Chongqing University, Shapingba District, Chongqing 400044, China Department of Epidemiology and Biostatistics, Tongji Medical College Huazhong University of Science and Technology Wuhan China The Institute of Vegetable and Flower Research, Chongqing Academy of Agricultural Sciences, Chongqing, China Pharmacy School, Guilin Medical University, Guilin 541004, China College of Aerospace Engineering; Chongqing University; Chongqing, China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming China Department of Chemistry, School of Science, Shanghai University School of Materials Science and Engineering; Tianjin Key Laboratory of Composite and Functional Materials; Tianjin University; Tianjin; China Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Beijing National Laboratory of Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China International Joint Cancer Institute, The Second Military Medical University, Shanghai, People's Republic of China State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China; School of Science, Tianjin Chengjian University, Tianjin JinJing Road, 26, Xiqing District, Tianjin 300384, P. R. China Department of Anesthesia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer, Tianjin, 300060, China Cadre Sanatorium of Hainan & Geriatric Hospital of Hainan (CSH), Hainan, Haikou, China. Henan Engineering Research Center of Industrial Enzymes, Biology Institute of Henan Academy of Sciences, Zhengzhou 450008, PR China School of Electronics and Information, Henan Key Laboratory of Magnetoelectronic Information Functional Materials, Zhengzhou University of Light Industry, Henan 450002, China Shenzhen Baoan Authentic TCM Therapy Hospital; Shenzhen; China Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China State Key Laboratory of Precision Measuring Technology and Instruments, College of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People's Republic of China. Department of Neuroscience, University of Connecticut Health Center, University of Connecticut, Farmington, CT 06032 Department of Hepatic Surgery and Liver Transplantation Center Guangdong Key Laboratory of Liver Disease Research The Third Affiliated Hospital of Sun Yat-Sen University Guangzhou 510630 China National Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Faculty of Basic Medicine of Peking Union Medical College, Beijing 100005, China. Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, Jiangsu, China Department of Ophthalmology, Qilu Children's Hospital of Shandong University China Academy of Engineering Physics, Institute of Nuclear Physics and Chemistry, Mianyang, Sichuan, China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States Department of Chemistry; University at Albany; SUNY; Albany; USA Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China Beijing National Laboratory for Condensed Matter Physics Institute of Physics Chinese Academy of Sciences Beijing 100190 P. R. China; College of Materials Science and Optoelectronic Technology University of Chinese Academy of Sciences Beijing 100049 P. R. China Department of Statistics, University of Georgia Franklin College of Arts and Sciences, Athens, GA, USA South China Agricultural University Key Laboratory of Horticultural Crop Biology and Germplasm Innovation in South China, Ministry of Agriculture, College of Horticulture, , Guangzhou 510642, China Anemia Therapeutic Centre, State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Tianjin China Institute of Genetics and Cytology, The Key Laboratory of Molecular Epigenetic of Ministry of Education (MOE), Northeast Normal University, Changchun 130024, China; Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing 100875, China School of Chemistry and Materials Science Jiangsu Normal University Xuzhou P. R. China Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), State Key Laboratory of Polymer Materials Engineering, National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), College of Chemistry, Sichuan University, Chengdu 610064, P. R. China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, College of Life Sciences Shaanxi Normal University Xi'an China West China Hospital of Stomatology, Sichuan University, Chengdu, China. Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Tsinghua University; Beijing; P. R. China Shenzhen Crystalo Biopharmaceutical Co, Ltd, Shenzhen, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu, China Department of Physics, Free University of Berlin , Arnimallee 14, D-14159 Berlin, Germany Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 Shanghai Roche Pharmaceuticals Ltd., Shanghai, PR China. Department of Biomedical Engineering; University of Virginia; Charlottesville; Virginia; USA Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China; College of Life Science, Northeast Agricultural University, Harbin 150030, China AbbVie Inc, North Chicago, Illinois State Key Laboratory of Reproductive Medicine Department of Histology and Embryology, Nanjing Medical University Nanjing China College of Food and Biological Engineering; Xiamen Key Laboratory of Marine Functional Food; Fujian Provincial Engineering Technology Research Center of Marine Functional Food; Jimei University; Xiamen Key Laboratory of Pollinating Insect Biology of Agriculture Institute of Apicultural Research, Chinese Academy of Agricultural Sciences Beijing China Departments of Medicine, Cardiovascular Division University of Virginia Health System Charlottesville Virginia Core Facility of Gene Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University Province-Ministry Co-construction Collaborative Innovation Center of Hebei Photovoltaic Technology, College of Physics Science and Technology, Hebei University, Baoding, Hebei 071002, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) , Breast Center, , No. 52 Fu Cheng Road, Hai Dian District, Beijing 100142 , China; Peking University Cancer Hospital & Institute , Breast Center, , No. 52 Fu Cheng Road, Hai Dian District, Beijing 100142 , China Department of Chemistry, University of Massachusetts─Amherst, 240 Thatcher Road, Amherst, Massachusetts 01003, United States College of Animal Sciences and Technology, Zhejiang A&F University, Lin'an, China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P.R. China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China Department of Cardiovasology, The First Affiliated Hospital, Hainan Medical University, Haikou 570100, China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, China Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi'an, Shaanxi 710071, China SKLORG & Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu, China; Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu, China; State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210097, China Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Department of Biological Sciences Purdue University, West Lafayette, Indiana, USA Department of Pathology and Laboratory Medicine, University of North Carolina , Chapel Hill , NC 27599 , USA; Lineberger Comprehensive Cancer Center, University of North Carolina , Chapel Hill , NC 27599 , USA State Grid Sichuan Electric Power Company, Information Communication Company, Chengdu 610041, China Department of Ophthalmology Renmin Hospital of Wuhan University Wuhan China National Observation and Research Station for Yangtze Estuarine Wetland Ecosystems Ministry of Education Key Laboratory for Biodiversity Science and Ecological Engineering Institute of Biodiversity Science School of Life Sciences Fudan University #2005 Songhu Road Shanghai 200438 China Institute of Human Virology, Department of Pathogen Biology and Biosecurity, and Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine Sun Yat‐sen University Guangzhou China Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 China School of Chemistry and Physics Faculty of Science Queensland University of Technology Brisbane QLD 4001 Australia; Centre for Materials Science Queensland University of Technology Brisbane QLD 4000 Australia Beijing Advanced Innovation Center for Food Nutrition and Human Health, College of Food Science and Nutritional Engineering, China Agricultural University, Beijing, China Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P. R. China Department of Ophthalmology, Affiliated Hospital of Weifang Medical University, No. 2428 Yuhe Road, Weifang 261031, Shandong, China Yang Yang is Assistant Professor of Sociology and faculty research associate of the Center on Aging and Population Research Center at NORC and the University of Chicago. Her current substantive interests include the demography of aging, social differentials in life course trajectories of health, and social stress and psychosocial coping resources. Her current methodological interests focus on new statistical models and methods for cohort analysis and mathematical demography. Organ Transplantation Center Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China School of Public Health Institute of Nutrition and Health Qingdao University Qingdao Shandong 266021 China The Collaborative Innovation Center for Eco‐Friendly and Fire‐Safety Polymeric Materials(MoE) National Engineering Laboratory of Eco‐Friendly Polymeric Materials (Sichuan) State Key Laboratory of Polymer Materials Engineering College of Chemistry Sichuan University Chengdu 610064 China State Key Joint Laboratory of Environment Simulation and Pollution Control, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. Department of Hematology The First Affiliated Hospital of Guangxi Medical University Nanning P.R. China Department of Thoracic Surgery, Shanghai Pulmonary Hospital, School of Medicine, Tongji University, Shanghai 200433, China; School of Materials Science and Engineering, Tongji University, Shanghai, 201804, P.R. China Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, 310003 Hangzhou, China; State Key Lab of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, People’ s Republic of China Ardelyx, Inc., Fremont, California State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Sciences, South China Agricultural University , Guangzhou 510642 , China Department of Chemistry Rice University 6100 Main Street Houston Texas 77005 USA; Smalley Institute for Nanoscale Science and Technology Rice University 6100 Main Street Houston Texas 77005 USA Department of Orthopedics, Academy of Orthopedics of Guangdong Province, the Third Affiliated Hospital, Southern Medical University, Guangzhou, China Department of Chemical Engineering, Imperial College London, London SW7 2AZ, UK The Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology; Department of Chemistry; Tsinghua University; Beijing 100084; China School of Materials, Sun Yat-Sen University, Guangzhou 510275, China Department of Pathology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou China College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005; China Department of Breast and Thyroid Surgery, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China Center for Infection and Immunity and Guangdong Provincial Key Laboratory of Biomedical Imaging, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai, Guangdong Province, China; The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, Guangdong Province, China Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, Connecticut 06520-8114, United States Shanghai Key Laboratory of Regulatory Biology; The Institute of Biomedical Sciences and School of Life Sciences; East China Normal University; Shanghai; China State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China; Department of Epidemiology, Shanghai Cancer Institute Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China Department of Biostatistics, College of Public Health and Health Professions, Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA Department of Breast Center, Peking University People's Hospital, No.11 Xizhimen South Street, Xicheng District, Beijing, People's Republic of China Department of Health Toxicology and Hygiene Inspection School of Public Health Xi'an Jiaotong University Health Science Center China Department of Gynecology and Obstetrics The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China; Department of Gynecology and Obstetrics The First Affiliated Hospital of Xi’an Medical University Xi’an China Department of Microbiology and Infectious Diseases and Laboratory of Viral and Immunopathogenesis of Diabetes, Julia McFarlane Diabetes Research Center, Faculty of Medicine, University of Calgary, Calgary, Alberta, Canada College of Food Science and Technology, Huazhong Agricultural University, Wuhan, China Department of Orthopaedics Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China for the TESTING Study Group Faculty of Health Sciences, University of Macau, Taipa, Macau S.A.R, China Department of Pathology, New York University School of Medicine, New York, NY, USA R&D Department Yunnan Baiyao Group Health Products Co., Ltd Kunming Yunnan China; R&D Department East Asia Skin Health Research Center Beijing China; R&D Department Yunnan Baiyao Group Shanghai Science & Technology Co., Ltd Shanghai China Research Programs Unit, Molecular Neurology, University of Helsinki, Fabianinkatu 33, Helsinki 00014, Finland UNIAX Corporation, 6780 Cortona Drive, Santa Barbara, California 93117 National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China State Key Laboratory of Molecular Oncology Cancer Institute (Hospital) Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China; Department of Histology and Embryology Anhui Medical University Hefei China Department of Infectious Diseases, Beijing You An Hospital Capital Medical University, Beijing Institute of Hepatology Beijing China College of Life Science, Northeast Agricultural University, Harbin, China. State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1679, USA Department of Spine Surgery, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou Guangdong, 510630, P. R. China. Department of Pharmaceutical Engineering, China Pharmaceutical University, Nanjing 211198, China Beijing Advanced Innovation Center for Future Internet Technology, Beijing University of Technology Beijing China; Department of Life Science and Informatics Maebashi Institute of Technology Maebashi Japan; Beijing International Collaboration Base on Brain Informatics and Wisdom Services Beijing China; Beijing Key Laboratory of MRI and Brain Informatics Beijing China Herman B Wells Center for Pediatric Research Department of Pediatrics Indiana University School of Medicine Indianapolis IN USA Department of Materials Science and Engineering University of California Los Angeles CA 90095 USA School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA Department of Chemical Engineering, Loughborough University, Loughborough, LeicestershireLE11 3TU, U.K. Department of Critical Care Medicine, Fifth Medical Center of PLA General Hospital, Beijing, China Department of Chemistry, College of Chemistry and Materials Science, Jinan University, Guangzhou 510632, P. R. China The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan 511518, Guangdong Province, People's Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces Pen‐Tung Sah Institute of Micro‐Nano Science and Technology College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Institute of Digestive Endoscopy and Medical Center for Digestive Diseases Second Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu 210000 P. R. China; Nanjing Medical University Nanjing Jiangsu 210000 P. R. China *Red Cell Physiology Laboratory and Department of Civil and Environmental Engineering Nanyang Technological University 50 Nanyang Avenue Singapore City 639798 Singapore Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Chongqing Clinical Research Center for Neurosurgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, China; Department of Neurosurgery, The 904th Hospital of PLA, School of Medicine of Anhui Medical University, Wuxi, Jiangsu Province, China School of Food and Biological Engineering, Hefei University of Technology, Hefei, P.R. China Department of Dermatology Xijing Hospital Fourth Military Medical University Xi'an China Department of Materials Science and Engineering, College of Chemistry and Materials Science, Jinan University, Guangzhou 511436, China Department of Chemical Engineering, ‡Department of Materials Science and Engineering, and §California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Department of Chemistry & The State Key Laboratory of Molecular Engineering of Polymers & Institute of Biomedicine Science; Fudan University; Shanghai, P. R. China Department of Statistics, Franklin College of Arts and Science, University of Georgia, Athens, Georgia, USA Dalian Institute of Chemical Physics Chinese Academy of Sciences 457 Zhongshan Road Dalian 116023 China National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China; Guangdong Provincial Medical Biomechanical Key Laboratory, School of Basic Medical Sciences, Southern Medical University, Guangzhou, P.R. China Department of Cell Biology and Institute of Biomedicine, College of Life Science and Technology, Jinan University, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, Guangzhou, Guangdong, China Department of Pathology, First Affiliated Hospital; Sun Yat-Sen University; Guangzhou People's Republic of China Department of Life Sciences, Datong University, Datong, China. Key Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission , Yanji 133000 , China; Research and Innovation Group of Yanbian University, Yanbian University Medical College , Yanji 133000 , China Department of Clinical Laborabtorial Examination, College of Integrated traditional Chinese and Western Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, Fujian Province, China. Electrical Engineering Division, Engineering Department, University of Cambridge, 9 JJ Thomson Avenue, CB3 0FA, Cambridge, U.K. Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China Zhejiang Key Laboratory of Radiation Oncology, Departments of Radiation Therapy Department of Neurology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China MOE Key Laboratory of Bioinformatics Center for Plant Biology School of Life Sciences Tsinghua University Beijing 100084 China Department of Clinical Pharmacy, School of Pharmacy Guangdong Pharmaceutical University Guangzhou China; Guangzhou Key Laboratory of Construction and Application of New Drug Screening Model Systems Guangdong Pharmaceutical University Guangzhou China; Key Laboratory of New Drug Discovery and Evaluation of Ordinary Universities of Guangdong Province Guangdong Pharmaceutical University Guangzhou China School of Chemical Engineering, Dalian University of Technology, Dalian 116024, China Wood Technology and Wood Chemistry, Department of Wood Technology and Wood-based Composites, Georg-August-University of Göttingen, Büsgenweg 4, D-37077 Göttingen, Germany; State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, 510640 Guangzhou, P. R. China Department of Chemistry, Zhejiang University, Hangzhou 310027, People’s Republic of China, and Department of Materials Science and Engineering, University of California, Los Angeles, California 90095 University of Georgia Department of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071; P. R. China National Clinical Research Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Key Laboratory of Radiopharmaceuticals, Beijing Normal University, Ministry of Education, Beijing 100875, China Department of Plastic and Reconstructive Surgery, Zhongshan Hospital, Fudan University, No. 180 Feng Lin Road, Shanghai, 200032, China. National Engineering Research Center for Biomaterials Sichuan University Chengdu 610064 China Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research and Utrecht Institute for Pharmaceutical Sciences, University of Utrecht, Padualaan 8, 3584 CH Utrecht, The Netherlands; Netherlands Proteomics Center, Padualaan 8, 3584 CH Utrecht, The Netherlands Department of Microbiology and Immunology, Albert Einstein College of Medicine Bronx, New York, USA State Key Lab of Clean Energy Utilization, State Environmental Protection Engineering Center for Coal-Fired Air Pollution Control, Zhejiang University, 38 Zheda Road, Hangzhou 310027, P. R. China Department of Materials Science and Engineering and California NanoSystems Institute; University of California Los Angeles; Los Angeles; USA Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China. Department of Industrial and Mechanical Engineering Northeastern University 360 Huntington Ave Boston MA 02115 USA Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, China Key Laboratory of Brain, Cognition and Education Sciences(South China Normal University), Ministry of Education, China; School of Psychology, South China Normal University, China; Center for Studies of Psychological Application, South China Normal University, China; Guangdong Key Laboratory of Mental Health and Cognitive Science, South China Normal University, China Epstein Department of Industrial and Systems Engineering Department of Aerospace and Mechanical Engineering Viterbi School of Engineering University of Southern California 3715 McClintock Ave Los Angeles CA 90089‐01932 USA Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, Guangdong, China. Department of Neurology, Xi’an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi’an No. 3 Hospital, the Affiliated Hospital of Northwest University. School of Life Sciences and Medicine, Northwest University, Xi’an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences, Northwest University, Xi’an, China State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China Department of Pediatrics, Division of Neonatology The Affiliated Hospital of Southwest Medical University Luzhou China; Department of Perinatology The Affiliated Hospital of Southwest Medical University Luzhou China; Sichuan Clinical Research Center for Birth Defects The Affiliated Hospital of Southwest Medical University Luzhou China State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology & Blood Diseases Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, China; Wenrui Yang, Xu Liu, Xin Zhao, Li Zhang, Guangxin Peng, Lei Ye, Kang Zhou, Yuan Li, Jianping Li, Huihui Fan, Yang Yang, Youzhen Xiong, Fengkui Zhang is also affiliated to Tianjin Institutes of Health Science, Tianjin, China Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering, CAS High Magnetic Field Laboratory, University of Science and Technology of China (USTC), Hefei 230026, China Department of Tumor and Blood Disease The Affiliated Hospital to Changchun University of Chinese Medicine Changchun China The Second Affiliated Hospital of Shenyang Medical College, Shenyang 110031, China Department of Tumor and Blood Disease, The Affiliated Hospital to Changchun University of Chinese Medicine, Changchun, Jilin 130021, P.R. China Department of Pharmacology, School of Basic Medical Sciences & State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai China; School of Pharmacy, Fudan University & Key Laboratory of Smart Drug Delivery, Ministry of Education Fudan University Shanghai China The 71st Group Army Hospital of CPLA Army (Affiliated Huaihai Hospital of Xuzhou Medical University), Xuzhou, China Department of Laboratory Medicine, Peking Union Medical College Hospital, Beijing, China; Beijing Key Laboratory for Mechanisms Research and Precision Diagnosis of Invasive Fungal Diseases, Beijing, China a Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China Department of Plastic Surgery Zhongshan Hospital Fudan University Shanghai 200032 P. R. China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Hepatology, Qilu Hospital of Shandong University; Institute of Hepatology, Shandong University University of Chinese Academy of Sciences, PR China; Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Department of Oncology, Xijing Hospital, The Fourth Military Medical University, Xi’an, China State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, Life Sciences School, Sun Yat-sen University, Guangzhou 510275, China; Key Laboratory of Tropical Marine Fish Germplasm Innovation and Utilization, Ministry of Agriculture, Sanya 572025, China; Key Laboratory of Tropical Aquatic Germplasm of Hainan Province, Sanya 572025, China Department of Oncology, Gulou Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Institute of Neuroscience, Zhejiang University School of Medicine Hangzhou 310058 China Department of Gastroenterology, The Second People's Hospital of Taizhou, Medical College of Yangzhou University, Jiangyan, Taizhou, Jiangsu 225500, P.R. China Department of Hematology; The First Affiliated Hospital of Guangxi Medical University; Nanning China School of Nursing, Shandong University, Jinan, China Department of Cardiac Surgery, Peking University First Hospital, Beijing 100034, China. yangsoleil@sohu.com Department of Biomedical Engineering, The Fourth Military Medical University, Xi’an, China; Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China Department of Thoracic Surgery Shanghai Pulmonary Hospital Institute for Advanced Study Tongji University Shanghai 200430 China School of Chemistry; Bio21 Institute of Molecular Science and Biotechnology; The University of Melbourne; Victoria 3010; Australia Key Lab of Inorganic Special Functional Materials; Chongqing Municipal Education Commission; School of Chemistry and Chemical Engineering; Yangtze Normal University; Fuling MOE Joint International Research Laboratory of Animal Health & Food Safety, Nanjing Agricultural University, Nanjing, People’s Republic of China; Key Laboratory of Animal Physiology & Biochemistry, Nanjing Agricultural University, Nanjing, People’s Republic of China Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, California 94720, United States Department of Obstetrics and Gynecology, Qilu Hospital of Shandong University , Jinan, Shandong, 250012 , China Center for Neuroimaging Shenzhen Institute of Neuroscience Shenzhen 518057 China Department of Neurology, Shanghai Second People’s Hospital, Shanghai 200011, China Department of Pathology and Cancer Research Center, Yanbian University Medical College, Yanji, China The Collaborative Innovation Center for Eco-Friendly and Fire-Safety Polymeric Materials (MoE), National Engineering Laboratory of Eco-Friendly Polymeric Materials (Sichuan), State Key Laboratory of Polymer Materials Engineering, College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China; Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Department of Neurology, Beijing Tiantan Hospital Capital Medical University Beijing China; China National Clinical Research Center for Neurological Diseases Beijing China Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Third People’s Hospital, Shenzhen, China. Ministry of Education, Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Xi’an 710069, China; Biomedicine Key Laboratory of Shaanxi Province, College of Life Sciences, Northwest University, Xi’an 710069, China Department of Health-related Social and Behavioral Sciences Department of Biostatistics, University of Florida, Gainesville, FL 32610;; Emerging Pathogens Institute, University of Florida, Gainesville, FL 32610; Department of Material Science and Engineering University of California Los Angeles Los Angeles CA 90095 USA Department of Neonatology, Children's Hospital Affiliated to Nanjing Medical University, Nanjing 210008, Jiangsu Province, China. College of Environmental & Resource Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province 410013, China; Xiangya School of Medicine, Central South University, Changsha, Hunan Province 410013, China State Key Lab of Physical Chemistry of Solid Surfaces; Collaborative Innovation Center of Chemistry for Energy Materials; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen Key Research Base of Humanities and Social Sciences of Ministry of Education, Academy of Psychology and Behavior, Tianjin Normal University, Tianjin, China; Faculty of Psychology, Tianjin Normal University, Tianjin, China; Tianjin Social Science Laboratory of Students' Mental Development and Learning, Tianjin, China School of Mechanical Engineering and Automation Beihang University Beijing China Department of Pharmacodynamics, College of Pharmacy, University of Florida, Gainesville, FL 32610, USA; Pharmacology and Therapeutics Graduate Program, Department of Pharmacology and Therapeutics, College of Medicine, University of Florida, Gainesville, FL 32610, USA Department of Neonatolgy, Nanjing Children′s Hospital of Nanjing Medical University, Nanjing 210008, China. yy860508@163.com. Department of Orthopedics, 960th Hospital