http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_9137fe389d3788dfc8786b5f58f9a09a
Outgoing Links
Predicate | Object |
---|---|
family-name | Yun Zhang Zhang |
name | Yun Zhang |
given-name | Yun |
organization-name | Key Laboratory of Industrial Ecology and Environmental Engineering; Ministry of Education; School of Environmental Science and Technology; Dalian University of Technology; Dalian 116024 Department of General Surgery, The Affiliated Yixing Hospital of Jiangsu University, Yixing, Jiangsu, China Department of Chemistry and Biochemistry, University of Erlangen‐Nuremberg Erlangen Germany Department of Cardiology, The Second Affiliated Hospital of Chongqing Medical University 76 Linjiang Road, Yuzhong District, Chongqing, 400010, China. From the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital (H.J., X.L., Y.Z.), and Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine (S.H., X.L., Z.-Y.C), Shandong University, Jinan, Shandong, China. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital Key Laboratory of Fisheries Information, Shanghai Marine Intelligent Information and Navigation Remote Sensing Engineering Technology Research Center, Ministry of Agriculture, College of Information, Shanghai Ocean University, Shanghai 201306, China Department of Immunology, the Fourth Military Medical University, 17 Changle West Road, Xi’an, Shaanxi 710032, PR China Department of Pulmonology, The Affiliated Hospital of Ningbo University, 247 Renmin Road, Ningbo, Zhejiang 315020, China Jiangsu Key Laboratory of Drug Screening China Pharmaceutical University Nanjing 210009 China; Biology Institute of Shandong Academy of Sciences 19 Keyuan Road, Lixia District Jinan 250014 Shandong Province China Northeast Key Laboratory of Arable Land Conservation and Improvement, Ministry of Agriculture, National Engineering Laboratory for Efficient Utilization of Soil and Fertilizer Resources, College of Land and Environment, Shenyang Agricultural University, Shenyang 110866, China Department of Urology, Division of Oncology and Dow Division of Health Services Research, Ann Arbor, Michigan Department of PsychiatryTownsend Family LaboratoriesThe University of British ColumbiaVancouverBritish ColumbiaCanada Department of Respiratory Diseases Children's Hospital affiliated to Shandong University Jinan China; Jinan Key Lab of Respiratory Diseases for Children Jinan Children's Hospital Jinan China Department of Radiology Children's Hospital of Chongqing Medical University Chongqing China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Ji’nan, Shandong Province, China and Department of Cardiology, Qilu Hospital of Shandong University, Ji’nan, Shandong Province, China Department of Biostatistics and Computational Biology, University of Rochester Medical Center , 601 Elmwood Ave., Box 630, Rochester, New York 14642 , U.S.A. Department of Chemistry Emory University Atlanta GA 30322 USA Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650201, China; Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming 650223, China Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, address, Kaifeng, 475004, China DuPont Pioneer, P.O. Box 1004, Johnston, IA 50131, USA Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China; Department of Plastic Surgery, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China College of Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan Shandong, 250001, P.R.China. School of Pharmacy, Lanzhou University Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Jinan, Shandong, China; and; Department of Cardiology, Qilu Hospital, Shandong University, Jinan, Shandong, China Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Key Laboratory of Basic Pharmacology of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi, 563000, China School of Mechanical Engineering Purdue University West Lafayette IN 47906 USA; Center for High Performance Buildings Purdue University West Lafayette IN 47906 USA Process Sciences, Global Pharmaceutical Operations AbbVie Bioresearch Center Worcester MA 01605 The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health and Department of Psychiatry, Townsend Family Laboratories The University of British Columbia Vancouver Canada State Key Laboratory of Vegetation and Environmental Changes, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China. Department of Geriatric Cardiology, Chinese People's Liberation Army General Hospital, Beijing 100853, China. Department of Urology China‐Japan Union Hospital of Jilin University Changchun China Molecular Science and Biomedicine Laboratory (MBL), State Key Laboratory of Chemo/Biosensing and Chemo-metrics, College of Chemistry and Chemical Engineering, Aptamer Engineering Center of Hunan Province, Hunan University, Changsha 410082, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, Shandong, China. Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, and Department of Chemistry, California State Polytechnic University, Pomona, California, 91768 Laboratory of Veterinary Mycoplasmology College of Veterinary Medicine Southwest University Chongqing China Institute of Developmental Biology, School of Life Science, Shandong University, Jinan 250100, China, Institute of Organic Chemistry, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China, and The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan 250100, China Department of Neonatology, Women's and Children's Hospital of Qinghai Province, Xining 810000, China. rtfnpr@163.com. Department of General Surgery, Yixing People's Hospital, Yixing, Wuxi 214200, China College of Science, China Agricultural University, Beijing 100193, China Key Laboratory of Colloid & Interface Chemistry of the Education Ministry of China, Shandong University, Jinan, 250100, China CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 P. R. China; Department of Translational Medicine, Xiamen Institute of Rare Earth Materials Chinese Academy of Sciences Xiamen 361024 P. R. China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; College of Life Science and Technology, Huazhong Agricultural University, Wuhan 430070, China The Institute of Chemical Physics, Environmental Molecular Science Laboratory (EMSL) 1 , School of Chemistry, Beijing Institute of Technology, Beijing 100081, People's Republic of China ownsend Family Laboratories, Department of Psychiatry, The University of British Columbia, 2255 Wesbrook Mall, Vancouver, BC V6T 1Z3, Canada Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China Department of Epidemiology and Health Statistics, School of Public Health, and Department of Cardiology, the First Affiliated Hospital of Harbin Medical University, Harbin, China Department of Experimental Medical Sciences Lund University Lund Sweden Authors' Affiliations: 1Department of Clinical Cancer Prevention, The University of Texas MD Anderson Cancer Center; 2Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas; and 3Ligand Pharmaceuticals, San Diego, California Department of Genetics, Department of Environmental Science and Engineering, University of Shanghai for Science and Technology, Shanghai, 200093, P. R. China School of Pharmaceutical Sciences Zhengzhou University Zhengzhou 450001 China; Henan Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou 450001 China; Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou University Zhengzhou 450001 China Medicinal Chemistry, Research and Early Development, Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States J. Craig Venter Institute, La Jolla, CA, USA. Guangxi University of Chinese Medicine Nanning 530200,China. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan, China Institute of Industrial Crops, Shandong Academy of Agricultural Sciences, Jinan, China Deutsches Zentrum für Neurodegenerative Erkrankungen e.V./German Center for Neurodegenerative Diseases (DZNE), 53127 Bonn, Germany; Present Address: School of Life Science, Sun Yat-Sen University, 510275, P.R. China Dow Division of Urology University of Michigan Ann Arbor MI The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology Qilu Hospital, Cheeloo College of Medicine, Shandong University Jinan China; Cardiovascular Disease Research Center of Shandong First Medical University Central Hospital Affiliated to Shandong First Medical University Jinan China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China; Department of Cardiology, Shandong University Qilu Hospital, Jinan, Shandong, China Pan Asia Microvent Tech (Jiangsu) Corporation & Zhejiang University Micro-Nano-Porous Materials United Research Development Center, Changzhou 213100, China The National Key Laboratory for Innovation and Transformation of Luobing Theory The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Science Department of Cardiology Qilu Hospital of Shandong University Jinan Shandong China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology; College of Chemistry and Chemical Engineering; Chongqing University; Chongqing, China Department of Thyroid and Breast Surgery, Zhuji People's Hospital, Zhuji City, China. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 28789, People’s Republic of China Department of Horticulture/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University Hangzhou China Department of Pathology and PathophysiologyZhejiang University School of MedicineHangzhouChina; Program in Molecular Cell BiologyZhejiang University School of MedicineHangzhouChina; Institute of Respiratory DiseaseZhejiang University School of MedicineHangzhouChina Department of Traditional Chinese Medicine, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China College of Information Technology, Shanghai Ocean University, Shanghai, China Department of Critical Care Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, PR China College of Tourism and Hotel Management, Hubei University of Economics, Wuhan 430205, China Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology University of Electronic Science and Technology of China Chengdu 610054 China University of Michigan Health System, Ann Arbor, MI (YZ); University of Michigan School of Public Health, Ann Arbor, MI (S-YDL); University of North Carolina at Chapel Hill, Chapel Hill, NC (DBG); LLamasoft, Inc., Ann Arbor, MI (YS); University of Michigan, Ann Arbor, MI (AP, JSM, JEM, JTW, BKH) Department of Ophthalmology, West China Hospital Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry Chinese Academy of Science Beijing 100190 China School of Pharmaceutical Sciences Zhengzhou University 100 Kexue Avenue Zhengzhou 450001 P.R. China Laboratory of Chemical Genomics; School of Chemical Biology and Biotechnology; Peking University Shenzhen Graduate School; Shenzhen 518055, China School of Life Sciences, Zhengzhou University, Zhengzhou 450001, China Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University Hefei China Department of Geriatric Cardiology National Clinical Research Center for Geriatric Diseases Chinese PLA General Hospital Beijing China Eastern Cereal and Oilseed Research Centre, Agriculture and Agri-Food Canada, 960 Carling Avenue, Ottawa, ON K1A 0C6, Canada.; Southern Crop Protection and Food Research Centre, Agriculture and Agri-Food Canada, 1391 Sanford Street, London, ON N5V 4T3, Canada. Department of Gastroenterology, The Affiliated Hospital of Yangzhou University, No. 368 Hanjiang Middle Road, Yangzhou 225001, China; Department of Emergency, The Affiliated Suqian Hospital of Xuzhou Medical University, Suqian 223800, China Beijing National Laboratory for Molecular Science (BNLMS) CAS Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences (CAS) Beijing 100190 P. R. China Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital, School of Medicine, Zhejiang University Department of Biology, The Hong Kong University of Science and Technology, Hong Kong, China Department of chemistry Xixi Campus Zhejiang University Hangzhou P. R. China College of Materials Science and Engineering Sichuan University Chengdu 611731 China Li Ka Shing Institute of Health Sciences and Department of Medicine and Therapeutics The Chinese University of HongKong Hong Kong China; School of Traditional Chinese Medicine Southern Medical University Guangzhou China Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China Department of Quality Management, Hangzhou Zhongmeihuadong China Pharmaceutical Co., Ltd, Hangzhou, P. R. China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health, Department of Cardiology, Qilu Hospital of Shandong University, Ji'nan, People's Republic of China. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China Plant Germplasm and Genomics Center, Germplasm Bank of Wild Species in Southwestern China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China Lanzhou Stomatology Hospital, Lanzhou 730000, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong, People's Republic of China Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing. The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Qilu Hospital of Shandong University Jinan Shandong China Department of Clinical Laboratory The District People's Hospital of Zhangqiu Jinan Shandong Province 250200 China Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90024 Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, School of Pharmacy, Zunyi Medical University, Zunyi 563003, P. R. China; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethno-medicine of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi 563003, P. R. China Department of Internal Medicine 3, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) and Universitätsklinikum Erlangen, Erlangen, Germany. Department of Advanced Energy Materials, College of Materials Science and Engineering, Sichuan University, Chengdu, 610064, P. R. China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, China. Department of Chemistry, Zhejiang University, Hangzhou 310027, China Nanjing University Department of Pharmacy, Changzhi Medical College, Shanxi, 046012, People’s Republic of China Department of Epidemiology, Center for Global Health, School of Public Health Nanjing Medical University Nanjing China; Institute of Epidemiology and Microbiology Eastern Theater Command Centers for Disease Prevention and Control Nanjing China Department of General Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, P.R. China Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong SAR; Department of Dermatology, Foshan Hospital of TCM, Foshan, China Macular Disease Research Laboratory, Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China Zhejiang Chinese Medical University, Hangzhou, China Beijing Key Lab for Immune-Mediated Inflammatory Diseases, Institute of Clinical Medical Science, China-Japan Friendship Hospital, Beijing, China Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10−14, 55128 Mainz, Germany Department of Cardiology Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education Chinese National Health Commission and Chinese Academy of Medical Sciences State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital of Shandong University Jinan Shandong P. R. China Knowledge and Data Engineering Laboratory of Chinese Medicine, School of Information and Software Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Microbiology and Immunology, College of Basic Medical Sciences, Zhengzhou University, Zhengzhou 450001, China. Medical Institute of Nanjing Army, Nanjing, PR China Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China. Electronic address: zhangyun@sdu.edu.cn. Key Laboratory of Cardiovascular Remodeling and Function Research of Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China Department of Developmental BiologyChina Medical University; Liaoning Cancer Hospital and InstituteShenyangChina Department of Chemistry, 55 N. Eagleville Road, University of Connecticut, Storrs, Connecticut 06269, and Department of Cell Biology, University of Connecticut Health Center, Farmington, Connecticut 06032 Radiation Therapy Department, Baoji Central Hospital, Baoji, Shaanxi 721008, P.R. China †Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan 250012, Shandong, China; and Institute of Materials for Energy and Environment Qingdao University Qingdao 266071 P. R. China College of Chemistry and Materials Science; Sichuan Normal University; Chengdu 610068; P.R. China Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi’an 710032, China The Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China Department of Hepatobiliary and Pancreatic Surgery First Affiliated Hospital, Zhejiang University Hangzhou 310009 Zhejiang China; Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou 310009 Zhejiang China; Innovation Center for the Study of Pancreatic Diseases Hangzhou 310009 Zhejiang China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, China Laboratory of Zhuang Medicine Prescriptions Basis and Application Research, Guangxi University of Chinese Medicine, Nanning, Guangxi 530001, P.R. China Department of Medicine, University of California School of Medicine, Los Angeles, CA 90024 Yun Zhang is a health economist at the University of Michigan. Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, the Chinese Academy of Sciences, Kunming, Yunnan 650223, China Department of Urology, China and Japan Union Hospital of Jilin University, Changchun, Jilin 130000, P.R. China Henan Key Laboratory of Immunology and Targeted Drug, School of Laboratory Medicine, Xinxiang, Henan, PR China; Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine, Xinxiang Medical University, Xinxiang, Henan, PR China College of Chemistry and Materials Engineering, Wenzhou University, Chashan University Town, Wenzhou, Zhejiang Province 325035, People’s Republic of China Key Laboratory of Cardiovascular Remodeling & Function Research Chinese Ministry of Education & Chinese Ministry of Public Health Qilu Hospital Shandong University Jinan China Department of Urology, Division of Health Services Research, University of Michigan, Ann Arbor, Michigan Yun Zhang, Department of Gastroenterology and Hepatology, First Hospital of Shanxi Medical University, Taiyuan 030001, Shanxi Province, China. The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, No 107 Wenhuaxi Road, Jinan, Shandong Province, China Key Laboratory of Cardiovascular Remodeling and Function Research (Chinese Ministry of Education and Chinese Ministry of Health) and State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Qilu Hospital Shandong University Jinan Shandong Province China Department of Basic Medicine, College of Medicine, Shaoxing University, Shaoxing 312000. Institute of Organic and Biomolecular Chemistry Georg-August University of Göttingen Tammannstr. 