http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_741734cd7dc29bb1028a5f74caeee1c9
Outgoing Links
Predicate | Object |
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family-name | Wei Jiang Jiang |
name | Wei Jiang |
given-name | Wei |
organization-name | Department of Pathophysiology, Anhui Medical University, Hefei 230032, China Department of Biological Repositories Zhongnan Hospital of Wuhan University Wuhan China; Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical Sciences Wuhan China; Medical Research Institute Wuhan University Wuhan China State Key Laboratory for Agro-biotechnology and Department of Microbiology, China Agricultural University, 100094, Beijing, China State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710049, China; School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an 710049, China Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences (BNLMS), State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China Department of Respiratory Oncology Guangxi Medical University Affiliated Tumor Hospital Nanning City Guangxi Zhuang Autonomous Region China Department of Medical Oncology, The Affiliated Tumor Hospital of Guangxi Medical University Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, China Shanghai Research Center for Modernization of Traditional Chinese Medicine, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 199 Guoshoujing Road, Shanghai 201203, People’s Republic of China, Department of Chemistry & Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001, and School of Pharmacy, East China University of Science & Technology, 130 Mei-Long Road, Shanghai 200237, People’s Republic of China Laboratory of Seafood Processing, Innovative and Application Institute Zhejiang Ocean University Zhoushan Zhejiang China Department of Orthopaedic Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing China Department of Surgery, Sidney Kimmel Medical College at Thomas Jefferson University Hospital, Philadelphia, Pennsylvania. School of Pharmaceutical Science, Key Laboratory of Chemical Biology, Ministry of Education, Shandong University, Jinan 250012, China Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001, and School of Pharmacy, East China University of Science & Technology, Shanghai 200237, People's Republic of China Biotechnology Institute Shanghai Academy of Agricultural Sciences Shanghai China; Shanghai Key Laboratory of Agricultural Genetics and Breeding Shanghai China Psychiatry and Behavioral Sciences Duke University Medical Center Durham NC USA Department of Molecular Imaging and Nuclear Medicine, National Clinical Research Center for Cancer, Tianjin Key Laboratory of Cancer Prevention and Therapy, Tianjin's Clinical Research Center for Cancer Tianjin Medical University Cancer Institute and Hospital Tianjin China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China Molecular Medicine Research Center State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu Sichuan P. R. China Department of Cardiology Second Affiliated Hospital of Xi'an Jiaotong University Xi'an Shanxi China Institute of Materials Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, P. R. China Key Lab of Organic Optoelectronics and Molecular Engineering of Ministry of Education, Department of Chemistry, Tsinghua University, Beijing, 100084, P. R. China Department of Chemical and Biomolecular Engineering, University of Tennessee, Knoxville, Tennessee 37996-2200;, Clinical Medical College, Yangzhou University, Department of Intensive Care Unit, Northern Jiangsu People's Hospital, Yangzhou 225001, Jiangsu, China. Corresponding author: Zheng Ruiqiang, Email: 13952721411@163.com. Department of Medical Oncology, the Third Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150081, China. Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China Department of Emergency, Affiliated Hospital of Nantong University, Nantong, China Department of Medical Intensive Care Unit, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China 1 Nephrology Department, Zhuji People's Hospital of Zhejiang Province, Zhuji, Zhejiang Province, People's Republic of China Department of Pediatric Rheumatoid Immunity, Ningbo Women and Children's Hospital, Ningbo, Zhejiang, China. Hefei National Laboratory for Physical Sciences at the Microscale; University of Science and Technology of China; Hefei; P. R. China State Key Laboratory of Microbial Technology, Shandong University, Qingdao, China Medical Research Institute Wuhan University Wuhan China Department of Cardiology, Molecular Medicine Research Center, Sichuan University, Chengdu, Sichuan, P.R. China.; State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China. Department of Gynecology, East Hospital Affiliated to Tongji University, Shanghai 200012, China Hefei National Laboratory for Physical Sciences at Microscale, University of Science & Technology of China, Hefei, Anhui, 230026, People's Republic of China, Department of Polymer Science and Engineering, University of Science & Technology of China, Hefei, Anhui, 230026, People's Republic of China, State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, and Graduate School of the Chinese Academy of Sciences, People's... Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, People’s Republic of China The Burnham Institute for Medical ResearchLa JollaCaliforniaUSA; Cancer InstituteChinese Academy of Medical SciencesBeijingChina Yantai Yuhuangding Hospital Qingdao University School of Medicine Yantai Shandong China Center of Infectious Diseases West China Hospital of Sichuan University Chengdu Sichuan PR China College of Mathematics and Statistics, Chongqing Jiaotong University, Chongqing 40074, China College of Chemistry and Molecular Engineering; Peking University; PR China Department of Chinese medicine; Taizhou Institute for Food and Drug Control; Taizhou; PR China Key Laboratory of Key Technical Factors in Zhejiang Seafood Health Hazards National Engineering Research Center for Marine Aquaculture Zhejiang Ocean University Zhoushan China State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550002, China. jiangwei8255@gmail.com Department of Burns, the First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China Department of Infective disease, First Center Hospital, TianJin City, China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, Shandong, China. Zhejiang Provincial Key Laboratory of Tissue Engineering and Regenerative Medicine, Hangzhou, Zhejiang 310058, P. R. China; Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cell and Regeneration Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P. R. China School of Chemistry and Materials Science, Ludong University, Yantai 264025, China School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, 131 Dong-An Road, Shanghai 200032, People’s Republic of China Department of Pathology, Thomas Jefferson University Hospital (Wei Jiang), Philadelphia, PA, USA. Department of Neurology, The First Hospital of Changsha, Changsha, Hunan, China Department of Intensive Care Unit, the Central Hospital, Wuhan, Hubei, China. thicu5853@yahoo.cn Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs; School of Chemistry and Chemical Engineering; Shanghai Jiao Tong University; Shanghai; China Institute of Environmental Medicine, Zhejiang University School of Medicine Hangzhou China Division of Infectious Disease, and CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China State Key Laboratory of Molecular Oncology and Department of Etiology and Carcinogenesis, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. *Division of Infectious Diseases and HIV Medicine, Case Western Reserve University, University Hospitals/Case Medical Center, Cleveland, OH 44106;; †Center for AIDS Research, Case Western Reserve University, University Hospitals/Case Medical Center, Cleveland, OH 44106; and Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. School of Chemistry and Chemical Engineering; Shandong University; Jinan 250100; P. R. China Department of Pharmacy, The Second Affiliated Hospital of Air Force Medical University, Xi’an, China National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei 230026, China Department of Anesthesiology, Shanghai Sixth People's Hospital Shanghai Jiaotong University Shanghai China Department of Applied Chemistry, College of Arts and Sciences, Northeast Agricultural University, Harbin, Heilongjiang 150030, People’s Republic of China Yichang Center for Disease Control and Prevention, Yichang City, Hubei Province, China. Department of Municipal Engineering School of Environmental Science and Engineering Huazhong University of Science and Technology Wuhan China Key Laboratory of Metabolism and Molecular Medicine Department of Biochemistry and Molecular Biology The Ministry of Education School of Basic Medical Sciences Fudan University Shanghai China Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China College of Chemical Engineering, Huaqiao University, 668 Jimei Blvd., Xiamen, Fujian, 361021, China Laboratory of New Fibre Materials and Modern Textile, The Growing Base for State Key Laboratory, Qingdao University, Qingdao 266071, People's Republic of China Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China Innovation Application Institute; Zhejiang Ocean University; Zhoushan; China; College of Food Science and Engineering Center for Surgery and Public Health, Department of Surgery, Brigham and Women’s Hospital, Boston, Massachusetts Department of Orthopaedics The First Affiliated Hospital of Anhui Medical University Hefei Anhui P. R. China Department of Biological Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 Rehabilitation Medicine Department, The Affiliated Hospital of Southwest Medical University, Lu zhou, 646000, Sichuan, People’s Republic of China. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P. R. China Sichuan University Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China Department of Oncology; The First Affiliated Hospital of Zhengzhou University; Zhengzhou 450052; China Department of Urology Huangshi Central Hospital Affiliated Hospital of Hubei Polytechnic University Edong Healthcare Group Huangshi China Rehabilitation Medicine Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China 1Laboratory of Gynecologic Oncology and Epidemiology, Department of Obstetrics and Gynecology and Reproductive Biology, Brigham and Women's Hospital, Dana-Farber Cancer Center, Harvard Medical School, Boston, Massachusetts and Institute for Energy Research Jiangsu University 301 Xuefu Road Zhenjiang 212013 PR China Department of Obstetrics and Gynecology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang 157000, P.R. China Brigham Young University, Department of Chemistry and Biochemistry, C100 BNSN, Provo, Utah 84602-5700, and Chemistry College of Shandong University, Shanda South Road #27, Jinan, Shandong, 250100, P. R. China Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China. National Key Laboratory of Science and Technology on Space Microwave; China Academy of Space Technology (Xi’an) Department of Traditional Chinese Medicine, First Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, China Tencent Media Lab, CA, U.S.A. Hefei National Laboratory for Physical Sciences at the Microscale, CAS Center for Excellence in Quantum Information and Quantum Physics, University of Science and Technology of China, 96 Jinzhai Road, Hefei 230026, China Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany, and Department of Chemistry, Nanoscience Center, University of Jyväskylä, P.O. Box 35, 40014 Jyväskylä, Finland Key Laboratory for Colloid and Interface Chemistry of Education Ministry; School of Chemistry and Chemical Engineering; Shandong University; 250100 Jinan; P. R. China Wei Jiang is a manager of biostatistics at Brigham and Women’s Hospital, in Boston. Department of Ultrasonography, Guangdong Women and Children Hospital, Guangzhou, P. R. China Science Technology and Industry Department, Nantong University, Nantong 226001, China. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China, and Department of Physics, Northeast Normal University, Changchun 130024, People's Republic of China Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA The Burnham Institute for Medical Research, 10901 North Torrey Pines Road, La Jolla, CA 92037 Department of Radiation Oncology, National Cancer Center/Cancer Hospital & Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Shenzhen China Department of Pathology, Thomas Jefferson University, Philadelphia, PA, USA Fujian Provincial Key Laboratory of Semiconductor Materials and Applications, Department of Physics, Xiamen University, Xiamen 361005, P. R. China; Xiamen Changelight Company Limited, Xiamen 361101, P. R. China Department of Orthopedics. Laixi People's Hospital College of Chemistry and Chemical Engineering; Northwest Normal University; Lanzhou; China Key Laboratory of Developmental Genes and Human Disease, Ministry of Education, Southeast University, Nanjing, Jiangsu 210009, China Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing; Department of Emergency, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology , No. 26 Shengli Street , Jiang'an District, Wuhan 430014, Hubei, China Shanghai Key Laboratory for Molecular Engineer of Chiral Drugs, School of Chemistry and Chemical Engineering & Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, P. R. China Center for Biophysical Modeling and Simulation and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850, and Institute of New Energy Material Chemistry, Nankai University, Tianjin 300071, China 1Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania. grid.12955.3a 0000000122647233 Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering Xiamen University 361005 Xiamen China; grid.12955.3a 0000000122647233 The Key Laboratory for Synthetic Biotechnology of Xiamen City Xiamen University 361005 Xiamen China Center for Precision Engineering, Harbin Institute of Technology 1 , Harbin 150001, China Department of Polymer Science, College of Chemistry and ‡Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, Jilin University, Changchun 130012, China Anatomic Pathology, Cleveland Clinic, Cleveland, OH (WJ,XL); Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, OH (HX); Department of Pathology, University of Chicago, Chicago, IL (SYX) Department of Emergency Medicine, Affiliated Hospital of Nantong University, Nantong City, Jiangsu Province, China Department of Pathology, Thomas Jefferson University Hospital, Philadelphia, PA, USA Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, People’s Republic of China The Department of Cardiology at Wuhan Third Hospital, Tongren Hospital of Wuhan University, Hubei Province, China Department of Oncology, The Affiliated Hospital of Guizhou Medical University; Department of Oncology, The Affiliated Cancer Hospital of Guizhou Medical University; Department of Oncology, The School of Clinical Medicine, Guizhou Medical University, Guiyang, China a College of Pharmaceutical Sciences, Zhejiang University , Hangzhou , 310058 , China Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, United States *Division of Human Gene Therapy, Department of Pediatrics, Stanford University, Stanford, CA 94305;; †Program in Immunology, Stanford University, Stanford, CA 94305; National Engineering Research Center of Seafood, Collaborative Innovation Center of Provincial and Ministerial Co-Construction for Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China Department of Nephrology The Affiliated Hospital of Qingdao University Qingdao China Changchun Institute of Biological Products Co. Ltd. Changchun P.R. China Department of Radiotherapy Yantai Yuhuangding Hospital, Qingdao University School of Medicine Yantai Shandong China Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and Chemistry Chinese Academy of Sciences No. 29, Zhongguancun East Road Beijing 100190 P. R. China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Sidney Kimmel Cancer Center at the Jefferson Pancreatic, Biliary, and Related Cancer Center, Thomas Jefferson University, Philadelphia, Pennsylvania, USA Department of Chemistry; South University of Science and Technology of China; Shenzhen; P. R. China Beijing Advanced Innovation Center for Food Nutrition & Human Health, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, PR China; State Key Laboratory of Agrobiotechnology, College of Biological Sciences, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, PR China Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, Department of Chemistry, Shandong University, Jinan 250100, China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, 510405 Guangzhou, China; Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, 510120 Guangzhou, China Forest Products Development Center, School of Forestry and Wildlife Sciences, Auburn University, 520 Devall Drive, Auburn, AL 36849, USA; College of Textiles, Qingdao University, 308 Ningxia Road, Qingdao 266071, China Department of