of PLA, Jinan 250031, China Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing 100191, China Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN 55455; Liver Transplantation Center, Third Affiliated Hospital/Institute of Organ Transplantation, Sun Yat-sen University, Guangzhou 510630, China. yysysu@163.com Organic Solids Laboratory; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190, China Department of Geriatric Hematology, Chinese PLA General Hospital, Beijing 100853, China. Zhejiang Agriculture and Forestry University Hangzhou 311300, China. Jiangsu Provincial Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University Key Laboratory of Animal Cellular and Genetics Engineering of Heilongjiang Province, College of Life Science Northeast Agricultural University Harbin China Institute of Port, Coastal and Offshore Engineering, Ocean College, Zhejiang University, Zhoushan, Zhejiang, China. Luzhou Pinchuang Technology Co., Ltd. (National Engineering Research Center of Solid‐State Brewing) Luzhou China Department of Pediatric, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang, China National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, People’s Republic of China Department of Bioinformatics, Megagenomics Corporation, Beijing 100875, China *Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, VA 22908;; †Department of Pharmacology, Dalian Medical University, Dalian 116044, China; State Key Laboratory for Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210046, China Department of Intensive Care Western Health Melbourne Victoria Australia Department of Pathology, The Second Affiliated Hospital, Guilin Medical University, Guilin, Guangxi 541199, P.R. China Department of Thoracic Surgery, The First Affiliated Hospital, Zhengzhou University Zhengzhou, Henan, China. Department of Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322, USA. Department of Obstetrics and Gynecology First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China Department of Pharmacology and Chemical Biology, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; Department of Chemistry, Duke University, Durham, North Carolina 27708, United States Guangdong Engineering Research Center for Translation of Medical 3D Printing Application, Guangdong Provincial Key Laboratory of Medical Biomechanics, National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China School of Materials Science and Engineering Beihang University Beijing 100191 P. R. China Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health Tongji Medical College, Huazhong University of Sciences and Technology Wuhan China Department of Oncology, The Second Affiliated Hospital of Anhui Medical University Hefei People's Republic of China International Joint Cancer Institute, Second Military Medical University, Shanghai 200433, China Department of Chemical Engineering, Imperial College London, London SW7 2AZ, U.K. Shanghai Key Laboratory of Functional Materials Chemistry and Laboratory of Organometallic Chemistry; School of Chemistry and Molecular Engineering; East China University of Science and Technology; Shanghai 200237; People's Republic of China College of Environmental Science and Engineering Key Laboratory of Environmental Biology and Pollution Control (Hunan University) Ministry of Education Changsha 410082 P. R. China College of Animal Science, Shanxi Agricultural University, No. 1 Mingxian South Road, Taigu 030801, China Beijing National Laboratory for Condensed Matter Physics; Institute of Physics; Chinese Academy of Sciences; Beijing 100190; China National Institute for Health and Care Research (NIHR) Older People and Frailty Policy Research Unit , School of Health Sciences, Faculty of Biology, Medicine and Health, , Manchester M13 9PL , UK; The University of Manchester , School of Health Sciences, Faculty of Biology, Medicine and Health, , Manchester M13 9PL , UK; Division of Nursing , Midwifery and Social Work, School of Health Sciences, , Manchester M13 9PT , UK; The University of Manchester , Midwifery and Social Work, School of Health Sciences, , Manchester M13 9PT , UK Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, P. R. China Department of Chemical and Materials Engineering University of Alberta Edmonton AB T6G 1H9 Canada Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520-8103;; Howard Hughes Medical Institute, Yale University, New Haven, CT 06520-8103; Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences Peking University Health Science Center Beijing China Moe Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences,Lanzhou University, Lanzhou, China Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China Department of Pharmacology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou China State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, No. 39 East Beijing Road, Nanjing 210008, China; University of Chinese Academy of Sciences, No. 19 (A) Yuquan Road, Shijingshan District, Beijing 100049, China Department of Pediatrics,the Third Xiangya Hospital of Central South University,Changsha 410013,China. Mental Hospital of Yunnan Province Kunming China Department of Radiology Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei‐MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School & Hospital of Stomatology Wuhan University Wuhan China; Department of Oral Implantology, School and Hospital of Stomatology Wuhan University Wuhan China Key Laboratory of Advanced Materials and Institute of Fine Chemicals, East China University of Science and Technology Departments of Electrical and Computer Engineering, Biomedical Engineering, and Physics, Duke University, Durham, North Carolina 27708, Institute for Inorganic Methodologies and of Plasmas (IMIP), CNR, 70126 Bari, Italy, and Army Aviation and Missile RD&E Center, Redstone Arsenal, Alabama 35898 Department of Epidemiology and Biostatistics and State Key Laboratory of Environment Health (Incubation), Ministry of Education Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China Affiliated Bayi Brain Hospital Army General Hospital of PLA Beijing China Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Shenzhen 518112, China Herman B. Wells Center for Pediatric ResearchDepartment of PediatricsSchool of MedicineIndiana UniversityIndianapolisIndianaUSA; Department of Cardiovascular SurgeryXiangya HospitalCentral South University School of MedicineChangshaChina Department of Chemistry and Center for Cancer Research, Purdue University, 720 Clinic Drive, West Lafayette, Indiana 47907, United States Department of Biostatistics, University of Florida, Gainesville, FL, USA Laboratory of Neuroscience, College of Medicine Dalian University Dalian 116622 People's Republic of China Department of Otorhinolaryngology Head and Neck Surgery Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology‐Head and Neck Surgery Beijing China Department of Biostatistics, College of Public Health and Health Professions University of Florida Gainesville Florida USA; Emerging Pathogens Institute University of Florida Gainesville Florida USA National & Local United Engineering Laboratory for Power Batteries, Faculty of Chemistry, Northeast Normal University, Changchun, Jilin 130024, P. R. China Department of Respiratory and Critical Care Medicine, Sichuan Provincial People’s Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, the Second Military Medical University, Shanghai, China National and Local United Engineering Laboratory for Power Batteries and Department of Chemistry Northeast Normal University Changchun Jilin 130024 P. R. China Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang Province, China Key Lab of Advanced Optoelectronic Quantum Architecture and Measurement (MOE) Beijing Key Lab of Nanophotonics, and Ultrafine Optoelectronic Systems, and School of Physics School of Physics Beijing Institute of Technology Beijing 100081 China Shenzhen Key Laboratory of Gene Regulation and Systems Biology, Department of Biology, School of Life Sciences, Southern University of Science and Technology , 1088 Xueyuan Rd, Nanshan District, Shenzhen, 518055, Guangdong, China Department of Pathology, The First Affiliated Hospital of Sun Yat-sen University Guangzhou 510080, People's Republic of China. Key Laboratory of Applied Marine Biotechnology Ministry of Education Ningbo University Ningbo China; Key Laboratory of Marine Biotechnology of Zhejiang Province Ningbo University Ningbo China; College of marine Sciences Ningbo University Ningbo China Department of Epidemiology and Biostatistics Institute of Basic Medicine Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Solar and Photovoltaics Engineering Research Center, Division of Physical Sciences and Engineering and ‡Advanced Nanofabrication and Imaging Core Lab, King Abdullah University of Science and Technology, Thuwal 23955-6900, Saudi Arabia Department of Computer Science, Shanghai Jiao Tong University, Shanghai 200240, China The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China Institute of Crystalline Materials Institute of Molecular Science Shanxi University Taiyuan 030006 China Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States AbbVie Inc., North Chicago, IL, USA National Center for Children’s Health, Beijing, People’s Republic of China; Department of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, Beijing, People’s Republic of China; Beijing Key Laboratory for Pediatric Diseases of Otolaryngology, Head and Neck Surgery, Beijing Pediatric Research Institute, Beijing Children’s Hospital, Capital Medical University, Beijing, People’s Republic of China Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, Hebei 071000, P.R. China University of the Chinese Academy of Sciences Hangzhou Institute for Advanced Study School of Pharmaceutical Science and Technology CHINA Department of Periodontics School of Dental Medicine University of Pennsylvania Philadelphia PA USA; State Key Laboratory of Oral Disease West China Hospital of Stomatology Sichuan University Chengdu Sichuan China Epstein Department of Industrial and Systems Engineering Viterbi School of Engineering University of Southern California 3715 McClintock Ave Los Angeles CA 90089‐0192 USA Division of Nephrology, Kidney Institution of Chinese People's Liberation Army (PLA), Chang Zheng Hospital, The Second Military Medical University, Shanghai, China;; Division of Nephrology, Kidney Diagnostic and Therapeutic Center of PLA, Beidaihe Sanatorium of PLA, Qinhuangdao, China; and Department of Immunology, The Scripps Research Institute, La Jolla, California, USA Zhejiang University Department of Horticulture, College of Agriculture and Biotechnology, , Hangzhou 310058, China The Institute of Vegetable Research, Chongqing Academy of Agricultural Sciences, Chongqing 401329, People’s Republic of China Department of Orthopedics Institute, Tianjin Hospital, Tianjin, China College of Life Sciences, Nanjing Agricultural University, Nanjing, China CAS Key Laboratory of Receptor Research, Drug Discovery and Design Center, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China Reproductive Medicine Center, Xi‘an People’s Hospital (Xi’an Fourth Hospital), Xi’an, Shaanxi Province, China; Department of Gynecology and Obstetrics, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China; Department of Obstetrics and Gynecology, Xi‘an Medical University, Xi’an, Shaanxi Province, China Key Laboratories of Crop Genetics and Physiology of the Jiangsu Province and Plant Functional Genomics of the Ministry of Education, Yangzhou University, Yangzhou 225009, China Department of Radiology & Functional and Molecular Imaging Key Lab of Shaanxi Province Tangdu Hospital, Military Medical University of PLA Airforce (Fourth Military Medical University) Shaanxi P.R. China University of Chinese Academy of Sciences , Beijing 100049 , China; State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences , Beijing 100101 , China †Department of Medicine, Division of Immunology and Rheumatology, Stanford University School of Medicine, Stanford, CA 94305 Department of Cell Biology and Nanobiology Institute, Yale University, West Haven, CT 06516, USA. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland 4072, Australia Center for Reproductive Medicine, Department of Obstetrics and Gynecology Qilu Hospital of Shandong University Jinan Shandong People's Republic of China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau SAR 999078, China. Institute of Neuroscience Zhejiang University School of Medicine Hangzhou 310058 China Department of Nutrition The University of Tennessee Knoxville TN USA Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, China CDC, Beijing, China Hefei National Laboratory for Physical Sciences at the Microscale, Department of Materials Science and Engineering, CAS Key Laboratory of Materials for Energy Conversion, University of Science and Technology of China, Hefei, Anhui 230026, China Jiangsu Simcere Pharmaceutical Co. Ltd, Nanjing, China Key Laboratory of Genomics and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing China; China National Center for Bioinformation, Beijing China; University of the Chinese Academy of Sciences, Beijing China Department of Orthopedic Surgery, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100730, China Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China Department of Biostatistics and Emerging Pathogens Institute University of Florida, Gainesville Florida 32611 U.S.A. 4State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai, China. Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry; Key Laboratory of Special Function Materials and Structure Design; Ministry of Education; College of Chemistry and Chemical Engineering; Lanzhou University Advanced Energy Storage Technology Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Department of Gynecology and Obstetrics, Development and Related Diseases of Women and Children Key Laboratory of Sichuan Province, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin, People’s Republic of China Department of Hepatic Surgery and Liver Transplantation Center, Guangdong Key Laboratory of Liver Disease Research Guangdong Province Engineering Laboratory for Transplantation Medicine The Third Affiliated Hospital of Sun Yat‐sen University 600 Tianhe Road Guangzhou 510630 China Department of Biopharmaceutical Sciences, College of Pharmacy, University of Illinois, Chicago, Illinois 60612, United States Department of Joint Surgery, Guangdong N0.2 Provincial People's Hospital, Guangzhou 510317, Guangdong, China. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States; Department of Material Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States Department of Radiology and Biomedical Imaging University of California, San Francisco San Francisco California USA Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China.; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China. Department of General Medicine, Fengxian People's Hospital, Xuzhou 221700, Jiangsu, China. First School of Clinical Medicine, Nanjing Traditional Chinese Medicine University, Nanjing 210000, Jiangsu, China. Department of Pathology, University of Alabama at Birmingham; The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University, Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, 210008, China Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun 130033, China; University of Chinese Academy of Sciences, Beijing 100049, China Research Centre of Ecology and Environment for Coastal Area and Deep Sea, Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou), Guangzhou 511458, China From the Donna D. and Donald M. Lambert Laboratory of Myeloma Genetics, Myeloma Institute for Research and Therapy, or Department of Pathology, University of Arkansas for Medical Sciences, Little Rock, and the Southwest Oncology Group, Fred Hutchinson Cancer Research Center, Seattle, WA. Department of Surgery, University of Melbourne, Melbourne, Australia; Department of Intensive Care, Western Health, Melbourne, Australia State Key Laboratory of Fine Chemicals Zhang Dayu College of Chemistry Dalian University of Technology Dalian 116024 China Department of Internal Medicine, First People's Hospital of Nanning, Lang Dong Branch 9 Yuebing Road, 7th Floor, Nanning 530021, China. Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Department of Biliary‐Pancreatic Surgery Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai China; Shanghai Research Center of Biliary Tract Disease Shanghai China; State Key Laboratory of Oncogenes and Related Genes Shanghai China Department of General Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, China Department of Respiratory and Critical Medicine, Sichuan Provincial People's Hospital Sichuan Academy of Medical Sciences Chengdu Sichuan China Division of Cardiology, David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China Department of Intensive Care Western Health Furlong Road St Albans Victoria 3021 Australia College of Electronic Science and Technology, Shenzhen University, Shenzhen 518060, P. R. China State Key Laboratory of Heavy Oil Processing, College of Chemical Engineering, China University of Petroleum Beijing, Beijing 102249, China Faculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver Campus, Vancouver, BC, Canada; Institute of Biochemistry and Cell Biology Shanghai Institutes for Biological Sciences Shanghai China Shanghai Key Laboratory of Functional Materials Chemistry and Laboratory of Organometallic Chemistry, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, P. R. China Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou 310058, China Department of Ophthalmology Shengjing Hospital of China Medical University Shenyang China Department of Neonates, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China National Laboratory of Medical Molecular Biology, Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Fujian Key Laboratory of Materials, College of Materials, Xiamen University, Xiamen 361005, China Department of Chemistry and Biochemistry, Rowan University, 201 Mullica Hill Rd., Glassboro, New Jersey 08028, United States Key Laboratory of Organofluorine Chemistry and Laboratory of Polymer Materials, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China Department of Mechanical Engineering, San Diego State University, San Diego, CA, USA Institute of Functional Material Chemistry, Faculty of Chemistry, Northeast Normal University, Changchun, Jilin 130024, People’s Republic of China Wuhan National Laboratory for Optoelectronics (WNLO) and School of Optical and Electronic Information Huazhong University of Science and Technology 1037 Luoyu Road Wuhan 430074 P. R. China Department of Pathology, University of Alabama at Birmingham, Birmingham, AL;; Comprehensive Cancer Center and the Center for Metabolic Bone Disease, and Department of Chemistry, Northeast Normal University, Changchun, 130024, People’s Republic of China College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China Department of Dermatology The 309th Hospital of Chinese PLA Beijing China Department of Biostatistics, College of Public Health and Health Professions, University of Florida, Gainesville, FL; Emerging Pathogens Institute, University of Florida, Gainesville, FL Department of Animal Nutrition and Feed Science College of Animal Science and Technology Huazhong Agricultural University Wuhan 430070 P. R. China Department of Respiratory Medicine, Zhejiang Provincial People's Hospital, Hangzhou, Zhejiang 310014, P.R. China State Key Laboratory of Physical Chemistry of Solid States, iChEM, College of Chemistry and Chemical Engineering & Pen-Tung Sah Institute of Micro-Nano Science and Technology, College of Materials, Xiamen University, Xiamen 361005, China Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences Xining 810008 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Pharmacology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shannxi, People’s Republic of China Departments of Materials Science and Engineering, ‡California NanoSystems Institute, and §Departments of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States Department of Gastroenterology The Second Hospital of Nanjing Nanjing University of Chinese Medicine Nanjing China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian National Laboratory for Clean Energy Dalian Liaoning 116023 China Tianjin First Central Hospital, Tianjin Medical University, Tianjin, China. Biometrics, Ardelyx, Inc., Fremont, California Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China; Department of Hepatobiliary Surgery and Center of Organ Transplantation, Shandong Provincial Hospital, Cheeloo College of Medicine,Shandong University,Jinan,Shandong Province,China Center for Big Data Research in Health and Medicine The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital Jinan China; Shandong Data Open Innovative Application Laboratory Jinan China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, China School of Public Health, Sichuan University, Chengdu, China Environment and Plant Protection Institute, Chinese Academy of Tropical Agricultural Sciences & National Collection of Microbial Resource for Fertilizer (Hainan), Haikou 571101, China School of Computer Science and Technology, Hangzhou Dianzi University, Hangzhou, China; Institute of Intelligent Media Technology, Communication University of Zhejiang, Hangzhou, China Life Sciences Research Center, School of Life Sciences and Technology, Xidian University, Xi’an, Shaanxi 710071, China Northwestern University Institute on Complex Systems, Evanston, IL 60208;; Kellogg School of Management, Northwestern University, Evanston, IL 60208 Shenzhen Key Laboratory of Pathogen and Immunity, Guangdong Key Laboratory for Diagnosis and Treatment of Emerging Infectious Diseases, State Key Discipline of Infectious Disease, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen Third People’s Hospital, Shenzhen, People’s Republic of China State Key Laboratory of Supramolecular Structure and Materials College of Chemistry Jilin University Changchun 130012 P. R. China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China. Department of Cell Biology & Institute of Biomedicine, College of Life Science and Technology, Jinan University, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine Guangzhou 510632, Guangdong, China. Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, PR China; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, PR China Department of Reproduction, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, 100026, China Lineberger Comprehensive Cancer Center, Carolina Population Center, Department of Sociology, University of North Carolina, Chapel Hill, NC, USA Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, The Second Military Medical University, Shanghai, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China Maize Research Institute, State Cultivation Base of Crop Stress Biology for Southern Mountainous Land, Southwest University, Beibei District, Chongqing, People’s Republic of China State Key Laboratory of Supramolecular Structure and Materials; Jilin University; Changchun; P. R. China Department of Cardiology The Third Hospital of Hebei Medical University Shijiazhuang China Chongqing Engineering Laboratory of Nanomaterials and Sensor Technologies, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 639798 Department of Surgery, Tianjin Nankai Hospital, Nankai Clinical School of Medicine, Tianjin Medical University, Tianjin 300070, China State Key Laboratory of Mechanical Transmissions, Chongqing University , Chongqing 400044, People's Republic of China School of Life Sciences Jilin University Changchun City Jilin China Department of Pathology, The Second Xiangya Hospital Central South University Changsha Hunan Province China School of Environmental Science and Engineering, Nanjing Tech University, Nanjing 211816, China University of Technology Sydney Beijing Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangdong Province Engineering Laboratory for Transplantation Medicine The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Pharmacy, Changzhi Medical College, Shanxi, 046012, People’s Republic of China Department of Urology, The First People’s Hospital of Jiujiang, Jiujiang, Jiangxi 332000, China Faculty of Environmental Science and Engineering, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, Yunnan, China Department of Mechanical and Aerospace Engineering The Hong Kong University of Science and Technology Clear Water Bay Hong Kong State Key Lab of Physical Chemistry of Solid Surfaces, State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China National Institute of Standards and Technology, Gaithersburg, Maryland 20899, United States State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei 430072, People's Republic of China Department of Obstetrics and Gynaecology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Mass Spectrometry Center of Maternal-Fetal Medicine, Chongqing Medical University, Chongqing, China Department of Chemistry; Northeast Normal University; Changchun, China School of Information Science and Engineering Shandong University Jinan 250000 China Shanghai Key Laboratory of Regulatory Biology, The Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, 200241, China The Institute of Technological Sciences; Wuhan University; Wuhan 430072; China; Key Laboratory of Hydraulic Machinery Transient State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of the Ministry of Education, College of Life Sciences Nankai University Tianjin China School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Neurosurgery, University Hospital Zurich, University of Zurich, Switzerland Department of Epidemiology and Biostatistics, MOE Key Laboratory of Environment & Health, School of Public Health Tongji Medical College, Huazhong University of Science and Technology Wuhan China Department of Respiratory Medicine, Second Hospital of Jilin University, Changchun 130041, China. College of Veterinary Medicine YangZhou University YangZhou China; Institute of Comparative Medicine YangZhou University YangZhou China Department of Animal Nutrition and Feed Science, College of Animal Science and Technology Huazhong Agricultural University Wuhan P. R. China Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China, and the State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China Department of Biliary-Pancreatic Surgery, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; Shanghai Research Center of Biliary Tract Disease, Shanghai 200092, China Department of Abdominal Oncology, West China Hospital of Sichuan University, Chengdu, Sichuan, P.R. China Liaoning Laboratory of Cancer Genomics and Epigenomics, College of Basic Medical Sciences, Dalian Medical University, Dalian116044, China Department of Surgical Oncology The Affiliated Suzhou Science & Technology Town Hospital of Nanjing Medical University Suzhou China National Center for Nanoscience and Technology; Beijing, China Pharmaceutical Research Department, Beijing Institute of Pharmacology and Toxicology, Beijing, China Department of Thoracic Radiotherapy, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China; Zhejiang Key Laboratory of Radiation Oncology, Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital), Hangzhou, China Key Experiments of Modern Medical Protobiology with Special Features, School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550025, Guizhou, China. Departments of †Medicinal Chemistry, ‡Drug Discovery Biology, §Pharmacology, ∥Pharmacokinetics, and ⊥Structural Biology, Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States School of New Energy, North China Electric Power University, 2 Beinong Road, Huilongguan Town, Changping District, Beijing 102206, P. R. China School of Management, Harbin Institute of Technology, Harbin 150006, China Key Laboratory of Low‐Grade Energy Utilization Technologies and Systems (Chongqing University) Ministry of Education Chongqing 400030 China; Institute of Engineering Thermophysics School of Energy and Power Engineering Chongqing University Chongqing 400030 China Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University Guangzhou, Guangdong Province, China. Second Department of Surgery, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China Research Center of Hydrobiology, Jinan University, Guangzhou, People’s Republic of China Department of Pharmaceutical Sciences Beijing Institute of Pharmacology and Toxicology Beijing China Syndrome Laboratory of Integrated Chinese and Western Medicine, School of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095;; California