2 37077 Göttingen Germany The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, China Department of Neurology, Mianyang Central Hospital, Mianyang, Sichuan, China Organ Transplant Center, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu 610072, China; Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital, Chengdu 610072, China State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Xujiaping 1, Lanzhou, Gansu 730046, PR China Department of Etiology, Institute of Basic Medical Science, CAMS and PUMC, Beijing 100005, China. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Mechanical, Aerospace, and Nuclear Engineering Department; Rensselaer Polytechnic Institute; Troy; USA Department of Gastrointestinal Oncology, The Fifth Medical Centre, Chinese People's Liberation Army General Hospital, Fengtai, Beijing 100071, P.R. China Department of Radiology, Medical College of Xi'an Jiaotong University, Xi'an, China. imagingzhang@126.com Department of Fetal Medicine and Prenatal Diagnosis Center Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China Department of Orthopedics of Traditional Chinese Medicine Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital Chengdu China Ocular Surface Center, Cullen Eye Institute, Department of Ophthalmology, Baylor College of Medicine, Houston, Texas, United States Department of Orthopaedics, Shanghai Tongji Hospital, Shanghai 200065, P.R. China Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121000, P.R. China Beijing National Laboratory for Molecular Sciences; Key Laboratory of Analytical Chemistry for Living Biosystems; Institute of Chemistry; Chinese Academy of Sciences; Beijing 100190 College of Wetlands/National Plateau Wetlands Research Center, Southwest Forestry University, Kunming 650224, China. Naitional Positioning Research Station for Dianchi Wetland Ecosystem, Kunming 650224, China. College of Food Engineering East University of Heilongjiang Harbin China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, 2 North first Street, Zhongguancun, Beijing 100190, China School of Sociology & Anthropology Sun Yat‐Sen University Guangzhou China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, Guangdong 510301, China; Southern Marine Science and Engineering Guangdong Laboratory, Guangzhou, Guangdong 511458, China Department of Metabolism and EndocrinologyMetabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of EducationNational Clinical Research Center for Metabolic DiseaseSecond Xiangya HospitalCentral South University Changsha China Graduate Student, Post-Doctoral Research Associate, and Associate Professor, respectively. Entomology and Nematology Department, University of Florida, Gainesville, FL 32611. Department of Informatics, Craig Venter Institute, La Jolla, CA 92037; Department of Psychosomatic Medicine Department of Emergency Surgery The First Affiliated Hospital School of Medicine Zhejiang University Hangzhou China State Key Laboratory of Power Transmission Equipment & System Security and New Technology, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China; Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, 2 North First Street, Zhongguancun, Beijing 100190, China Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Department of Orthopedics, Shanghai Tongji Hospital, Shanghai, 200065, P.R.China. Center for S and P Block Chemistry, Department of Chemistry, University of California, Riverside, California 92521 Department of Civil Engineering, University of Nebraska-Lincoln, Peter Kiewit Institute, Omaha, Nebraska 68182-0178, United States State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China Department of Immunology, Air Force Medical University, Xi’an 710032, China College of Chemistry and Bioengineering; Guilin University of Technology; Guilin 541004; P. R. China Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China Department of Industrial Microbiology and Biotechnology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China National Engineering Research Center for Colloidal Materials and School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China Department of Radiation Oncology, Jiangxi Cancer Hospital of Nanchang University, Nanchang, Jiangxi 330029, China Department of Medicine, UCLA, Los Angeles, CA 90024, USA. Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, School of Medicine, Shandong University, Jinan, P.R. China Department of Orthopaedics, People’s Hospital of Zhongjiang County, Zhongjiang, Sichuan, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Taipa, Macau 999078, P.R. China Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Science Beijing 100190 China School of Chemistry, MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter, Xi’an Key Laboratory of Sustainable Energy Material Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. China Artificial Intelligence Aided Drug Discovery Institute, College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China 1Department of Pharmacology and Physiology, Drexel University College of Medicine, Philadelphia, Pennsylvania. Department of Immunology, Basic Medical College Zhengzhou University No.100 of Science Road, Zhengzhou 450001 Henan Province PR China From the Key Laboratory of Cardiovascular Remodeling and Function Research (B.D., C.Z., J.B.F., Y.X.Z., S.Y.L., Y.P.Y., Q.L.D., B.P.D., L.Z., Q.T.Y., C.X.L., B.L., M.X.Z., Y.Z.), Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, P.R. China; the Department of Cardiology (B.D), Shandong Provincial Hospital, Shandong University, Jinan, Shandong, P.R. China; Center of Molecular Medicine (C.M.P., H.D.S.), Shanghai Institute of Endocrinology,... School of Mechanical Engineering Purdue University West Lafayette IN 47907 USA *Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, 250012 China; Department of Pharmacology and Cancer Biology, Duke University Medical Center, 3813, Research Drive, Durham, NC, 27710, USA. Department of Chemistry; University of Oxford; Chemistry Research Laboratory; Oxford; UK Department of Nephrology, The Sixth Hospital of Wuhan (Affiliated Hospital of Jianghan University) , Wuhan 430015 , Hubei , China Department of Chemistry, Emory University, Atlanta, GA 30322; Semiconductor Lighting Technology Research and Development Center; Institute of Semiconductors; Chinese Academy of Sciences; Beijing 100083; China School of Materials Science and Engineering; Georgia Institute of Technology; Atlanta; USA Key Laboratory of Industrial Ecology and Environmental Engineering (China Ministry of Education), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China Department of Obstetrics and Gynecology, Third Affiliated Hospital of Liaoning Medical College, Jinzhou, Liaoning, China Department of Genetics The University of Texas MD Anderson Cancer Center Houston TX USA Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Key Laboratory for Biosensors of Shandong Province, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, Shandong Province, PR China College of Chemistry & Chemical Engineering, Central South University, Changsha, Hunan 410083, China Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Xiamen, China; Department of Translational Medicine, Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Fuzhou, China Department of Radiology, The Socond Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, 510120, PR China. Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming Yunnan 650223, China.zhangy@mail.kiz.ac.cn. 1Breast Center, Departments of Medicine and Molecular and Cellular Biology, Baylor College of Medicine; Department of Endocrine Surgery, Zhuji People’s Hospital of Zhejiang Province, Zhuji, Zhejiang, China (mainland) Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P. R. China School of Pharmaceutical Sciences Zhengzhou University Zhengzhou 450001 China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou University Zhengzhou 450001 P. R. China; Key Laboratory of Key Drug Preparation Technology Ministry of Education Zhengzhou 450001 P. R. China; State Key Laboratory of Esophageal Cancer Prevention & Treatment Zhengzhou 450001 P. R. China Whitehead Institute for Biomedical Research, Cambridge, MA 02142; Shenzhen Aventis Pasteur Biological Products Limited Company, Beijing Branch, Beijing 100022, China Department of Chemistry, Graduate School of Science, Hiroshima University, 1-3-1 Kagamiyama, Higashi-Hiroshima 739-8526, Japan, Department of Chemistry, Faculty of Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 165-8555, Japan, Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 165-8555, Japan, Department of Chemistry, University of California, Riverside, California 92521, Molecular Characterization Team, RIKEN (Institute of... Department of Emergency Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Department of Emergency Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China College of Materials Science and Engineering and ‡Department of Advanced Energy Materials, Sichuan University, Chengdu, 610064, P. R. China Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan 430072, People’s Republic of China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong, China Department of Hepatobiliary and Pancreatic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, 88 Jiefang Road, Hangzhou, 310009 Zhejiang, China Drug Delivery Research Center, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100193, China; Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription, Beijing 100700, China; Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100094, China; Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Beijing 100700, China; Joint Research Center for Chinese Medicinal Herbs, IMPLAD, ABRC & ACCL, Beijing 100193, China Department of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio 43210, Department of Chemistry, Oakland University, Rochester, Michigan 48309, and Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China School of Medicine and Life Sciences, University of Jinan Shandong Academy of Medical Sciences, Jinan, Shandong, China; Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong, China Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, MD 21201; Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201 College of Chemistry & Chemical Engineering, Central South University, Changsha 410083, China Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, 189 South Jiuhua Road, Wuhu, Anhui 241002, P. R. China Department of Neurology Kaifeng Central Hospital Kaifeng China College of Chemistry, Fuzhou University, 2 Xueyuan Road, Fuzhou, Fujian 350116, People’s Republic of China; Fujian Key Laboratory of Medical Instrument and Pharmaceutical Technology, Fuzhou University, 523 Gongye Road, Fuzhou, Fujian 350002, People’s Republic of China College of Food Science and Technology, Nanjing Agricultural University, Nanjing 210095, People’s Republic of China Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China School of Economics and Management, Anhui Polytechnic University, Wuhu, P. R. China Authors' Affiliations: 1Global Discovery Chemistry, 2Disease Area Oncology, Novartis Institutes for BioMedical Research, Basel, Switzerland; 3Disease Area Oncology, 4Developmental and Molecular Pathways, and 5Oncology Translational Research, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts; 6Developmental and Molecular Pathways, 7Oncology Translational Medicine, China Novartis Institutes for BioMedical Research, Shanghai, China; 8Sir Peter MacCallum Department of Oncology, University of Melbourne and Peter MacCallum Cancer Centre, St. Andrew's Place, East Melbourne, Australia Department of Electrical and Computer Engineering; University of Alberta; Edmonton; Canada Tiangong Fangyuan Construcion Group, Xinyu 338000, China. Department of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, China; Innovation Center for the Study of Pancreatic Diseases, Hangzhou, China *Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Qilu Hospital, Jinan, Shandong 250012, China; and State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-Sen University, Guangzhou, People's Republic of China Institute of Military Medicine, Nanjing Command of Chinese People's Liberation Army, Nanjing 210002, China. Department of Epidemiology and Health Statistics School of Public Health Anhui Medical University Hefei Anhui China Plant Germplasm and Genomics Center, Germplasm Bank of Wild Species in Southwest China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China; Procreation and Medicine Centre, Wuxi Maternal and Child Health Hospital, Wuxi 214002, China Department of Immunology, Institute of Laboratory Medicine, Jiangsu University, Zhenjiang 212013, China Diabetes Research Laboratories Oxford, U.K Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China School of Life Science and Technology, Xidian University, Xi’an, P. R. China Department of immunity, Guang' anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Veterinary Medicine Shandong Agricultural University Taian China Department of Medicine, Baylor College of Medicine, Houston, Texas; Department of Pathology and Immunology, Baylor College of Medicine, Houston, Texas Department of Chemistry and Biochemistry, The Ohio State University, 484 W. 12th Ave., Columbus, Ohio 43210, United States Department of Urology Changhai Hospital, Naval Medical University Shanghai China Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Yunnan Provincial Key Lab of Agricultural Biotechnology, Key Lab of Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming, Yunnan 650205, P.R. China State Key Laboratory of Veterinary Etiological Biology, OIE/China National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, People’s Republic of China Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, 45701, Athens, OH, USA The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, 250012, China Thyroid Center Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai Center for Thyroid Diseases Shanghai China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China College of Chemistry and Bioengineering, Guilin University of Technology, Guangxi 541004, China Institute of Pharmaceutics, School of Pharmacy and Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, China 1Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia, United States Program in Public Health, Renaissance School of Medicine, Stony Brook University, Stony Brook, NY, USA CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Center for Translational medical Research, The First Affiliated Hospital of Shandong First Medical University, Jinan 250014, Shandong Province, China. CAS Key Laboratory of Tropical Marine Bio‐Resources and Ecology South China Sea Institute of Oceanology, Chinese Academy of Sciences Guangzhou Guangdong China; Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology, Chinese Academy of Sciences Guangzhou Guangdong China Department of Cardiology, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan, China College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China Department of Chemistry, University of Virginia, Charlottesville, Virginia, Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada, Department of Experimental Radiation Oncology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, CONRAD, Department of Ob/Gyn, Eastern Virginia Medical School, Norfolk, Virginia 23507, and Department of Pharmacology, University of Maryland School of Medicine, Baltimore, Maryland Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health Department of Diagnostic Radiology, Second Hospital, Sun Yat-sen University, Guangzhou 510120, China. Department of Obstetrics Jiangxi Provincial Maternal and Child Health Hospital Nanchang China Department of Pathology, The First Affiliated Hospital of Soochow University College of Medicine, Shaoxing University Biology Institute of Shandong Academy of Sciences, Jinan, People's Republic of China; Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences, Jinan, People's Republic of China Department of General Surgery, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China. Department of Environmental Science and Engineering, Fudan University, Shanghai 200433, China. State Key Laboratory for Animal Disease Control and Prevention, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences , Lanzhou, Gansu, China Guangxi School of Traditional Chinese Medicine, Guangxi University of Traditional Chinese Medicine, Nanning, Guangxi, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology Qilu Hospital of Shandong University, Ji'nan 250012, P.R. China Biology Institute of Shandong Academy of Sciences 19 Keyuan Road, Lixia District Jinan 250014 Shandong Province People's Republic of China Institute of Optics and Electronics; National Key Laboratory of Optical Field Manipulation Science and Technology; University of Chinese Academy of Sciences Department of Geriatrics Tianjin Geriatric Institute Tianjin Medical University General Hospital Tianjin China Department of Chemistry, Oakland University, Rochester, Michigan 48309, and Department of Chemistry, Wayne State University, Detroit, Michigan 48202 Shanghai Chest Hospital, Clinical Research