Thoracic and Cardiovascular Surgery The First Affiliated Hospital of Nanjing Medical University Nanjing China Molecular Medicine Research Center,West China Hospital of Sichuan University,Chengdu,China AstraZeneca, Shanghai 200085, China Department of Rheumatology, The Key Laboratory of Myositis, China-Japan Friendship Hospital, Beijing, China Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering and ‡School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250100, China Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, People’s Republic of China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, People’s Republic of China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, People’s Republic of China; Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Key Laboratory of Agricultural Genetics and Breeding, Shanghai 201106, People’s Republic of China Marine Science and Technology Institute Yangzhou University Yangzhou 225127 P. R. China Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences, Hohhot 010031, China Center for Surgery and Public Health, Brigham and Women’s Hospital and Harvard Medical School, One Brigham Circle, 1620 Tremont St, Boston, MA School of Life Sciences, Nantong University, 226019 Nantong, China Department of Infection Control, First Affiliated Hospital of Chinese PLA General Hospital, The Second Military Medical University, Beijing 100048, China Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China Department of Radiation Physics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA.; Department of Chemistry, Pennsylvania State University, University Park, PA 16802, USA. State Key Laboratory of Oncology in South China Sun Yat‐sen University Cancer Center Guangzhou People's Republic of China Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu, China National Special Superfine Powder Engineering Technology Research Center Nanjing University of Science and Technology Nanjing 210094 P. R. China State Key Laboratory for Manufacturing Systems Engineering Xi'an Jiaotong University Xi'an 710049 China Department of Pharmaceutics, School of Pharmacy, Lanzhou University Department of Chemistry; Stanford University; USA College of Biological Sciences, China Agricultural University, Beijing 100193, China 1Department of Anesthesiology, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, P.R. China, and School of Pharmacy, Shandong University, 250012 Jinan, P.R. China Department of Science Technology and Industry, Nantong University, Nantong, Jiangsu 226019, China Department of Chemistry, South University of Science and Technology of China, Xueyuan Boulevard 1088, Nanshan District, Shenzhen 518055, China The third Affiliated Hospital of Inner Mongolia Medicial University Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Cardiovascular Research Institute, University of California, San Francisco, CA 94158; Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China. State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266237, P. R. China College of Engineering, Huazhong Agricultural University, Wuhan, China; Key Laboratory of Agricultural Equipment in Mid-lower Yangtze River, Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University, Wuhan, China Division of Orthodontics and Dentofacial Orthopedics, Graduate School of Dentistry Tohoku University Sendai Japan Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China Authors' Affiliation: Galaxy Biotech, LLC, Sunnyvale, California The Burnham Institute, La Jolla, CA 92037 Department of Neurology, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Neurological Institute, Key Laboratory of Post-neurotrauma Neuro-repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, China Department of Anatomy, Physiology, and Genetics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814;Department of Pediatrics, University of Texas Medical Branch, Galveston, TX 77555; Department of Neurology and Center for Molecular Medicine and Genetics, Wayne State University School of Medicine, 421 East Canfield Avenue, Detroit, MI 48201; Department of Pathology, Albert Einstein College of Medicine, 711 Belfer Building, 1300 Morris Park Avenue, Bronx,... Department of Anesthesiology Shanghai Sixth People's Hospital, Shanghai Jiao Tong University Shanghai China Center for Medical Ultrasound, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China; Center for Medical Ultrasound, Suzhou Municipal Hospital, Suzhou, Jiangsu, China Molecular Medicine Research Center, West China Hospital, Sichuan University Chengdu, Sichuan, PR China. Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Jiangsu, China Department of Neurology Tianjin Medical University General Hospital Tianjin China Department of Microbiology and Immunology Division of Infectious Diseases Department of Medicine Medical University of South Carolina 96 Jonathan Lucas Street Suite 803, MSC 623, Charleston, SC 29425 USA The Burnham Institute 10901 North Torrey Pines Road La Jolla California 92037 USA School of Aeronautics and Astronautics, Shenzhen Campus of Sun Yat-Sen University 1 , Shenzhen 518107 , China Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Biochemistry and Molecular Biology, Shanghai Medical College, Fudan University, Shanghai, China;; Cardiovascular Research Institute and; Department of Physiology, University of California San Francisco, San Francisco, CA; National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing 210094, China Institute of Materials China Academy of Engineering Physics Jiangyou 621908 China Molecular Medicine Research Center, West China Hospital , Sichuan University , Chengdu, Sichuan , P.R. China Department of Echocardiography; Beijing Chao-Yang Hospital, Capital Medical University; Beijing China Chengdu Development Center of Science and Technology of CAEP College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China (M.Y., W.J.). Guangdong Province Key Laboratory of Rare Earth Development and Application, Institute of Rare Metals, Guangdong Academy of Sciences, Guangzhou 510651, China Centre for Organic Photonics & Electronics, School of Chemistry and Molecular Biosciences, and School of Mathematics and Physics, The University of Queensland, Brisbane, Queensland, Australia 4072 1 College of Bioinformatics Science and Technology, 2Department of Internal Neurology, Fourth Affiliated Hospital and 3Institute of Cancer Prevention and Treatment, Harbin Medical University, Harbin 150081, China Department of Gastroenterology; Zhongshan Hospital, Fudan University; Shanghai China Department of Radiation Oncology, Affiliated Hospital of Guilin Medical University, Guilin 541001, P.R. China Department of Clinical Laboratory The Second Affiliated Hospital of Dalian Medical University Dalian Liaoning People's Republic of China Department of Neurology The Third Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong Province China Department of Emergency Centre, Affiliated Hospital of Nantong University, Nantong, Jiangsu 226001, P.R. China Center of Gerontology and Geriatrics (L.M.), Department of Pharmacy (J.S., J.K., S.P., S.C., M.Z., J.H.), Laboratory of Clinical Pharmacy and Adverse Drug Reaction (Q.L., J.H.), Division of Endocrinology and Metabolism (Y.Z.), Molecular Medicine Research Center (W.J.), State Key Laboratory of Biotherapy and Cancer Center, West China Hospital of Sichuan University and Collaborative Innovation Cent National Engineering Research Center for Organic Pollution Control and Resource Reuse; State Key Laboratory of Pollution and Resource Reuse; School of the Environment; Nanjing University; Nanjing Department of Anesthesiology, Minhang Hospital, Fudan University, Shanghai, People's Republic of China Center for Disease Control and Prevention of Zhejiang Province; Hangzhou P. R. China Institute of Materials Engineering College of Engineering and Applied Sciences Nanjing University Jiangsu 210093 China CAS Key Laboratory of Mental Health, Institute of Psychology Chinese Academy of Sciences Beijing China; Department of Psychology University of Chinese Academy of Sciences Beijing China Department of Obstetrics, Jiaxing Maternity and Child Health Care Hospital, Jiaxing, China Institute of Amorphous Matter Science, School of Materials Science and Engineering & Anhui Provincial Key Lab of Functional Materials and Devices, Hefei University of Technology, Hefei 230009, China Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; College of Stomatology, Shanghai Jiao Tong University; National Center for Stomatology; National Clinical Research Center for Oral Diseases; Shanghai Key Laboratory of Stomatology, Shanghai, China Hubei Collaborative Innovation Center for Grain Industry/Engineering Research Centre of Ecology and Agricultural Use of Wetland, Ministry of Education, Yangtze University, Jingzhou, China Obstetrics and Gynecology Hospital, Shanghai Medical School, and Institute of Biomedical Sciences, Fudan University; and Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China. Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA; Department of Pathology, Cleveland Clinics, Cleveland, OH 44195, USA State Key Laboratory of Silicon Materials; Department of Materials Science and Engineering; Zhejiang University; Hangzhou, P. R. China Civil Aviation Medicine Center, Civil Aviation Administration of China (Civil Aviation Hospital), Gaojing No. A1, Chaoyang District, Beijing 100123, China State Key Laboratory of Genetic Engineering,Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University,Shanghai,China Department of Thoracic Surgery, Dushu Lake Hospital Affiliated to Soochow University, Suzhou, Jiangsu, China Department of Chemistry; Stanford University; Stanford; USA Key Laboratory of Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China Department of Medical Oncology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310003, P.R. China The CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Sciences; University of Science and Technology of China; Hefei; China School of Mathematical Sciences, Anhui University, Hefei 230039, China Jiangsu Key Laboratories of Crop Genetics and Physiology and Plant Functional Genomics of the Ministry of Education Yangzhou University Yangzhou Jiangsu China Department of Orthopaedic Surgery (A.J.S., K.N., and J.D.K.), Department of Surgery (W.J., M.A.C., R.E.S., and A.H.H.), and Center for Surgery and Public Health (A.J.S., W.J., M.A.C., R.E.S., and A.H.H.), Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Chemistry; University of Southern California; Los Angeles; USA College of Chemistry and Life Sciences Chengdu Normal University Chengdu China; Sichuan Provincial key Laboratory for Development and Utilization of Characteristic Horticultural Biological Resources Chengdu Normal University Chengdu China Hebei Collaborative Innovation Center for Cardio-Cerebrovascular Disease, Shijiazhuang 050000, China; Hebei Key Laboratory of Vascular Homeostasis, Shijiazhuang 050000, China Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, People’s Republic of China Laboratory for Computational Materials Engineering Division of Energy and Environment Graduate School at Shenzhen Tsinghua University Shenzhen 518055 P. R. China Pediatric Research Institute, National Clinical Research Center for Child Health and Disorders, China International Science and Technology Cooperation Base of Child development and Critical Disorders, Chongqing Key Laboratory of Pediatrics Children's Hospital of Chongqing Medical University Chongqing P.R. China School of Information Science and Technology, Fudan University; Heraeus Quarzglas GmbH & Co. KG Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China; National Engineering Researcher Center of Cereal Fermentation and Food Biomanufacturing, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China; Key Laboratory of Agricultural Genetics and Breeding, Biotechnology Research Institute, Shanghai Academy of Agricultural Sciences, Shanghai 201106, People’s Republic of China Ningbo Academy of Agricultural Sciences Ningbo China Department of Molecular Pathology, Application Center for Precision Medicine, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China; Nanozyme Medical Center, School of Basic Medical Sciences, Academy of Medical Sciences, Zhengzhou University, Zhengzhou 450001, China Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, P. R. China Shanghai Veterinary Research InstituteChinese Academy of Agricultural ScienceShanghaiChina Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China Department of Cardiovascular Surgery, The First Medical Center of Chinese PLA General Hospital, Beijing 100853, China National Key Laboratory for Screening of New Microbial Drugs, Institute of Medical Biotechnology, Chinese Academy of Medical Science Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland; and Shandong University of TCM, Jinan 250014. National Special Superfine Powder Engineering Research Center School of Chemistry and Chemical Engineering Nanjing University of Science and Technology Nanjing Jiangsu 210094 China Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China Research Center of Laser Fusion, China Academy of Engineering Physics , Mianyang 621900, China Department of Gastroenterology Zhongshan Hospital Fudan University Shanghai China Key Laboratory for Colloid and Interface Chemistry of Education Ministry; School of Chemistry and Chemical Engineering; Shandong University; Jinan 250100; P. R. China Departments of Biochemistry and Molecular Biology and ‡Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States Department of Clinical Medicine, School of Basic Medical, Nanjing Medical University, Nanjing, China. Department of Orthopedics, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Pathology and Genomic Medicine, Thomas Jefferson University , Philadelphia, PA , USA School of Chemistry and Chemical Engineering, Shandong University, 250100, Jinan, PR China Research Center of Laser Fusion, China Academy of Engineering Physics 1 , Mianyang 621900, China Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Science, Shanghai, China State Key Laboratory of Bio-Fibers and Eco-Textiles, College of Textiles and Clothing, Qingdao University, Qingdao 266071, China Umeå Stroke Center, University of Umeå, Umeå, Sweden; Department of Neurology, University of Umeå, Umeå, Sweden Department of Orthopedics, The East Area of First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710089, China Imunoprevention institute, Hangzhou Center for Disease Control and Prevention, Hangzhou, China Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin 300387, China; The Third Affiliated Teaching Hospital of Xinjiang Medical University (Affiliated Cancer Hospital), Xinjiang, Urumqi 830011, China;; State Key Laboratory of Molecular Oncology, National Cancer center Cancer Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Department of Gynecologic Oncology, Fudan Univeristy Shanghai Cancer Center , Shanghai; Department of Oncology , Shanghai Medical College, , Shanghai, People's Republic of China; Fudan University , Shanghai Medical College, , Shanghai, People's Republic of China College of Animal Science, Inner Mongolia Agricultural University , Hohhot 010018 , China Guizhou Provincial Engineering Research Center for the Development and Application of Ethnic Medicine and Ministry of Education/State Key Laboratory of Functions and Applications of Medicinal Plants Guizhou Medical University Guiyang 550004 China; School of Pharmacy Guizhou Medical University Guiyang 550004 China Institute of Medicinal Biotechnology; Chinese Academy of Medical Science and Peking Union Medical College; Beijing 100050; China Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, China; Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University, China. School of Life Sciences and Medical Center University of Science and Technology of China Hefei Anhui 230027 P. R. China Department of Orthopedic Surgery, The First Affiliated Hospital, Chongqing Medical University, Chongqing, China. Leadership Computing Facility, Argonne National Laboratory, Argonne, Illinois 60439, United States Department of Respiratory Oncology, Guangxi Medical University Affiliated Tumor Hospital, Nanning, 530021 Guangxi, China Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China Institute of Materials Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing 210093, China Department of Kidney Transplantation The First Affiliated Hospital of Zhengzhou University Zhengzhou 450001 China; Nanozyme Medical Center School of Basic Medical Sciences Academy of Medical Science Zhengzhou University Zhengzhou 450001 China Molecular Oncology Laboratory, Department of Surgery, University of Chicago Medical Center, Chicago, Illinois. National Laboratory of Solid State Microstructures; Nanjing University; Ministry of Education Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, and Graduate School of the Chinese Academy of Sciences, Beijing 100190, China. Department of Polymer Science, College of Chemistry and ‡Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, Jilin