NanoSystems Institute, University of California, Los Angeles, CA 90095; Department of Otolaryngology, the Union Hospital, Tongjing Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China. Department of Chemistry, Massachusetts Institute of Technology (MIT), Cambridge, MA 02139, USA. Institute of Modern Optics, Nankai University, Tianjin 300071, China; State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Medical Epigenetics, Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China. Department of Chemistry, ‡Smalley Institute for Nanoscale Science and Technology, §Department of Materials Science and NanoEngineering, Rice University, 6100 Main Street, Houston, Texas 77005, United States Department of Endocrinology and Metabolism, Institute of Endocrinology, Liaoning Provincial Key Laboratory of Endocrine Diseases, The First Affiliated Hospital of China Medical University, Shenyang, P. R. China. Key Laboratory of Flexible Electronics (KLOFE) Institute of Advanced Materials (IAM) Nanjing Tech University Nanjing 211800 China School of Chemistry and Chemical Engineering Shanghai Electrochemical Energy Devices Research Center Shanghai Jiao Tong University Shanghai 200240 P. R. China College of Marine Science Ningbo University Ningbo China; Key Laboratory of Marine Biotechnology of Zhejiang Province Ningbo University Ningbo China; Collaborative Innovation Center for Zhejiang Marine High‐efficiency and Healthy Aquaculture Ningbo China; Key Laboratory of Applied Marine Biotechnology Ningbo University Ministry of Education Ningbo China Nanotechnology Group, Institute of Microsystems Engineering (IMTEK), Albert-Ludwigs-University Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany, and Freiburger Materialforschungszentrum, Stefan-Meier-Straβe 21, 79104 Freiburg, Germany Center for Life Science, School of Life Sciences, Yunnan University Kunming People's Republic of China; Key Laboratory of the University in Yunnan Province for International Cooperation in Intercellular Communications and Regulations, Yunnan University Kunming People's Republic of China Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; The Key Laboratory of Anti-inflammatory of Immune Medicines, Ministry of Education, Hefei, China; Institute for Liver Diseases of Anhui Medical University, Hefei, China; School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; Department of Anesthesiology, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, U.S.A. Department of Animal Nutrition and Feed Science, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Department of Neonates, Children’s Hospital of Nanjing Medical University, Nanjing, China Jilin University State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China Department of Prosthodontics; Peking University School of Stomatology; Haidian District Beijing 100081 People's Republic of China Key Laboratory of Low-Carbon and Green Agriculture Chemistry in Universities of Shandong, Key Laboratory of Agricultural Film Application of Ministry of Agriculture and Rural Affairs, College of Chemistry and Material Science, Shandong Agricultural University, Tai’an 271018, Shandong, China Zuckerberg Institute for Water Research, Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sede Boqer Campus, Midreshet Ben-Gurion 8499000, Israel Department of Cardiothoracic Suergery, Xiangya Hospital, Central South University, Changsha 410078,China. memo_xy@163.com Department of Chemistry and Theoretical Chemistry Institute, University of Wisconsin—Madison, 1101 University Avenue, Madison, Wisconsin 53706, Department of Chemistry, University of Minnesota, 207 Pleasant Street Southeast, Minneapolis, Minnesota 55455, and Department of Physical and Theoretical Chemistry, Technische Universität Braunschweig, Hans-Sommer-Strasse 10, D-38106 Braunschweig, Germany Fudan University National Center for NanoScience and Technology (NCNST) Beijing 100190 China Department of Cell Biology Shandong University School of Medicine Jinan Shandong China Department of Pediatric Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, State Key Laboratory of Cardiovascular Diseases, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing, China Shenzhen Crystalo Biopharmaceutical Co., Ltd., Shenzhen, China Department of Orthopaedics Guangdong Second Provincial General Hospital Guangzhou China Department of Respiratory Medicine Department of Pharmacology, School of Pharmacy , Ningxia Medical University , Yinchuan 750004 , China Department of Neurosurgery, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China University of California 2 Department of Materials Science and Engineering, , Berkeley, California 94720, USA Ningxia Medical University, The General Hospital of Ningxia Medical University, 804 Shengli South Street, Ningxia Hui Autonomous Region, Yinchuan, China Chinese Academy of Inspection and Quarantine, Beijing, People’s Republic of China Beijing Institute of Pharmacology and Toxicology, 27 Taiping Road, Haidian District, Beijing 100850, China Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health Sun Yat‐sen University Guangzhou China Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China; Capital Institute of Pediatrics, Beijing 100020, PR China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine,Sun Yat‐sen University Cancer Center,Guangzhou,China Department of Cardiothoracic Surgery, Xin Hua Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200092, China 1Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, People’s Republic of China Department of Medicinal Chemistry and Molecular Pharmacology College of Pharmacy, Purdue University West Lafayette IN 47907 USA; Purdue Institute for Integrative Neuroscience 575 Stadium Mall Drive West Lafayette IN 47907 USA Australian Institute for Bioengineering and Nanotechnology The University of Queensland Brisbane Queensland 4072 Australia College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Anhui Vocational College of Grain Engineering, Hefei, China School of Life Sciences, Beijing University of Chinese Medicine, No. 11 East Road, North 3rd Ring Road, Beijing 100029, China Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and Engineering Nankai University Tianjin 300350 P. R. China State Key Lab of Physical Chemistry of Solid Surfaces State‐Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 P. R. China Department of Genetics and Molecular Biology/Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China Shenyang Medical College, Shenyang 110000, Liaoning Province, China State Key Laboratory for Crop Stress Resistance and High‐Efficiency Production, and College of Agronomy Northwest A&F University Yangling Shaanxi China; State Key Laboratory for Crop Stress Resistance and High‐Efficiency Production, and College of Plant Protection Northwest A&F University Yangling Shaanxi China Functional Laboratory of Laser and Terahertz Technology, Wuhan National Laboratory for Optoelectronics (WNLO), Huazhong University of Science and Technology (HUST), Wuhan, Hubei430074, PR China Engineering Science and Mechanics, Penn State University , University Park, PA , United States 1Department of Epidemiology and Biostatistics, and State Key Laboratory of Environment Health, MOE (Ministry of Education) Key Laboratory of Environment & Health, Ministry of Environmental Protection Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Pharmacology, School of Basic Medical Sciences Center of Medical Research and Innovation, Shanghai Pudong Hospital State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200032 China Institute of Pharmacology and Toxicology, Academy of Military Medicine Sciences, Beijing 100850, China Department of Breast Center Peking University People's Hospital Breast Center Beijing China Linde + Robinson Laboratories California Institute of Technology Pasadena, California 91125, United States Institute of Brain and Behavioral Sciences, College of Life Sciences, Shaanxi Normal University, Xi’an, China State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu China Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cummings School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1 Canada; Department of Biochemistry and Molecular Biology, Cummings School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1 Canada Laser Aesthetic Center, Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing P. R. China Department of Plastic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA Department of Biochemistry, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China State Key Lab Urban Water Resource and Environment, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, Harbin 150001, China Tianjin Key Laboratory of Environmental Remediation and Pollution Control College of Environmental Science and Engineering Nankai University 38 Tongyan Rd. Tianjin 300350 P. R. China Department of Chemistry and Center for Cancer Research; Purdue University; West Lafayette, USA Department of Computer Science and Engineering Shanghai Maritime University 1550 Haigang Ave Lingang New City Shanghai 201306 China Institute of Animal Nutrition; Northeast Agricultural University; Harbin 150030; People's Republic of China State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle, Engineering Research Center of Electrochemical Technology, Ministry of Education, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China AbbVie Inc. North Chicago Illinois State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China Chongqing Key Laboratory of Ultrasound Molecular Imaging; Institute of Ultrasound Imaging; Chongqing Medical University; Chongqing 400016; P. R. China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Yunnan China Key Laboratory of Environment and Genes Related to DiseasesMinistry of Education of ChinaXi'an Jiaotong University Xi'an China; School of Public HealthXi'an Jiaotong University Xi'an China State key Laboratory of Toxicology and Medical Countermeasure, Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, PR China; Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function Department of Biochemistry and Molecular Biology Peking University Health Science Center Beijing China NMPA Key Laboratory for Research and Evaluation of Drug Metabolism & Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, China Department of Materials Science and Engineering University of California Los Angeles Los Angeles California 90095 USA; California NanoSystems Institute University of California Los Angeles Los Angeles California 90095 USA Department of Oncology China‐Japan Union Hospital of Jilin University Changchun China Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, P. R. China School of Chemistry and Physics, Faculty of Science, Queensland University of Technology, Brisbane, QLD 4001, Australia; Centre for Materials Science, Queensland University of Technology, Brisbane, QLD 4001, Australia Department of General surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China Centre for Nanoscale Science and Technology Key Laboratory of Functional Polymer Materials Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) School of Materials Science and Engineering Nankai University Tianjin 300071 P.R. China Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450000, P.R. China Department of Biostatistics, University of Florida, Gainesville, Florida, USA; Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA The key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education & School of Public Health Guizhou Medical University Guiyang China College of Veterinary Medicine, Northwest A&F University, Yangling 712100, China Department of Neurology Yale University School of Medicine New Haven CT USA; Center for Neuroscience and Regeneration Research Yale University School of Medicine New Haven CT USA; Rehabilitation Research Center VA Connecticut Healthcare System West Haven CT USA Department of Cardiovascular Surgery, The First Affiliated Hospital of Medical School, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences, University of Macau Macau 999078 China Hefei National Laboratory for Physical Science at Microscale, Department of Materials Science & Engineering & Collaborative InnovationCenter of Suzhou Nano Science and Technology, University of Science and Technology of China, Hefei 230026, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300071, P. R. China; School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, P. R. China MPI of Microstructure Physics, Weinberg 2, Halle 06120, Germany, Micro-Nano Technologies Research Center, Hunan University, Changsha 410082, China, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China, and Institute of Microsystems Engineering, Albert Ludwigs University Freiburg, D-79110 Freiburg, Germany State Key Laboratory of Oncogene and Related Genes Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Department of Epidemiology Shanghai Cancer Institute Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Ophthalmology, China Medical University, Shengjing Hospital, Shenyang 110004, Liaoning Province, China. Tianjin First Central Hospital Clinic Institute, Tianjin Medical University, Tianjin 300070, China State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, People’s Republic of China Department of Chemistry and Theoretical Chemistry Institute, University of Wisconsin, Madison 1101 University Avenue, Madison, Wisconsin 53706 Australian Institute for Bioengineering and Nanotechnology The University of Queensland St. Lucia Brisbane QLD 4072 Australia Department of Dermatology, Plastic Surgery and Burn Repair Center, the 309th Hospital of Chinese PLA, Beijing, China. Frazer Institute, Faculty of Medicine The University of Queensland Brisbane QLD Australia; Shandong Artificial Intelligence Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan China Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. gfhong@sunm.shcnc.ac.cn Hefei National Laboratory for Physical Science at Microscale Department of Materials Science & Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology University of Science and Technology of China Hefei Anhui 230026 P. R. China Department of Trauma Center Affiliated Hospital of Nantong University, Medical school of Nantong University Nantong China Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Scientific Research Section, Zhumadian Central Hospital, Affiliated Hospital of Huanghuai University, Zhumadian, People’s Republic of China School of Pharmacy, Xi'an Medical University, Xi'an 710021, China Key Laboratory of Animal Protein Food Processing Technology of Zhejiang Province Ningbo University Ningbo China Yunnan Key Laboratory of Biomass Big Data, Yunnan Agricultural University, Kunming, Yunnan, China; College of Science, Yunnan Agricultural University, Kunming, Yunnan, China Key Laboratory of New Energy and Rare Earth Resource Utilization of State Ethnic Affairs Commission; Key Laboratory of Photosensitive Materials & Devices of Liaoning Province; School of Physics and Materials Engineering; Dalian Minzu University; Dalian 116600 State Key Laboratory of Virology, Modern Virology Research Center, College of Life Sciences, Wuhan University, Wuhan, People’s Republic of China College of Chinese Medicine Materials, Jilin Agricultural University, Changchun, P.R. China. Nanjing University of Posts and Telecommunications, Nanjing 210003, China Department of Nutrition and Food Hygiene, West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu 610041, China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming Yunnan 650500 China Department of Materials Science and Engineering, University of California—Los Angeles, Los Angeles, California 90095, United States; California NanoSystems Institute, University of California—Los Angeles, Los Angeles, California 90095, United States Department of Materials Science and Engineering University of California, Los Angeles Los Angeles CA 90095 USA Department of Thoracic and Cardiac Surgery, Xiangya Hospital, Central South University, Changsha 410008, China. Key Laboratory of Applied Surface and Colloid Chemistry Ministry of Education Shaanxi Key Laboratory for Advanced Energy Devices School of Materials Science and Engineering Shaanxi Normal University Xi'an 710119 P. R. China Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Champaign, IL 61820, USA; Center for Taiji & Qigong Studies, P.O. Box 308, NY 10028, USA Key Laboratory of Medical Molecular Virology (Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences), Shanghai Frontiers Science Center of Pathogenic Microbes and Infection, Department of Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China Department of Anesthesia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, China Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia Department of General Surgery Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Key Laboratory of Biliary Tract Disease Research Shanghai China; Shanghai Research Center of Biliary Tract Disease Shanghai China Key Lab of Industrial Fermentation Microbiology of the Ministry of Education School of Biotechnology, Tianjin University of Science and Technology Tianjin China Department of Orthopaedics, Tianjin Hospital, Tianjin, China Department of Biology, Indiana University, Bloomington, IN 47405 Shenzhen University; Shenzhen Key Laboratory of Intelligent Optical Measurement and Detection Department of Trauma Center, Affiliated Hospital of Nantong University Nantong 226001, Jiangsu, China. College of Pharmaceutical Science & Collaborative Innovation Centre of Yangtze River Delta Region Green Pharmaceuticals; Zhejiang University of Technology; Hangzhou 310014; China Department of Biological Sciences, St. John's University, 8000 Utopia Parkway, Queens, New York 11439 Department of Internal Medicine, Medical Intensive Care Unit and Division of Respiratory Diseases, Institute of Respiratory Disease and the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China College of Chemistry and Chemical Engineering, Southwest Petroleum University, Chengdu 610500, P. R. China NanoScience Technology Center Department of Materials Science and Engineering Energy Conversion and Propulsion Cluster University of Central Florida 12424 Research Parkway Suite 423 Orlando FL 32826 USA Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Key Laboratory of Stomatology, Shanghai Jiao Tong University, Shanghai, China. School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou People's Republic of China Department of Biostatistics Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, P.R. China. Department of Materials Science and Engineering University of California Los Angeles CA 90095 USA; California NanoSystems Institute University of California Los Angeles CA 90095 USA School of Public Health, Ningxia Medical University, Ningxia, China. School of Public Health, Qingdao University, Shandong, China. Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University, Chengdu 610041, China. Key Laboratory of Birth Defects and Related Diseases of Women and Children of the Ministry of Education, Sichuan University, Chengdu 610041, China. Dalian National Laboratory for Clean Energy, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305; Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Biostatistics, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida , Gainesville, Florida , USA The Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Department of Chemistry Tsinghua University Beijing 100084 China Beijing National Laboratory for Molecular Science, International Joint Laboratory, CAS Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, Max Planck Institute of Colloids and Interfaces, Golm/Potsdam, D-14476, Germany, Northwest Institute of Nuclear Technology, Xi’an 710024, China, and National Center for Nanoscience and Technology, Beijing 100190, China Department of Ophthalmology, Shengjing Hospital, China Medical University, Shenyang 110021, Liaoning Province, China. Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310006 Zhejiang, China Department of Materials Science and Engineering and ‡California NanoSystems Institute, University of California—Los Angeles, Los Angeles, California 90095, United States Department of Geoscience, University of Wisconsin, Madison, 1215 West Dayton Street, Madison, Wisconsin 53706 Department of Rehabilitation, Affiliated Jiangmen Traditional Chinese Medicine Hospital of Ji’nan University, Ji’nan University, Jiangmen Department of Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University, School of Medicine, Shanghai 200025, China West China School of Stomatology Sichuan University Chengdu China Department of Urology Peking University First Hospital Xicheng District Beijing China; Institute of Urology Peking University National Urological Cancer Center Xicheng District Beijing China Department of Neonatology, Nanjing Children's Hospital of Nanjing Medical University, Nanjing, China. Department of Pain Management China‐Japan Friendship Hospital Beijing China Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China; Department of General Dentistry West China Hospital of Stomatology Sichuan University Chengdu China AECC Beijing Institute of Aeronautical Materials, Beijing 100190, China Department of Cardiology, The Second Affiliated Hospital of Shenyang Medical University, Shenyang 110000, China Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, P. R. China Shenzhen Lubon Technology Co. Ltd School of Oil & Natural Gas Engineering; Southwest Petroleum University; Chengdu; People's Republic of China; CSIRO Department of Computer Science Shanghai Jiao Tong University, and Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering Shanghai China Department of neonates, Children’s hospital of Nanjing Medical University, Nanjing, China College of Environment and Public Health; Xiamen Huaxia University; Xiamen; China Thoracis Surgery Department, Affiliated Hospital of Yan’an University (Shanxi), No. 43 North Street, Yan’an, Shanxi Province 716000, P.R. China College of Biodiversity Conservation, Southwest Forestry University, Kunming 650224, China; Yunnan Key Laboratory of Gastrodia and Fungal Symbiotic Biology, Zhaotong University, Zhaotong 657000, China; Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Forestry University, Kunming 650224, China Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400716, China Department of Otorhinolaryngology Head and Neck Surgery, Beijing Children’s Hospital Capital Medical University, National Center for Children’s Health, Beijing Key Laboratory for Pediatric Diseases of Otolaryngology-Head and Neck Surgery, Beijing, China Center for Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China.; National Institute for Advanced Materials, Nankai University, Tianjin 300350, China. Department of Pediatric Surgery The First Affiliated Hospital of Zhengzhou University Zhengzhou China Translational Medical Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences Northwest University Xi'an China; Department of Biomedical Engineering The Fourth Military Medical University Xi'an China Department of Urology Peking University First Hospital and Institute of Urology Peking University, National Urological Cancer Center Beijing China Research Center for Clinical System Biology , Translational Medicine Center, No. 1 Jianshe Dong Road, ErQi District, , Zhengzhou 450052, China; The First Affiliated Hospital of Zhengzhou University , Translational Medicine Center, No. 1 Jianshe Dong Road, ErQi District, , Zhengzhou 450052, China Nanotechnology, Institute of Microsystems Engineering (IMTEK), Albert Ludwigs University of Freiburg, Georges-Köhler-Allee 103, D-79110 Freiburg, Germany Department of Biostatistics, University of Florida, Gainesville Anhui Provincial Key Laboratory for Microbial Pest Control, Anhui Agricultural University, Hefei, China Institute of Advanced Functional Materials for Energy School of Chemistry and Chemical Engineering Jiangsu University of Technology Changzhou 213001 China Department of Microbiology and Biotechnology, College of Life Sciences, Northeast Agricultural University, Harbin, 150030, PR China Shanghai Electrochemical Energy Devices Center; School of Chemistry and Chemical Engineering; Shanghai Jiao Tong University; Shanghai; China Guangdong Provincial Key Laboratory of Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515, Guangdong, China; Affiliated Foshan Maternity & Child Healthcare Hospital, Southern Medical University, Foshan 528000, Guangdong, China Department of Radiology University Medical Center Mainz Mainz Germany Department of Medical Oncology, Affiliated Hospital of Hebei University, Hebei Key Laboratory of Cancer Radiotherapy and Chemotherapy, Baoding, China. Institute of Port, Coastal and Offshore Engineering, Ocean College, Zhejiang University, Zhoushan 3216021, Zhejiang, China Department of Plastic Surgery, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Hematology, the Second Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China. Department of Obstetrics and Gynecology, First Affiliated Hospital of Xi'an Medical University, Xi'an, Shaanxi 710082, P.R. China Department of Neurology, Nanjing First Hospital, Nanjing Medical University, People’s Republic of China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering and ‡Department of Biochemistry and Molecular Biology, College of Life Sciences, Nankai University, Tianjin 300071, P. R. China Institute of Plastic Surgery of Xijing Hospital, Fourth Military Medical University of People's Liberation Army, Xi'an, China. University of North Carolina-Chapel Hill Central Hospital Affiliated to Shandong First Medical University Jinan Shandong China Medical School of Chinese PLA, Beijing, China. ChemBridge Research Laboratories, Inc., 16981 Via Tazon, Suite K, San Diego, California 92127 School of Life Sciences; Tsinghua University; Beijing; China Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials Shanxi Medical University School and Hospital of Stomatology Taiyuan 030001 China Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, and Canon Development Americas, Irvine, California 92618 Department of Microbiology, Yongchuan Hospital of Chongqing Medical University, Chongqing, China College of Mechanical and Vehicle Engineering, Chongqing University , Chongqing 400044, China Department of Dermatology Plastic Surgery and Burn Repair Center, The 309 Hospital of Chinese PLA Beijing China Department of Neurology, The Fourth Affiliated Hospital of China Medical University, Shenyang, China Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Key Laboratory of Breast Cancer Prevention and Therapy (Ministry of Education), Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China The University of Queensland Diamantina Institute Faculty of Medicine The University of Queensland Brisbane QLD Australia; Shandong Artificial Intelligence Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan China College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China Department of Food Science and Engineering, School of Marine Sciences, Ningbo University, Ningbo 315211, P. R. China Department of Dermatology Shanghai Skin Disease Hospital Shanghai China Max Planck Institute of Microstructure Physics, Weinberg 2, 06120 Halle, Germany State Key Laboratory of Natural and Biomimetic Drugs, Department of Chemical Biology, School of Pharmaceutical Sciences Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, NJ, USA; Department of Anatomy, University of California San Francisco, CA, USA Department of Pharmacology, University of Minnesota Medical School, Minneapolis, Minnesota, USA Yang Yang is Staff Scientist, Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 . M. Elizabeth Halloran is Full Member, Center for Statistics and Quantitative Infectious Diseases, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 and Professor, Department of Biostatistics, University of Washington, Seattle, WA 98195. Michael J. Daniels is Professor, Department of Statistics, University of Florida, Gainesville, FL 32611. Ira M.... Key Laboratory for Environment and Health (Ministry of Education), Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College Huazhong University of Sciences and Technology Wuhan China Departments of Medicine Cardiovascular Division, University of Virginia Health System Charlottesville Virginia USA College of Environment and Chemical Engineering; Dalian University; Dalian 116622; China; CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation Beijing Tongren Eye Center, Tongren Hospital, Capital Medical University, Beijing 100730, China; Beijing Retinal and Choroidal Vascular Disorders Study Group, Tongren Hospital, Capital Medical University, Beijing 100730, China Department of Chemistry, ‡Richard E. Smalley Institute for Nanoscale Science and Technology, §Department of Mechanical Engineering and Materials Science, Rice University, 6100 Main Street, Houston, Texas 77005, United States Key Laboratory of Entomology and Pest Control Engineering, College of Plant Protection, Southwest University, Chongqing 400716, China Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 P.R. China State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Energy Materials, Xiamen University, Xiamen 361005, China College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, China Department of Dermatology, Xining First People's Hospital, Xining, Qinghai 810000, P.R. China Engineering and Technology Center For Space Applications, Chinese Academy of Sciences, Beijing 100094, P. R. China National Key Laboratory of Plant Molecular Genetics Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai China Institute of Pharmacology and Toxicology, Medical Faculty, RWTH Aachen University, Aachen, Germany Departments of Genetics, Pediatrics, and Microbiology and Immunology and Division of Oncology, Departments of Medicine and Pathology, Stanford University School of Medicine, Stanford, CA 94305 College of Electronics and Information Engineering; Sichuan University; Chengdu 610065; China Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China School of Medicine Sun Yat‐Sen University Guangzhou China School of Nursing Shandong University Jinan China Department of Pharmacology, University of Minnesota Medical School, Minneapolis, MN, USA National Key Discipline of Human Anatomy, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong, China (mainland) School of Nursing Shandong University Jinan Shandong China Department of Integrated Traditional and Western Medicine West China Hospital, Sichuan University Chengdu China School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China 3Department of Medical Imaging, Xi'an PLA 451 Hospital, Xi'an, Shaanxi, P. R. China.; 7School of Basic Medicine, Xi'an Jiao Tong University, Xi'an, Shaanxi, P. R. China. Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 Advanced Energy Storage Technology Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, P. R. China Department of Hepatic Surgery, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510630, Guangdong Province, P. R. China; Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou 510630, Guangdong Province, P. R. China Department of Endocrinology Kunming Children’s Hospital Kunming Yunnan China Key Laboratory of Pathobiology, State Ethnic Affairs Commission, Yanbian University, Yanji, Jilin 133000, P.R. China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, People’s Republic of China Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Shanghai, China College of Textiles; Donghua University; Shanghai 201620; China Xiangya School of Medicine, Central South University, Hunan, China Laboratory for Nanotechnology; Department of Microsystems Engineering – IMTEK; University of Freiburg; Freiburg 79110, Germany Beijing Gencode Diagnostics Laboratory Beijing China State Key Laboratory of Clean Energy Utilization, State Environmental Protection Engineering Center for Coal-Fired Air Pollution Control, Zhejiang University, Hangzhou, People’s Republic of China Department of Clinical Laboratory, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University, Shanghai, P. R. China; College of Food and Biological Engineering; Xiamen Key Laboratory of Marine Functional Food; Fujian Provincial Engineering Technology Research Center of Marine Functional Food; Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources; Jimei University Department of Orthopaedics, Guangdong Second Provincial General Hospital, Guangzhou, Guangdong, China School of Food Engineering, Harbin University of Commerce, Harbin, China Department of Linguistics University of Hong Kong Pokfulam Road Hong Kong; State Key Laboratory of Brain and Cognitive Sciences University of Hong Kong Pokfulam Road Hong Kong Department of Hematology, Bone Marrow Transplantation Center and Multiple Myeloma Treatment Center, The First Affiliated Hospital of Zhejiang Medical College, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China College of Chemistry, Chemical Engineering and Materials Science, Soochow University; Suzhou; China Department of Cardiology, People's Hospital of Ningxia Hui Autonomous Region, Yinchuan, Ningxia Hui Autonomous Region 750001, P.R. China Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong, People’s Republic of China Department of Engineering Science, University of Oxford, Oxford, United Kingdom School of Computer Science and Technology, Harbin Institute of Technology, Harbin, China Department of Diagnostic and Interventional Radiology, University Medical Center Mainz, Langenbeckstrasse 1, 55131 Mainz, Germany Department of Applied Physics and Materials Research Centre; The Hong Kong Polytechnic University; Kowloon; China Department of Pharmacology, Chongqing Medical University, the Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 400016, China Nanjing University of Information Science & Technology Department of Orthopaedics, Tianjin Hospital, Tianjin, 300211, P. R. China. Department of Medicine, Cardiovascular Division University of Virginia Health System Charlottesville Virginia; Translational and Molecular Imaging Institute and Department of Radiology Icahn School of Medicine at Mount Sinai New York New York Department of Gastrointestinal Surgery, Affiliated Tumour Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China West China School of Public Health and West China Fourth Hospital, Sichuan University, Chengdu, China Department of Cardiovascular Xiang'an Hospital of Xiamen University Xiamen 361102 China Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, P.R. China.; Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, P.R. China. Department of Orthopaedics The Affiliated Guangdong Second Provincial General Hospital of Jinan University Guangzhou People's Republic of China The College of Public Health; Qingdao University; Qingdao; China Jiangsu Engineering and Technology Research Center of Environmental Cleaning Materials (ECM); Jiangsu Key Laboratory of Atmospheric Environment Monitoring and Pollution Control (AEMPC); Jiangsu Joint Laboratory of Atmospheric Pollution Control (APC); Collaborative Innovation Center of Atmospheric Environment and Equipment Technology (AEET); School of Environmental Science and Engineering School of Automation, Nanjing University of Information Science and Technology, Nanjing, China. Department of Dermatology, The First Hospital of China Medical University and Key Laboratory of Immunodermatology, Ministry of Health and Ministry of Education, National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Liaoning Department of Neurology, Affiliated Hospital of Southwest Medical University, Sichuan, China School of Chemical Engineering, Dalian University of Technology, Linggong Road 2#, Ganjingzi District, Dalian, Liaoning 116024, China Department of Pneumology, The Third Xiangya Hospital, Central South University, Changsha, China. State Key Laboratory of Physical Chemistry of Solid Surfaces Department of Chemical and Biochemical Engineering College of Chemistry and Chemical Engineering, Graphene Industry and Engineering Research Institute, iChEM Xiamen University Xiamen 361005 China Animal Experimental Center, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China College of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China Department of Chemistry Massachusetts Institute of Technology 77 Massachusetts Avenue Cambridge MA 02139 USA Laboratory for Nanotechnology, Institute of Microsystems Engineering (IMTEK), Albert-Ludwigs-University Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Science, Dalian 116023, China Oncology Department, People’s Hospital of Xishuangbanna Dai Autonomous Prefecture, Xishuangbanna 666100, Yunnan, China Department of Stomatology Daping Hospital Army Medical University (The Third Military Medical University) Chongqing 400042 China Department of Chemistry and Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; Institute of New Energy; iChEM (Collaborative Innovation Center of Chemistry for Energy Materials); Fudan University; Shanghai 200433 The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu 210008, P.R. China MOE Key Laboratory of Bioinformatics Tsinghua University Beijing 100084 China; Center for Synthetic & Systems Biology Tsinghua University Beijing 100084 China; School of Life Sciences Tsinghua University Beijing 100084 China Department of Gastroenterology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China College of Agriculture, Institute of Agricultural Bioengineering, Shanxi Agricultural University, Taigu, Shanxi 030801, China; Shanxi Key Laboratory of Minor Crops Germplasm Innovation and Molecular Breeding, Taiyuan, Shanxi 030031, China Department of Materials Science and Engineering, University of California, Los Angeles, California 90095 Cancer Biology Research Center; Tongji Hospital; Tongji Medical College, Huazhong University of Science and Technology; Wuhan, Hubei, China Department of cell Biology and Genetics School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center China; Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong University Health Science Center China; Institute of Genetics and Developmental Biology Translational Medicine Institute School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis; Department of Chemistry; Northeast Normal University; 130024 Changchun; China Mendoza College of Business, University of Notre Dame, Notre Dame, IN 46556; Northwestern Institute on Complex Systems and Data Science, Northwestern University, Evanston, IL 60208; Lucy Family Institute for Data and Society, University of Notre Dame, Notre Dame, IN 46556 School of Radiation Medicine and Protection, State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, China Shanghai First People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200080, China Department of Gynecologic Oncology The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research Nanjing China Department of Oral and Cranio Maxillofacial Surgery, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine & Shanghai Research Institute of Stomatology & Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. Paediatric Cardiac Surgery Center, State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Disease, Fuwai Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China Sunnybrook Research Institute and Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, ON, Canada. Department of Hematology, Zhongshan Hospital Fudan University Shanghai China; Cancer Centre, Zhongshan Hospital Fudan University Shanghai China Department of Statistics, University of Georgia, Athens, Georgia, USA Key Laboratory of Resource Biology and Biotechnology Western China, College of Life Sciences, Northwest University, Xi'an, Shaanxi 710069, P.R. China Department of Gynecology, the Fourth Affiliated Hospital of Jiangsu University, Zhenjiang, China. State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Province Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou 510275, China CAS Key Laboratory of Low-Carbon Conversion Science and Engineering, Shanghai Advanced Research Institute, Chinese Academy of Sciences,, Shanghai 201210, China Department of Cell Biology & Institute of Biomedicine, National Engineering Research Center of Genetic Medicine, Guangdong Provincial Key Laboratory of Bioengineering Medicine, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong, China School of Public Health Sciences, Canada. Ocean University of China Department of Spine Surgery, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong 510630, China Key Laboratory of Musculoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province, Hangzhou, Zhejiang 310016, China; Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou, Zhejiang 310016, China Institute of Nuclear and Biological Technologies, Xinjiang Academy of Agricultural Sciences, 403 Nanchang Road, Urumqi 830091, China Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, Jiangsu, China Affiliated Bayi Brain Hospital, The Seventh Medical Center of P.L.A. Army General Hospital, 100700, Beijing, China; Department of Neurosurgery, University Hospital of Zurich, CH-8091, Zurich, Switzerland Department of Gastrointestinal Surgery The Third Hospital of Hebei Medical University Shijiazhuang China Department of Chemistry; University of Kansas; Lawrence; USA Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; Department of Biochemistry and Molecular Biology, Neurobiology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA; College of Life Sciences, Nankai University, Tianjin, People's Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Department of Pediatric The First Affiliated Hospital of Xiamen University Xiamen China From the Robert M. Berne Cardiovascular Research Center (X.S., C.A.R., T.C.S.K., A.S.K., Y.Y., M.E.G., A.K.B., B.E.I.), University of Virginia School of Medicine, Charlottesville; College of Pharmacy, Dalian Medical University, China (X.S., Y.Y.) Innovation Centre for Efficient Use of Nitrogen Fertilizer, Henan Xinlianxin Chemical Industry Group Co., Ltd., Xinxiang 453700, China College of Ocean Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Jimei University, Xiamen, Fujian 361021, People’s Republic of China CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology (NCNST) No. 11 Beiyitiao Zhongguancun Beijing China Research Center of Hydrobiology Department of Ecology Jinan University Guangzhou China; Research Center of Tropical and Subtropical Aquatic Ecological Engineering Ministry of Education Engineering Jinan University Guangzhou China 2Guangdong Provincial Key Laboratory of Liver Disease Research, Guangzhou, China.; 4Department of Hepatic Surgery, The 3rd Affiliated Hospital of Sun Yat-sen University, Guangzhou, China. State Key Laboratory of Fine Chemicals, Zhang Dayu College of Chemistry, Dalian University of Technology, 116024, P. R. China School of Management and Economics, North China University of Water Resources and Electric Power, Zhengzhou 450046, China Department of Ophthalmology, the First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, Chongqing Eye Institute, Chongqing, China. College of Ethnic Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China. esmexyy0508@163.com 1Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.; 2Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, China. Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, Jilin Province, China Key Laboratory of Neurological Disease, Ministry of Education, China, and Department of Pathophysiology, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Thoracic Surgery Shanghai Pulmonary Hospital 507 Zhengmin Road Shanghai 200433 China; Institute for Advanced Study Tongji University 1239 Siping Road Shanghai 200430 China Liver Transplant Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China Department of Prosthodontics; Peking University School and Hospital of Stomatology; National Clinical Research Center for Oral Diseases; National Engineering Laboratory for Digital and Material Technology of Stomatology; Beijing Key Laboratory of Digital Stomatology Department of Dentistry, People's Hospital of Taizhou City, Jiangsu Province, China. State Key Laboratory of Biotherapy and Cancer Center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu P. R. China State Key Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, People’s Republic of China Farming and Animal Husbandry Bureau of Ganzi County, Ganzi 626700, China Department of Thoracic Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China 3Transplantation Research Institute of Sun Yat-Sen University, Guangzhou, China; and Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, China Department of Respiratory, The Second Hospital of LianYunGang, Lianyungang, Jiangsu, China (mainland) Yang Yang is Assistant Professor of Sociology and faculty research associate at the Center on Aging and Population Research Center at NORC, which is affiliated with the University of Chicago. Her current substantive interests include demography of aging, social differentials in life course trajectories of health, and social stress and psychosocial coping resources. Her current methodological interests focus on new statistical models and methods for cohort analysis and mathematical demography. Core Facility of Genetically Engineered Mice, West China Hospital, West China School of Medicine Sichuan University Chengdu P. R. China Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang 330000 Jiangxi Province China Institute of Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China. Genetic Diagnosis Center, The Affiliated Hospital of Kunming University of Science and Technology,Kunming 650032, Yunnan Province, China. Institute of Plastic Surgery of Chinese PLA, Xijing Hospital, the Fourth Military Medical University of Chinese PLA, Xi'an Shaanxi, 710032, P.R. China. School of Chemical and Biomedical Engineering, Nanyang Technological University 1 Division of Bioengineering, , Singapore, 637457, Singapore Martin J. Edelman, Josephine Feliciano, Yang Yang, and Michelle Medeiros, University of Maryland Greenebaum Cancer Center, Baltimore, MD; Ming T. Tan, Georgetown University, Washington, DC; Mary J. Fidler, Rush University Medical Center, Chicago, IL; Rachel E. Sanborn, Providence Portland Medical Center, Portland, OR; Greg Otterson, The Ohio State University Comprehensive Cancer Center, Columbus, OH; Lecia V. Sequist, Massachusetts General Hospital Cancer Center, Boston, MA; Tracey L. Evans, University... Gene Therapy Program, Department of Medicine, University of Pennsylvania, Philadelphia, PA;; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China; and Beijing Institute of Pharmacology and Toxicology, Beijing, P.R. China The Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology; Department of Chemistry; Tsinghua University; Beijing 100084; China Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan Province, 410013, China School of Environmental Science and Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, P. R. China Department of Anesthesiology and Intensive Care, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China; and College of Chemistry & Chemical Engineering, Key Laboratory of Interface Science and Engineering in Advanced Material, Ministry of Education, Taiyuan University of Technology, Taiyuan, Shanxi 030024, P. R. China Shanghai Student Physical Health Monitoring Center Shanghai China Department of Neurosurgery Shengjing Hospital of China Medical University Shenyang China; Liaoning Clinical Medical Research Center in Nervous System Disease Shenyang China; Key Laboratory of Neuro‐oncology in Liaoning Province Shenyang China Department of Thoracic and Cardiovascular Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Science and Technology on Monolithic Integrated Circuits and Modules Laboratory, Nanjing Electronic Device Institute, Nanjing, Jiangsu 210016, P. R. China School of Pharmacy, Shenyang Pharmaceutical University, Benxi, Liaoning, PR China Chemistry and Biochemistry Division; Rowan University; Glassboro; USA Department of Orthopedics, Tianjin Hospital, Tianjin 300211, PR China. International Joint Cancer Institute and Department of Pharmaceutical Sciences, The Second Military Medical University, Shanghai, People's Republic of China Department of Health Toxicology and Hygiene Inspection, School of Public Health , Xi’an Jiaotong University Health Science Center , No. 76, Yanta West Road , Xi’an, Shaanxi 710061 , China Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China Clinical Bioinformatics Experimental Center; Henan Provincial People's Hospital; People's Hospital of Zhengzhou University; Zhengzhou; China Department of Cadiovascular Surgery, Xi'an Jiaotong University, Xi'an, Shaanxi?710061, P.R.?China Department of Anesthesiology and Intensive Care Unit, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Tumor Immunology and Gene Therapy Center, Eastern Hepatobiliary Surgery Hospital, Second Military Medical University, Shanghai, China. State Key Laboratory of Chemical Biology and Drug Discovery, Department of Applied Biology and Chemical Technology, The Hong Kong Polytechnic University, Hong Kong, SAR 999077, China Institute of Behavioral Research, Texas Christian University, Fort Worth, TX, USA First School of Clinical Medicine of Lanzhou University, Department of Orthopedics, First Hospital of Lanzhou University, Lanzhou, Gansu, China Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, China (mainland) Hefei National Research Center for Physical Sciences at the Microscale and Department of Materials Science & Engineering University of Science and Technology of China Hefei 230026 P. R. China Department of Chemical and Biological Engineering Northwestern University, Evanston, Illinois. Department of Gynecology and Obstetrics, Key Laboratory of Obstetric and Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, West China Second Hospital, Sichuan University, Chengdu The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, China School of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China Department of Biomedical Engineering, The Fourth Military Medical University, Xi'an, China California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California 90095, United States; Department of Materials Science and Engineering, University of California, Los Angeles, Los Angeles, California 90095, United States School of Science, Beijing Jiaotong University, Beijing 100044, PR China Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Key Laboratory, Beijing 100875, People’s Republic of China College of Life Sciences, Northwest Normal University, Lanzhou 730070, China. Department of Intensive Care Medicine, The Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310016, China ICU Center; First Affiliated Hospital; School of Pharmacy; Heilongjiang University of Chinese Medicine; Harbin 150040 School of Chemistry, Physics and Mechanical Engineering, Science and Engineering Faculty, Queensland University of Technology, Brisbane, QLD 4001, Australia Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, PR China; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, PR China Department of Radiology and Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Hepatopancreatobiliary Surgery Department I, Peking University Cancer Hospital & Institute, Beijing 100142, China Department of Chemistry, Duke University, Durham, NC 27708; Department of Clinical Laboratory, Nanjing Jinling Hospital, Nanjing University School of Medicine Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital, Sun Yat‑Sen University, Guangzhou, Guangdong 510630, P.R. China State Key Laboratory of Hollow Fiber Membrane Materials and Processes, School of Materials Science and Engineering, Tianjin Polytechnic University, 399 Binshui West Road, Tianjin 300380, P. R. China; Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201210, P. R. China Ardelyx Inc., Fremont, California The First Affiliated Hospital of Guangxi University of Chinese Medicine, Nanning, People's Republic of China College of Pharmacy, Dalian Medical University, Dalian, Liaoning, China; Academy of Integrative Medicine, Dalian Medical University, Dalian, Liaoning, China Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Institute of Urology Nanjing University China Department of Hematology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Geriatrics, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China Department of Forest Botany and Tree Physiology Georg August University Göttingen Göttingen Germany State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine Shanghai China Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China Department of Orthopaedics, Guangdong Second Provincial General Hospital, NO.466 Xingang Road, Haizhu District, Guangzhou 510317, China Harvard School of Public Health , Boston , USA State Key Laboratory of Chemical Resource Engineering, College of Chemistry, Beijing University of Chemical Technology, Beijing 100029, P. R. China Hefei National Laboratory for Physical Sciences at Microscale and Department of Materials Science & Engineering University of Science and Technology of China Hefei 230026 China Department of Hepatic Surgery and Liver Transplantation Center of the Third Affiliated Hospital of Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, Guangdong Province Engineering Laboratory for Transplantation Medicine; Guangzhou, China; Guangdong Key Laboratory of Liver Disease Research, Key Laboratory of Liver Disease Biotherapy and Translational Medicine of Guangdong Higher Education Institutes, the Third Affiliated Hospital of Sun Yat-sen University; Guangzhou, China School of Life Science Liaoning University Shenyang 110036 P. R. China From the Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; *Department of Immunology, University of Washington, Seattle, WA 98195; Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China Department of Gastrointestinal Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China Maize Research Center Beijing Academy of Agriculture and Forestry Sciences/Beijing Key Laboratory of Maize DNA Fingerprinting and Molecular Breeding Beijing 100097 China Department of Dentistry, People's Hospital of Taizhou City, Taizhou 225300, Jiangsu Province, China. Basic Medical Laboratory, Affiliated Jinling Hospital, Clinical School of Medical College Nanjing University Nanjing China Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095; Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China. First Affiliated Hospital, Department of Obstetrics and Gynecology, Xi'an Medical University, Xi'an 710077, China. National Center for Nanoscience and Technology; Zhong Guan Cun, Bei Yi Tiao 11 Beijing 100190 P. R. China School of Chemistry, Dalian University of Technology, Dalian, 116024, China School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, P. R. China State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Sichuan, The People's Republic of China. Department of Neonates Children's Hospital of Nanjing Medical University Nanjing China Center for Molecular Virology, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China; Graduate School of the Chinese Academy of Sciences, Beijing, People's Republic of China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong Universtiy, Shanghai, P.R. China Department of Physiology and PathophysiologySchool of Basic Medical SciencesFudan UniversityShanghaiChina Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, 507 Zheng Min Road, Shanghai 200433, China Department of Orthopedics, Academy of Orthopedics of Guangdong Province, The Third Affiliated Hospital, Southern Medical University, Guangzhou, China China State Institute of Pharmaceutical Industry Shanghai Institute of Pharmaceutical Industry, Shanghai, China 1Department of Hematology and Respiratory Medicine, Kochi University, Nankoku, Kochi, Japan; Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China Department of Materials Science and Engineering, University of California, Berkeley, Berkeley, CA 94720, USA. School of Materials Science and Engineering; and Tianjin Key Laboratory of Composite and Functional Materials; Tianjin University; Tianjin 300072; China State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China Shandong Provincial Hospital, Jinan 250021, China Duke University 1 Department of Chemistry, , Durham, NC 27708, USA Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao-Tong University Shanghai, China. School of Environmental Science and Engineering, State Key Laboratory of Metal Matrix Composites, Shanghai Jiao Tong University, Shanghai 200240, China; College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China; Key Laboratory of Oil Crops Biology of Ministry of Agriculture in China, Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, Wuhan, China School of Materials Science and Engineering; Tianjin Key Laboratory of Composite and Functional Materials; Tianjin University; Tianjin 300072; China School of Electronic and Information Engineering, Beihang University, Xueyuan Road No. 37, Beijing 100191, China Jiangsu Key Laboratory for Microbes and Functional Genomics, Jiangsu Engineering and Technology Research Center for Industrialization of Microbial Resources, College of Life Sciences Nanjing Normal University Nanjing China Department of Radiology, Huashan Hospital, Fudan University, Shanghai, PR China