Center, Chest Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200030, China. School of Automation, Guangdong University of Technology, Guangzhou 510006, China National Clinical Research Center for Ocular Disease, Eye Hospital, Wenzhou Medical University, Wenzhou, Zhejiang, China (mainland) Institute of Basic Medical Sciences and Key Laboratory of Cardiovascular Remodeling and Function Research Qilu Hospital of Shandong University Jinan Shandong China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University College of Science, Beijing Key Laboratory of Environmentally Harmful Chemical Analysis, Beijing University of Chemical Technology, Beijing, China 100029 Southwest Medical University, Luzhou, Sichuan, China Department of Respiratory Diseases, Qilu Children’s Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Analytical Development, Operations Science & Technology AbbVie Bioresearch Center Worcester Massachusetts USA Jinan No. 6 People's Hospital; Clinical Laboratory; No. 38, Hui Quan Road Jinan Shandong Province China 250200 Children's Hospital of Chongqing Medical University, Chongqing, China. zhangyu306@126.com Dow Division of Health Services Research, University of Michigan, Ann Arbor, Michigan Contribution from the Groupe de Cristallographie Biologique, Institut de Pharmacologie et de Biologie Structurale du CNRS, 205 route de Narbonne, 31077 Toulouse Cedex, France, and Institute for Drug Design and the Department of Chemistry, Wayne State University, Detroit, Michigan 48202-3489 Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing PR China National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China Institute for Energy Research, Jiangsu University, Zhenjiang 212013, P. R. China Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, China; Zhejiang University of Media and Communications, Hangzhou, Zhejiang 310018, China Department of Horticulture Zhejiang University Hangzhou China Wuhan Institute of Physics and Mathematics 1 State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, , Chinese Academy of Sciences, Wuhan 430071, People's Republic of China; Graduate School of the Chinese Academy of Sciences 2 , Beijing 100049, People's Republic of China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital , Shandong University, Jinan, Shandong 250012, China West China Hospital, Sichuan University; Department of Neurology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041 Clinical Medicine Department, Fujian Health College, Fuzhou, China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital, Zhejiang University School of Medicine Hangzhou China; Zhejiang Provincial Key Laboratory of Pancreatic Disease Hangzhou China; Innovation Center for the Study of Pancreatic Diseases Hangzhou China Department of Immunology, School of Basic Medicine, Fourth Military Medical University , Xi’an 710032 , China Janssen Research & Development, LLC, Fremont, California, USA Graduate School, Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China Oncology R&D, AstraZeneca, Waltham, Massachusetts 02451, United States Whitehead Institute for Biomedical Research, Cambridge, MA 02142; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, School of Medicine, Shandong University, Jinan, China College of Food Engineering, Heilongjiang East University, Harbin, China Key Laboratory of Cardiovascular Remodelling and Function Research Affiliated to Ministry of Education of the P.R. China and Ministry of Health of the P.R. China, Shandong University, Jinan, China, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China State Key Laboratory of Surface Physics and Department of Physics, Fudan University, 220 Handan Road, Shanghai, 200433, China Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing, China Department of Pharmaceutical Sciences, Joan M. Lafleur College of Pharmacy and Health Sciences, Texas Southern University, Houston, TX 77004 School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States; College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Gansu 730000, P.R. China Jiangsu Key Laboratory of Infection and Immunity, Institute of Biology and Medical Sciences, Soochow University, Suzhou, China Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, People's Republic of China State Key Laboratory of Freshwater Ecology and Biotechnology, China Zebrafish Resource Center, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China. Department of Neurology The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Wenhuaxi Road, Jinan 250012, China Department of Emergency Medicine, Beijing Tongren Hospital Affiliated to Capital Medical University, Beijing, 100730, China The State Key Laboratory of Power Transmission Equipment & System Security and New Technology Chongqing Key Laboratory of Chemical Process for Clean Energy and Resource Utilization School of Chemistry and Chemical Engineering Chongqing University Chongqing 400044 China Department of Surgery University of British Columbia Vancouver British Columbia Canada From the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Qilu Hospital, Jinan, Shandong, China (X.-p.W., Y.-g.C., W.-d.Q., W.Z., S.-j.W., J.W., F.S.A., Y.Z., M.-X.Z.); Department of Endocrinology, Qilu Hospital, Shandong University, Jinan, Shandong, China (F.Q.L., L.G.); Department of Neurobiology, Shandong Provincial Key Laboratory of Mental Disorders, School of Medicine, Shandong University... Department of Chemistry, California State Polytechnic University, 3801 West Temple Avenue, Pomona, California 91768, and Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115 Department of General Surgery, Renji Hospital, Shanghai Jiaotong University, Shanghai 200127, China. Department of Nephrology, Wuhan Sixth Hospital, Affiliated Hospital of Jianghan University, Wuhan 430014, Hubei, China Department of Dermatology, Foshan Hospital of Traditional Chinese Medicine, Foshan, China; Department of Medicine and Therapeutics and Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China Department of Basic Nursing, School of Nursing, Guangdong Pharmaceutical University, Guangzhou, China. Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, P.R. China State Key Laboratory for Advanced Metals and Materials, School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, P. R. China School of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, P.R. China. Biology Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan China Department of Endocrinology, PUMC Hospital, CAMS and PUMC, Beijing 100730, China. Biology Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan 250103 China College of Chemistry & Chemical Engineering; Central South University; Changsha; P. R. China Chengdu University of TCM, Chengdu 611130, China. Xinqiao Hospital, Army Medical University, Chongqing 400037, China. Key Laboratory of Design and Assembly of Functional Nanostructures; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou 350002; China State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou 730046, China; Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou 730046, China Department of General Surgery, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China. Department of Radiology, Sichuan University West China Hospital, Chengdu, Sichuan 610041, P.R. China School of Chemical Science and Technology, Yunnan University, Kunming 650091, China Rensselaer Polytechnic Institute, Department of Mechanical, Aerospace, and Nuclear Engineering, Troy, NY 12180, USA Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA, USA Department of Ophthalmology and Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, 610041, China Department of Chemistry, California State Polytechnic University, 3801 West Temple Avenue, Pomona, California 91768 daklumpp@csupomona.edu Department of Clinical Laboratory The District People's Hospital of Zhangqiu Jinan Shandong China Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA *Department of Pathology and Pathophysiology, Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou 310058, China; and; †Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, Zhejiang 310003, China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Pharmaceutics, School of Pharmacy, and Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, P. R. China; Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, No. 1 Xian Nong Tan Street, Beijing 100050, P. R. China Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138 Laboratory of Chemical Genomics School of Chemical Biology and Biotechnology Peking University Shenzhen Graduate School Shenzhen 518055 P. R. China School of Basic Medical Science and Clinical Pharmacy, China Pharmaceutical University, Nanjing 210000, China Authors' Affiliations: 1Lester and Sue Smith Breast Center, Dan L. Duncan Cancer Center, Baylor College of Medicine; 2Department of Clinical Cancer Prevention, University of Texas M. D. Anderson Cancer Center, Houston, Texas; 3Laboratory of Cancer Prevention, National Cancer Institute-Frederick, Frederick, Maryland; and 