University, Changchun 130012, China The Application Center for Precision Medicine The Second Affiliated Hospital of Zhengzhou University Zhengzhou Henan 450052 China; Nanozyme Medical Center School of Basic Medical Sciences Academy of Medical Science Zhengzhou University Zhengzhou 450001 China Department of Echocardiography Beijing Chaoyang Hospital Capital Medical University Beijing China Guangdong Province Key Laboratory of Rare Earth Development and Application, Institute of Resources Utilization and Rare Earth Development, Guangdong Academy of Sciences, Guangzhou 510651, PR China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China Department of Medical ICU, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Quality Inspection Center Yantai Academy of Agricultural Sciences in Shandong Province Yantai P. R. China State Key Laboratory for Agrobiotechnology, College of Biological Sciences China Agricultural University Beijing 100193 P. R. China; France‐China Bio‐mineralization and Nano‐structure Laboratory Beijing 100193 P. R. China Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430034, China Department of Endocrinology the First Affiliated Hospital of Harbin Medical University Harbin China Department of Endocrinology and Metabolism, The Third Affiliated Hospital of Southern Medical University , Guangzhou, Guangdong , China Department of Microbiology and Immunology, Medical University of South Carolina , Charleston, South Carolina, USA; The First Affiliated Hospital of Hu-Nan University of Chinese Medicine , Changsha, China Key Laboratory of Preparation and Application of Environmental Friendly Materials (Jilin Normal University); Ministry of Education; Changchun 130103; P. R. China; College of Chemistry Shanghai Institute of Technical Physics of the Chinese Academy of Sciences, Shanghai 200083, P. R. China College of Chemistry Nanchang University Nanchang 330031 P. R. China Innovation Application Institute, Zhejiang Ocean University, Zhoushan, Zhoushan, 316022, China. Department of Cardiology, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510120, China; The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, China Department of Urology, Dongying People's Hospital, Dongying 257091, Shandong, China Research Center of Basic Medicine Central Hospital Affiliated to Shandong First Medical University Jinan 250013 P. R. China Department of Psychiatry Duke University Medical Center Durham North Carolina From the Department of Psychiatry and Behavioral Sciences (W.J., E.J.C., G.L.C., R.R.K.), Aging Center (M.K.), and Department of Medicine (W.J., M.S.C., E.J.C., G.L.C., M.A.B., L.H.G., R.M.C., C.M.O.), Duke University Medical Center, Durham, NC, and Medicine/Psychiatry Services (J.D.A.), Shady Grove Adventist Hospital, Rockville, Md. Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Cancer Prevention and Lymphoma/Myeloma, University of Texas M. D. Anderson Cancer Center, Houston, Texas State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China Department of Microbiology and Immunology , Medical University of South Carolina , Charleston , SC , USA; Ralph H. Johnson VA Medical Center , Charleston , SC , USA; Divison of Infectious Diseases, Department of Medicine , Medical University of South Carolina , Charleston , USA CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of MicrobiologyChinese Academy of Sciences Beijing China *Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences, Fudan University, Shanghai, China;; †Department of Trauma-Emergency & Critical Care Medicine, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, China; CAS Key Laboratory of Pathogen and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Chaoyang District, Beijing 100101, China College of Environmental Science and Engineering; Jilin Normal University; Siping; P. R. China Department of Urology, The Union Hospital of Fujian Medical University, Fuzhou, China *Program in Immunology, Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305; Department of Ophthalmology, General Hospital of Western Theater Command, Chengdu 610083, PR China 1 Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, California 92037, USA Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yutian Road, Shanghai 200083, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China College of Chemical Engineering, State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing Tech University, Nanjing 210009, P. R. China School of Chemistry and Chemical Engineering National Special Superfine Powder Engineering Research Center Nanjing University of Science and Technology Nanjing 210094 China State Key Laboratory of Microbial Technology, Shandong University, 266237 Qingdao, China Department of Biostatistics University of Kansas Medical Center 3901 Rainbow Boulevard Kansas City Kansas 66160 USA 1 College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China and Bone and Joint Department of Shenzhen People's Hospital Shenzhen, Guangdong, China. The First Affiliated Hospital of Nanfan University of Science and Techenology Shenzhen, Guangdong, China. The Second Clinical Medical College of Jinan University Shenzhen 518020, Guangdong, China. Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology Department of Occupational Health and Environment Health, School of Public Health, Anhui Medical University, China Department of Chemistry Southern University of Science and Technology Shenzhen 518055 China Molecular Oncology Laboratory Department of Orthopaedic Surgery The University of Chicago Medical Center Chicago IL USA Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine and Department of Orthopedic Surgery of the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou 310058 China; Department of Sports Medicine Zhejiang University School of Medicine Hangzhou 310058 China; Zhejiang University‐University of Edinburgh Institute Zhejiang University School of Medicine and Key Laboratory of Tissue Engineering and Regenerative Medicine of Zhejiang Province Zhejiang University School of Medicine Hangzhou 310058 China Shandong University, Jinan, Shandong 250014, China; Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266011, China. 2Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania. Institute of New Energy Material Chemistry and Department of Material Chemistry, Nankai University, Tianjin 300071, China, Institute of Scientific Computing, Nankai University, Tianjin 300071, China, and Center for Biophysical Modeling and Simulation and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850 Key Laboratory for Human Disease Gene Study of Sichuan Province, Prenatal Diagnosis Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, Sichuan 610072, China.yangjiyun@yeah.net. Department of Respiratory and Critical Medicine, Yantai Yuhuangding Hospital, Yantai, China Department of Ultrasonography China‐Japan Union Hospital of Jilin University Changchun Jilin China Burnham Institute for Medical Research, La Jolla, CA 92037 Department of Rehabilitation, Southwest Medical University, Sichuan, China. State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center, Guangzhou 510060, China. Department of Gastroenterology, Hospital of Liaoning University of Traditional Chinese Medicine, Shenyang, Liaoning 110032, P.R. China *The Burnham Institute for Medical Research, La Jolla, CA 92037; and Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Gastroenterology, The First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China Center of Infectious Diseases, Tangdu Hospital, Fourth Military Medical University, Xi'an, Shaanxi Province, China. Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, People's Republic of China; and Institute of Environmental Medicine Zhejiang University School of Medicine Hangzhou Zhejiang China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences , Shanghai 200031 , China Department of General Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China Department of Neurosurgery, Changzhou Wujin People's Hospital of Jiangsu University Changzhou 213100, Jiangsu, China. 1Burnham Institute for Medical Research, La Jolla, California and Department of Gynecologic Oncology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China 2Department of Biochemistry, New York University Medical Center, New York, NY 10016 Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Bone and Joint, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong 518020. China. Department of Etiology and Carcinogenesis and State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Air Force Engineering University Department of medicine, Union Shenzhen Hospital, Huazhong University of Science and Technology , Shenzhen, China Department of Clinical Laboratory, First Affiliated Hospital of Chinese People's Liberation Army General Hospital, Beijing 100048, People's Republic of China Xi’an Jiaotong University State Key Laboratory for Manufacturing Systems Engineering, , Xi’an 710049, China Department of Respiratory Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, P.R. China Department of Rheumatology; China-Japan Friendship Hospital; Beijing China Department of Biostatistics, University of Kansas Medical Center, Kansas City, Kansas, USA Department of Gastroenterology Zhongshan Hospital, Fudan University Shanghai China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China Institute of Materials Engineering College of Engineering and Applied Sciences Nanjing University Nanjing Jiangsu 210093 China; Shenzhen Research Institute of Nanjing University Shenzhen 518057 China Department of Physics Xiamen University Xiamen 361005 People's Republic of China Taizhou Institute for Food and Drug Control, Taizhou, 225300, China Department of Radiation Oncology, National Cancer Center/Cancer Hospital and Shenzhen Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Qingdao University of Science and Technology, Qingdao 266042, People's Republic of China Department of Orthopedics People’s Hospital of Deyang City China Eppley Institute, University of Nebraska Medical Center, Omaha, Nebraska 68198-5950, United States USC Dornsife College of Letters, Arts and Sciences, Department of Chemistry, University of Southern California, Los Angeles, CA, USA Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Cardio‑Thoracic Surgery, The People's Hospital of Zhangqiu Area, Jinan, Shandong 250200, P.R. China Heart Center, Guangdong Provincial Hospital of Traditional Chinese Medicine, Guangzhou 510120. Department of General Surgery & Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University , Guangzhou, Guangdong, P. R. China; School of Science, Jimei University , Xiamen, Fujian, P. R. China National Special Superfine Powder Engineering Research Center, Nanjing University of Science and Technology, Nanjing, China Department of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, Zhejiang, China Department of Chemistry, University of Southern California , Los Angeles , CA 90089, USA National Engineering Research Center of Seafood, Collaborative Innovation Center of Provincial and Ministerial Co-construction for Seafood Deep Processing, School of Food Science and Technology, Dalian Polytechnic University, Dalian, Liaoning 116034, People’s Republic of China Department of Microbiology and Immunology, Medical University of South Carolina , Charleston, South Carolina, USA Department of Materials Science and Engineering, Yonsei University, Seoul 03722, Korea Department of Echocardiography Heart Center Beijing Chao Yang Hospital Capital Medical University Beijing China Physics Division, Argonne National Laboratory, Argonne, IL 60439; Department of Orthopedics The Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University Changzhou China Department of Urology, Fujian Medical University Union Hospital, Fujian, China Analytic Science, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, United States Department of Pharmacy, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510030, China Centre for Quantum Physics, Key Laboratory of Advanced Optoelectronic Quantum Architecture and Measurement (MOE), School of Physics, Beijing Institute of Technology, Beijing 100081, China Institute of Resources Utilization and Rare Earth Development, Guangdong Academy of Sciences, Guangzhou510651, P. R. China Department of Neurology, The First Hospital of Changsha, Changsha, Hunan, PR China Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiaotong University School of Medicine, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China Department of Chemistry, University of South Florida, Tampa, Florida 33620, United States; Institute of Materials Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China Department of Biostatistics Yale School of Public Health New Haven Connecticut USA Heart Center, The Children's Hospital, National Clinical Research Center for Child Health Zhejiang University School of Medicine Hangzhou China Department of Chemistry and Biochemistry, 405 Hilgard Avenue, University of California, Los Angeles, California 90095 Center of Infectious Diseases, West China Hospital Sichuan University Chengdu 610041 China China Volleyball College, Beijing Sport University, Beijing 100089, China Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Department of orthopaedic Surgery, Shenzhen People’s Hospital, Shenzhen City, China; The Second Clinical Medical College, Jinan University, Shenzhen, Guangdong, China; The First Affliated Hospital, Southern University of Science and Technology, Shenzhen, Guangdong, China; Shenzhen Clinical Research Centre for Geriatrics, Shenzhen People’s Hospital Leadership Computing Facility, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, United States State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Marine Science & Technology Institute, College of Environmental Science & Engineering, Yangzhou University, Yangzhou, Jiangsu 225127, People’s Republic of China; Molecular Targets Program, Center for Cancer Research, National Cancer Institute, Frederick, Maryland 21702-1201, United States Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Orthopedic Laboratory of Chongqing Medical University, Chongqing 400016, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, and Graduate School of the Chinese Academy of Sciences, Beijing 100190, China Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, Jiangsu 210003, China State Key Laboratories for Agrobiotechnology and College of Biological Sciences, China Agricultural University, Beijing, China; France-China Bio-Mineralization and Nano-Structure Laboratory, Beijing, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, China Department of Infectious Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Intensive Care Unit, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai 200072, P.R. China Center for Surgery and Public Health Harvard Medical School and Harvard T. H. Chan School of Public Health Department of Surgery Brigham & Women’s Hospital Boston Massachusetts USA State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, Jiangsu 210023, China Key Lab for Polyoxometalate Science; Department of Chemistry; Northeast Normal University; Changchun 130024; People's Republic of China Department of Critical Care Medicine Shanghai Tenth People's Hospital Tongji University Shanghai China Department of Plastic and Aesthetic Surgery; Nanfang Hospital of Southern Medical University; Guangzhou; China Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA Department of Cardiology The General Hospital of the PLA Rocket Force Beijing 100088 China From Thomas Jefferson University Hospital, Philadelphia, Pennsylvania Department of Orthopedics, The First Affiliated Hospital of Anhui Medical University, 218 Jixi Road, Shushan District, Hefei, Anhui, 230022, PR China College of Chemistry and Chemical Engineering State Key Laboratory of Chemo/Biosensing and Chemometrics Hunan University 410082 Changsha China Department of Pediatrics, The People’s First Hospital of Foshan, Foshan, 528000, China Department of Dermatology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China Department of Thoracic Surgery Zhongshan Hospital, Fudan University Shanghai China Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina 173 Ashley Ave., Charleston, SC 29425, USA. State Key Laboratory of Food Nutrition and Safety Tianjin University of Science and Technology Tianjin China; Key Laboratory of Food Nutrition and Safety, Ministry of Education Tianjin University of Science and Technology Tianjin China; College of Food Science and Engineering Tianjin University of Science and Technology Tianjin China Department of Pharmacy, Women’s Hospital, Zhejiang University School of Medicine, Hangzhou, China Institute for Energy Research and ‡School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, P. R. China Department of Chemical and Biological Engineering Monash University Clayton Victoria Australia; Imperial College Centre for Synthetic Biology Imperial College London London UK; Department of Bioengineering Imperial