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endingPage 3282
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publicationName Journal of Medicinal Chemistry
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bibliographicCitation Phillips DP, Gao W, Yang Y, Zhang G, Lerario IK, Lau TL, Jiang J, Wang X, Nguyen DG, Bhat BG, Trotter C, Sullivan H, Welzel G, Landry J, Chen Y, Joseph SB, Li C, Gordon WP, Richmond W, Johnson K, Bretz A, Bursulaya B, Pan S, McNamara P, Seidel HM. Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy. J Med Chem. 2014 Apr 24;57(8):3263–82. doi: 10.1021/jm401731q. PMID: 24666203.
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date 2014-04-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
identifier https://doi.org/10.1021/jm401731q
https://pubmed.ncbi.nlm.nih.gov/24666203
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http://rdf.ncbi.nlm.nih.gov/pubchem/journal/4938
language English
source https://www.crossref.org/
https://pubmed.ncbi.nlm.nih.gov/
title Discovery of Trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as Potent, Orally Bioavailable TGR5 (GPBAR1) Agonists: Structure–Activity Relationships, Lead Optimization, and Chronic In Vivo Efficacy
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621332_AID1125917_PMID24666203_VALUE18
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621318_AID1125959_PMID24666203_VALUE4
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621344_AID1125919_PMID24666203_VALUE12
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621346_AID1125920_PMID24666203_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621315_AID1125959_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621640_AID1125916_PMID24666203_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125919_PMID24666203_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125916_PMID24666203_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125953_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125924_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621351_AID1125940_PMID24666203_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621642_AID1125942_PMID24666203_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621328_AID1125959_PMID24666203_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621334_AID1125959_PMID24666203_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621333_AID1125959_PMID24666203_VALUE19
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621347_AID1125958_PMID24666203_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125924_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621325_AID1125958_PMID24666203_VALUE11
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621336_AID1125919_PMID24666203_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621323_AID1125959_PMID24666203_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621344_AID1125920_PMID24666203_VALUE10
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621315_AID1125916_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621326_AID1125959_PMID24666203_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621352_AID1125916_PMID24666203_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621644_AID1125955_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125961_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125938_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125931_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621333_AID1125919_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621349_AID1125958_PMID24666203_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125920_PMID24666203_VALUE15
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621326_AID1125958_PMID24666203_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621351_AID1125916_PMID24666203_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621334_AID1125920_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621336_AID1125959_PMID24666203_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621331_AID1125959_PMID24666203_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125929_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125935_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621317_AID1125959_PMID24666203_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621319_AID1125917_PMID24666203_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621335_AID1125958_PMID24666203_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621350_AID1125917_PMID24666203_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621342_AID1125916_PMID24666203_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621335_AID1125917_PMID24666203_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125952_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621349_AID1125959_PMID24666203_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125921_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621641_AID1125942_PMID24666203_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621338_AID1125920_PMID24666203_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621340_AID1125959_PMID24666203_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125960_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621641_AID1125959_PMID24666203_VALUE40
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621338_AID1125925_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125932_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125935_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621345_AID1125919_PMID24666203_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621322_AID1125916_PMID24666203_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125936_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621320_AID1125916_PMID24666203_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621347_AID1125920_PMID24666203_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621344_AID1125917_PMID24666203_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621346_AID1125917_PMID24666203_VALUE32
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621316_AID1125958_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621328_AID1125916_PMID24666203_VALUE14
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621317_AID1125917_PMID24666203_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125960_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621350_AID1125942_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125917_PMID24666203_VALUE23
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125945_PMID24666203_VALUE1
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http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621322_AID1125958_PMID24666203_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621339_AID1125920_PMID24666203_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125944_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125926_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621339_AID1125919_PMID24666203_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621315_AID1125917_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621350_AID1125959_PMID24666203_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621640_AID1125958_PMID24666203_VALUE39
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621348_AID1125916_PMID24666203_VALUE34
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621640_AID1125925_PMID24666203_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621349_AID1125925_PMID24666203_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621339_AID1125958_PMID24666203_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621317_AID1125916_PMID24666203_VALUE3
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621343_AID1125920_PMID24666203_VALUE9
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621342_AID1125920_PMID24666203_VALUE8
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621332_AID1125959_PMID24666203_VALUE18
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125919_PMID24666203_VALUE17
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621351_AID1125917_PMID24666203_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621352_AID1125959_PMID24666203_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621333_AID1125920_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621335_AID1125959_PMID24666203_VALUE21
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621318_AID1125917_PMID24666203_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621341_AID1125959_PMID24666203_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621351_AID1125959_PMID24666203_VALUE37
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621334_AID1125918_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621338_AID1125916_PMID24666203_VALUE24
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621344_AID1125958_PMID24666203_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621347_AID1125959_PMID24666203_VALUE33
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621350_AID1125916_PMID24666203_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125937_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621334_AID1125916_PMID24666203_VALUE20
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621342_AID1125917_PMID24666203_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621344_AID1125959_PMID24666203_VALUE30
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125925_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621327_AID1125916_PMID24666203_VALUE13
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125933_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621350_AID1125940_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621352_AID1125958_PMID24666203_VALUE38
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621319_AID1125958_PMID24666203_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621336_AID1125916_PMID24666203_VALUE22
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621318_AID1125916_PMID24666203_VALUE4
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125922_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621319_AID1125916_PMID24666203_VALUE5
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621321_AID1125916_PMID24666203_VALUE7
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621642_AID1125917_PMID24666203_VALUE41
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621339_AID1125917_PMID24666203_VALUE25
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125959_PMID24666203_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125962_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621320_AID1125958_PMID24666203_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125929_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621341_AID1125958_PMID24666203_VALUE27
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125936_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621337_AID1125934_PMID24666203_VALUE1
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621350_AID1125958_PMID24666203_VALUE36
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621342_AID1125958_PMID24666203_VALUE28
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125947_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621349_AID1125916_PMID24666203_VALUE35
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125958_PMID24666203_VALUE42
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621340_AID1125958_PMID24666203_VALUE26
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621643_AID1125930_PMID24666203_VALUE2
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621326_AID1125917_PMID24666203_VALUE12
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621351_AID1125925_PMID24666203_VALUE6
http://rdf.ncbi.nlm.nih.gov/pubchem/endpoint/SID242621642_AID1125925_PMID24666203_VALUE10
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID9971
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID227289
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID151306
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID2078
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID5144
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1559
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1565
http://rdf.ncbi.nlm.nih.gov/pubchem/gene/GID1576

Total number of triples: 374.