Department of Pathology, The Second Xiangya Hospital of Central South University Changsha, Hunan, China. Biomedical Engineering and Micro/Nanotechnology Research Centre, School of Mechanical Engineering, University of Birmingham, Birmingham B15 2TT, United Kingdom The Biodesign Institute, Arizona State University, Tempe, AZ 85287, USA.; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. College of Mathematics & Information Science, Guiyang University, Guiyang, China Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai China State Key Lab of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials (iChEM), Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, Fujian, P. R. China Department of Hematopoietic Stem Cell Transplantation, Fifth Medical Center of Chinese PLA General Hospital, Beijing, China; Beijing Key Laboratory of Stem Cell Therapy and Transformation Research, Beijing, China Institute of Environmental Research at Greater Bay Area, Key Laboratory for Water Quality and Conservation of the Pearl River Delta, Ministry of Education, Guangzhou University, Guangzhou 510006, P. R. China Reproductive Medicine Center, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China Yunnan Provincial Key Laboratory of Public Health and Biosafety & School of Public Health Kunming China Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute of Hematology, Zhejiang University, Hangzhou, Zhejiang, China Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for Infectious Disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, State Key Laboratory of Natural and Biomimetic Drugs, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell FunctionDepartment of Biochemistry and Molecular BiologyPeking University Health Science CenterBeijingChina State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 China Center for Reproductive Medicine , Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, , Jinan, P. R. China; Shandong University , Department of Obstetrics and Gynecology, Qilu Hospital, Cheeloo College of Medicine, , Jinan, P. R. China Organ Transplant Center Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China; Tianjin Key Clinical Discipline (Organ Transplantation) Tianjin China Department of Neurosurgery, the Third Medical Center, Chinese PLA (People's Liberation Army) General Hospital, Beijing, China. Department of Orthopedic Surgery Peking Union Medical College Hospital Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China; Beijing Key Laboratory for Genetic Research of Skeletal Deformity Beijing China Vegetable Genetics and Breeding Laboratory, College of Horticulture, Anhui Agricultural University; Hefei 230036, China; Anhui Provincial Engineering Laboratory of Horticultural Crop Breeding, Hefei 230036, China Department of Hepatic Surgery VI, Eastern Hepatobiliary Surgery Hospital Second Military Medical University Shanghai China Environmental Simulation and Pollution Control State Key Joint Laboratory, School of Environment, Tsinghua University, Beijing, P.R. China Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, No. 16, South Section 2, the first Ring Road, Chengdu 610041, China; University of Chinese Academy of Sciences, Beijing 100049, China Technology Center, China Tobacco Zhejiang Industrial Co., Ltd., Hangzhou, China Department of Physics, Duke University, Durham, North Carolina 27708, United States College of Food and Biological Engineering Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources Jimei University Xiamen China State Key Laboratory of North China Crop Improvement and Regulation, Key Laboratory for Farmland Eco-Environment of Hebei Province, Hebei Collaborative Innovation Center for Green & Efficient Vegetable Industry, College of Resources and Environmental Science, Hebei Industrial Technology Institute of Microbial Fertilizers, Hebei Agricultural University, Baoding 071000, China Department of Surgery University of Melbourne Australia Monash University Eastern Clinical School Melbourne Victoria Australia *Institute of Translational Medicine, The First Hospital of Jilin University, Changchun, Jilin 130021, China; Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. State Key Laboratory of Biocontrol Life Sciences School Sun Yat‐sen University Guangzhou China Institute of Mechanical Engineering, Materials and Transportation, Peter the Great Saint-Petersburg Polytechnic University, Saint-Petersburg 195251, Russia Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Northwest University, Xi'an, 710021, China. yang200214yy@nwu.edu.cn. Xi'an Key Laboratory of Innovative Drug Research for Heart Failure, Faculty of Life Sciences and Medicine, Northwest University, 229 Taibai North Road, Xi'an, 710069, China. yang200214yy@nwu.edu.cn. College of Marine Sciences Ningbo University Ningbo China; Key Laboratory of Applied Marine Biotechnology Ningbo University, Ministry of Education Ningbo China; Key Laboratory of Marine Biotechnology of Zhejiang Province Ningbo University Ningbo China State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University Chengdu China Shanghai Key Laboratory of Materials Protection and Advanced Materials in Electric Power, College of Environmental and Chemical Engineering, Shanghai University of Electric Power, 2588 Changyang Road, Yangpu District, Shanghai 200090, China 1Department of Human Reproductive Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; 2Department of Human Reproductive Medicine, Beijing Maternal and Child Health Care Hospital, Beijing, China Institute of Rock and Soil Mechanics, Chinese Academy of Sciences, 430071, Wuhan, China MSU-Department of Energy, Plant Research Laboratory, East Lansing, Michigan 48824; Great Lakes Bioenergy Research Center, Michigan State University, East Lansing, Michigan 48824 Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, People’s Republic of China Department of Biostatistics University of Florida Gainesville, Florida 32611 U.S.A. Department of Cell Biology and Nanobiology Institute Yale University 850 West Campus Drive West Haven CT 06516 USA; Institute of Molecular Medicine Renji Hospital Shanghai Jiao Tong University School of Medicine 160 Pujian Road Shanghai 200120 China Berkeley Sensor and Actuator Center, Department of Mechanical Engineering, University of California, Berkeley, California 94720, United States; Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Advanced Catalysis and Green Manufacturing Collaborative Innovation Center, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China Institute of Pharmacology and Toxicology, University Hospital Aachen, Aachen, Germany 3Department of Biopharmaceutical Sciences College of Pharmacy, The University of Illinois, Chicago, Illinois. Liver Transplant Center, Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou 510630, China. State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, People's Republic of China Department of Trauma Center, Affiliated Hospital of Nantong University, Jiangsu, China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China Departmentof Pharmacology; Xi'an Jiaotong University Health Science Center; Xi'an Shaanxi P.R. China College of Veterinary Medicine, Hunan Agricultural University, Changsha 410125, China; Hunan Key Laboratory, Chinese Veterinary Medicine, Changsha 410125, China Julia McFarlane Diabetes Research Centre, Department of Microbiology and Infectious Diseases, the University of Calgary, Calgary, Alberta, Canada Yunnan Key Laboratory of Disaster Reduction in Civil Engineering, Kunming 650500, China; Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650500, China Department of Energy and Hydrocarbon Chemistry, Graduate School of Engineering, Kyoto University, Kyoto 615-8510, Japan Beijing Key Laboratory of Quality Evaluation Technology for Hygiene and Safety of Plastics, College of Chemistry and Materials Engineering, Beijing Technology and Business University, Beijing100048, China Faculty of Environment and Life, Beijing University of Technology, Beijing 100124, P. R. China. School of Physical Science and Technology, Wuhan University, Wuhan, 430072. Department of Physics, Freie Universitaet Berlin, Arnimallee 14, 14195 Berlin, Germany National Center for Nanoscicence and Technology, No. 11, Bei Yi Tiao, Zhong Guan Cun, Beijing 100190, PR China Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 611731, P.R. China Department of Radiology, Suining Central Hospital , 127 Desheng West Road, Suining 629099, Sichuan Province , China; Medical Imaging Center of Guizhou Province , Department of Radiology, , 149 Dalian Road, Zunyi 563000, Guizhou Province , China; The Affiliated Hospital of Zunyi Medical University , Department of Radiology, , 149 Dalian Road, Zunyi 563000, Guizhou Province , China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China 1; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing, China 2 Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science Fudan University Shanghai 200433 China Duke University 2 Department of Chemistry, , Durham, North Carolina 27708, USA College of Bioinformatics Science and Technology, Harbin Medical University, China 1Key Laboratory of Drug Targets and Drug Leads for Degenerative Diseases, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China.; 2Laboratory of Cellular and Molecular Biology, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing, Jiangsu, China. Department of Cadiovascular Surgery, Xi'an Jiaotong University, Xi’an, Shaanxi 710061, P.R. China College of Life Science, Shihezi University, Shihezi, Xinjiang, People’s Republic of China, 832000.; College of Life Science, Shihezi University, Shihezi, Xinjiang, People’s Republic of China, 832000. Department of Clinical Laboratory The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem, Fudan University, Shanghai 200438, People’s Republic of China Department of Emergency, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Shangcheng, China CAS Key Laboratory of Receptor Research; CAS Center for Excellence in Molecular Cell Science; Shanghai Institute of Materia Medica; Chinese Academy of Sciences; Shanghai College of Horticulture, Northeast Agricultural University, Harbin 150030, China. yyang_311@yahoo.cn Department of Anesthesiology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Clinical Laboratory Center, Gansu Provincial People's Hospital, Lanzhou 730000, China. Department of Pathology, St. Luke's Internal Hospital, Japan Shenzhen Key Laboratory of Pathogen and Immunity, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital Second Hospital Affiliated to Southern University of Science and Technology Shenzhen China Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Department of Ophthalmology, Shengjing Hospital of China Medical University, No. 36 Sanhao Street, Heping District, Shenyang 110004, China Department of Thoracic Surgery Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Department of Radiology, Capital Institute of Pediatrics, Beijing, China Xinjiang Key Laboratory of Crop Biotechnology, The State Key Laboratory of Genetic Improvement and Germplasm Innovation of Crop Resistance in Arid Desert Regions (Preparation), Institute of Nuclear and Biological Technology, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China Key Laboratory of the Ministry of Education for Experimental Teratology Shandong Provincial Key Laboratory of Mental Disorders Department of Histology and Embryology Shandong University School of Medicine Jinan China Academy of Integrative Medicine Shanghai University of Traditional Chinese Medicine Shanghai China School of Food Engineering Harbin University of Commerce Harbin China Beihang University, School of Biological Science and Medical Engineering, Beijing Biomedical Research Institute Shenzhen Peking University ‐ The Hong Kong University of Science and Technology Medical Center Shenzhen China Department of Newborn Infants, Children’s Hospital of Nanjing Medical University, Nanjing, China Department of Chinese Medicine, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, China Department of Translational Medicine Center the First Affiliated Hospital of Zhengzhou University Zhengzhou China Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, College of Pharmacy, Chongqing Medical University, Chongqing 400016, China Department of Pharmacology, Chongqing Medical University, Chongqing 400016, China; The Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing 400016, China Department of Emergency, Chinese PLA General Hospital, Beijing, China State key Laboratory of Toxicology and Medical Countermeasure Department of Pharmaceutics Beijing Institute of Pharmacology and Toxicology Beijing 100039 China College of Geography and Environmental Science, Henan University, Kaifeng 475001, China; Key Laboratory of Geospatial Technology for the Middle and Lower Yellow River Regions, Henan University, Ministry of Education, Kaifeng 475004, China Hubei Collaborative Innovation Center of Targeted Antitumor Drug, Jingchu University of Technology, Jingmen, China and National Clinical Research Center for Cardiovascular Diseases, NHC Key Laboratory of Clinical Research for Cardiovascular Medications, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing, People's Republic of China Nanjing Medical University Nanjing Jiangsu China; Department of Hepatic‐Biliary‐Pancreatic Center Zhongda Hospital of Southeast University Nanjing Jiangsu China; Department of Hepatobiliary Surgery Research Institute Southeast University Nanjing Jiangsu China Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Northwestern Institute on Complex Systems, Northwestern University, Evanston, IL 60208;; Kellogg School of Management, Northwestern University, Evanston, IL 60208 Department of Integrated Chinese and Western Medicine, West China Hospital Affiliated to Sichuan University, Chengdu 610041, China. Shenzhen Lubon Technology Co., Ltd. Department of Intensive Care, Western Health, Melbourne, Victoria, Australia. Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305; and State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China. Infertility Center, Qilu Hospital Shandong University School of Medicine No. 44, Wenhua Xi Road Jinan Shandong 250012 PR China Faculty of Vehicle Engineering, Chongqing Industry Polytechnic College , Chongqing 401120, People's Republic of China Additive Manufacturing & Advanced Materials Lab Department of Mechanical Engineering San Diego State University 5500 Campanile Drive San Diego CA 92182‐1323 USA Institute of Geographic Sciences and Natural Resources Research, CAS, Beijing 100101, China; College of Resource and Environment, University of Chinese Academy of Sciences, Beijing 100049, China Department of Materials Science and Engineering and California Nanosystems Institute, University of California, Los Angeles, California 90095, and Solarmer Energy, Inc., El Monte, California 91731 Department of Radiology, Suining Central Hospital , Suining , China Institute of Nutrition and Health, School of Public Health, Qingdao University, Qingdao, China Department of Pediatric Surgery, West China Hospital, Sichuan University/West China School of Nursing, Sichuan University, Chengdu, China. Department of Radiology, Huashan Hospital, Fudan University, P. R. China Department of Respiratory and Infectious Disease of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Neurology, Qilu Hospital of Shandong University, Jinan, China School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 P.R. China Department of Nursing Fudan University Shanghai Cancer Center Shanghai China Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen 518112, China School of Bioscience and Bioengineering South China University of Technology Guangzhou China Department of Orthopedics, 960th Hospital of PLA, Jinan 250031, Shandong, PR China Department of Urology First Affiliated Hospital of Zhengzhou University Zhengzhou China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine, Peking Union Medical College, Beijing 100005, China Key Laboratory of Applied Surface and Colloid Chemistry of Ministry of Education, School of Chemistry and Materials Science, Shaanxi Normal University, Xi’an 710062, P. R. China The Neurology Department, Fourth Affiliated Hospital of China Medical University, Shenyang, Liaoning 110032, P.R. China School of Chemical Engineering and Technology, Hebei University of Technology, Tianjin 300130, People's Republic of China Department of Ultrasound, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China Department of Materials Science and Engineering, University of California, Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095, United States State Key Laboratories for Agrobiotechnology Key Lab of Animal Epidemiology and Zoonosis Ministry of Agriculture, National Animal Transmissible Spongiform Encephalopathy Laboratory College of Veterinary Medicine China Agricultural University Beijing China Chinese Kidney Center of PLA First Affiliated Hospital of Beidaihe Sanatorium of Beijing Military Region Qinhuangdao China State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China Department of Physics and Electronic Science, Weifang University, Weifang 261061, China State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, Department of Chemistry, Lanzhou University, Lanzhou 730000, China Department of Neonatology, Nanjing Children's Hospital, Nanjing, Jiangsu, China. CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration & National Clinical Research Center for Oral Diseases & Shaanxi International Joint Research Center for Oral Diseases, Department of General Dentistry & Emergency, School of Stomatology, The Fourth Military Medical University, Xi’an, Shaanxi, China Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210023, China State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu 730046, China Nanjing University-Nanjing Forestry University Joint Institute for Plant Molecular Biology, School of Life Sciences, Nanjing University, Nanjing 210093, People’s Republic of China Qingdao University of Science and Technology, Chemical Engineering Institute, Qingdao, China Faculty of Engineering; University of Nottingham; Nottingham NG7 2RD; UK The Comprehensive Cancer Centre of Drum Tower Hospital Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University Nanjing 210008 China Institute of Brain and Behavioral Sciences College of Life Sciences Shaanxi Normal University Xi'an China Department of Gastroenterology Institute of Surgery Research, Daping Hospital, Third Military Medical University Chongqing China MOE Key Laboratory of Bioinformatics, Center for Synthetic and Systems Biology, School of Life Sciences, Tsinghua University, Beijing, China Division of Pharmaceutical Quality Research, Office of Testing and Research, Office of Pharmaceutical Quality, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, Maryland School of Materials Science and Engineering Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Tianjin 300350 P. R. China State Key Laboratory of Heavy Oil Processing China University of Petroleum Beijing 102249 P.R. China), Fax: (+86) 10-89734979 State Key Laboratory of Environment Health (Incubation) Key Laboratory of Environment & Health (Ministry of Education) Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan) Department of Epidemiology and Biostatistics, School of Public Health Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Pharmacology, School of Pharmacy, Ningxia Medical University, Yinchuan, China Operating Room VIP Department Jinshan Hospital The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Urology Peking University First Hospital Beijing China; Institute of Urology, National Urological Cancer Center Peking University Beijing China State Key Laboratory of Fine Chemicals; College of Zhang Dayu; Dalian University of Technology; Dalian; P. R. China State Key Laboratory of Urban Water Resource and Environment, School of Civil and Environmental Engineering, Harbin Institute of Technology, Shenzhen 518055, China Analysis and Testing Center, Department of Chemistry, Capital Normal University, Beijing 100048, China. *State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China; Shanghai Key Laboratory of Functional Materials Chemistry and Laboratory of Organometallic Chemistry School of Chemistry & Molecular Engineering East China University of Science and Technology P.O. Box 310, 130 Meilong Road 200237 Shanghai P.R. China College of Civil Engineering and Architecture, Zhejiang University of Technology, Hangzhou 310023, China; Key Laboratory of Civil Engineering Structures & Disaster Prevention and Mitigation Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310023, China Department of Basic Veterinary Science, College of Veterinary Medicine Northeast Agricultural University Harbin People's Republic of China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education Northwest University Xi'an 710069 China; Biomedicine Key Laboratory of Shaanxi Province, College of Life Science Northwest University Xi'an 710069 China Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an 710061, China. E-mail: yysmile_ok@stu.xjtu.edu.cn. State Key Laboratory of Oncology in South China, and Collaborative Innovation Center for Cancer Medicine,Sun Yat‐Sen University Cancer Center,Guangzhou,China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, People’s Republic of China Department of Oncology and Hematology, China-Japan Union Hospital of Jilin University, Changchun, P.R. China College of Chemistry and Chemical Engineering, Qiqihar University, Qiqihar 161006, China Department of Genetics and Molecular Biology, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi, China Department of Chemistry and Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education); Tsinghua University; Beijing 100084 PR China Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai 200433, China;; School of Materials Science and Engineering, Tongji University, Shanghai 201804, China; State Key Laboratory of NBC Protection for Civilian, Beijing 102205, P. R. China Institute of Cancer and Basic Medicine (IBMC), Chinese Academy of Sciences, Hangzhou, Zhejiang, China Energy Materials & Physics Group, Department of Physics, Shanghai University, Shanghai 200444, China; Institute of Low-Dimensional Carbon and Device Physics, Shanghai University, Shanghai 200444, China Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Vascular Biology Research Institute, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, China State Key Laboratory of Bioactive Substrate and Function of Natural Medicine, Institute of Materica Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050, P. R. China Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science and Technology of China, Hefei, 230026, China School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an, Shaanxi 710061, P.R. China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, 510060,PR China Core Facility of Genetically Engineered Mice, State Key Laboratory of Biotherapy and Cancer Center Key Laboratory of Chemical Biology of Jiangxi Province, College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China Institute of Materials, Ningbo University of Technology, Ningbo City, 315016, P.R. China State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, People's Republic of China. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States Department of Materials Science and Engineering and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California, 90095, and Department of Chemistry and Biochemistry and California NanoSystems Institute, University of California, Los Angeles, Los Angeles, California, 90095 Biomedical Engineering and Imaging Institute and Department of Radiology Icahn School of Medicine at Mount Sinai New York New York USA Department of Oncology and Hematology, The Third Hospital of Jilin University, Xiantai Street No. 126, Changchun 130021, China Department of Otorhinolaryngology, The Children's Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Departments of Chemical Engineering and Materials Science Engineering, University of California, Los Angeles, California 90095, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China, Department of Physics, Washington State University, Richland, Washington 99354, and Institute of Chemistry, Chinese Academy of Sciences, Beijing, 10080 China Shanghai Key Lab. of D&A for Metal‐Functional Materials School of Materials Science & Engineering Tongji University Shanghai 201804 P. R. China Department of Pathophysiology, Xiangya School of Medicine, Central South University, Changsha City, Hunan, PR China. Chongqing Engineering Laboratory of Nanomaterials & Sensor Technologies; College of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715; P. R. China The Key Laboratory of Biochemistry and Molecular Pharmacology, Department of Pharmacology, Chongqing Medical University, Chongqing 400016, China Department of Periodontics, School of Dental Medicine University of Pennsylvania Philadelphia PA USA; State Key Laboratory of Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu PR China Genetics Department, Stanford University, Stanford, United States College of Environment and Plant Protection, Hainan University, Haikou Hainan, People’s Republic of China Department of Urology, Drum Tower Hospital Affiliated with Nanjing University School of Medicine, Institute of Urology, Nanjing University, Nanjing 210008, China; School of Medicine, Nanjing University, Nanjing 210093, China Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States; Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, United States Key Laboratory of Nanosystem and Hierarchical Fabrication, National Center for Nanoscience and Technology, Beijing 100190, China Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Neurology, The Third Affiliated Hospital of The Second Military Medical University, Shanghai 200438, P.R. China Yunnan Key Laboratory of Biomass Big Data, Yunnan Agricultural University, Kunming, China;; College of Science, Yunnan Agricultural University, Kunming, China; Research Center of Hydrobiology, Jinan University, Guangzhou 510632, China; Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering, Ministry of Education, Guangzhou 510632, China Department of Urology, Second Affiliated Hospital Army Medical University Chongqing Shapingba P.R. China Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St. Lucia, Brisbane, Queensland 4072, Australia Department of Head-neck Otolaryngology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Immunology, GuangXi University of Chinese Medicine, Nanning, China.; GuangXi Medical Transformational Key Laboratory of Combine Traditional Chinese and Western Medicine and High Incidence of Infectious Diseases, Nanning, China. State Key Laboratory of Oncogenes and Related Genes and Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Institute for Advanced Study, Nanchang University, No. 999 Xuefu Avenue, Nanchang 330031, China Shenzhen Key Laboratory of Energy Electrocatalytic Materials Guangdong Research Center for Interfacial Engineering of Functional Materials College of Materials Science and Engineering Shenzhen University 518055 Shenzhen China; College of Physics and Optoelectronic Engineering Shenzhen University 518060 Shenzhen China Pediatric Cardiac Surgery Center, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Department of Rehabilitation, The First Affiliated Hospital, China Medical University, Huaxiang Road No. 39, Tiexi District, Shenyang 110001, China Nanjing Qique Electronic Technology Co., Ltd. Zhongnan Zhigu Industrual Park Xiongzhou Street, Liuhe District Nanjing City Jiangsu Province 211599 P. R. China National Engineering Research Center of Solid-State Brewing, Luzhou 646000, PR China; Luzhou Pinchuang Technology Co., Ltd., Luzhou 646000, PR China; Luzhou Laojiao Co., Ltd., Luzhou 646000, PR China Department of Pediatrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China MOE Joint International Research Laboratory of Animal Health & Food Safety, Nanjing Agricultural University, Nanjing 210095, P. R. China; Key Laboratory of Animal Physiology & Biochemistry, Nanjing Agricultural University, Nanjing 210095, P. R. China Department of Chemistry; Lehigh University; Bethlehem; USA Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection & Internet Technology, College of Animal Science and Technology & College of Veterinary Medicine of Zhejiang A&F University, Hangzhou, Zhejiang, China Department of Paediatrics Shengjing Hospital of China Medical University Shenyang Liaoning China State Key Laboratory of NBC Protection for Civilian, Beijing 102205, China; Laboratory of Analytical Chemistry, Institute of Chemical Defence, Beijing 102205, China Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China School of Nursing, Nantong University, Nantong, China. Haikou Experimental Station Chinese Academy of Tropical Agricultural Sciences Haikou China *Julia McFarlane Diabetes Research Centre, Department of Biochemistry and Molecular Biology, and Key Laboratory of Mariculture and Enhancement, Marine Fishery Institute of Zhejiang Province , Zhoushan , China Beijing Advanced Innovation Center for Soft Matter Science and Engineering College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Great Lakes Bioenergy Research Center Michigan State University East Lansing MI 48824 USA; Department of Energy Plant Research Laboratory Michigan State University East Lansing MI 48824 USA; Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI 48824 USA Chinese Academy of Forestry State Key Laboratory of Tree Genetics and Breeding, , Beijing, 100091, China; Chinese Academy of Forestry Research Institute of Subtropical Forestry, , Hangzhou, Zhejiang, 311400, China ICU Center; First Affiliated Hospital; Heilongjiang University of Chinese Medicine; Harbin 150040; China School of Pharmacy, Guilin Medical University, Guilin, PR China; School of Basic Medical Sciences, Youjiang Medical University for Nationalities, Baise, PR China Shenzhen University Institute of Traditional Chinese Veterinary Medicine, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China Key Laboratory of Artificial Micro- and Nano-Structures of Ministry of Education School of Physics and Technology; Wuhan University; Wuhan 430071; China Department of Hepatic Surgery and Liver Transplantation CenterThe Third Affiliated HospitalOrgan Transplantation Research Center of Guangdong ProvinceOrgan Transplantation InstituteSun Yat-sen UniversityGuangzhouChina; Guangdong Key Laboratory of Liver Disease ResearchKey Laboratory of Liver Disease Biotherapy and Translational MedicineGuangdong Higher Education InstitutesThe Third Affiliated HospitalSun Yat-sen UniversityGuangzhouChina School of Basic Medical Sciences, Wuhan University,Wuhan,China Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China. Department of Medical Microbiology and Parasitology, School of Basic Medical Sciences, Shanghai Institute of Infectious Diseases and Biosecurity, Shanghai Medical College, Fudan University, Shanghai, China. 