College London London UK Medical Research Institute School of Medicine Wuhan University Wuhan China School of Environmental Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225127, People’s Republic of China the State University of New Jersey 2 Electrical and Computer Engineering Department, Rutgers, , Piscataway, New Jersey 08854, USA Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Basic Medical Sciences Shenzhen University Health Science Centre Shenzhen China Argonne Leadership Computing Facility, Argonne National Laboratory, Lemont, Illinois 60439, United States Department of Prosthodontics and Orthodontics, Shanghai Jiading Dental Diseases Prevention and Cure Center. Shanghai 201899, China. E-mail:fukuoka2009@163.com. Ministry of Agriculture and Rural Affairs Key Laboratory of East China Sea Fishery Resources Exploitation, East China Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Shanghai 200090, China. College of Fishery and Life Science, Shanghai Oceanography University, Shanghai 201300, China. Department of Dermatology Peking University Third Hospital Beijing China 1Department of Surgery, University of Michigan Medical School, Ann Arbor, Michigan. Jiangsu Province Hi-Tech Key Laboratory for Bio-Medical Research Jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device School of Chemistry and Engineering Southeast University 211189 Nanjing Jiangsu P. R. China Department of Medicine, Division of Infectious Diseases, Case Western Reserve University/University Hospitals of Cleveland, OH; Department of Chemistry, University of South Florida, 4202 E. Fowler Ave, Tampa, Florida 33620, United States; Institute of Materials Engineering, College of Engineering and Applied Sciences, Nanjing University, Nanjing, Jiangsu 210093, China Department of Thoracic Surgery Zhongshan Hospital of Fudan University Shanghai China Department of General Surgery Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor Nanfang Hospital The First School of Clinical Medicine Southern Medical University Guangzhou China; School of Science Jimei University Xiamen China Department of Chemistry; South University of Science and Technology of China; Nanshan District; P. R. China Shandong Provincial Hospital Affiliated to Shandong University No. 324 Jingwuweiqi Road Jinan 250021 Shandong Province China Center for Disease Control and Prevention of Zhejiang Province, Hangzhou 310021, People’s Republic of China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; Institute of Zhejiang University-Quzhou, Quzhu 324000, China Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China; Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University Changzhou, Jiangsu, China. Department of Psychiatry, Institute of ECT Treatment Center, Beijing Anding Hospital, Capital Medical University; and 5Pathology Department, Thomas Jefferson University, Philadelphia, Pennsylvania. Key Laboratory of Functional Molecular Engineering of Guangdong Province, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510641, P. R. China Department of Pathology, West China Second University Hospital Sichuan University Chengdu China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University Ministry of Education Chengdu China Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA; Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA Key Laboratory of Bio-Resources and Eco-Environment, Ministry of Education, College of Life Science, Sichuan University, Chengdu, China.; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, China. Environment Research Institute, Shandong University, Binhai Road 72, Qingdao 266237, P. R. China GRIMAT Engineering Institute Co., Ltd., Beijing 101407, China; China GRINM Group Corporation Limited, Beijing 100088, China Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, and Aptamer Engineering Center of Hunan Province, Hunan University, Changsha, Hunan 410082, P. R. China Department of Respiration, Second Medical Center of Chinese PLA General Hospital, Beijing 100853, China Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University. Chongqing 400016, China. E-mail:863611202@qq.com. College of Chemistry and Molecular Engineering; Peking University; Beijing 100871; China Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104; and Department of Pathology Thomas Jefferson University Hospital Philadelphia Pennsylvania Department of Orthopaedics Xiangya Hospital Central South University Changsha Hunan China Department of Bone and Joint, The Second Clinical Medical College (Shenzhen People’s Hospital), Jinan University, Shenzhen 518020, China Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei 230027, China; and School of Pharmacy, Shandong University, Jinan 250002, China Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China School of Chemistry and Chemical Engineering; Southeast University; Nanjing; P. R. China Department of Cardiology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China The School of Chemistry and Chemical Engineering/QUILL Research Centre, Queen’s University of Belfast, David Keir Building, Stranmillis Road, Belfast BT9 5AG, Northern Ireland, U.K. Department of Pathology and Genomic Medicine Thomas Jefferson University Hospital Philadelphia Pennsylvania USA , Dalian University of Technology, , China Broad Institute, Cambridge, MA 02142; Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Science, Beijing 100190, China Beijing Normal University School of Psychology, , Beijing 100875, China jiangvi@126.com Laboratory of Marine Organism Taxonomy and Phylogeny, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China National Special Superfine Powder Engineering Research Center; Nanjing University of Science and Technology; Nanjing 210094, China The Skaggs Institute for Chemical Biology and Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, United States Key Lab of Polyoxometalate Science Department of Chemistry Northeast Normal University Changchun 130024 P. R. China School of Chemistry and Chemical Engineering Shandong University Jinan 250100 P. R. China Department of Immunology, MOE & MOH Key Laboratory of Medical Molecular Virology, School of Basic Medical Sciences, Fudan University, Shanghai, China 1 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, People’s Republic of China 304 Hospital, Haidian District, Beijing, 100037, People's Republic of China Deparment of Molecular Medicine Research Center, West China Hospital, Sichuan University Chengdu Sichuan People's Republic of China Pain Management Center Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Analytical Sciences Novartis Institutes for Biomedical Research Cambridge MA USA Department of Dermatology The 78th group army hospital of Chinese PLA Mudanjiang China National Laboratory for Infrared Physics; Shanghai Institute of Technical Physics; Chinese Academy of Sciences; Shanghai 200083; China Department of Pediatrics, Stanford School of Medicine, Palo Alto, CA 94305, USA. Institute of Materials Engineering College of Engineering and Applied Sciences Nanjing University Nanjing Jiangsu 210093 China Department of Plant, Soil and Insect Sciences Department of Cardiopulmonary Rehabilitation, Jiangsu Rongjun Hospital, Wuxi City, Jiangsu Province, 214000, China Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, P. R. China; School of Materials Science and Engineering, Shenyang University of Technology, Shenyang 110870, P. R. China School of Physics and Technology, Center for Nanoscience and Nanotechnology, and Key Laboratory of Artificial Micro- and Nanostructures of Ministry of Education, Wuhan University, Wuhan 430072, China Department of Infectious Diseases, Tianjin First Central Hospital, Tianjin, China 2Department of Radiation Oncology, Guilin Medical University Affiliated Hospital, Guilin, PR China. Argonne Leadership Computing Facility, Argonne National Laboratory, United States Blood Transplant and Cell Therapies Program Westmead Hospital Sydney New South Wales; Sydney Medical School, Faculty of Medicine and Health University of Sydney Sydney New South Wales Center for Biophysical Modeling and Simulation and Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850 Center for Surgery and Public Health, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Bone and Joint Department, Shenzhen People's Hospital, The Second Clinical Medical College of Jinan University and The First Affiliated Hospital of Southern University of Science and Technology, Shenzhen, Guangdong 518020, P.R. China Department of Thoracic Surgery, Affiliated Taixing People’s Hospital of Yangzhou University, Taixing, People’s Republic of China Department of Anesthesiology, Shanghai Jiaotong University Affiliated, Shanghai Sixth People's Hospital, Shanghai - China Animal Disease Prevention and Food Safety, Key Laboratory of Sichuan Province, College of Life Science, Sichuan University, Chengdu, China Laboratory Medicine Department, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, Chengdu, China. Biosciences Division, Argonne National Laboratory, Argonne, IL 60439 Institute for Energy Research, School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang 212013, China Department of Medicine and Department of Immunology and Microbiology, Medical University of South Carolina, 173 Ashley Avenue, The Basic Science Building, Room 208D, Charleston, SC 29425, USA Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, PR China; College of Environmental and Chemical Engineering, Nanchang Hangkong University, Nanchang 330063, PR China Department of Anesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, IL, USA Department of Chemistry, University of New Mexico, Albuquerque, New Mexico 87131-0001 Department of Critical Care Medicine Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Building 240, Argonne, Illinois 60439, and Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, 929 57th Street, Chicago, Illinois 60637 Key Laboratory of Functional Molecular Engineering of Guangdong Province; School of Chemistry and Chemical Engineering; South China University of Technology; Guangzhou 510640; China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College Qingdao University; Qingdao 266071; China; State Key Laboratory of Bio-Fibers and Eco-Textiles; Qingdao University Wei Jiang, Jing Zhou, Lu Ke, Gang Li, Zhi-Hui Tong, Wei-Qin Li, Jie-Shou Li, Research Institute of General Surgery, Jinling Hospital, Medical School of Nanjing University, Nanjing 210000, Jiangsu Province, China. Department of Rheumatology, China-Japan Friendship Hospital, Beijing, China. Department of Burn, The First Affiliated Hospital of Anhui Medical University Department of Burn, The First Affiliated Hospital of Anhui Medical University CSD IDEA (Beijing) Institute of Environmental Innovation Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China State Key Laboratory of Molecular Oncology, Department of Etiology and Carcinogenesis Cancer Institute and Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Key Laboratory of Molecular and Cellular Systems Biology, Tianjin Normal University, Tianjin, China; Tianjin Key Laboratory of Animal and Plant Resistance, College of Life Sciences, Tianjin Normal University, Tianjin, China College of Chemistry, Nanchang University, Nanchang 330031, China; Nanchang Institute for Food and Drug Control, Nanchang 330038, China Division of Molecular Medicine Hefei National Laboratory for Physical Sciences at Microscale The CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences University of Science and Technology of China Hefei 230027 P. R. China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China Division of Oncology, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305 Department of Pharmacy; The Second Affiliated Hospital of Air Force Medical University; Xi'an 710038; PR China Department of Anesthesiology Shanghai Jiaotong University Affiliated Shanghai Sixth People's Hospital Shanghai China Key Laboratory of Preparation and Application of Environmental Friendly Materials (Jilin Normal University); Ministry of Education; Changchun 130103; P. R. China Key Laboratory of Eco-Environment-Related Polymer Materials Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China Key Laboratory of Swine Genetics and Breeding of Ministry of Agriculture and Rural Affairs & Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of Ministry of Education College of Animal Science and Technology Huazhong Agricultural University Wuhan P.R. China Multiphase Mass Transfer & Reaction Engineering Lab; College of Chemical Engineering; Sichuan University; Chengdu; 610065 China Molecular Medicine Research Center, State Key Laboratory of Biotherapy and Cancer Center West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy Chengdu Sichuan China Jiangsu Key Laboratory of Advanced Manufacturing Technology, Huaiyin Institute of Technology, Huai’an 223003, China Operation Room, The First Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161041, China School of Chemistry and Chemical Engineering Southeast University Nanjing 211189 P. R. China School of Mechanical, Electrical and Information Engineering, Wuxi Vocational Institute of Arts & Technology, Wuxi, Jiangsu Province, China State Key Laboratory of Applied Organic Chemistry Lanzhou University Tianshui Southern Road 222 Lanzhou 730000 Gansu, Province China *Institute of Immunology and the Chinese Academy of Sciences Key Laboratory of Innate Immunity and Chronic Disease, Chinese Academy of Sciences Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China;; §Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230027, China; and Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences, 518 Ziyue Road, Minhang, Shanghai, 200241, PR China Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China, Graduate School of the Chinese Academy of Sciences, Beijing 100190, China, and Performance Chemicals Research, BASF SE, Ludwigshafen 67056, Germany National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 100050, China. Hospital of Chengdu University of Traditional Chinese Medicine Chengdu China School of Mechanical Engineering and Automation, Wuhan Textile University, Wuhan, Hubei 430074, P. R. China Health Economic Outcome Research, Medtronic Inc., Mansfield, MA 02048, USA College of Bioinformatics Science and Technology, Harbin Medical University, 194 Xuefu Road, Harbin 150081, People's Republic of China State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources and College of Life Science and Technology, 100 Daxue Road, Nanning, Guangxi 530004, China Department of Interventional Radiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230026, China Department of Gynecologic Oncology Fudan University Shanghai Cancer Center, Fudan University Shanghai China; Department of Oncology Shanghai Medical College, Fudan University Shanghai China *The Burnham Institute for Medical Research, La Jolla, CA 92037; Medical Research Institute, School of Medicine, Wuhan University, Wuhan, China Department of Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China; Beijing National Laboratory for Molecular Sciences Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences (ICCAS) Beijing 100190 P. R. China Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Departments of Biochemistry and Molecular Biology and of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802 Department of Electrical and Computer Engineering; University of Minnesota; Minneapolis; USA *Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China; Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, P. R. China Department of Hematology, Benxi Central Hospital, Benxi 117000, Liaoning Province,China. Institute of Optics Engineering, Shanghai Jiaotong University, 200030, Shanghai, China Department of Biological Repositories Frontier Science Center for Immunology and Metabolism Medical Research Institute Zhongnan Hospital of Wuhan University Wuhan University Wuhan 430071 China Department of Thoracic Surgery Dushu Lake Hospital Affiliated to Soochow University Suzhou China Biosciences Division, Argonne National Laboratory, 9700 South Cass Avenue, Building 221 Argonne, Illinois 60439, Center for Molecular Modeling, National Institute of Chemistry, Hajdrihova 19, SI-1000 Ljubljana, Slovenia, and Department of Biochemistry and Molecular Biology, Gordon Center for Integrative Science, University of Chicago, 929 57th Street, Chicago, Illinois 60637 School of Chemical Engineering and ‡National Special Superfine Powder Engineering Research Centre, Nanjing University of Science and Technology, Nanjing 210094, China Department of Echocardiography Heart Center Capital Medical University Chaoyang Hospital Beijing China Institute of Immunology, Hefei National Laboratory for Physical Sciences at Microscale and School of Life Sciences, University of Science and Technology of China, Hefei, China Department of Radiation Oncology Cancer Hospital & Institute Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Radiotherapy Department, HuanHu Hospital, Tianjin 300060, China. Institut für Chemie und Biochemie, Freie Universität Berlin, Takustrasse 3, 14195 Berlin, Germany Center for Surgery and Public Health, Brigham and Women’s Hospital, Boston, Massachusetts Shaanxi Key Laboratory for Animal Conservation, Shaanxi Institute of Zoology, Xi'an 710032, China. School of Chemistry & Environmental Engineering, International Healthcare Innovation Institute, Wuyi University, Jiangmen 529020, China Key Laboratory of Textile Fiber and Products (Wuhan Textile University), Ministry of Education, Wuhan 430200, China Shionogi, Inc, Florham Park, NJ Department of Cardiology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences; Fudan University Taizhou Institute of Health Sciences, Taizhou Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. Department of Oncology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Department of Industrial Engineering and Decision Analytics, Hong Kong University of Science and Technology, Hong Kong 999077, China Department of Scientific Technology and Property, Nantong University, Nantong 226019, Jiangsu Province, China. Key Laboratory of Organic Solids; Beijing National Laboratory for Molecular Sciences; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190 Department of Pediatrics, Program in Immunology, Stanford University, Stanford, CA 94305; and State Key Laboratory of Complex Severe and Rare Diseases, Medical ICU, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, College of Biology, Aptamer Engineering Center of Hunan Province, Hunan University Changsha, Hunan, 410082, China Department of Rehabilitation, Affiliated Hospital of Southwest Medical University Luzhou, Sichuan 646000, China. CAST Department of Pharmacy, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China Zhejiang Zhenyuan Pharmaceutical Co., Ltd, 1015 West Shengli Road, Shaoxing, Zhejiang 312000, China College of Chemical Engineering, Huaqiao University, 668 Jimei Boulevard, Xiamen, Fujian 361021, P. R. China Key Laboratory for Tumor Precision Medicine of Shaanxi Province and Department of Endocrinology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, P.R. China Department of General Surgery, Xiangya Hospital, Central South University, 410008 Changsha, Hunan Province, China 1Novartis Institutes for Biomedical Research, Cambridge, Massachusetts. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA. jiang001@mc.duke.edu Department of Endocrinology, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China Department of Radiation Oncology Affiliated Hospital of Guilin Medical University Guilin Guangxi 541001 P. R. China Department of Breast Surgery, Guangxi Medical University Cancer Hospital, 71 Hedi Road, Qingxiu District, Nanning 530021, Guangxi Province, China Center for Surgery and Public Health, Division of Urologic Surgery, Brigham and Women’s Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts State Key Laboratory of Polymer Physics and Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022, People's Republic of China Department of Bone and Joint, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen Guangdong, 518020, P.R.China. From Duke University School of Medicine, Veterans Affairs Mid-Atlantic Mental Illness Research, Education and Clinical Center (MIRECC), Durham Veterans Affairs Evidence Synthesis Center, Durham, North Carolina, and Southern California Permanente Medical Group, Anaheim, California; and University of Washington, Boise, Idaho. Department of Echocardiography Heart Center Beijing ChaoYang Hospital Capital Medical University Beijing China College of Automation Engineering Nanjing University of Aeronautics and Astronautics Nanjing China Department of Chemistry, Stanford University, Stanford, CA 94305, USA Department of Gynecology, Fudan University, Shanghai, China. xucj@hotmail.com Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Technology and Business University, Beijing, China; School of Food and Health, Beijing Technology and Business University, Beijing, China School of Biomedical Sciences, Leeds University, Leeds LS2 9JT, United Kingdom; Enzyme Engineering Laboratory, Jilin University, Changchun, China; and Department of Biochemistry, Eastern Virginia Medical School, Norfolk, VA 23507 Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7#, Qingdao 266071, China Department of Reproductive Medicine, Women’s Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, China Department of Thoracic Surgery, Zhongshan Hospital Fudan University No. 180, Fenglin Road 200032 Xuhui District Shanghai China Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China; Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science & Technology 1095# Jiefang Avenue, Wuhan 430030, Hubei, PR China. Key Laboratory for Colloid and Interface Chemistry of Education Ministry; Department of Chemistry; Shandong University; Jinan, P. R. China Department of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China; Shanghai Institute of Liver Disease Shanghai China; Department of Gastroenterology and Hepatology Xiamen Branch of Zhongshan Hospital Fudan University Shanghai China Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, PR China Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Pathology, West China Second University Hospital of Sichuan University , Chengdu , China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education , Chengdu , China Key Laboratory of Eco-Environment-Related Polymer Materials, Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei 230027, China 1; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei 230027, China 3 Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China. State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, National Center for Soybean Improvement, Key Laboratory for Biology and Genetic Improvement of Soybeans (General, Ministry of Agriculture), Jiangsu Collaborative Innovation Center for Modern Crop Production, Nanjing Agricultural University , Nanjing 210095 , China; Zhongshan Biological Breeding Laboratory , Nanjing, Jiangsu 210014 , China Department of Chemistry and Chemical Biology; University of New Mexico; Albuquerque; USA College of Life Science, Sichuan University, Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, Chengdu, China.; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, China. Center for Medical Ultrasound The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital Suzhou Jiangsu China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, People's Republic of China National Academy of Agriculture Green Development Department of Plant Nutrition, College of Resources and Environmental Sciences China Agricultural University Beijing 100193 China Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China From the Departments of Public Health and Clinical Medicine, Medicine (W.J., W.G., P.W.); Medical Biosciences, Pathology (T.B.); and Cell and Molecular Biology (R.R.), Umeå Stroke Center, Umeå University (Sweden). Department of Radiation Oncology, Affiliated Hospital of Guilin Medical University, Key Laboratory of Oncology (Guilin Medical University), Education Department of Guangxi Zhuang Autonomous Region, Guilin, China Department of Chemistry, South University of Science and Technology of China, No. 1088 Xueyuan Boulevard, Nanshan District, Shenzhen, 518055, P. R. China Shaanxi Key Laboratory of Natural Products & Chemical Biology, College of Chemistry & Pharmacy, Northwest A&F University, 22 Xinong Road, Yangling 712100, Shaanxi, China China National Research Institute of Food & Fermentation Industries International Joint Research Center of Quality and Safety of Alcoholic Beverages Beijing China Center for Nanochemistry, Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry and Molecular Engineering Peking University Beijing 100871 P. R. China Department of Biochemistry, Robert Wood Johnson Medical School, Piscataway, New Jersey 08854 School of Mechanical Engineering, Dalian University of Technology, Dalian, China Department of Internal Medicine and Clinical Immunlogy Sorbonne Université Pitié‐Salpêtrière University Hospital Paris France; Centre de Recherche en Myologie UMRS974 Institut National de la Santé et de la Recherche Médicale Association Institut de Myologie Sorbonne Université Paris France Department of Biochemistry and Molecular Biology and Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 From the Department of Psychiatry and Behavioral Sciences, University of California, Davis, CA (G.L.X.); Department of Psychiatry and Behavioral Sciences (M.F., R.K., W.J.), Center for Aging (M.F.), and Division of Cardiology, Department of Medicine (C.M.O.), Duke University Medical Center, Durham, NC; and Duke Clinical Research Institute, Durham, NC (M.K.). Health Economic Outcome Research, Medtronic Inc, Mansfield, MA, USA Southern University of Science and Technology, Department of Chemistry, Xueyuan Boulevard 1088, Nanshan District, 518055 Shenzhen, China Department of Oncology, the First Affiliated Hospital of Zhengzhou University; Zhengzhou; China; Academy of Medical Science; Zhengzhou University Department of Bioengineering, Imperial College London, London SW7 2AZ, U.K.; Centre for Synthetic Biology, Imperial College London, London SW7 2AZ, U.K. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People’s Republic of China CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, 11 Fucheng Road, Beijing 100048, China Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China Psychiatry and Behavioral Sciences, Duke University Medical Center, USA; Department of Medicine, Duke University Medical Center, USA School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, P. R. China Xinjiang Production and Construction Corps, Key Laboratory of Korla Fragrant Pear Germplasm Innovation and Quality Improvement and Efficiency Increment, Xinjiang Academy of Agricultural and Reclamation Sciences, Shihezi 832061, China; College of Horticulture and Landscape Architecture, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China 4Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania. College of Horticulture and Landscape Architecture, Zhongkai University of Agriculture and Engineering, Guangzhou 510225, China Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Detroit, MI, USA Department of Quality Control, Changchun Institute of Biological Products Co. Ltd, Changchun, China The Department of Cardiology, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuchang, Hubei, China Department of Microbiology and Immunology and; Divison of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston; *Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, Heping District 300052, China; Department of Biochemistry and Molecular Biology; Department of Chemistry Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an, China *State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, People's Republic of China; and Key Lab for Polyoxometalate Science, Department of Chemistry, Northeast Normal University, Changchun 130024, People’s Republic of China Department of Gastrointestinal Surgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology , 430000 , Wuhan , China Department of Physics, Jiangsu University of Science and Technology, Zhenjiang 212003, China Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Chinese Medicine , Nanchang 330004 , China College of Chemistry Fuzhou University Fuzhou 350002 China College of Information Science and Technology, Dalian Maritime University, Dalian 116026, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People’s Republic of China CAS Key Laboratory of Pathogenic Microbiology and Immunology; Institute of Microbiology; Chinese Academy of Sciences; Beijing; 100101; China National Synchrotron Radiation Laboratory CAS Center for Excellence in Nanoscience University of Science and Technology of China Hefei Anhui 230029 China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China College of Chemistry, Nanchang University, Nanchang 330031, China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease, CAS Center for Excellence in Molecular Cell Sciences, School of Life Sciences and Medical Center, University of Science and Technology of China, Hefei, China 1; Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, Hefei, China 3 1 Laboratory of Bioinformatics and Computational Biology, Department of Electronic and Computer Engineering and 2Department of Computer Science and Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Organic Solids and Laboratory of New Materials Institute of Chemistry, Chinese Academy of Sciences (ICCAS), Beijing, 100190, P. R. China Molecular Biology and Virology Laboratory, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA 92037 State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao 266071, China School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China Department of General Surgery, Xiangya Hospital, Central South University, Changsha, 410008, China From the Department of Psychiatry and Behavioral Sciences (J.A.B., W.J., M.B., E.T.T.), the Department of Medicine (R.A.W., D.J.F., J.J.M., C.O.), and the Department of Radiology (R.E.C., M.H.), Duke University Medical Center, Durham, NC; and the Department of Medical and Clinical Psychology (D.S.K.), Uniformed Services University of the Health Sciences, Bethesda, Md. Department of Surgery, Jefferson Pancreas, Biliary and Related Cancer Center Thomas Jefferson University Philadelphia Pennsylvania USA State Key Laboratory of Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences 500 Yu Tian Road Shanghai 200083 China; University of Chinese Academy of Sciences 19 Yuquan Road Beijing 100049 China Department of Biomedical Mathematics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China Argonne Leadership Computing Facility; Argonne National Laboratory; Argonne; USA Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China;; Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Institute of Chinese Sturgeon, China Three Gorges Corporation, Yichang, China Pharmaceutical Informatics Institute, Zhejiang University, Zijingang Campus, Hangzhou, P. R. China Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA Yunnan Key Laboratory of Tobacco Chemistry, R&D Center of China Tobacco Yunnan Industrial Co. Ltd., Kunming 650231, China School of Automation Engineering, University of Electronic Science and Technology of China 2 , Chengdu 611731, China Department of Anesthesiology, Minhang Hospital, Fudan University, Shanghai, China Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Peking University Health Science Center, Beijing 100191, P. R. China State Key Laboratory of Media Convergence and Communication, Communication University of China, Beijing 100024, China; Key Laboratory of Acoustic Visual Technology and Intelligent Control System, Ministry of Culture and Tourism, Communication University of China, Beijing 100024, China; Beijing Key Laboratory of Modern Entertainment Technology, Communication University of China, Beijing 100024, China; School of Information and Communication Engineering, Communication University of China, Beijing 100024, China College of Agriculture, Northeast Agricultural University, Harbin 150030, China (J.W., W.J., Q.C., G.H.); Cigarette Product Quality Test Center Technology Center of China Tobacco Yunnan Industrial Co., Ltd. Kunming P. R. China Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai 201203, People’s Republic of China; School of Life Science and Technology, Wuhan Polytechnic University, Hubei 430023, People’s Republic of China Molecular Medicine Research Center West China Hospital of Sichuan University Chengdu China Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Jiangjun Avenue, Jiangning District, Nanjing, P.R. China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China. Key Laboratory of Preparation and Application of Environmental Friendly Materials, Jilin Normal University, Ministry of Education, Changchun 130103, P.R. China; College of Chemistry, Jilin Normal University, Siping 13600, P.R. China Molecular Medicine Research Center, West China Hospital of Sichuan University, Chengdu, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China, and Graduate University of the Chinese Academy of Sciences Department of Endocrinology, Third Affiliated Hospital of Southern Medical University, Guangzhou 510630, China.E-mail: 527705916@qq.com. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China, Graduate School of the Chinese Academy of Sciences, People's Republic of China, and Department of Polymer Science and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China Zhuhai Interventional Medical Center; Zhuhai Precision Medical Center; Zhuhai People's Hospital; Zhuhai Hospital Affiliated with Jinan University; Zhuhai 519000 Department of Biological Repositories; Zhongnan Hospital of Wuhan University; Medical Research Institute; School of Medicine; Wuhan University State Key Laboratory of Genetic Engineering, Human Phenome Institute, and School of Life Sciences, Fudan University, Shanghai, China; Fudan University Taizhou Institute of Health Sciences, Taizhou, China Gastrointestinal Cancer Research Institute, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China Department of Pharmacy Changzheng Hospital Second Military Medical University No. 415 Fengyang Road Shanghai 200003 People's Republic of China College of Textiles and Clothing, State Key Laboratory of BioFibers and Eco-textiles, Qingdao University, Qingdao 266071, China Department of Orthopedics, Deyang People’s Hospital/Orthopedic Center of Deyang City, Deyang, China. Key Laboratory of Bio-resources and Eco-environment, Ministry of Education, College of Life Science, Sichuan University, Chengdu, China.; Animal Disease Prevention and Food Safety Key Laboratory of Sichuan Province, Chengdu, China. Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University , Chengdu, Sichuan , P.R. China State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, Jiangsu, P. R. China; Departments of Clinical Cancer Prevention, Gastrointestinal Medical Oncology, and Biostatistics, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030; Nuclear Receptor System Research, GlaxoSmithKline, Inc., Research Triangle Park, NC 27709; and Department of Carcinogenesis, University of Texas M. D. Anderson Cancer Center, P.O. Box 789, Smithville, TX 78957 Department of Bone and Joint, Shenzhen People’s Hospital, 2nd Clinical Medical College of Jinan University, Shenzhen 518020, China Beijing Advanced Innovation Center for Food Nutrition and Human Health and State Key Laboratory of Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing, China; Department of Pathology West China Second University Hospital of Sichuan University Chengdu China Institute of Petrochemical Technology, Jilin Institute of Chemical Technology, Jilin 132022, P. R. China Department of Ultrasound, Superficial and Obstetric Direction, Union Medical College Shenzhen Hospital of Huazhong University of Science and Technology, Shen Zhen, China Department of Orthopedics, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Department of Pediatrics, Yidu Central Hospital of Weifang, Weifang, China Departments of Neurosurgery and Department of Respiratory Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi, P.R. China Department of Nephrology, The Affiliated Huai'an Hospital of Xuzhou Medical University and The Second People's Hospital of Huai'an, Huai'an 223002, China Davidson Laboratory of Cell Signaling and Tumorigenesis, Hermelin Brain Tumor Center, Department of Neurosurgery, Henry Ford Hospital, Detroit, MI, USA Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China Biotechnology Research Institute Shanghai Academy of Agricultural Sciences Shanghai People's Republic of China; Shanghai Key Laboratory of Agricultural Genetics and Breeding Shanghai People's Republic of China Molecular Medicine Research Center, West China Hospital, Chengdu, Sichuan 610041, China; Department of Radiation Oncology, National Cancer Center/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College , Shenzhen , 518116 , China Beijing Advanced Innovation Center for Soft Matter Science and Engineering; Beijing University of Chemical Technology; Beijing 100029; P. R. China 5Department of Pathology, Thomas Jefferson University, Philadelphia, Pennsylvania. Department of Pediatrics–Human Gene Therapy Stanford University School of Medicine Stanford California; Stanford Immunology Stanford University School of Medicine Stanford California Department of Thoracic Surgery, Zhongshan Hospital, Fudan University , Shanghai, China State Key Laboratory of Microbial Technology, Shandong University, Qingdao, 266000, China Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu, China College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China State Key Laboratory of Agro-Biotechnology, College of Biological Sciences, China Agricultural University, Beijing 100193, China Nanjing Jiangning District Maternal and Child Health and Family Planning Service Center, Nanjing, Jiangsu, China Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming, P.R. China Department of Neurology and Neuroscience Center, The First Hospital of Jilin University, Changchun, China Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine & Key Laboratory of Modern Preparation of Traditional Chinese Medicine of Ministry of Education, Jiangxi University of Traditional Chinese Medicine, Nanchang, 330004, P. R. China Department of Spine Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing 400016, China Yunnan Key Laboratory of Tobacco Chemistry, Research and Development Center of China Tobacco Yunnan Industrial Co. Ltd, Kunming, Yunnan 650231, China Department of Radiology The First Affiliated Hospital of USTC University of Science and Technology of China Hefei Anhui 230001 P. R. China Institute of Medicinal Biotechnology; Chinese Academy of Medical Sciences; Peking Union Medical College; Beijing 100050; China School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu, P. R. China, 211189 Institute of Materials, China Academy of Engineering Physics, Jiangyou 621908, China Department of Gynaecology Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine Suzhou Jiangsu China Department of Civil Engineering Johns Hopkins System Institute Johns Hopkins University Baltimore MD 21218 USA Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital, Sun Yat‐Sen University Guangzhou PR China; Department of Pharmacy, Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou PR China Department of Materials Science and Engineering, Yonsei University, Yonsei-ro 50, Seodaemun-gu, Seoul 03722, Korea Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, PRC Department of Chemistry, University of Southern California, 3430 South Vermont Avenue, Los Angeles, California 90089, United States College of Chemistry and Chemical Engineering, State Key Laboratory of Chemo/Biosensing and Chemometrics, Hunan University, 410082, Changsha, China School of Electronic Information, Wuhan University, Wuhan 430072, China Department of Bone and Joint, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, Guangdong 518020, China Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA, United States Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, People’s Republic of China; Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Cancer, People’s Republic of China School of Chemistry and Chemical Engineering, Shandong University, Jinan, 250100, P. R. China Department of Chemistry; University of Tennessee; Knoxville; USA Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907;; National Center for Soybean Improvement, Key Laboratory of Biology and Genetics and Breeding for Soybean, Ministry of Agriculture, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China; Department of Radiation Oncology, Affiliated Hospital of Guilin Medical University, Guilin, PR China Department of General Surgery, Nanjing First Hospital Nanjing Medical University Nanjing Jiangsu China; The Third Clinical Medical College Nanjing Medical University Nanjing Jiangsu China Department of Orthopedics, West Hospital, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730060, China Pharmaceutical Informatics Institute Zhejiang University Hangzhou 310058 China Huazhong University of Science and Technology Department of Occupational Health and Environmental Health, School of Public Health, Anhui Medical University, Hefei, China Center for Precision Medicine of Zhengzhou University, Zhengzhou, China The Johns Hopkins University School of Medicine Department of Pathology and Division of Medical Microbiology and the Johns Hopkins Hospital, Baltimore, Maryland Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China Department of Quantitative and Computational Biology, University of Southern California, Los Angeles, California, USA. Environment Research Institute, Shandong University, Jinan 250100, China Medtronic, Minneapolis, Minnesota Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, 29 Zhongguancun East Road, Beijing 100190, P.R. China Department of Biological Mathematics, College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China; Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China Key Laboratory for Molecular Enzymology and Engineering of Ministry of Education, School of Life Sciences, and ‡Department of Polymer Science, College of Chemistry, Jilin University, Changchun 130012, China Department of Pharmacy The Second Affiliated Hospital of Air Force Medical University Xi'an China Institute of Cancer Stem Cells and The First Affiliated Hospital, Dalian Medical University, Dalian, China Department of Orthopedic, Sixth Affiliated Hospital of Xinjiang Medical University, Urumqi 830002, China School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, People’s Republic of China Department of Urology, Dongying People's Hospital , Dongying , China Molecular Medicine Research Center, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital of Sichuan University Chengdu China Department of Plant, Soil and Insect Sciences and ‡Biopolymer and Colloids Research Laboratory, Department of Food Science, University of Massachusetts, Amherst, Massachusetts 01003, United States 1Division of Endocrine and Oncologic Surgery, Department of Surgery, University of Pennsylvania Medical Center; Department of Medicine, Duke University Medical Center, Durham, North Carolina; Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, North Carolina. Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao 266003, China From the Department of Medicine, Baylor College of Medicine, Houston, Tex (C.-H.C., W.J., D.P.V., S.L., P.D.H.), and the Department of Internal Medicine, National Taiwan University Hospital, Taipei (T.-R.L., Y.-T.L.). Department of Neurosurgery Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China College of Chemical Engineering; Huaqiao University; Xiamen; China Department of Chemistry and Biochemistry, University of California at Los Angeles, 405 Hilgard Avenue, Los Angeles, California 90095-1569 Authors' Affiliations: 1Key Laboratory of Diagnostic Medicine designated by the Chinese Ministry of Education and the Affiliated Hospitals; 2Department of Pharmacology, School of Pharmacy, Chongqing Medical University; 3Department of Dermatology, Daping Hospital of the Third Military Medical University, Chongqing, China; 4Molecular Oncology Laboratory, Department of Surgery, The University of Chicago Medical Center, Chicago, Illinois; and 5Department of Orthopaedic Surgery, Huaxi Hospital Affiliated with Sichuan University School of Medicine, Chengdu, Sichuan, China College of Bioinformatics Science and Technology; Harbin Medical University; Harbin 150081; China State Key Laboratory of Biotherapy, Molecular Medicine Research Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Jiangsu, China (M.Y., W.J.) Department of Chemistry and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 Department of Materials Science and Engineering Yonsei University Yonsei‐ro 50, Seodaemun‐gu Seoul 03722 Republic of Korea Key Laboratory of Protein and Peptide Drugs National Laboratory of Biomacromolecules Institute of Biophysics Chinese Academy of Sciences Beijing 100101 China; College of Life Sciences University of Chinese Academy of Sciences Beijing 100049 China Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, Hubei, China, and Department of Chemistry, Huazhong Normal University, Wuhan 430079, Hubei, China Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of Chemistry Tsinghua University Beijing 100084 China State Key Laboratory of Pollution Control and Resources Reuse, School of the Environment, Nanjing University, Nanjing 210023, People’s Republic of China Department of Biochemistry and Molecular Biology, Peking University Health Science Center, Peking University , Beijing , China Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China Department of Thoracic Surgery, the First Affiliated Hospital of Soochow University, Suzhou, PR China. Department of Thoracic Surgery, Taixing People's Hospital of Jiangsu Province, Taixing, PR China. School of Life Sciences; University of Science and Technology of China; Hefei; P.R. China State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510020, China; Guangdong Provincial Key Laboratory of Chinese Medicine for Prevention and Treatment of Refractory Chronic Diseases, Guangzhou 510020, China; Guangdong Provincial Hospital of Chinese Medicine, Guangzhou 510020, China Institute of Field Surgery, Daping Hospital, The Third Military Medical University, Chongqing, PR China. Department of Biology, Syracuse University, Syracuse, New York 13244 School of Environmental Science and Engineering, Huazhong University of Science and Technology, Wuhan, China CAS Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China Center for Surgery and Public Health, Brigham and Women’s Hospital, Boston, MA 02110, USA Research Center for Traditional Chinese Medicine Resources and Ethnic Minority Medicine; Jiangxi University of Traditional Chinese Medicine; China School of Medicine, Nanchang University, Nanchang, Jiangxi, China; Department of Oncology, Jiangxi Maternal and Child Health Hospital, Nanchang, Jiangxi, China Department of Microbiology and Immunology, Medical University of South Carolina; Ralph H. Johnson VA Medical Center, Charleston, SC, USA. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China, and Graduate University of Chinese Academy of Sciences Engineering Laboratory for Functionalized Carbon Materials and Shenzhen Key Laboratory for Graphene‐Based Materials Graduate School at Shenzhen Tsinghua University Shenzhen 518055 China Key Laboratory of Molecular and Cellular Systems Biology, Tianjin Normal University, Tianjin 300387, China; State Key Laboratory of Molecular Oncology, Cancer Institute and Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, USA, Department of Medicine, Duke University Medical Center, Durham, NC, USA Key Laboratory for Colloid and Interface Chemistry of Education Ministry; Department of Chemistry; Shandong University; Jinan, China Argonne Leadership Computing Facility, Argonne National Laboratory, 9700 South Cass Avenue, Building 240, Argonne, Illinois 60439, United States Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China Zhejiang Zhenyuan Pharmaceutical Co., Ltd, Zhejiang 312000, China. Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital of Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan 610041, China Department of Anatomy, Histology & Developmental Biology, School of Basic Medical Sciences, Shenzhen University Health Science Centre, Shenzhen, P.R. China Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Pennsylvania, United States Department of Orthopedics Chinese PLA General Hospital Beijing, 100853 China Department of General Surgery, Tianjin First Central Hospital, tianjin 300192, China. Department of Pathology, West China Second University Hospital of Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China College of Chemical Engineering; State Key Laboratory of Materials-Oriented Chemical Engineering; Nanjing Tech University; Nanjing 210009; P. R. China School of Life Science and Technology, Wuhan Polytechnic University, Wuhan 430023, P. R. China The Second Affiliated Hospital of Guangzhou University of Chinese Medicine Guangzhou China; Department of Cardiology Guangdong Provincial Hospital of Chinese Medicine Guangzhou China State Key Laboratory of Agro-Biotechnology and Laboratoire International Associe Franco-Chinois de Bio-Mineralisation et Nano-Structures, College of Biological Sciences, China Agricultural University, Beijing 100193, China Department of Anesthesiology, Shanghai Jiao Tong University Affiliated Shanghai Sixth People’s Hospital, 600 Yishan Road, Shanghai 200233, China Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing, People's Republic of China; Chongqing Municipal Key Laboratory of Oral Biomedical Engineering of Higher Education, Chongqing, People's Republic of China; Department of Stomatology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China Department of Medicine, Duke University Medical Center, Durham, North Carolina; Department of Psychiatry, Duke University Medical Center, Durham, North Carolina. Radiochemistry and Radiation Chemistry Key Laboratory of Fundamental Science, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Neurosurgery, Minhang Hospital Fudan University Shanghai China Department of Radiation Oncology, Affiliated Hospital of Guilin Medical University, Guilin, China Department of Cell Biology and Genetics, College of Life Sciences, Peking University, Beijing, China Department of Gastroenterology and Hepatology Zhongshan Hospital Fudan University Shanghai China; Shanghai Institute of Liver Disease Shanghai China; Department of Gastroenterology Xiamen Branch Zhongshan Hospital Fudan University Xiamen Fujian China Center for Surgery and Public Health, Department of Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts College of Resource and Environment, Southwest University, Chongqing 400716, China. Innovative Monitoring and Prediction of