1 School of Public Health, Fudan University, Shanghai 200032, China ; 2 State Key Laboratory of Oncogene and Related Genes & Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200032, China ; 3 Cancer Surveillance Section, International Agency for Research on Cancer, 150 Cours Albert Thomas, F-69372 Lyon Cedex 08, France. 3Department of Pathology and the University of Alabama at Birmingham Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama. Thoracic surgery department, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430022, P. R. China; Equal contribution Department of Biological Sciences, University at Buffalo, State University of New York, Buffalo, New York State Key Laboratory of Fine Chemicals Dalian University of Technology Dalian 116024 China Chemotherapy Department, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China Sepsis Translational Medicine Key Lab of Hunan Province Central South University Changsha Hunan China; Department of Pathophysiology Xiangya School of Medicine Central South University Changsha Hunan China College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China Department of Radiology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Laboratory of Immunology and Virology Shanghai University of Traditional Chinese Medicine Pudong Shanghai P. R. China College of Life Sciences State Key Laboratory of Crop Stress Biology for Arid Areas Northwest A&F University Yangling 712100 Shaanxi China Department of Materials Science and NanoEngineering Rice University Houston TX 77005 USA Institute of Pharmacology and Toxicology, Academy of Military Medical Sciences, Beijing, PR China Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Cardiology; The Second Xiangya Hospital; Central South University; Changsha Hunan China Department of Biomedical Engineering, The Fourth Military Medical University, 169 Changle West Road, Xi’an 710032, China Department of Radiation Oncology, The Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital, Zhengzhou, Henan 450008, P.R. China School of Mechanical Engineering and Automation Beijing University of Aeronautics and Astronautics Beijing People's Republic of China State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Diseases Reference Laboratory, Key Laboratory of Animal Virology of Ministry of Agriculture, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China 788 Petit Science Center, Department of Chemistry, Center for Diagnostics and Therapeutics, Georgia State University, Atlanta, Georgia 30302, United States School of Psychology, Northwest Normal University, Lanzhou, China Department of Hepatic Surgery,The Third Affiliated Hospital of Sun Yat‐sen University,Guangzhou,China Department of Pharmacy, The Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou, Jiangsu 213003, China Guangdong Provincial Medical Biomechanical Key Laboratory, Department of Anatomy, Southern Medical University, Guangzhou, P.R. China State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy West China Hospital Sichuan University Chengdu Sichuan China Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital and Tianjin Institute of Endocrinology, Tianjin Medical University, 300070 Tianjin, China National Key Laboratory of Plant Molecular Genetics,Chinese Academy of Sciences Center for Excellence in Molecular Plant Sciences, Shanghai Institute of Plant Physiology and Ecology, Chinese Academy of Sciences, Shanghai, 200032, China; University of the Chinese Academy of Sciences, Beijing, 100049, China Basic Medical Laboratory Nanjing Jinling Hospital Clinical School of Medical College Nanjing University Nanjing China Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 430014, China Department of Cardiology, First Hospital of China Medical University, Shenyang, Liaoning, China Department of Metabolic Regulation, Shinshu University Graduate School of Medicine; Department of Cardiology, The Third Hospital of Hebei Medical University Department of Ophthalmology, Beijing Friendship Hospital, Capital Medical University, Beijing, China; Department of General Surgery, Xinqiao Hospital, The Third Military Medical University, Chongqing 400037, China. hwbyang@126.com. Sargent Joint Research Center, Wuhan National Laboratory for Optoelectronics (WNLO), School of Optical and Electronic Information, Huazhong University of Science and Technology (HUST), Wuhan, Hubei 430074, China International Joint Research Center of Aerospace Biotechnology and Medical Engineering of Ministry of Science and Technology of China, School of Biological Science and Medical Engineering, Beihang University, No. 37 Xueyuan Road, Haidian District, Beijing 100191, China Department of Medicinal Chemistry and Molecular Pharmacology Purdue University College of Pharmacy and Purdue Institute for Integrative Neuroscience West Lafayette Indiana USA State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 China CAS Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China School of Life Science, Nanchang University, Nanchang, China; Institute of Life Science, Nanchang University, Nanchang, China Department of Orthopedics, Peking Union Medical College Hospital, 1st Shuai Fu Yuan, Dongcheng District, Beijing, China State Key Laboratory of Precision Measuring Technology & Instruments; School of Precision Instruments and Optoelectronics Engineering; Tianjin University; People's Republic of China Shanghai Skin Disease and STD Hospital, Shanghai China. Department of Metabolic Regulation, Shinshu University Graduate School of Medicine College of Food and Biological Engineering, Jimei University, Xiamen, Fujian 361021, P.R. China City University of Hong Kong Center of Super-Diamond and Advanced Films (COSDAF), and Department of Physics and Materials Science, , Tat Chee Avenue, Kowloon, Hong Kong, China From the Departments of Radiology (T.W., Y.Y., X.S.) and Thoracic Surgery (Y.S., X.L., Y.Z., J.D., M.Z., D.X., C.C.), Shanghai Pulmonary Hospital, Tongji University School of Medicine, Zhengmin Rd 507, Shanghai 200443, China; and Department of Computer Science and Technology, College of Electronics and Information Engineering, Tongji University, Shanghai, China (S.C.). Department of Prosthodontics, National Clinical Research Center for Oral Diseases, National Engineering Laboratory for Digital and Material Technology of Stomatology, Beijing Key Laboratory of Digital Stomatology Peking University School and Hospital of Stomatology Beijing China Department of Radiation Oncology, Zhejiang Cancer Hospital, Hangzhou, People's Republic of China. Engineering Research Center of Chinese Ministry of Education for Edible and Medicinal Fungi; Jilin Agricultural University; Changchun; P. R. China School of Sports and Human Sciences, Shanghai Sport University, Shanghai 200438, China. School of Life Sciences Northwestern Polytechnical University Xi'an Shaanxi China Department of Neonates; Nanjing Children's Hospital; Nanjing Medical University; Nanjing China The Institute of Vegetables and Flowers, Chongqing Academy of Agricultural Sciences School of Pharmacy, Shanghai University of Traditional Chinese Medicine (SHUTCM), Shanghai 201203, China Research Institute for Energy Conservation, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Umezono, Tsukuba 305-8568, Japan; Graduate School of System and Information Engineering, University of Tsukuba, 1-1-1, Tennoudai, Tsukuba 305-8573, Japan China Pharmaceutical University Nanjing China State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China Department of Medicine University of Virginia Health System Charlottesville Virginia; Translational and Molecular Imaging Institute and Department of Radiology Icahn School of Medicine at Mount Sinai New York New York Institute of Neuroscience, Zhejiang University School of Medicine, Hangzhou, China Department of Radiology University Medical Center Mainz (Johannes Gutenberg‐University Mainz) Mainz Germany Department of Respiratory Medicine Affiliated Jiangning Hospital of Nanjing Medical University Nanjing Jiangsu 211100 China Department of Neurosurgery The 904th Hospital of PLA School of Medicine of Anhui Medical University Wuxi Jiangsu Province China; Department of Neurosurgery and State Key Laboratory of Trauma, Burn and Combined Injury Southwest Hospital Third Military Medical University (Army Medical University Chongqing China; Chongqing Key Laboratory of Precision Neuromedicine and Neuroregenaration Third Military Medical University (Army Medical University Chongqing China; Wuxi Translational Medicine Center Wuxi Jiangsu China College of Nuclear Science and Technology, Fundamental Science on Nuclear Safety and Simulation Technology Laboratory, Harbin Engineering University, Harbin 150001, P. R. China Department of Chemistry, Stanford University, Stanford, California 94305, United States State Key Laboratory of Genetic Engineering Ministry of Education Key Laboratory of Contemporary Anthropology Collaborative Innovation Center for Genetics and Development, and Center for Genetic Epidemiology School of Life Sciences Fudan University Shanghai China California NanoSystems Institute, ‡Department of Materials Science and Engineering, §Department of Pharmacology, ∥Department of Chemistry and Biochemistry, and ⊥Department of Psychiatry, Hatos Center for Neuropharmacology, and Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California 90095, United States The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources Ministry of Science and Technology of China School of Chemistry and Pharmaceutical Sciences Guangxi Normal University Guilin 541004 P.R. China Shandong Academy of Grape, Jinan, China Collaborative Innovation Center of Assessment Toward Basic Education Quality, Beijing Normal University, Beijing 100875, China Faculty of Health Sciences, University of Macau, E12 Avenida da Universidade, Taipa, Macau S.A.R., China State Key Laboratory of Physical Chemistry of Solid Surfaces, Collaborative Innovation Center of Chemistry for Energy Materials, State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle, College of Chemistry and Chemical Engineering, Xiamen University, No. 422 Siming South Road, Xiamen, Fujian 361005, China Department of Cardiothoracic Surgery, The Third Hospital of Shijiazhuang, Shijiazhuang, P.R. China. Department of Radiology and Biomedical Imaging University of California San Francisco San Francisco California USA MOE Joint International Research Laboratory of Animal Health & Food Safety Nanjing Agricultural University Nanjing 210095 P. R. China; Key Laboratory of Animal Physiology & Biochemistry Nanjing Agricultural University Nanjing 210095 P. R. China Key Laboratory of Low-Grade Energy Utilization Technologies and Systems (Chongqing University) 1 , Ministry of Education, Chongqing 400030, China; Chongqing University 2 Institute of Engineering Thermophysics, , Chongqing 400030, China State Key Lab of Physical Chemistry of Solid Surfaces, State−Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, People’s Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering & Pen-Tung Sah Institute of Micro-Nano Science and Technology, IKKEM, Xiamen University, Xiamen 361005, China Department of Kinesiology and Community Health, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA; Center for Taiji Studies, Champaign, IL 61826, USA Department of Nuclear Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Cell Biology, Shandong University Medical School, Jinan, China. Department of Prosthodontics, College of Stomatology, Jilin University. Changchun 130021, Jilin Province, China.E-mail:chen_xi121@163.com. California NanoSystems Institute, ‡Department of Materials Science and Engineering, and §Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, California 90095, United States Department of Chemistry and Chemical Biology, Indiana University−Purdue University Indianapolis, Indianapolis, Indiana 46202, United States The Comprehensive Cancer Center Nanjing University Medical School Affiliated Nanjing Drum Tower Hospital Clinical Cancer Institute of Nanjing University Nanjing China Centre of Nanoscale Science and Technology and Key Laboratory of Functional Polymer Materials, College of Chemistry, Nankai University, Tianjin 300071, China COVID‐19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, The First School of Clinical Medicine Southern Medical University Nanjing Jiangsu China Tangshan Hongci Hospital, Tangshan, Hebei Province, China. Department of Neurobiology, Southern Medical University, Guangzhou 510515, China. yangyang_story@126.com Great Lakes Bioenergy Research Center Michigan State University East Lansing MI 48824 USA; Department of Biochemistry and Molecular Biology Michigan State University East Lansing MI 48824 USA School of Public Health Sciences, University of Waterloo, Canada. Jilin Provincial Key Laboratory of Advanced Energy Materials Department of Chemistry Northeast Normal University Changchun 130024 P. R. China The Institute of Seawater Desalination and Multipurpose Utilization Ministry of Natural Resources Tianjin 300192 China Department of Automation, Tsinghua National Laboratory for Information Science and Technology, Tsinghua University, Beijing 100084, P. R. China Department of Biochemistry and Molecular Biology, Molecular Oncology and Biomarkers Program, Georgia Cancer Center, Medical College of Georgia Augusta University Augusta Georgia; Department of Otorhinolaryngology, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Functional Thin Films Research Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China.; Department of Materials Science and Engineering, City University of Hong Kong, Kowloon, Hong Kong SAR, China. Institute of Port, Coastal and Offshore Engineering, Department of Ocean Engineering, Ocean College, Zhejiang University, Zhoushan, China. The Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology; Department of Chemistry; Tsinghua University; Beijing; China Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Chemistry, Duke University , Durham, North Carolina 27708, USA Key Laboratory of Clinical Pharmacology of Antibiotics, Ministry of Health, Shanghai, People's Republic of China; Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People's Republic of China State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, and Key Laboratory of System Control and Information Processing, Ministry of Education of China, Shanghai 200240, China National Centre for Nanoscience and Technology; Beijing 100190; P. R. China Department of Respiratory and Critical Care Medicine, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 210002, China Functional and Molecular Imaging Key Lab of Shaanxi Province, Department of Radiology, Tangdu Hospital Air Force Medical University (Fourth Military Medical University) Xi'an Shaanxi China Hefei National Laboratory for Physical Science at Microscale and Department of Materials Science & Engineering, University of Science and Technology of China, Hefei 230026, People’s Republic of China Ardelyx, Inc. Waltham Massachusetts USA These senior authors contributed equally to this manuscript; Department of Biostatistics, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, United States School of Mechatronics Engineering and AutomationShanghai University Shanghai China Laboratory for Nanotechnology, Institute of Microsystems Engineering (IMTEK), Albert-Ludwigs-University of Freiburg, Georges-Köhler-Allee 103, 79110 Freiburg, Germany Institute of Biomedical Engineering, Department of Engineering Science, University of Oxford , Oxford, UK; Oxford-Suzhou Centre for Advanced Research , Suzhou, China Department of Biotechnology, College of Life Sciences, Wuhan University, Wuhan 430072, China. Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Changsha Hunan China; Department of Microbiology, School of Basic Medical Science Central South University Changsha Hunan China; NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute Central South University Changsha Hunan China; Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Changsha Hunan China; China‐Africa Research Center of Infectious Diseases Central South University Changsha Hunan China Institute of Modern Optics, Nankai University Chongqing University Department of Dermatology, The First Hospital of China Medical University, Shenyang China; Key Laboratory of Immunodermatology, Ministry of Education and NHC, Shenyang, China; National Joint Engineering Research Center for Theranostics of Immunological Skin Diseases, Shenyang, China College of Food Engineering Harbin University of Commerce Harbin China Department of Abdominal Oncology, West China Hospital Sichuan University Chengdu China Department of Thoracic Surgery Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, First Affiliated Hospital of University of Science and Technology of China, School of Life Sciences, University of Science and Technology of China (USTC), 230027 Hefei, Anhui, China;; Chinese Academy of Sciences (CAS) Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, USTC, 230027 Hefei, Anhui, China; MOE Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology; Department of Chemistry; Tsinghua University; Beijing 100084; China Department of Clinical Psychology Clinical Medical College of Yangzhou University Yangzhou People's Republic of China College of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China Key Laboratory of Microelectronic Devices & Integrated Technology Institute of Microelectronics Chinese Academy of Sciences Beijing 100029 China; University of Chinese Academy of Sciences Beijing 100049 China Institute of Tropical and Subtropical Cash Crops, Yunnan Academy of Agricultural Sciences, Baoshan 678000, China Department of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200433 China Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, 614 Brinkhous-Bullitt Building, Chapel Hill, NC 27599, USA Yunnan Normal University, Kunming, 650500, China.; The Engineering Research Center of GIS Technology in Western China, Ministry of Education of China, Kunming, 650500, China. Key laboratory of Carcinogenesis and Translational Research, Ministry of Education, Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Beijing 100191, China State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Collaborative Innovation Center of Chemistry for Energy Materials, Xiamen University, Xiamen 361005, China School of Chemistry and Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, 3010, Parkville, Victoria, Australia Department of Obstetrics and Gynecology, The First Affiliated Hospital of Harbin Medical University, Harbin, China. State Key Laboratory of Supramolecular Structure and Materials, Jilin University, Changchun 130012, People’s Republic of China Key Laboratory for Stem Cells and Tissue Engineering Ministry of Education, the 1st Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Department of Chemistry, University of Illinois at Urbana-Champaign , 600 South Mathews Ave., Urbana, Illinois 61801, USA The First Affiliated Hospital of University of Science and Technology of China (USTC), Hefei National Laboratory for Physical Sciences at Microscale, School of Basic Medical Sciences, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230027, China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau , Macau SAR 999078 , China Department of Neurology, Yale University School of Medicine, New Haven, Connecticut4Neurorehabilitation Research Center, Department of Neurology, Veterans Affairs Medical Center, West Haven, Connecticut School of Chemistry and Chemical Engineering, Southwest University, Chongqing, 400715, China Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA Department of Biostatistics, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, FL, USA Department of Gynaecology, Shenyang Women’s and Children’s Hospital, Shenyang, Liaoning, China †Department of Genetics, Stanford University School of Medicine, Stanford, CA 94305 Department of Thoracic Surgery, First Affiliated Hospital, Zhengzhou University, Open Key Clinical Medical Experimental Laboratory Institute of Henan Province, Institute of Molecular Cancer Surgery of Zhengzhou University, the Key Thoracic Tumour Experimental Laboratory of Zhengzhou, Zhengzhou, Henan 450052, China. Center of Super‐Diamond and Advanced Films (COSDAF) and Department of Physics and Materials Science City University of Hong Kong Hong Kong SAR Institute for Infectious Disease and Endemic Disease Control Beijing Center for Disease Prevention and Control Beijing China Collaborative Innovation Center of Tianjin for Medical Epigenetics Tianjin Key Laboratory of Medical Epigenetics Key Laboratory of Immune Microenvironment and Disease (Ministry of Education) Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Tianjin Medical University Tianjin 300070 China Key Laboratory of Drug Targeting & Drug Delivery System, Ministry of Education, West China School of Pharmacy, Sichuan University, Number 17, Block 3, Southern Renmin Road, Chengdu 610041, China Shanghai Key Laboratory of Brain Functional Genomics (Ministry of Education), Affiliated Mental Health Center (ECNU), Institute of Brain and Education Innovation, School of Psychology and Cognitive Science East China Normal University Shanghai China; Shanghai Changning Mental Health Center Shanghai China; Shanghai Center for Brain Science and Brain‐Inspired Technology Shanghai China Department of Paediatric Transplantation Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China Institute of Translational Medicine, The First Hospital, Jilin University, Changchun, 130061, China Department of Dermatology, The First Hospital of China Medical University, Shenyang 110001, P.R. China Department of Thoracic Surgery, Shanghai Chest Hospital Shanghai Jiao Tong University Shanghai China Department of Ophthalmology, The Hospital of Shunyi District Beijing, 3 Guangming South Street, Shunyi, Beijing 101300, China Trimeris, Inc., 3500 Paramount Parkway, Morrisville, North Carolina 27560, ChemBridge Research Laboratories, Suite K, 16981 Via Tazon, San Diego, California 92127, and ChemBridge Corporation, Suite G, 16981 Via Tazon, San Diego, California 92127 Institute of Pediatric Research, Children’s Hospital of Soochow University, Suzhou, People’s Republic of China College of Chemistry; Northeast Normal University; Changchun, China a State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy Liver Transplantation Center, Third Affiliated Hospital of Sun Yat-sen University, Transplantation Research Institute of Sun Yat-sen University, Guangzhou, Guangdong 510630, China. Department of Electromyography Tianjin Hospital Tianjin China Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University, Changsha, China School of Bioscience and Bioengineering South China University of Technology Guangzhou China; Pre‐incubator for Innovative Drugs and Medicine South China University of Technology Guangzhou China; Guangdong Provincial Key Laboratory of Fermentation and Enzyme Engineering South China University of Technology Guangzhou China Inner Mongolia Key Lab of Carbon Nanomaterials, Nano Innovation Institute (NII), College of Chemistry and Materials Science, Inner Mongolia Minzu University (IMUN), Tongliao 028000, Inner Mongolia, People’s Republic of China Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province and State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China School of Automotive Engineering, Chongqing University , Chongqing 400044, People's Republic of China lyanli@cqu.edu.cn , zgchu@cqu.edu.cn , yangyang911127@cqu.edu.cn Department of Pharmacology (the State-Province Key Laboratories of Biomedicine-Pharmaceutics of China, Key Laboratory of Cardiovascular Research, Ministry of Education), College of Pharmacy, Harbin Medical University, Harbin, China. Affiliated Bayi Brain Hospital, The P.L.A Army General Hospital, Beijing, China State Key Laboratory of Precision Measuring Technology & Instruments; Tianjin University; Tianjin 300072; China State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA.; California NanoSystems Institute, University of California, Los Angeles, CA 90095, USA. College of Furniture and Art Design, Central South University of Forestry and Technology, Green Furniture Engineering Technology Research Center in Hunan, National Forestry & Grassland Administration, Green Home Engineering Technology Research Center, Changsha, Hunan410004, China College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, Xiamen, Fujian China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China Department of Pharmacy, Jinling Hospital, Medical School of Nanjing University, Nanjing, China. Stem Cells and Metabolism Research Program, Research Programs Unit, Faculty of Medicine, University of Helsinki, 00014 Helsinki, Finland; School of Life and Health Sciences, Faculty of Science, The Chinese University of Hong Kong, 518172 Shenzhen, China School of Chemical Engineering and Technology; Hebei University of Technology; Tianjin; P. R. China College Pharmacy, Qiqihar Medical University, Qiqihar, China;; College Pharmacy, Jiamusi University, Jiamusi, China;; Beijing Institute of Pharmacology and Toxicology, Beijing, China From the Arkansas Cancer Research Center, Departments of Pathology and Anatomy & Neurobiology, and the Myeloma Institute for Research and Therapy, University of Arkansas for Medical Sciences, Little Rock. College of Public Health; University of South China; Hengyang 421001; PR China 2011 Collaborative Innovation Center of Tianjin for Medical Epigenetics, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China Department of Materials Science and Engineering University of California, Los Angeles Los Angeles CA 90095 USA; California Nano Systems Institute University of California, Los Angeles Los Angeles CA 90095 USA Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA State Key Laboratory of Fine Chemicals; Department of Chemistry; Dalian University of Technology; Dalian; P. R. China CAS Key Laboratory of Coastal Environmental Processes and Ecological Remediation; Yantai Institute of Coastal Zone Research; Chinese Academy of Sciences; Yantai 264003; China College of Animal Science and Technology, College of Veterinary Medicine, Key Laboratory of Applied Technology on Green‐Eco‐Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology Zhejiang A&F University Hangzhou China School of Mechanical