Non-point Sources Pollution and Water Quality in the Three Gorges Reservoir Catchment, Chongqing 400716, China. Department of Organic Chemistry Stockholm University 10691 Stockholm Sweden State Key Laboratory of Food Nutrition and Safety, Tianjin University of Science & Technology, Tianjin, P.R. China; Key Laboratory of Food Nutrition and Safety, Ministry of Education, Tianjin University of Science and Technology, Tianjin, P.R. China; College of Food Science and Engineering, Tianjin University of Science and Technology, Tianjin, P.R. China Department of Urology, The Third Affiliated Hospital of Soochow University, Changzhou, China National Special Superfine Powder Engineering Research Center Nanjing University of Science and Technology 1 Guanghua Road Nanjing 210094 P. R. China National Synchrotron Radiation Laboratory CAS Center for Excellence in Nanoscience University of Science and Technology of China Hefei 230026 China Shanghai Veterinary Research Institute The Chinese Academy of Agricultural Sciences (CAAS) Shanghai China Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China Rehabilitation Medicine Department, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of China.; Rehabilitation Medicine Department, The Southwest Medical University, Luzhou, Sichuan, People’s Republic of China. Department of Orthopaedic Surgery, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Rd, Chongqing 400016, China. Department of Pediatrics, Dahua Hospital of Shanghai Xuhui District, Shanghai, China The Key Laboratory for Human Disease Gene Study of Sichuan Province Prenatal Diagnosis Center Sichuan Provincial People's Hospital the University of Electronic Science and Technology of China Chengdu PR China; School of Medicine University of Electronic Science and Technology of China Chengdu PR China State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Diseases & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology The Fourth Military Medical University 145 West Changle Road Xi'an Shaanxi 710032 China Department of Thoracic Surgery, Central Hospital Affiliated to Shenyang Medical College, Shenyang, Liaoning 110024, P.R. China Beijing National Laboratory for Molecular Science, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Gastroenterology, Zhongshan Hospital,Fudan University,Shanghai,China Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Precision Pharmacy & Drug Development Center; Department of Pharmacy; the Second Affiliated Hospital of Air Force Medical University; Xi'an 710038; China Department of Medical Genetics, School of Basic Medical Sciences, Guangdong Provincial Key Laboratory of Single Cell Technology & Application, and Key Laboratory of Mental Health of the Ministry of Education, Southern Medical University, Guangzhou, Guangdong, China State Key Laboratory of Bio-Fibers and Eco-Textiles; Qingdao University; Qingdao 266000; China Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin 300052, China;; Department of Neurology, Barrow Neurological Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ 85013 National Laboratory of Solid-State Microstructures The University of Chicago Medical Center, Chicago, IL, USA Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China, and Key Laboratory of Pesticide & Chemical Biology, Ministry of Education, Central China Normal University, Wuhan 430079, China Division of Infectious Diseases, Center For AIDS Research, Department of Medicine College of Environmental Science and Engineering, Jilin Normal University, Siping, Jilin 136000, People’s Republic of China School of Information Science and Engineering, Shandong University, Jinan 250100, P.R.China.jwimage@sdu.edu.cn. *Ludwig Institute for Cancer Research Ltd., Lausanne Branch, 1066 Epalinges, Switzerland; Molecular Oncology Laboratory, The University of Chicago Medical Center, Chicago, IL 60637, USA National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, China Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, New Mexico 87131-0001 Department of Materials Science and Engineering Department of Gastroenterology, The First Affiliated Hospital of Jiamusi Medical University, Jiamusi, Heilongjiang, China (mainland) Leadership Computing Facility, Argonne National Laboratory, Argonne, Illinois 60439-8643, United States Brigham and Women’s Hospital, Boston, MA, USA Department of Gynecology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China; Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Shanghai, China Center for Surgery and Public Health Brigham and Women's Hospital Harvard School of Medicine and Harvard School of Public Health Boston MA USA Institute of Environmental Medicine, Zhejiang University School of Medicine, Hangzhou, China Department of Thoracic Surgery, Zhongshan Hospital Fudan University No. 180, Fenglin Road, XuHui District 200032 Shanghai China Center of Infectious Diseases West China Hospital of Sichuan University Chengdu China Hubei Collaborative Innovation Center for Grain Industry, College of Agriculture, Yangtze University , Jingzhou 434025, China Key Laboratory for Colloid and Interface Chemistry of Education Ministry; school of Chemistry and Chemical Engineering; Shandong University; 250100 Jinan; P.R. China Department of Rheumatology Key Lab of Myositis China‐Japan Friendship Hospital Beijing China State Key Laboratory of Military Stomatology & National Clinical Research Center for Oral Disease & Shaanxi Key Laboratory of Oral Diseases, Department of Oral and Maxillofacial Surgery, School of Stomatology, The Fourth Military Medical University, Xi’an 710032, People’s Republic of China University of Science and Technology of China Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, , Hefei 230026, China *Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, Epalinges, Switzerland; Department of Rehabilitation, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Key Laboratory of Eco-functional Polymer Materials of the Ministry of Education, College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs & School of Chemistry and Chemical Engineering; Shanghai Jiao Tong University; Shanghai 200240; P. R. China; School of Chemistry and Environmental Engineering & International Healthcare Innovation Institute Department of Gastroenterology, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Heilongjiang University of Chinese Medicine, Harbin 150040, China Medical Intensive Care Unit, PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Department of Immunization and Prevention, Hangzhou Center for Disease Control and Prevention, Hangzhou, China Laboratory of Molecular Neurosurgery, Department of Stereotactic and Functional Neurosurgery, Neurocentre, Albert-Ludwigs-University of Freiburg, Freiburg, Germany; Department of Neurosurgery, Tongji Hospital of Tongji Medical College, Huazhong University of Science & Technology, Wuhan, China Department of Neurosurgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Radiation Oncology, Guilin Medical University Affiliated Hospital, Guilin, China National Special Superfine Powder Engineering Research Center; School of Chemical Engineering; Nanjing University of Science and Technology; Nanjing 210094; China MARA Key Laboratory of Sustainable Crop Production in the Middle Reaches of the Yangtze River, College of Agriculture, Yangtze University , Jingzhou, 434025 , China; School of Science, Western Sydney University , Penrith, NSW 2751 , Australia School of Chemistry and Chemical Engineering, ‡School of Pharmacy, Shandong University, 250100 Jinan, P. R . China *State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences and School of Chemical Engineering, Nanjing University of Science and Technology, 210094 Nanjing, P. R. China Department of Radiation Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China Department of Orthopedics the First Hospital Affiliated to Anhui Medicine University Hefei China Nursing Department, The Second Affiliated Hospital of Air Force Military Medical University, Xi’an 710038, China Department of Radiology, The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230026 , China Computational Science Division, Argonne National Laboratory, 9700 S. Cass Avenue, Lemont, Illinois 60439, United States Department of Pharmacy Tangdu Hospital Air Force Medical University Xi’an China Programs of Cancer Genetics and Epigenetics and Signal Transduction, The Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037 Peking‐Ausnutria Maternal and Infant Nutrition Research Center Peking University Beijing China Department of Rehabilitation, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, P.R. China Carolinas Medical Center Charlotte North Carolina Institute for Energy Research, Jiangsu University, Zhenjiang 212013, P. R. China Division of Molecular Medicine; Hefei National Laboratory for Physical Sciences at Microscale; CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Sciences; University of Science and Technology of China Department of Neurosurgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan430030, China Molecular Medicine Research Center, State Key Laboratory of Biotherapy West China Hospital of Sichuan University Chengdu Sichuan, 610041 China School of Physical Education, South China Normal University, Guangzhou 510006, China Department of Urology, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, PR China; Key Laboratory of Preparation and Application of Environmental Friendly Materials (Jilin Normal University); Ministry of Education; Changchun 130103; People's Republic of China Obstetrics and Gynecology Hospital, Fudan University, Shanghai, P.R. China Institut für Chemie und Biochemie Freie Universität Berlin Takustrasse 3 14195 Berlin Germany; Department of Chemistry South University of Science and Technology of China (SUSTC) No.1088 Xueyuan Blvd, Nanshan District Shenzhen 518055 China Biotechnology Research Institute Shanghai Academy of Agricultural Sciences Shanghai People's Republic of China; Key Laboratory of Agricultural Genetics and Breeding Shanghai Academy of Agricultural Sciences Shanghai People's Republic of China Multi‐phase Mass Transfer and Reaction Engineering Laboratory College of Chemical Engineering Sichuan University Chengdu China The Salk Institute, La Jolla, California 92037 Department of Nephrology, Huai'an Second People's Hospital and The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, China Department of Anaesthesiology and Critical Care Medicine, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of General Surgery, Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Nanfang Hospital, The First School of Clinical Medicine Southern Medical University Guangzhou People's Republic of China; School of Science Jimei University Xiamen Fujian People's Republic of China Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi 214122, People’s Republic of China; National Engineering Laboratory for Cereal Fermentation Technology, Jiangnan University, Wuxi 214122, People’s Republic of China; Jiangsu Provincial Research Center for Bioactive Product Processing Technology, Jiangnan University, Wuxi 214122, People’s Republic of China; Biotechnology Research Institute, Key Laboratory of Agricultural Genetics and Breeding, Shanghai Academy of Agricultural Sciences, Shanghai 201106, People’s Republic of China School of Chemistry and Chemical Engineering National Special Superfine Powder Engineering Research Center Nanjing University of Science and Technology Nanjing 210094 P. R. China Key Laboratory of Preparation and Application of Environmentally Friendly Materials (Jilin Normal University); Ministry of Education; Changchun 130103; P. R. China; College of Environmental Science and Engineering Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong, China Intelligent Nanomedicine Institute, the First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230001, China Department of Nephrology Affiliated Huai’an Hospital of Xuzhou Medical University Huai’an, Jiangsu China Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Department of Radiology, The Second Affiliated Hospital of Chongqing Medical University, No. 74 Linjiang Rd., Yuzhong District, Chongqing 400010, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China Department of Plant Sciences, University of Cambridge, Cambridge, United Kingdom Department of Neurosurgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China; Department of Neurosurgery, The Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China. Department of Nephrology, Attached Hospital of Medical School, Qingdao University, Shangdong Qingdao 266003,China. jw-qy@163.com Center for Surgery and Public Health Brigham and Women's Hospital Harvard Medical School Boston MA USA Department of Thoracic Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China National Laboratory of Pattern Recognition (NLPR), Institute of Automation, Chinese Academy of Sciences , Beijing, 100190, People's Republic of China sliang@nlpr.ia.ac.cn , lwj@nlpr.ia.ac.cn , wjiang@nlpr.ia.ac.cn , wxue@nlpr.ia.ac.cn Department of Pharmacy, Tangdu Hospital The Fourth Military Medical University Xi'An PR China From the *Department of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin; Departments of †Nuclear Medicine and ‡Infectious Diseases, Tianjin First Central Hospital, Tianjin; and §Department of Radiology, The Sixth Affiliated People’s Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China. Department of Thoracic Cardiovascular Surgery; The People's Hospital of Guangxi Zhuang Autonomous Region; Nanning P. R. China Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin 300072 China Key Laboratory of Swine Genetics and Breeding of the Ministry of Agriculture and Rural Affairs, Huazhong Agricultural University , Wuhan , China; Key Laboratory of Agriculture Animal Genetics, Breeding and Reproduction of the Ministry of Education, Huazhong Agricultural University , Wuhan , China Department of Radiotherapy , Yantai Yuhuangding Hospital, Yantai, 264000 , China; Academy of Medical Engineering and Translational Medicine , Department of Biomedical Engineering, School of Precision Instrument and Opto-electronics Engineering, , Tianjin, 300072 , China; Tianjin University , Department of Biomedical Engineering, School of Precision Instrument and Opto-electronics Engineering, , Tianjin, 300072 , China 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, People's Republic of China. Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States Center for Surgery and Public Health, Division of Vascular and Endovascular Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Environmental Science, Zhejiang University, Hangzhou 310028, China, and Department of Plant, Soil and Insect Sciences, University of Massachusetts, Amherst, Massachusetts, 01003 Department of Biochemistry and Molecular Biology School of Basic Medical Sciences, Peking University Health Science Center Beijing China Department of Recuperation 1, Hangzhou Special Service Sanatorial Center of PLA Air Force, Hangzhou, Zhejiang 310007, China. Department of Nephrology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatric Metabolism and Inflammatory Diseases , Chongqing , P.R. China Department of Horticulture and Landscape Architecture, Purdue University, West Lafayette, IN 47907, USA; National Center for Soybean Improvement, Key Laboratory of Biology and Genetics and Breeding for Soybean, Ministry of Agriculture, State Key Laboratory of Crop Genetics and Germplasm Enhancement, Nanjing Agricultural University, Nanjing 210095, China 1Institute of Medicinal Biotechnology, Peking Union Medical College & Chinese Academy of Medical Sciences, and Department of Neurosurgery, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China; Department of Neurosurgery, The Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China Beijing Jiaotong University Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China School of Chemistry and Chemical Engineering, Southeast University, Nanjing, Jiangsu 211189, China Department of Microbiology and Immunologys; Department of Medicine, Division of Infectious Diseases, Medical University of South Carolina, Charleston, South Carolina, USA Division of Infectious Diseases, Center For AIDS Research, Department of Medicine, Case Western Reserve University and University Hospital of Cleveland, Cleveland, Ohio 44106 Shionogi Inc, Florham Park, NJ. Department of Ophthalmology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong Province, China; State Key Laboratory of Biotherapy, Cancer Center, West China Hospital, Sichuan University, Chengdu 610041; Molecular Medicine Research Center, West China Hospital, Sichuan University, Chengdu 610041, China. *Corresponding author, E-mail: wcumsjw@scu.edu.cn. Shionogi, Inc., Florham Park, New Jersey. Reproductive Medical Centre Renmin Hospital of Wuhan University Wuhan China Molecular Oncology Laboratory, Department of Surgery, University of Chicago Medical Center, Chicago, Illinois 60637 School of Pharmacy, Shenyang Pharmaceutical University, Shenyang, China; Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen, China Multiphase Mass Transfer & Reaction Engineering Lab; College of Chemical Engineering; Sichuan University; Chengdu; China 610065 The Eye Center of Tianjin Medical University, Tianjin 300070, China. Department of Pathology, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Orthopaedics, Xiangya Hospital, Central South University, ChangSha, Hunan, China Institute of Oceanology Chinese Academy of Sciences Qingdao China Laboratory of Structural Immunology, CAS Key Laboratory of Innate Immunity and Chronic Disease School of Life Sciences and Medical Center University of Science and Technology of China Hefei China Zhejiang Provincial Center for Disease Control and Prevention; Hangzhou 310051; China School of Materials Science and Physics, China University of Mining and Technology, Xuzhou 221116, China Heraeus (China) Investment Co., Ltd. Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China; Department of Stomatology, Shanghai Hudong Hospital, Shanghai, China; Department of Endodontics and Operative Dentistry, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, College of Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai, China Medical Research Center, Second Affiliated Hospital of Zhengzhou University, Zhengzhou, China Peking Union Medical College Hospital, Beijing, China Division of Molecular medicine; Hefei National Laboratory for Physical Sciences at Microscale; the CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Sciences and Medical Center; University of Science and Technology of China College of Bioinformatics Science and Technology; Harbin Medical University; Harbin 150081; PR China Program of Cancer Genetics and Epigenetics, Burnham Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, U.S.A. National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University , Shizishan Street, Hongshan District, Wuhan, Hubei 430070, China Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, Department of Chemistry, Pomona College, Claremont, California 91711, and Department of Biochemistry and Molecular Biology and Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 Department of Infectious Disease, Tianjin First Central Hospital, Tianjin 300000, P.R. China College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China; College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China Center of Infectious Diseases, West China Hospital of Sichuan University, Chengdu 610041, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease, West China Hospital, Sichuan University, Chengdu 610041, China School of Information and Communication Engineering, Communication University of China, No.1 Dingfuzhuang East Street, Chaoyang District, Beijing 100024, China; State Key Laboratory of Media Convergence of Communication, Communication University of China, Beijing 100024, China; Key Laboratory of Acoustic Visual Technology and Intelligent Control System, Ministry of Culture and Tourism, Beijing 100024, China Center for Biophysical Modeling and Simulation and Department of Chemistry, University of Utah, 315 South 1400 East Room 2020, Salt Lake City, Utah 84112-0850, and Institute of New Energy Material Chemistry and Department of Material Chemistry, Nankai University, Tianjing 300071, China Department of Bone and Joint, Shenzhen People's Hospital, The First Affiliated Hospital of Nanfan University of Science and Technology, The Second Clinical Medical College of Jinan University Shenzhen 518020, Guangdong, P. R. China. Pharmacy Department; Tangdu Hospital; Fourth Military Medical University; Xi'an, 710038; China Center of Infectious Diseases West China Hospital of Sichuan University Chengdu China; Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Disease West China Hospital, Sichuan University Chengdu China Department of Expanded Program on Immunization, Hangzhou Center for Disease Control and Prevention, Hangzhou, China *Chinese Academy of Sciences Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, 100101 Beijing, People’s Republic of China; Pharmaceutical Informatics Institute, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, P.R. China State Key Laboratory of Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, 500 Yu Tian Road, Shanghai 200083, China; University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China State Key Laboratory of Organic Solids Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 PR China Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, P. R. China College of Bioinformatics Science and Technology; Harbin Medical University; Harbin; China Department of Neurosurgery, Wujin Hospital Affiliated with Jiangsu University; Department of Neurosurgery, The Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China. Department of Pharmacy The Second Affiliated Hospital of Air Force Medical University Xi’an PR China Department of Gastroenterology and Hepatology Zhongshan Hospital, Fudan University Shanghai China; Shanghai Institute of Liver Diseases Shanghai China Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China Inner Mongolia Key Laboratory of Animal Genetics, Breeding and Reproduction, Inner Mongolia Agricultural University, Hohhot 010018, China. School of Chemical Engineering, ‡Computational Institute for Molecules and Materials, and §National Special Superfine Powder Engineering Research Centre, Nanjing University of Science and Technology, Nanjing 210094, China Division of Cardiology The Second Affiliated Hospital of Xi'an Jiao Tong University Xi'an China NHC Key Laboratory for Microbial Drug Bioengineering, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China Department of Pathology, Anatomy, and Cell Biology, Sidney Kimmel Medical College of Thomas Jefferson University, Philadelphia, PA, U.S.A Department of Hepatobiliary Surgery, Xijing Hospital, Fourth Military Medical University, Xi'an 710032, China School of Chemistry and Chemical Engineering Southeast University Si Pai Lou 2 China) Nanjing 211189 1 Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China Department of Biomedical Engineering, College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, China. weijiang@nuaa.edu.cn. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China. weijiang@nuaa.edu.cn. Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, #308 Ningxia Road, Qingdao 266071, P. R. China; College of Textile, Qingdao University, #308, Ningxia Road, Qingdao 266071, P. R. China Department of Biochemistry and Molecular Biology Peking University Health Science Center Peking University Beijing 100191 China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China, Key Laboratories of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China, and State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China Department of Plastic Surgery, Southern Hospital of Southern Medical University, Guangzhou Guangdong, 510515, P.R.China. Center of Infectious Diseases West China Hospital, Sichuan University Chengdu China Department of Radiation Oncology, Yantai Yuhuangding Hospital, School of Medicine, Qingdao University, Yantai, China School of Information Engineering Lingnan Normal University Zhanjiang China Brigham Young University, Department of Chemistry and Biochemistry, C100 BNSN, Provo, Utah 84602, and Chemistry College of Shandong University, Shanda Road #100, Jinan, Shandong, 250100, P. R. China National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, 430070 Wuhan, China Department of Gastroenterology, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu 210006, P.R. China College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 200 Longwood Ave, Boston, Massachusetts 02115, United States Department of Chemistry and ‡Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, United States; Department of Chemistry and ∥Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Molecular Medicine Research Center, State Key Laboratory of Biotherapy, West China Hospital Sichuan University Chengdu China Medical Intensive Care Unit, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, People’s Republic of China Department of Microbiology and Immunology, Division of Infectious Diseases, Department of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA Key Laboratory of Biotechnology of Antibiotics of Ministry of Health, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, 29425, United States Department of Traditional Chinese Medicine, Affiliated Hospital of Guilin Medical University, Guilin 541001, Guangxi Zhuang Autonomous Region, P. R. China Key Laboratory of Liver and Kidney Diseases (Ministry of Education), Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China Department of Electrical and Computer Engineering, University of Minnesota, Minneapolis, Minnesota 55455, United States Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China | Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing, China | National Clinical Research Centre for Digestive Diseases, Beijing, China Laboratory of Chemical Genomics, Shenzhen Graduate School of Peking University, Shenzhen, People's Republic of China; Key Laboratory of Cell Proliferation and Differentiation of the Ministry of Education, College of Life Sciences, Peking University, Beijing, People's Republic of China Department of Materials Science and Engineering Yonsei University 50 Yonsei‐ro, Seodaemun‐gu Seoul 03722 Republic of Korea Departments of Department of Department of Nephrology The Affiliated Hospital of Qingdao University Qingdao China Departments of Chemistry and Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, and Department of Biochemistry and Molecular Biology and Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802 State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P.R. China Sichuan Provincial Key Laboratory for Development and Utilization of Characteristic Horticultural Biological Resources, Chengdu Normal University Chengdu, Sichuan, China. Department of Medicinal Chemistry, University of Michigan, Ann Arbor, Michigan 48109, United States; Rogel Cancer Center, University of Michigan, Ann Arbor, Michigan 48109, United States Department of Ultrasound Huazhong University of Science and Technology Union Shenzhen Hospital Shenzhen China Department of Rehabilitation Medicine The Second Affiliated Hospital of Chongqing Medical University Chongqing China Department of Medicine, University of Cambridge , Cambridge Biomedical Campus , Cambridge, UK Department of Immunology, Key Laboratory of Medical Molecular Virology (MOE, NHC, CAMS), School of Basic Medical Sciences & Shanghai Institute of Infectious Disease and Biosecurity, Fudan University Department of Technology and Industry, Nantong University, Nantong 226001, China. Centre for Organic Photonics & Electronics, School of Chemistry and Molecular Biosciences, The University of Queensland, St Lucia, Brisbane, Queensland 4072, Australia China–Japan Friendship Hospital Beijing China St Vincent’s Pathology (SydPath) St Vincent’s Hospital Sydney Australia; Haematology Department St Vincent’s Hospital Sydney Australia Oncology Department The First Affiliated Hospital of Zhengzhou University Zhengzhou 450052 China Institute of Immunology and the CAS Key Laboratory of Innate Immunity and Chronic Disease CAS Center for Excellence in Molecular Cell Sciences School of Life Sciences and Medical Center University of Science and Technology of China Hefei China School of Science; Shenyang University of Technology; Shenyang; China Department of Etiology and Carcinogenesis, Cancer Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China. Department of Molecular Imaging and Nuclear Medicine Tianjin Medical University Cancer Institute and Hospital Tianjin China; National Clinical Research Center for Cancer Tianjin China; Key Laboratory of Cancer Prevention and Therapy Tianjin China; Tianjin's Clinical Research Center for Cancer Tianjin China Panorama Research, Inc., 2462 Wyandotte Street, Mountain View, California 94043, Analytical Center, Shandong Academy of Sciences, Jinan 250014, China, and Department of Medicinal Chemistry, Institute of Medicinal Biotechnology, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100050, China School of Pharmaceutical Science Key Laboratory of Chemical Biology (Ministry of Education) Shandong University 44 West Wenhua Road Jinan Shandong Province 250012 P. R. China The National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders Beijing Anding Hospital Capital Medical University Beijing China; Advanced Innovation Center for Human Brain Protection Capital Medical University Beijing China From the Departments of Medicine (C.-H.C., T.J., W.J., J.L., H.J.P., C.M.B., P.D.H., C.-Y.Y.) and Ophthalmology (J.-H.Y.), Baylor College of Medicine, Houston, Tex, and the Department of Internal Medicine (G.K.M., T.M.M.), University of Utah, Salt Lake City. Guangdong Provincial Key Laboratory of Advanced Energy Storage Materials, School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China School of Pharmacy, East China University of Science and Technology, Shanghai, China Department of Physics, Xiamen University, Xiamen 361005, People’s Republic of China Department of Anesthesiology, Huishan District People’s Hospital, Wuxi, Jiangsu, China Division of Molecular Medicine; Hefei National Laboratory for Physical Sciences at Microscale; the CAS Key Laboratory of Innate Immunity and Chronic Disease; School of Life Sciences; University of Science and Technology of China Medical Research Institute, Wuhan University, Wuhan, China; Center for Medical Science Research, Zhongnan Hospital of Wuhan University, Wuhan, China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, Guangdong, China Department of Materials Science and Engineering; University of Utah; Salt Lake City; USA Huazhong University of Science and Technology Department of Gastrointestinal Surgery, Tongji Hospital of Tongji Medical College, , Wuhan 4300030, PR China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, China Department of Geosciences, Princeton University, Princeton, New Jersey 08544, Department of Microbiology, University of Guelph, Guelph, Canada, and Earth Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California 94720 Guangdong Provincial Key Laboratory of Precision Medicine for Gastrointestinal Tumor, Department of General Surgery, Nanfang Hospital, The First School of Clinical Medicine, Southern Medical University, Guangzhou, China; School of Science, Jimei University, Xiamen, China Department of Chemistry Southern University of Science and Technology Xueyuan Blvd 1088 Shenzhen 518055 China State Key Laboratories for Agrobiotechnology and College of Biological Sciences, China Agricultural University, Beijing 100193, China; France-China Bio-Mineralization and Nano-Structures Laboratory, Beijing 100193, China Department of Urology, Dongying People's Hospital, Dongying, Shandong 257091, P.R. China Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA. jiang001@mc.duke.edu Shenzhen Key Laboratory of Sludge Treatment & Resource Reuse, Shenzhen Water (Group) Co. Ltd, Shenzhen, PR China; State Key Laboratory of Pollution Control and Resource Reuse, Tongji University, Shanghai, PR China; Department of Civil and Environmental Engineering, University of California, Berkeley, CA, USA Department of Chemistry, and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 Department of Nephrology and Urology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, China; Department of Nephrology and Urology, The Wujin Clinical College of Xuzhou Medical University, Changzhou, China; Department of Nephrology, People’s Hospital of Hainan Tibetan Autonomous Prefecture, Hainan Tibetan Autonomous Prefecture, Qinghai, China. Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs & School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, PR China Key Laboratory for Colloid and Interface Chemistry of Education Ministry, School of Chemistry and Chemical Engineering, Shandong University, 250100 Jinan, People’s Republic of China School of Environmental Science & Engineering, Huazhong University of Science and Technology, Wuhan, People’s Republic of China 1Department of Gynecological Oncology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai, China.; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China. Department of Surgery, Center for Surgery and Public Health, Brigham and Women’s Hospital, Boston, MA, USA College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, People’s Republic of China; College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing, People’s Republic of China Hubei Key Laboratory of Three Gorges Project for Conservation of Fishes, Chinese Sturgeon Research Institute, China Three Gorges Corporation, Yichang 443100, China Key Laboratory of Metabolism and Molecular Medicine The Ministry of Education Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Fudan University Shanghai China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People′s Republic of China |
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