Engineering, Wuhan Polytechnic University, Wuhan 430023, China Department of Computer Science and Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China College of Mechanical Science and Engineering, Jilin University 1 , Changchun 130022, China CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, No. 189 Songling Road, Qingdao 266101, China State Key Lab of Physical Chemistry of Solid Surfaces; Collaborative Innovation Center of Chemistry for Energy Materials (iChEM); Department of Chemistry; College of Chemistry and Chemical Engineering; Xiamen University Department of Biostatistics and Emerging Pathogens Institute, University of Florida, Gainesville, FL; University of Louisiana at Lafayette, Lafayette, Louisiana, USA Department of Sociology and Population Research Center and Center on Aging at NORC, The University of Chicago, 1126 E. 59th Street, Chicago, IL 60637 College of Animal Science, Shanxi Agricultural University, Jinzhong 030801, China Basic Medical Laboratory Institute of Clinical Laboratory Science Jinling Hospital Clinical School of Medical College Nanjing University Nanjing China Key Laboratory of Low-Grade Energy Utilization Technologies and Systems (Chongqing University), Ministry of Education, Chongqing 400030, China; Institute of Engineering Thermophysics, School of Energy and Power Engineering, Chongqing University, Chongqing 400030, China Section of Cardiology, Department of Medicine, Baylor College of Medicine, Texas Heart Institute and Baylor–St. Luke's Medical Center; Houston, Texas 77030 Key Laboratory of Key Technical Factors in Zhejiang Seafood Health Hazards National Engineering Research Center for Marine Aquaculture Zhejiang Ocean University Zhoushan China Key Laboratory for Renewable Energy, Beijing Key Laboratory for New Energy Materials and Devices, Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China Key Laboratory of Low-grade Energy Utilization Technologies and Systems (Chongqing University); Ministry of Education; Chongqing 400030; China; Institute of Engineering Thermophysics Department of Materials Science and Engineering and California NanoSystems Institute, University of California, Los Angeles, California, 90095 Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China Department of Biochemistry and Molecular Biology, Tianjin Medical University, Tianjin 300052, P.R. China Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China; and Center for Bio-inspired Energy Science, Northwestern University, 2145 Sheridan Road, Evanston, IL 60208, USA Henan Engineering Research Center of Chiral Hydroxyl Pharmaceutical, Collaborative Innovation Center of Henan Province for Green Manufacturing of Fine Chemicals, Key Laboratory of Green Chemical Media and Reactions, Ministry of Education, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China; State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China 1. Key Laboratory of Animal Genetics, Breeding and Reproduction of Ministry of Agriculture and Rural Affairs, Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, China. Faculty of Psychology, Tianjin Normal University, Tianjin, China Central Laboratory of Yan'an Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, People's Republic of China.; Yunnan Cell Biology and Clinical Translation Research Center, Kunming, Yunnan, People's Republic of China.; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Kunming, Yunnan, People's Republic of China. State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, People’s Republic of China Department of Thoracic Surgery Shanghai Pulmonary Hospital Tongji University School of Medicine Shanghai 200092 P. R. China Hospital of Stomatology, Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Guangzhou China State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, China Department of Genetics, School of Medicine, Stanford University, Stanford, CA 94305; Prenatal Diagnosis Center, Hangzhou Maternity and Child Care Hospital, Hangzhou, Zhejiang 310000, China. loster2010@outlook.com. State Key Laboratory of Precision Measuring Technology & Instruments and College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China Key Laboratory of Drug-Targeting and Drug Delivery System of the Ministry of Education, West China School of Pharmacy, and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China Department of Anesthesia; China-Japan Union Hospital of Jilin University; Changchun 130033; China The Key Laboratory of Oral Biomedicine, Jiangxi Province, The Affiliated Stomatological Hospital of Nanchang University, Nanchang, Jiangxi 330080, China Department of Liver Transplantation The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong China Experiment Center for Science and Technology, Shanghai University of Traditional Chinese Medicine, Shanghai 200032, China Zhuhai Interventional Medical Center Zhuhai Hospital Affiliated with Jinan University (Zhuhai People's Hospital) Zhuhai China Department of Tuberculosis, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China Guangdong Provincial Key Laboratory of Precision Medicine and Clinical Translational Research of Hakka Population Meizhou People's Hospital, Meizhou Academy of Medical Sciences Meizhou China; Department of Gastroenterology Meizhou People's Hospital, Meizhou Academy of Medical Sciences Meizhou China School of Physics & Materials Engineering; Dalian Nationalities University; Dalian 116600; China Department of Surgery, Shanghai Pulmonary Hospital Tongji University School of Medicine No. 507, Zhengmin Road, Yangpu District Shanghai 200433 P. R. China Radiology Department of Huashan Hospital Fudan University Shanghai China The Comprehensive Cancer Centre of Drum Tower Hospital Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University Nanjing China The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; Department of Orthopedics, Guangdong Second Provincial General Hospital, Guangzhou, China Cardiovascular Division, Department of Medicine University of Virginia Health System Charlottesville Virginia USA; Biomedical Engineering and Imaging Institute and Department of Radiology Icahn School of Medicine at Mount Sinai New York New York USA Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China Division of Product Quality Research Food and Drug Administration, Center for Drug Evaluation and Research, Office of Testing and Research Silver Spring MD USA Key Laboratory of Carcinogenesis & Translational Research (Ministry of Education), Breast Cancer Prevention & Treatment Center, Peking University Cancer Hospital & Institute, Beijing 100142, China. Institute of Hydrobiology, Jinan University, Huangpu Street 601, Guangzhou 510632, China Department of Pathology St. Luke's International Hospital Tokyo Japan; Department of Pathology Tohoku University Graduate School of Medicine Sendai Japan Faculty of Medicine University of Melbourne Melbourne Vic. Australia; Western Health Melbourne Vic. Australia; Monash University Melbourne Vic. Australia; Eastern Health Melbourne Vic. Australia Department of Orthopedics of Peking Union Medical College Hospital, Beijing; Medical team supporting Hubei and Department of Hepatic Surgery and Liver transplantation Center, the Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, Guangdong, China. Department of Cell Biology and Genetics School of Basic Medical Sciences Xi'an Jiaotong University Health Science Center Xi'an China; Key Laboratory of Environment and Genes Related to Diseases Xi'an Jiaotong University Health Science Center Xi'an China; Institute of Genetics and Developmental Biology School of Basic Medical Sciences Translational Medicine Institute Xi'an Jiaotong University Health Science Center Xi'an China Department of the Eighth Healthcare , Second Medical Center, National Clinical Research Center for Geriatric Diseases, , Beijing 1000853, China; Chinese People’s Liberation Army General Hospital , Second Medical Center, National Clinical Research Center for Geriatric Diseases, , Beijing 1000853, China Department of Neonatology Nanjing Children's Hospital of Nanjing Medical University Nanjing P.R. China Department of Psychology, Rutgers University-Newark; National Institute of Education, Nanyang Technological University Department of Veterinary and Biomedical Sciences, College of Veterinary Medicine, University of Minnesota, Saint Paul, Minnesota, USA Photonics Laboratory, Computer, Electrical, and Mathematical Sciences and Engineering (CEMSE); ‡Imaging & Characterization Core Lab; and §Solar & Photovoltaics Engineering Research Center (SPERC), Physical Sciences and Engineering (PSE), King Abdullah University of Science & Technology (KAUST), Thuwal 23955-6900, Saudi Arabia State Key Laboratory of Environment Health (Incubation), Key Laboratory of Environment & Health (Ministry of Education), Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics School of Public Health, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Authors' Affiliations: 1Department of Pathology and 2Comprehensive Cancer Center and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, Alabama and 3Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas; Authors' Affiliations: 1Department of Pathology and 2Comprehensive Cancer Center and the Center for Metabolic Bone Disease, University of Alabama at Birmingham, Birmingham, Alabama and 3Department of Orthopaedic Surgery, Center for Orthopaedic Research, University of Arkansas for Medical Sciences, Little Rock, Arkansas Department of Emergency and Intensive Care, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Mechanical Engineering, The University of Hong Kong, Pokfulam Road, Hong Kong, China. CAS Key Laboratory of Green Process and Engineering, Institute of Process Engineering, Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing 100190, P. R. China; National Engineering Laboratory for Flue Gas Pollutants Control Technology and Equipment, Tsinghua University, Beijing 100084, P. R. China State Key Laboratory of Coordination Chemistry, Chemistry and Biomedicine Innovation Center (ChemBIC), School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China. School of Chemical Engineering and Pharmacy; Key Laboratory of Novel Biomass-based Environmental and Energy Materials in Petroleum and Chemical Industry, Wuhan Institute of Technology, LiuFang Campus, No. 206, Guanggu 1st Road, Donghu New & High Technology Development Zone, Wuhan 430205, Hubei Province, PR China Sustainable Materials and Chemistry Department of Wood Technology and Wood‐based Composites University of Goettingen Büsgenweg 4 D‐37077 Göttingen Germany; State Key Laboratory of Pulp and Paper Engineering South China University of Technology Guangzhou 510640 P. R. China School of Basic Medical Sciences and State Key Laboratory of Molecular Engineering of Polymers Fudan University Shanghai 200032 P. R. China University of Delaware. Department of Materials Science and Engineering and ‡California NanoSystems Institute, University of California, Los Angeles, California 90095, United States School of Computer Science and Technology, Soochow University, Suzhou 215006, China Jiangxi Provincial Key Laboratory of Drug Design and Evaluation, School of Pharmacy Jiangxi Science & Technology Normal University Nanchang China Faculty of Life Science, Northwest University, Xi’an, Shaanxi 710069, China; Department of Biomedical Engineering, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China Department of Gastroenterology, Daping Hospital, Army Medical University, Chongqing, China The Affiliated Cancer Hospital of Nanjing Medical University & Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing, Jiangsu 210009, China School of Life and Health Sciences The Chinese University of Hong Kong Shenzhen 518172 P.R. China Energy Materials & Physics Group; Department of Physics; Shanghai University; Shanghai 200444; China Department of Pain Management, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing, Jiangsu, China Department of Chemistry and Biochemistry & The Biodesign Institute, Arizona State University, Tempe, Arizona 85287, United States School of Materials, Sun Yat-sen University, Shenzhen 510817, China The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Clinical Cancer Institute of Nanjing University, Nanjing, China Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing China Paleontological Institute, Shenyang Normal University, Shenyang, Liaoning, China Department of Otolaryngology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing, 100045, China. Nanjing University Medical School,Nanjing 210093, China. Department of Physics, Freie Universität Berlin 1 , Arnimallee 14, 14195 Berlin, Germany; Center for Supramolecular Interactions 2 , Takustr. 3, 14195 Berlin, Germany Key Laboratory for Environment and Health (Ministry of Education), Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, 430030, China Cancer Center, Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu, ChinaWest China Biomedical Big Data Center, Sichuan University, Chengdu, China Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Department of Chemistry Northeast Normal University Changchun 130024 P. R. China UNIAX Corporation, 6780 Cortona Drive, Santa Barbara, CA 93117, USA. State Key Laboratory of Molecular Reaction Dynamics; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian 116023, China; Key Laboratory of Chemical Lasers College of Pharmacy, Chongqing Medical University, Chongqing Key Laboratory of Biochemistry and Molecular Pharmacology, Chongqing, China Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA, United States; Biomolecular Science and Engineering (BMSE) Program, University of California, Santa Barbara, CA, United States. Electronic address: yang@chem.ucsb.edu. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY, USA. Department of Robot Engineering, School of Mechanical Engineering, Jiangsu Ocean University, Lianyungang 222005, China Department of Horticulture, College of Agriculture and Biotechnology Zhejiang University Hangzhou Zhejiang 310058 China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, China, 130021 Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, 210029, Nanjing, Jiangsu, People’s Republic of China Department of Neurosurgery Xijing Hospital The Fourth Military Medical University Xi'an China; Department of Biomedical Engineering The Fourth Military Medical University Xi'an China Department of Gastroenterology, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences , Beijing , China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of the Ministry of Education College of Life Sciences Nankai University Tianjin China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, Beijing 100190, China Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou 450001, China. tangshuiyy@163.com Division of Biology, University of California San Diego, La Jolla, CA 92093-0377; and Department of Chemistry, State Key Laboratory of Molecular Engineering of Polymers Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials and iChem Fudan University Shanghai 200433 China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Institute of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui Hospital of Zhejiang University Lishui 323000 China; Clinical College of The Affiliated Central Hospital School of Medicine Lishui University Lishui 323000 China The Comprehensive Cancer Centre of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, People's Republic of China School of Petrochemical Engineering, Changzhou University, Changzhou 213164, P. R. China School of Pharmacology, Shandong Technology Innovation Center of Molecular Targeting and Intelligent Diagnosis and Treatment, Binzhou Medical University, Yantai 264003, P.R. China Institute of Special Materials and Technology, Fudan University, Shanghai 200433, P. R. China Department of Materials Science and Engineering, University of California, Los Angeles, California 90095, United States Biomechanics Labs of Orthopaedics Institute, Tianjin Hospital, Tianjin, People’s Republic of China Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, 200030, P.R. China Department of Gastroenterology, Daping Hospital, Army Medical University , Chongqing, China Institute of Translational Medicine, The First Hospital of Jilin University , Changchun, Jilin, China Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, Department of Macromolecular Science, Fudan University, Shanghai 200433, People’s Republic of China Department of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Medical Oncology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, Jiangsu, China (mainland) Department of Pathology, The Second Xiangya Hospital Central South University Changsha Hunan China Shandong University Jinan, Shandong Province, P. R. China. Department of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China Hefei 230001, Anhui Province, P. R. China. Anhui Province Key Laboratory of Brain Function and Brain Disease Hefei 230001, Anhui Province, P. R. China. Novo Nordisk Research Center China, Novo Nordisk A/S, Shengmingyuan West Ring Rd, Changping District, Beijing, China Department of Biostatistics, College of Public Health and Health Professions, and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA MOE Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China Department of Chemistry, Stanford University, Stanford, CA 94305; School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China; Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, Nanjing 210094, China Department of Oncology, The First Affiliated Hospital of Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi 530000, P.R. China Institute of Mechanical Engineering, Materials and Transportation, Peter the Great Saint-Petersburg Polytechnic University, Saint Petersburg 195251, Russia Department of Radiology & Functional and Molecular Imaging, Key Lab of Shaanxi Province, Tangdu Hospital, the Military Medical University of PLA Airforce (Fourth Military Medical University), Xi'an, Shaanxi 710038, P. R. China. Department of Pediatric transplantation, Organ Transplantation Center Tianjin First Central Hospital Tianjin China School of Geography and Environmental Sciences Northwest Normal University Lanzhou P. R. China Department of Haematology and BMT Centre Chinese PLA General Hospital Beijing China; Department of Haematology Chinese PLA Air Force General Hospital Beijing China Department of Neuropsychiatry & Behavior Neurology and Clinical Psychology, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; China National Clinical Research Center for Neurological Disease, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; Department of Psychology, Capital Medical University, Beijing, China; Branch Institute of Sleep and Consciousness, Beijing Institutes of Brain Diseases, Beijing, China Department of Neurology, the Fourth Affiliated Hospital, China Medical University, Shenyang, 110032, China Department of Pathophysiology, School of Basic Medicine, Key Laboratory of Ministry of Education of China for Neurological Disorders, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Key Laboratory for Environmental and Urban Sciences, School of Urban Planning and Design, Shenzhen Graduate School, Peking University, Shenzhen 518055, Guangdong, China. Key Laboratory of Pollinating Insect Biology, Institute of Apicultural Research, Chinese Academy of Agricultural Sciences, Beijing 100093, China State Key Laboratory of Physical Chemistry of Solid Surfaces Pen-Tung Sah Institute of Micro-Nano Science and Technology College of Chemistry and Chemical Engineering, iChEM Xiamen University 361005 Xiamen China Yang Yang is an associate professor in the Department of Sociology and the Lineberger Comprehensive Cancer Center at the University of North Carolina, , in Chapel Hill. National Center for NanoScience and Technology, China, Beijing 100190, China School of Electronic Information Engineering, Changchun University of Science and Technology, Changchun 130022, China Department of Pharmacy Beijing Institute of Pharmacology and Toxicology Beijing China Department of Pharmaceutics, Beijing Institute of Pharmacology and Toxicology, Beijing, PR China, Department of Pharmacy, Beijing Institute of Pharmacology and Toxicology, Beijing, People's Republic of China Department of Orthopaedics The 960th Hospital of the PLA Joint Logistice Support Force Jinan China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine 280 South Chongqing Road Shanghai 200025 P. R. China State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, PR China Department of Obstetrics The First Affiliated Hospital of Chongqing Medical University Chongqing China; International Collaborative Laboratory of Reproduction and Development, Ministry of Education Chongqing Medical University Chongqing China; State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality The First Affiliated Hospital of Chongqing Medical University Chongqing China Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Engineering Research Center of Tropical and Subtropical Aquatic Ecological Engineering, Ministry of Education, Guangzhou 510632, China. Department of Thoracic Surgery the First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Pharmacodynamics, College of Pharmacy University of Florida Gainesville Florida USA Anhui Key Laboratory of Environmental Toxicology and Pollution Control Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, China Department of Internal Medicine, First People's Hospital of Nanning, Lang Dong Branch 9 Yuebing Road, Nanning 530021, Guangxi, China. Monash University, Melbourne, Victoria, Australia. Shenzhen Key Laboratory of Pathogen and Immunity, National Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People’s Hospital, Second Hospital Affiliated to Southern University of Science and Technology , Shenzhen, China Hunan Cancer Hospital/the Affiliated Cancer Hospital of Xiangya School of Medicine Central South University Hunan Changsha China; Department of Microbiology, School of Basic Medical Science Central South University Hunan Changsha China; NHC Key Laboratory of Carcinogenesis, The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute Central South University Hunan Changsha China; Department of Hematology, National Clinical Research Center for Geriatric Disorders, Xiangya Hospital Central South University Hunan Changsha China; China‐Africa Research Center of Infectious Diseases Central South University Hunan Changsha China CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety National Center for Nanoscience and Technology Beijing 100190 China Neurobiology, Yale University School of Medicine, New Haven, CT 06511; and Department of Endocrinology and Metabolism, Institute of Endocrinology, NHC Key Laboratory of Diagnosis and Treatment of Thyroid Diseases, The First Affiliated Hospital of China Medical University, Shenyang, P.R. China. Department of Orthopaedics, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China Department of Otolaryngology Head and Neck Surgery, Tianjin Union Medical Center, Tianjin 300121, P.R. China Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China From the Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences, Northwest University, Taibai, Xi’an, China (Z.W., C.L., Y.Y.) Department of Radiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430014, China National Center for Chronic and Non-communicable Disease Control and PreventionChinese Center for Disease Control and Prevention, Beijing, China Hefei National Laboratory for Physical Science at Microscale Department of Materials Science & Engineering National Synchrotron Radiation Laboratory University of Science and Technology of China Hefei 230026 China Department of Cardiovascular Surgery Xijing Hospital Xi'an China Department of Gastroenterology, Beijing Key Laboratory of Functional Gastrointestinal Disorders Diagnosis and Treatment of Traditional Chinese Medicine, Wangjing Hospital, China Academy of Chinese Medical Sciences Department of Biostatistics, University at Buffalo, Buffalo, New York. Key Lab of Restoration and Reconstruction of Degraded Ecosystem in Northwest China of Ministry of Education, Ningxia University, Yinchuan, China; State Key Laboratory of Loess and Quaternary Geology, Institute of Earth Environment, Chinese Academy of Sciences, Xi’an, China; CAS Center for Excellence in Quaternary Science and Global Change, Xi’an, China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, P. R. China School of Petrochemical Engineering; Chang Zhou University; Changzhou, P. R. China Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People’s Republic of China Pharmaceutical Orthopaedic Research Lab, Faculty of Pharmacy and Pharmaceutical Sciences University of Alberta Edmonton Alberta Canada Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy of Tianjin Key Laboratory of Breast Cancer Prevention and Therapy Tianjin Medical University Ministry of Education Tianjin China Department of Otolaryngology–Head and Neck Surgery, Chongqing, China Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University); Ministry of Education; College of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715 The Genomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, California 92121, United States State Key Lab of Physical Chemistry of Solid Surfaces, State-Province Joint Engineering Laboratory of Power Source Technology for New Energy Vehicle, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P.R. China College of Food and Biological Engineering, Xiamen Key Laboratory of Marine Functional Food, Fujian Provincial Engineering Technology Research Center of Marine Functional Food, Fujian Collaborative Innovation Center for Exploitation and Utilization of Marine Biological Resources, Jimei University, 43 Yindou Road, Xiamen, 361021, Fujian, P.R. China Beijing Key Laboratory of Mental Disorders, National Clinical Research Center for Mental Disorders and National Center for Mental Disorders, Department of integrated traditional Chinese and Western medicine, Beijing Anding Hospital, Capital Medical University, Beijing, China. 2 Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing 100088, China. National Laboratory of Medical Molecular Biology; Institute of Basic Medicine Sciences and School of Basic Medicine, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100005, China School of Nursing Hangzhou Normal University Hangzhou Zhejiang China School of Public Health, Imperial College London, London SW7 2AZ, United Kingdom Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Songhu Rd. 2005, 200438 Shanghai, China Sunnybrook Research Institute Sunnybrook Health Sciences Centre Toronto ON M4N 3M5 Canada; Department of Laboratory Medicine and Pathobiology University of Toronto Toronto ON M5S 1A8 Canada 1Department of Anesthesiology, Critical Care and Pain Medicine and Center for Perioperative Medicine, McGovern Medical School, University of Texas Health Science Center at Houston, Houston, TX 77030 Shenzhen Bao’an Authentic TCM Therapy Hospital, Shenzhen 518102, China Department of Obstetrics, Hainan General Hospital/Affiliated Hainan Hospital of Hainan Medical College, Haikou, Hainan 570311, P.R. China Department of Computer Science and Engineering, Shanghai Jiao Tong University, Shanghai, China; Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering, Shanghai, China Australian Institute for Bioengineering and Nanotechnology; The University of Queensland; Australia Department of Hepatic Surgery, the Third Affiliated hospital, Sun Yat-san University, Guangzhou 510630, China State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University Chengdu Sichuan China State Key Laboratory of Environment Health (Incubation), MOE (Ministry of Education) Key Laboratory of Environment and Health, Ministry of Environmental Protection Key Laboratory of Environment and Health (Wuhan), and Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Laboratory Medicine, The Affiliated Hospital of Yangzhou University, Yangzhou University, Yangzhou, China Institute of Information on Traditional Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, China School of Pharmaceutical Science and Technology, Hangzhou Institute of Advanced Study, Hangzhou 310024, China Julia McFarlane Diabetes Research Centre, Department of Biochemistry and Molecular Biology, University of Calgary, Canada 1State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, China. The Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University Hefei Anhui China; The Key Laboratory of Anti‐inflammatory of Immune Medicines, Ministry of Education Hefei China; Institute for Liver Diseases of Anhui Medical University, Anhui Medical University Hefei China; Anhui Key Laboratory of Bioactivity of Natural Products, School of Pharmacy, Anhui Medical University Hefei China Department of Chemistry, University of Massachusetts-Amherst, Amherst, Massachusetts 01003, USA Key Laboratory of Colloid and Interface Chemistry of the Ministry of Education School of Chemistry and Chemical Engineering Shandong University Jinan Shandong 250100 P. R. China Department of Anesthesia, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. Department of Cardiology, the Second Affiliated Hospital of Harbin Medical University, Harbin, China;; The Key Laboratory of Myocardial Ischemia, Harbin Medical University, Ministry of Education, Harbin, China; Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen 518051, China Institute for Advanced Study and College of Chemistry, Nanchang University, 999 Xuefu Road, Nanchang, 330031, P. R. China Key Laboratory of Luminescence Analysis and Molecular Sensing (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, PR China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials, Fudan University, Shanghai 200438, China Department of Pharmacology Chongqing Medical University Chongqing 400016 China Department of Neonatology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, P.R. China Beijing Institute of Pharmacology and Toxicology, Beijing, China,; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China, College of Food Science and Engineering Inner Mongolia Agricultural University Hohhot China Division of Molecular Pharmaceutics, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, United States State Key Laboratory of Green Building in Western China, Xi’an University of Architecture & Technology, Xi’an 710055, China; College of Architecture and Art, Hefei University of Technology, Hefei 230601, China Tech Lab, School of Electrical and Data Engineering, University of Technology Sydney, Botany, New South Wales 2019, Australia Department of Thoracic Surgery Shanghai Pulmonary Hospital Institute for Advanced Study Tongji University Shanghai 200430 P. R. China National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, China Texas Christian University National and local Joint Engineering Research Center of Biomedical Functional Materials Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Changzhou Institute of Innovation and Development School of Chemistry and Materials Science Nanjing Normal University Nanjing P. R. China Center for Systems Biology, Soochow University, No1. Shizi Street, Suzhou, Jiangsu 215006, China; School of Computer Science and Technology, Soochow University, No1. Shizi Street, Suzhou, Jiangsu 215006, China; Department of Experimental Medical Science, Lund University, SE-221 84 Lund, Sweden and 1Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.; 2Molecular Oncology and Biomarkers Program, Georgia Cancer Center, Augusta, Georgia.; 3Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, Georgia. Department of Radiation Therapy, Zhejiang Cancer Hospital, Hangzhou, China; Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, China; School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China Department of Gastroenterology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Medical Imaging, Qiqihar Tuberculosis Control Institute, Qiqihar, 161000, Heilongjiang Province, China Institute of Ultrasound Imaging, the Second Affiliated Hospital of Chongqing Medical University, Chongqing; School of Pharmacy Institute for Liver Diseases of Anhui Medical University ILD‐AMU Key Laboratory of Anti‐inflammatory and Immune Medicine Anhui Medical University Hefei China Beijing National Laboratory for Molecular Sciences, Organic Solids Laboratory, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Writing Committee for the REMAP-CAP Investigators Department of Radiology Affiliated Hospital of Zunyi Medical University Guizhou China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education. Faculty of Life Sciences and Medicine Northwest University Xi'an China; Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No. 3 Hospital The Affiliated Hospital of Northwest University Xi'an China Division of Nephrology, Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese Medicine Nanjing People's Republic of China; No. 1 Clinical Medical College Nanjing University of Chinese Medicine Nanjing People's Republic of China Key Laboratory of Medical Virology, Ministry of Health, National Institute for Viral Disease Control and Prevention, Chinese Centers for Disease Control and Prevention, Beijing, China. State Key Laboratory of Mechanical Transmissions, Chongqing University , Chongqing 400044, People's Republic of China 20163413037t@cqu.edu.cn , zgchu@cqu.edu.cn , yangyang911127@cqu.edu.cn , yongxingzhang@cqu.edu.cn Department of Chemistry and Department of Physics, University of Michigan, Ann Arbor, Michigan 48109-1055 Key Laboratory of Systems Bioengineering (Tianjin University), Ministry of Education; Department of Pharmaceutical Engineering, School of Chemical Engineering & Technology, Tianjin University, Tianjin, People's Republic of China. Department of Thoracic Radiotherapy Zhejiang Cancer Hospital Hangzhou Zhejiang China Department of Mechanical and Industrial Engineering Northeastern University Boston MA 02115 USA Hefei National Research Center for Physical Sciences at the Microscale and Department of Materials Science and Engineering University of Science and Technology of China Hefei 230026 China From the Department of Cardiothoracic Surgery (M.T., R.-J.S., F.G., A.D.C., J.L.d.B., R.C.R.), Departments of Pediatrics, Radiology, and Microbiology and Immunology (Y.-A.C., C.H.C.), and Department of Genetics (Y.Y.), Stanford University School of Medicine, Stanford, Calif. From the Stanford University School of Medicine, Department of Medicine, Division of Immunology and Rheumatology, Stanford, California 94305-5111 MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P. R. China; Key Laboratory of Animal Physiology and Biochemistry, Nanjing Agricultural University, Nanjing, P. R. China Department of Electronic Engineering, The Chinese University of Hong Kong, Hong Kong, China.; Department of Biomedical Engineering (BME), National University of Singapore, Singapore, Singapore.; Institute of Port, Coastal and Offshore Engineering, Ocean College, Zhejiang University, Zhoushan, Zhejiang, China. Plant Genetic Engineering Center of Hebei Province, Institute of Biotechnology and Food Science, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang 050051, China Department of Chemistry; Purdue University; West Lafayette; USA Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310020, China Department of Biological Engineering, School of Biology, Food and Environment Engineering, Hefei University, Hefei230601, Anhui, China School of Preclinical Medicine, Wannan Medical College, Wuhu, China Basic Medical Laboratory Institute of Clinical Laboratory Science Jinling Hospital Nanjing University School of Medicine Nanjing China Department of Thoracic and Cardiovascular Surgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China; Department of Biomedical Engineering, The Fourth Military Medical University, Xi'an, China Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi'an Jiaotong University, Xi'an, Shaanxi, P. R. China Department of Materials Science and Engineering, and ‡California NanoSystems Institute, University of California, Los Angeles, California 90095, United States Department of Biomedical Engineering University of Virginia Health System Charlottesville Virginia USA Institute of Animal Nutrition; Northeast Agricultural University; Harbin; P.R. China Department of Pathology, Yanbian University Medical College, Yanji 133002, China. Department of Medical Oncology, The First Affiliated Hospital of Bengbu Medical College, Anhui Province Key Laboratory of Translational Cancer Research, Bengbu Medical College, Bengbu, Anhui 233004, P.R. China State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College Beijing China; Department of Biochemistry and Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and School of Basic Medicine Peking Union Medical College Beijing China Xi’an Institute of Optics and Precision Mechanics Department of Urology, the third Medical Centre, Chinese PLA General Hospital; Medical School of Chinese PLA Department of Materials Science & Engineering, ‡California NanoSystems Institute, and §Department of Chemistry & Biochemistry, University of California, Los Angeles, California 90095, United States Department of Thoracic Surgery The First Affiliate Hospital of Zhengzhou University Zhengzhou China Key Laboratory of Experimental Animal and Safety Evaluation, Zhejiang Academy of Medical Sciences, Hangzhou 310013, China Department of Building and Real Estate, The Hong Kong Polytechnic University, The Hong Kong Special Administrative Region, China; State Key Laboratory of Physical Chemistry of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China; Institute of Artificial Intelligence Xiamen University Xiamen 361005 China Department of Biological Sciences, Center for Systems Biology, the University of Texas at Dallas, Richardson, TX 75080, USA Jiangsu Province Key Laboratory of Fine Petrochemical Engineering, Jiangsu Polytechnic University, Changzhou 213164, China. yangyang@jpu.edu.cn Department of Cardiology, Chongqing Institute of Cardiology, Chongqing Cardiovascular Clinical Research Center, Daping Hospital, The Third Military Medical University, P.R. China (J.Y., Y.Y., Z.X., C.L., C.C., C.L., Z.C., C.Y., X.X., Q.L., C.Z., G.W.). Department of Urology, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China Department of thoracic surgery Shanghai Pulmonary Hospital Tongji University Shanghai 200433 China Shenzhen Key Laboratory of Pathogen and Immunity, Shenzhen Clinical Research Center for infectious disease, State Key Discipline of Infectious Disease, Shenzhen Third People's Hospital, Second Hospital Affiliated to Southern University of Science and Technology, Shenzhen, Guangdong, China. Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD 4072, Australia Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461; and Department of Orthopedics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei 430071, P.R. China Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, China. Department of Urology, Third Medical Center, Chinese PLA General Hospital, Beijing, P.R. China.; Medical School of Chinese PLA, Beijing, P.R. China. National Key Laboratory of Medical Immunology & Institute of Immunology, Second Military Medical UniversityShanghai 200433, China. Department of Mechanical Engineering, Vanderbilt University, Nashville, Tennessee 37235, United States Department of Chemical Engineering, School of Chemistry and Chemical Engineering, Chongqing University, Chongqing 401331, PR China Department of Materials Science and Engineering, University of California, Los Angeles, CA 90095, USA The Zuckerberg Institute for Water Research, The Jacob Blaustein Institutes for Desert Research, Ben-Gurion University of the Negev, Sde Boker 8499000, Israel School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 China Department of Oncology, Xijing Hospital, Fourth Military Medical University, Xi'an, P. R. China National Institute of Education, Nanyang Technological University, Singapore; Cornell University, Ithaca, NY, US Department of Materials Science and Engineering and California NanoSystems Institute, University of California Los Angeles, Los Angeles, California 90095, United States Department of Gastroenterology, The first affiliated hospital of Nanjing Medical University, Nanjing, China Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.; Key Laboratory of Organ Transplantation, Ministry of Education, Wuhan, Hubei, China.; NHC Key Laboratory of Organ Transplantation, Wuhan, Hubei, China.; Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Wuhan, Hubei, China. Department of Cardiothoracic Surgery, Shijiazhuang Third Hospital, Shijiazhuang, China Department of Pharmaceutical Engineering; College of Life Science & Biotechnology; Heilongjiang August First Land Reclamation University; Daqing High-Tech Industrial Development Zone; P. R. China Center for MRI Research, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing, China College of Energy Materials and Chemistry, State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, Inner Mongolia University, Hohhot 010021, China Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195 Department of Materials Science and Engineering University of California Los Angeles Los Angeles CA 90095 USA; California NanoSystems Institute University of California Los Angeles Los Angeles CA 90095 USA Department of Radiation Oncology; Zhejiang Cancer Hospital; Hangzhou 310022 People's Republic of China; Zhejiang Key Laboratory of Radiation Oncology, Hangzhou, China Linde + Robinson Laboratories California Institute of Technology 1200 E. California Blvd. MC 131-24 Pasadena, California 91125, United States School of Materials, Sun Yat-sen University, Shenzhen518107, PR China Department of Nephrology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China Institute of Pediatric Research, Children’s Hospital of Soochow University , Suzhou 215003 , China Intelligent Institute of Media, Communication University of Zhejiang, Hangzhou, China Department of Gastroenterology, Daping Hospital, Army Medical University, Chongqing Nanjing University-Nanjing Forestry University Joint Institute for Plant Molecular Biology, State Key Laboratory for Pharmaceutical Biotechnology, College of Life Sciences, Nanjing University , Nanjing 210093, China Guangzhou Cellprotek Pharmaceutical Co., Ltd., G Building F/4, 3 Lanyue Road, Science City, Guangzhou 510663, China Chinese Academy of Inspection and Quarantine Beijing China Yunnan Key Laboratory of Disaster Reduction in Civil Engineering, Faculty of Civil Engineering and Mechanics, Kunming University of Science and Technology, Kunming 650500, China State Key Laboratory of Agricultural Microbiology and College of Life Science and Technology, Huazhong Agricultural University, Wuhan, China Howard Hughes Medical Institute, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, TX, USA Beijing United Imaging Research Institute of Intelligent Imaging UIH Group Beijing China Fred Hutchinson Cancer Research Center, Seattle, Washington, USA College of Pharmacy, Changchun University of Chinese Medicine, Changchun 130117, China Faculty of Health Sciences, University of Macau, Macau, China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education/College of Life Science Northwest University Xi'an China; Department of Pharmacology, School of Basic Medical Science Xi'an Jiaotong University Xi'an China State Key Laboratory of Agricultural Microbiology, College of Veterinary Medicine, Huazhong Agricultural University, Wuhan, China; Department of Pathology, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA State Key Laboratory of Medicinal Chemical Biology College of Life Sciences Nankai University Tianjin China Department of Computer Science, Shanghai Jiao Tong University, and Key Laboratory of Shanghai Education Commission for Intelligent Interaction and Cognitive Engineering, Shanghai 200240, China Outpatient Department, Beijing Tiantan Hospital, Capital Medical University, Beijing, China (mainland) Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, P.R. China Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University & Clinical Cancer Institute of Nanjing University, Nanjing, Jiangsu, P. R. China Department of Chemistry, University of Copenhagen, 2100 Copenhagen, Denmark; Department of the General Surgery State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, 22 Hankou Road, Nanjing 210093, China Department of Neurosurgery Sanbo Brain Hospital, Capital Medical University Beijing China Department of Pharmacy, The Affiliated Changzhou Children’s Hospital of Nantong University, Changzhou, Jiangsu, China REMAP-CAP Writing Committee for the REMAP-CAP Investigators College of Chemistry and Chemical Engineering Xinyang Normal University Xinyang 464000 People's Republic of China School of Biomedical and Pharmaceutical Sciences Guangdong University of Technology Guangzhou P. R. China Key Laboratory of Green Chemistry and Technology (Ministry of Education), College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, China Department of Nuclear Medicine, The Fourth Hospital of Hebei Medical University and The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050011, P.R. China Department of Gastroenterology, Daping Hospital, Army Military Medical University, Chongqing, China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Life Sciences Northwest A&F University Yangling People's Republic of China The Comprehensive Cancer Center of Drum Tower Hospital, Nanjing University Medical School and Clinical Cancer Institute of Nanjing University, Nanjing 210008, PR China; Nanjing Xianlin Drum Tower Hospital, Nanjing 210046, PR China School of Public Health, Division of Biostatistics, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA Beijing Advanced Innovation Center for Soft Matter Science and Engineering and Beijing Engineering Research Center for the Synthesis and Applications of Waterborne Polymers Beijing University of Chemical Technology Beijing 100029 China The Sixth Department of Hepatic Surgery, Eastern Hepatobiliary Surgery Hospital, Shanghai, China Department of Orthopedics, Peking Union Medical College Hospital & Chinese Academy of Medical Science, Beijing, China and; Key Laboratory of Big Data for Spinal Deformities, Chinese Academy of Medical Science, Beijing, China State Key Laboratory of Pulp and Paper Engineering; South China University of Technology; Guangzhou 510640; China Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200000 China College of Science, Yunnan Agricuture University, Kunming, Yunnan, China Key Laboratory of Xinjiang Endemic Phytomedicine Resources, Ministry of Education, School of Pharmacy, Shihezi University, Shihezi 832002, China Key Laboratory of Hematology, The Second Affiliated Hospital of Nanchang University,Nanchang 330006, Jiangxi Province, China; Medical Department of Nanchang University Graduate School, Nanchang 330006, Jiangxi Province, China. State Key Laboratory of Catalysis, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China University of Chicago Department of neonates Children's Hospital of Nanjing Medical University Nanjing China Julia McFarlane Diabetes Research Centre (JMDRC) and Departments of Microbiology Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, the University of Calgary Calgary AB Canada; Department of Biochemistry and Molecular Biology Faculty of Medicine, the University of Calgary Calgary AB Canada School of Biology and Biological Engineering South China University of Technology Guangzhou P. R. China Department of Internal Medicine, Baylor College of Medicine, Houston, TX, US Department of Nosocomial Infection Management, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, PR China National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangdong Key Laboratory of Integrated Agro-Environmental Pollution Control and Management, Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China Department of Cardiology Daping Hospital Third Military Medical University Chongqing P.R. China; Chongqing Institute of Cardiology Chongqing P.R. China; Chongqing Cardiovascular Clinical Research Center Chongqing P.R. China Department of Hematology The Fifth Medical Center of Chinese PLA General Hospital Beijing PR China Department of Urology, Peking University First Hospital; Institute of Urology, Peking University; National Urological Cancer Center, Beijing 100034, China. Jilin Province Key Laboratory of Organic Functional Molecular Design & Synthesis Advanced Energy Materials Research Center, Faculty of Chemistry Northeast Normal University Changchun 130024 China Department of Trauma Orthopedics Affiliated Hospital of Jiangxi University of Chinese Medicine Nanchang China Department of Thoracic Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Weather Modification Office of Hebei Province, Shijiazhuang 050800, China. Department of Cardiovascular Surgery Xijing Hospital The Fourth Military Medical University Xi'an China State Key Laboratory of Medicinal Chemical Biology, College of Life Sciences, Nankai University, Tianjin 300071, China Cardiology The First Hospital of Jilin University Changchun Jilin China The University of Queensland Diamantina Institute Translational Research Institute Brisbane QLD Australia Department of Wood Technology and Wood‐Based Composites University of Göttingen Büsgenweg 4 Göttingen 37077 Germany Department of Joint Surgery and Sports Medicine Tokyo Medical and Dental University Tokyo Japan Tsinghua University, School of Medicine, Haidian District, Beijing, China; School of Life Sciences, Ningxia University, Yinchuan, China Department of Respiratory and Critical Care Medicine, Sichuan Academy of Medical Sciences & Sichuan Province People’s Hospital, Chengdu, P.R. China Institute for Regenerative Medicine, Ji'an Hospital, Shanghai East Hospital School of Life Sciences and Technology Tongji University School of Medicine Shanghai China; Shanghai Engineering Research Center of Stem Cells Translational Medicine Shanghai China Shanghai Key Laboratory of Atmospheric Particle Pollution and Prevention, Department of Environmental Science & Engineering, Fudan University, Shanghai 200433, China School of Chemical Engineering, The Research Center of Chemical Engineering Applying Technology for Resource of Shaanxi, Northwest University, Xi’an, Shaanxi 710069, China State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 158-40, Zhongshanlu, Xigang District 116012, Dalian, China, Department of Chemistry and State Key Laboratory of Fine Chemicals, Dalian University of Technology, No. 2, Linggonglu, Ganjingzi District 116024, Dalian, China, Department of Chemistry, The University of Akron, Akron, Ohio 44325, and Department of Chemistry, Organic Chemistry, School of Chemical Science and Engineering, Royal Institute of Technology (KTH), Teknikringen... Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi’an 710069, China Department of Trauma Center, Affiliated Hospital of Nantong University , No. 20 Xisi Road, Chongchuan District , Nantong City , Jiangsu Province 226001 , China NIBR Biologics Center, Novartis Institutes for BioMedical Research, Klybeckstrasse 141, CH-4057, Basel, Switzerland State Key Laboratory of Precision Measuring Technology and Instruments, College of Precision Instruments and Opto-electronics Engineering, Tianjin University, Tianjin 300072, China Department of Pediatric, The First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550001, China Department of Otorhinolaryngology Head and Neck Surgery, Union Hospital of Tongji medical college, Huazhong University of Science and Technology, Wuhan 430022, China. Translational Research Program, Department of Anesthesiology and Center for Shock, Trauma and Anesthesiology Research, Baltimore, Maryland CAS High Magnetic Field Laboratory; Department of Chemistry; University of Science and Technology of China; Hefei Anhui; China Guangdong Key Laboratory of Integrated Agro-Environmental Pollution Control and Management, Institute of Eco-Environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou 510650, China; National-Regional Joint Engineering Research Center for Soil Pollution Control and Remediation in South China, Guangzhou 510650, China CAS Key Laboratory of Behavioral Science Center for Brain Science and Learning Difficulties Institute of Psychology,Chinese Academy of Sciences Beijing China; Department of Psychology University of Chinese Academy of Sciences Beijing China Department of Pediatric General Surgery and Liver Transplantation Department of Neurology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan Province, China From the Cardiovascular Division, Department of Medicine (M.S., A.T., S.K., M.R., C.M.K.) and Department of Radiology and Medical Imaging (M.S., C.H.M., C.M.K.), University of Virginia Health System, Charlottesville; and Department of Biomedical Engineering, University of Virginia, Charlottesville (M.S., Y.Y., C.H.M.). Academy of Orthopedics, Guangdong Province, Department of Orthopedics, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China The 986th Hospital of Chinese People's Liberation Army, Xi’an, Shaanxi 710054, China Julia McFarlane Diabetes Research Centre (JMDRC) and Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases and Hotchkiss Brain Institute, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Alberta T2N 4N1, Canada Department of Hepatobiliary Surgery and Center of Organ Transplantation, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250021, China College of Animal Science, Shanxi Agricultural University , Shanxi, Taigu 030801 , China Photosynthesis Research Center, Key Laboratory of Photobiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; Laboratory for Ecology of Tropical Islands, Ministry of Education, College of Life Sciences, Hainan Normal University, Haikou 571158, China School of computer science and technology, Soochow University, Suzhou 215006, China State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China College of Chemical Engineering and Materials Science and ‡China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry, Sino-French Joint Lab of Food Nutrition/Safety and Medicinal Chemistry, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, Tianjin Key Laboratory of Industry Microbiology, College of Biotechnology, Tianjin University of Science & Technology, No. 29, 13th Avenue, TEDA, Tianjin 300457, China Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, P.R. China. Clinical Systems Biology Laboratories, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, P. R. China Department of Urology, Peking University First Hospital, Institute of Urology, National Urological Cancer Center, Peking University, Beijing 100034, China State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics (DICP), Chinese Academy of Sciences, Dalian 116023, China School of Environmental Science and Engineering, State Key Lab of Metal Matrix Composites, Shanghai Jiao Tong University, 800 Dongchuan RD, Shanghai 200240, China Department of Hematology The First Affiliated Hospital of Guangxi Medical University Nanning People’s Republic of China School of Mechatronic Engineering and Automation; Shanghai University; Shanghai; China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China Department of Food and Nutrition, School of Human Environmental Sciences, Wonkwang University, Iksan 570-749, Republic of Korea Department of Anesthesia, China-Japan Union Hospital of Jilin University Department of Liver Transplantation, The Third Affiliated Hospital of Sun Yat-Sen University, Guangdong Province Key Laboratory of Hepatology Research, Guangzhou, Guangdong, People’s Republic of China Department of Hematology, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, Shaanxi Province, China. Department of Chemistry, Bohai University and Liaoning Province Silicon Materials Engineering Technology Research Centre, Jinzhou 121000, P. R. China Functional Thin Films Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China 518055; Center of Super-Diamond and Advanced Films (COSDAF), City University of Hong Kong, Kowloon, Hong Kong SAR China Beijing Institute of Pharmacology and Toxicology, Beijing, PR China Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiao Tong University , Shanghai , P. R. China School of Electrical and Data Engineering, Tech Lab, University of Technology Sydney, Sydney, NSW 2019, Australia Department of Biliary-Pancreatic Surgery, Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200127, People’s Republic of China *Department of Microbiology and Infectious Diseases, Snyder Institute, University of Calgary, Calgary, Alberta T2N 4N1, Canada;; †Julia McFarlane Diabetes Research Centre, University of Calgary, Calgary, Alberta T2N 4N1, Canada; and State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM College of Chemistry and Chemical Engineering Xiamen University Siming South Road Xiamen China Center of Respiratory Disorders, Children's Hospital, Chongqing Medical University, Chongqing 400014, China. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Diseases and Biosecurity, School of Basic Medical Sciences, Shanghai Medical College Fudan University Shanghai China Biomechanics Laboratory of Orthopaedics Institute Tianjin Hospital Tianjin China |
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Total number of triples: 10000.