4Department of Cancer Biology, Abramson Family Cancer Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania Department of Advanced Energy Materials College of Materials Science and Engineering Sichuan University Chengdu 610064 P. R. China Laboratory of Nanomedicine, Medical Science Research Center, School of Medicine Shaoxing University Shaoxing China Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated to Tongji University, Shanghai, China; Institute of Regenerative Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China Institute of Industrial Crops Shandong Academy of Agricultural Sciences Jinan China Department of Plastic and Reconstructive Surgery, Shanghai 9th People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, P.R. China. Department of Chemistry, California State Polytechnic University, 3801 West Temple Avenue, Pomona, California 91768 Department of General Surgery, The Affiliated Yixing Hospital of Jiangsu University, Wuxi, China J. Craig Venter Institute, La Jolla, California, USA Department of Neurology, Mianyang Central Hospital, Mianyang, China Department of Clinical Laboratory The District People's Hospital of Zhangqiu Jinan China From the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China d Management office of China-UK HIV/AIDS Prevention and Care Project , Beijing , China Institute of Hepatopathy, Changzhi Medical College, Changzhi, Shanxi 046011, P.R. China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, China From the The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China. Chinese Medicine College, Jinan University, 601 Huangpu West Avenue, Guangzhou 510632, Guangdong, China Eye Hospital and School of Ophthalmology and Optometry, Wenzhou Medical University, Wenzhou, Zhejiang, China;; National Clinical Research Center for Ocular Diseases, Wenzhou, Zhejiang, China; and Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Jinan University, Guangzhou 511443, China Department of Clinical Biostatistics, Janssen Research and Development LLC, Fremont, California Department of Gastroenterology, Huangyan Hospital of Wenzhou Medical University, Taizhou First People’s Hospital Department of Ultrasound the Affiliated Hospital of Qingdao University Qingdao Shandong China Chongqing Research Institute of Environmental Sciences, Chongqing 401147, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, Shandong, 250012, P.R. China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China Ames LaboratoryUSDOE and Department of Chemistry, Iowa State University, Ames, Iowa 50011 Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of Critical Care Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, P.R. China Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, 250103, China Institute of Basic Medical Sciences, Qilu Hospital, Shandong University, Jinan Shandong People's Republic of China Department of Immunology Fourth Military Medical University Xi'an China Center of Reproduction Medicine, Maternal and Child Health Hospital of Wuxi, Wuxi, Jiangsu 214002, P.R. China Institute of Inorganic and Analytical Chemistry, Johannes Gutenberg University, 55128 Mainz, Germany Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang University Nanchang P. R. China Department of Immunology, The Fourth Military Medical University Xi'an China Guizhou Ruihe Pharmaceutical Co.,Ltd. Guiyang 550000,China. Department of Chemistry, University of Connecticut, Storrs, Connecticut 06269, United States School of Mechanical Engineering, Purdue University, West Lafayette, Indiana 47907, United States Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, the State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital, Cheeloo College of Medicine, Shandong University, 107 Wenhuaxi Road, Jinan, Shandong, 250012, China No. 2 Affiliated Hospital, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, People's Republic of China. Department of Hematology, Zhejiang Provincial Hospital of Traditional Chinese Medical The First Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou Zhejiang China From the Division of Cardiovascular Surgery (C.Z., M.-X.Z., Y.H.S., J.K.B., J.W., S.A.L., J.S.C., X.L.W.), the Texas Heart Institute at St. Luke’s Episcopal Hospital, and the Division of Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Tex; The Key Laboratory of Cardiovascular Remodeling and Function Research (C.Z., Y.Z.), Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University, Qilu Hospital, Jinan, Shandong,... College of Pharmacy, Nanjing University of Chinese Medicine, Nanjing, China Department of Pharmacology and Neurobiology, Nanjing Medical University, Nanjing 210029, China. Department of Medical Bioinformatics, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China Department of Immunology, Fourth Military Medical University, Xi'an 710032,China. College of Chemistry and Materials Science; Sichuan Normal University; Chengdu; P.R. China zy_fld@yahoo.com State Key Laboratory of Material Processing and Die & Mould Technology, School of Materials Science and Engineering Huazhong University of Science & Technology Wuhan 430074 P. R. China Emergency Department of Navy General Hospital Beijing China 1Medicine and Departments of Institute of Musculoskeletal Sciences, University of Oxford, The Botnar Research Centre, Nuffield Orthopaedic Centre, Headington, Oxford, United Kingdom Xi'an People's Hospital (Xi'an Fourth Hospital), Xi'an 710004, Shaanxi Province, China. Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030; Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Department of Cardiology Qilu Hospital of Shandong University Ji'nan China Department of Endocrinology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China State Key Laboratory of Vegetation and Environmental Change Institute of Botany Chinese Academy of Sciences Beijing 100093 China Department of Immunology, The Fourth Military Medical University, Xi’an, China; Agriculture and Agri-Food Canada, London, Ontario, Canada N5V 4T3 Department of Renal Medicine Second Affiliated Hospital of Fujian Medical University Quanzhou Fujian China From the Department of Cardiology, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan (X. Yan, J.J., X. Yin, J.G., X.W., S.Z., P.B., Y.Z., Q.Z.) State Key Laboratory of Microbial Resource at Institute of Microbiology, Beijing 100080 Department of Pathogenic Biology, Guangzhou Medical College, Guangzhou 510182, China. From the Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Jinan, Shandong, China (J.J.L., X.M., C.Z., H.X.L., Y.X.Z., J.M.Y., M.D., K.Z., S.X.L., X.Q.Z., F.G., X.L.L., Y.Z.); the Department of Orthopedics, Second Hospital, Shandong University, Jinan, Shandong, China (H.P.S.); and the Department of Cell Biology and Anatomy, University of South Carolina School of Medicine, Columbia, SC (T.X.C.). Department of Oncology Linyi People's Hospital Affiliated to Shandong University Linyi China Baylor College of Medicine One Baylor Plaza Houston TX USA Department of Epidemiology and Health Statistics School of Public Health Anhui Medical University Hefei China for the STABILITY Investigators Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai’an 271000, China CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Beijing National Research Center for Molecular Sciences, CAS Research/Education Center for Excellence in Molecule Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministries of Education and Public Health, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, China; and CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China; Innovation Academy for Green Manufacture, Chinese Academy of Sciences, Beijing 100190, China Institute of Biology, Qilu University of Technology, Jinan, 250103, China Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital, Shandong University, Jinan, Shandong Province, China State Key Laboratory of Applied Organic Chemistry; Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province; College of Chemistry and Chemical Engineering; College of Resources and Environment; Institute of Biochemical Engineering & Environmental Technology Biology Institute; Qilu University of Technology (Shandong Academy of Sciences); Jinan 250103; China National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research (Wuhan), Hubei Hongshan Laboratory Huazhong Agricultural University Wuhan China; Hubei Key Laboratory of Plant Pathology Huazhong Agricultural University Wuhan China CAS Key Laboratory of Tropical Marine Bio‐Resources and Ecology, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou Guangdong China; Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou Guangdong China School of Life Science and Technology, Xidian University, Xi’an, China From The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital, Shandong University, Jinan, Shandong, People’s Republic of China. Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine from Ministry of Education, Beijing Key Laboratory of Innovative Drug Discovery of Traditional Chinese Medicine (Natural Medicine) and Translational Medicine, Key Laboratory of New Drug Discovery Based on Classic Chinese Medicine Prescription from Chinese Academy of Medical Sciences, Department of Pharmaceutics, Institute of Medicinal Plant Development, Peking Union Medical College & Chinese Academy of...; Joint Research Center for Chinese Medicinal Herbs, IMPLAD, ABRC & ACCL, Beijing, China Department of Medical Oncology, The First Affiliated Hospital of Xiamen University, Xiamen, Fujian, China; Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences and Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Xiamen, Fujian, China From the Division of Nephrology and Hypertension (W.F., P.H., E.A.J.) and the Vascular Biology and Hypertension Program, Division of Cardiovascular Diseases (D.X., Y.Z., Y.-F.C., S.O.), University of Alabama at Birmingham, Birmingham, Ala; Department of Veterans Affairs Medical Center (E.A.J.), Birmingham, Ala. School of Pharmacy, Lanzhou University, Lanzhou, China; School of Basic Medical Sciences, Key Laboratory of Preclinical Study for New Drugs of Gansu Province, Lanzhou University, Lanzhou, China Authors' Affiliations: 1Department of Molecular and Cellular Biology and 2Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, Texas and 3Ligand Pharmaceuticals, San Diego, California Department of Biochemistry and Molecular Biology, School of Basic Medical Science Guizhou Medical University Guiyang PR China Beijing Chaoyang Hospital-Beijing Institute of Respiratory Medicine, Capital Medical University, 100020, China. Laboratory of Chemical Genomics; School of Chemical Biology and Biotechnology; Peking University Shenzhen Graduate School; Shenzhen 518055; China Department of Physiology, Cardiovascular Research Institute, University of California, San Francisco, California, USA Department of Chemistry, Oakland University, Rochester, Michigan 48309, and Department of Biochemistry and Chemistry, The Ohio State University, Columbus, Ohio 43210 Department of Advanced Energy Materials College of Material Science and Engineering Sichuan University Chengdu 610064 P. R. China Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250103, China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Jinan, China; Shandong Provincial Engineering Laboratory for Biological Testing Technology, Jinan, China Key Laboratory of Design and Assembly of Functional Nanostructures; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou 350002; P.R. China Department of Chemistry and Key Laboratory for Chemical Biology of Fujian Province; College of Chemistry and Chemical Engineering; Xiamen University; Xiamen 361005; China The Key Laboratory of Cardiovascular Remodeling and Function Research; Chinese Ministry of Education and Chinese Ministry of Health; Qilu Hospital; Shandong University; Jinan, China Department of Geriatric Cardiology Chinese PLA General Hospital Beijing China Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, People's Republic of China Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, Chemical Biology Research Center, School of Pharmaceutical Sciences, Chongqing University, Chongqing 401331, P. R. China Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan, China Townsend Family Laboratories Department of Psychiatry The University of British Columbia Vancouver BC Canada The first affiliated Hospital, College of Medical Sciences, Zhejiang University, Hangzhou 310003, China. Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Polymer Physics and Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China College of Food Science and Technology, Huazhong Agricultural University, Wuhan 430070, and College of Food Science, Biotechnology & Environmental Engineering, Zhejiang Gongshang University, Hangzhou 310035, People's Republic of China 1Department of Clinical Cancer Prevention, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. Department of Immunology, The Fourth Military Medical University, Xi'an, Shaanxi Province, P.R. China. Department of Medicine, University of California, Los Angeles School of Medicine, Los Angeles, CA 90024. Authors' Affiliations: 1Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center of Cancer Medicine; 2State Key Laboratory of Targeted Drug for Tumors of Guangdong Province, Guangzhou Double Bioproduct Inc., Guangzhou; and 3Institute of Cancer Stem Cell, Dalian Medical University Cancer Center, Dalian, China Department of Respiratory, The First Affiliated Hospital of Ningbo University, Ningbo, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology Qilu Hospital of Shandong University Jinan China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China. Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, Massachusetts 02138 Department of Radiology, Sichuan University West China Hospital, Chengdu, China Key Laboratory of Cardiovascular Remodeling and Function Research, Ministry of Education and Ministry of Public Health of People's Republic of China, Qilu Hospital, Shandong University, Ji'nan, China; Department of Cardiology, Qilu Hospital, Shandong University, Ji'nan, China Department of Biomedical Engineering, Key Laboratory of Biomedical Engineering of Ministry of Education, Zhejiang University Department of Urology China‐Japan Union Hospital of Jilin University Changchun P.R. China Department of Neurobiology, Neurobiology Key Laboratory, Education Department of Heilongjiang Province, Harbin Medical University , Harbin , China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, China; Department of Supramolecular & Biomaterials Chemistry, Leiden Institute of Chemistry, Leiden University, Einsteinweg 55, 2333 CC Leiden, The Netherlands Department of Tuberculosis, Beijing Chest Hospital Affiliated to Capital Medical University, Beijing Tuberculosis & Thoracic Tumor Research Institute, Beijing, China School of Computer Science and Engineering, University of Electronic Science and Technology of China, Chengdu, China School of Life Science, Sichuan Normal University, Sichuan 610101, China Department of Neurology, Jinling Hospital, Southern Medical University, Nanjing, China; Department of Neurology, Mianyang Central Hospital, Mianyang, China State Key Laboratory of Veterinary Etiological Biology, National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, China Department of Nephrology, The Sixth Hospital of Wuhan, Wuhan, China The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Shandong University Qilu Hospital Jinan 250012 China The Fourth Hospital of Xi’an, Xi’an Jiaotong University, No. 21, Jiefang Road, Xi’an 710004, P. R. China Department of Food Science, University of Tennessee, Knoxville, Tennessee 37996, United States State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University, Guangzhou, People's Republic of China J. Craig Venter Institute , La Jolla, California, USA Department of Urology, China and Japan union hospital of Jilin University, 126 Xiantai Street, Changchun City, Jilin province, China. 986062616@qq.com. CAS Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen 361024, China ArmaGen Technologies, Inc., Santa Monica, California 90401, and Department of Medicine, University of California Los Angeles, Los Angeles, California 90024 Department of Immunology, The Fourth Military Medical University, Xi'an, China Department of Foreign Languages, Army Medical University , Chongqing , People’s Republic of China State Key Laboratory of Microbial Resources Department of Immunology, School of Basic Medicine, Air Force Medical University, Xi'an 710032, China. *Corresponding authors, E-mail: immuzy@fmmu.edu.cn. State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, China; Department of cardiology, Qilu Hospital, Shandong University, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China. Ames LaboratoryUSDOE and the Department of Chemistry, and Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa 50011 Institute of Military Medicine, Nanjing Command of PLA, Nanjing 210002, China. Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province Kunming Institute of Zoology The Chinese Academy of Sciences Kunming China; Center for Excellence in Animal Evolution and Genetics Chinese Academy of Sciences Kunming China Department of General Internal Medicine, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing Department of Endocrinology of Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University, Zhengzhou, Henan, China ArmaGen Technologies, Inc., Santa Monica, California 90401, and Department of Medicine, UCLA, Los Angeles, California 90024 Department of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University National Engineering Research Center for Colloidal Materials, School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences Jinan China; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology Qilu Hospital of Shandong University Jinan China School of Life Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China Department of Basic Pharmaceutical Sciences, School of Pharmacy, West Virginia University, P.O. Box 9530, Morgantown, West Virginia 26506, and Pathology and Physiology Research Branch, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Morgantown, West Virginia 26505 Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province; Key Laboratory for Biosensor of Shandong Province; Biology Institute; Qilu University of Technology (Shandong Academy of Sciences); Jinan State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 P. R. China; School of Chemistry and Chemical Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China West China School of Stomatology, Sichuan University; Department of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University. Chengdu 610041, China. E-mail: 1145875662@qq.com. Department of Immunology, School of Basic Medicine, Air Force Medical University, Xi'an 710032, China. E-mail: immuzy@fmmu.edu.cn. 1Department of Gastrointestinal Oncology, The Fifth Medical Center, Chinese PLA General Hospital, Beijing, China. Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, PR China School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, Georgia 30332, United States Department of Immunology the Fourth Military Medical University Xi'an Shaanxi China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital of Shandong University, 107 Wenhuaxi Road, Jinan 250012, China zhangyun@sdu.edu.cn. Department of Immunology, Fourth Military Medical University, Xi'an, P.R. China. Division of Health Services Research, Department of Urology, University of Michigan, Ann Arbor, Michigan State Key Laboratory of Cellular Stress Biology School of Life Sciences Xiamen University Xiamen Fujian China William R. Wiley Environmental Molecular Sciences Laboratory; Pacific Northwest National Laboratory; Richland; USA; Institute of Optics and Electronics School of Perfume & Aroma and Cosmetics, Shanghai Institute of Technology, Shanghai 201418, China Department of Clinical Laboratory The District People’s Hospital of Zhangqiu Jinan China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, 250012 Jinan, China; Department of Renal Medicine, The Second Affiliated Hospital of Fujian Medical University, Quanzhou, Fujian 362000, P.R. China *Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Public Health, Department of Biostatistics and Computational Biology, University of Rochester, Rochester, NY, USA South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China. zhangyun@scbg.ac.cn Ames Laboratory, United States Department of Energy, and Department of Chemistry, and the Department of Veterinary Microbiology and Preventive Medicine, Iowa State University, Ames, Iowa 50011 Engineering Research Center of Alternative Energy Materials & Devices Ministry of Education College of Materials Science and Engineering Sichuan University Chengdu Sichuan 610065 China Department of Urology China‐Japan Union Hospital of Jilin University Changchun P. R. China Macular Disease Research Laboratory Department of Ophthalmology West China Hospital of Sichuan University Chengdu China School of Pharmaceutical Sciences Zhengzhou University Zhengzhou 450001 China; Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases Zhengzhou Henan Province 450001 China; Collaborative Innovation Center of New Drug Research and Safety Evaluation Zhengzhou University Zhengzhou 450001 China; State Key Laboratory of Esophageal Cancer Prevention & Treatment Science and Technology Department of Henan Province Zhengzhou 450001 China BeiGene (Beijing) Co., Ltd, Beijing, 102206, China School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450002, China, Beijing National Laboratory for Molecular Sciences; Key Laboratory of Analytical Chemistry for Living Biosystems; Institute of Chemistry, Chinese Academy of Sciences; Beijing 100190; China Xiamen Institute of Rare-earth Materials; Chinese Academy of Sciences; Xiamen 361005, China Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province, Key Laboratory for Biosensor of Shandong Province, Biology Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250103, China Department of Cardiology Institute of Molecular Medicine Renmin Hospital of Wuhan University College of Chemistry and Molecular Sciences School of Computer Science Wuhan University Wuhan 430072 China College of Chemistry and Molecular Sciences Key Laboratory of Biomedical Polymers of Ministry of Education Institute of Molecular Medicine Renmin Hospital of Wuhan University School of Microelectronics Wuhan University Wuhan 430072 P. R. China Jiangsu Key Laboratory of Anaerobic Biotechnology, School of Environment and Civil Engineering, Jiangnan University, Wuxi, Jiangsu Province 214122, P. R. China Department of General Internal Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China EICU of Department of Emergency Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology The Chinese Academy of Sciences Kunming Yunnan 650223 China West China School of Basic Medical Sciences and Forensic Medicine 3Department of Pharmaceutical Sciences, Texas Southern University, Houston, Texas. Guangxi Beitou Highway Construction and Investment Group Co., Ltd., Nanning 530029, China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China Department of Respiratory and Critical Care Medicine The Affiliated Hospital of Medical School of Ningbo University Ningbo City Zhejiang Province China Key Laboratory of Beijing on Regional Air Pollution Control, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing, People’s Republic of China College of Pharmacy School of Medicine Hangzhou Normal University Hangzhou Zhejiang 311121 China Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, Key Laboratory of Molecular and Nano Probes, Ministry of Education, College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, China, 250014, and Chemical and Materials Sciences Division, Pacific Northwest National Laboratory, P.O. Box 999, MSIN K8-88, Richland, Washington 99352 CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China Department of Orthopedics, Shanghai Tongji Hospital Tongji University School of Medicine 389 Xincun Road Shanghai 200065 P. R. China Environmental Monitoring Station of Changxing County, Zhejiang Province, Huzhou 313100, China. Department of Retina Center, Affiliated Eye Hospital of Wenzhou Medical University, Hangzhou, Zhejiang Province, China Authors' Affiliations: Departments of 1Clinical Cancer Prevention and 2Systems Biology, The University of Texas MD Anderson Cancer Center; and 3Lester and Sue Smith Breast Center, Department of Medicine, Baylor College of Medicine, Houston, Texas State Key Lab of Veterinary Biotechnology, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin, China Ganzhou Municipal Key Laboratory of Bone and Joint Research The Affiliated Ganzhou Hospital of Nanchang University Ganzhou 341000 China Department of Clinical Laboratory The District People's Hospital of Zhangqiu Jinan Shandong Province China Department of Emergency, Beijing Tong‑Ren Hospital Affiliated to Capital Medical University, Beijing 100043, P.R. China Department of Endocrinology, Henan Provincial Key Medicine Laboratory of Intestinal Microecology and Diabetes, Henan Provincial People’s Hospital, People’s Hospital of Zhengzhou University 1 , Zhengzhou, Henan 450003 , China Department of Hepatobiliary and Pancreatic Surgery, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China Institute of Epidemiology and Microbiology, Huadong Research Institute for Medicine and Biotechnics, Nanjing, China Eye Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, Shanghai 200240, PR China Novartis Institutes for Biomedical Research Inc., Global Discovery Chemistry, 100 Technology Square, Cambridge, Massachusetts 02139, United States, and Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Immunology, The Fourth Military Medical University, Xi'an, Shaanxi, P.R. China Department of Radiology, Children’s Hospital of Chongqing Medical University, Chongqing 400014, China West China Hospital, Sichuan University; Department of Neurology; Wai Nan Guo Xue Xiang #37 Chengdu Sichuan China 610041 Department of Endocrinology, Henan Provincial People’s Hospital, Zhengzhou, Henan, China Department of Chemistry and the Tsinghua Center for Frontier Polymer Research, Tsinghua University, Beijing, 100084, P. R. China Inflammation & Allergic Diseases Research Unit, The Affiliated Hospital of Southwest Medical University, Luzhou, China; Department of Respiratory and Critical Care Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou, China From Institute of Developmental Biology (L.Z., J.Z., L.S., B.H., L.W., H.S., S.Z., J.M.), School of Life Science, Shandong University, Jinan, China; The Key Laboratory of Cardiovascular Remodeling and Function Research (L.Z., J.Z., L.S., B.H., L.W., H.S., Y.Z., S.Z., J.M.), Chinese Ministry of Education and Chinese Ministry of Health, Shandong University, Qilu Hospital, Jinan, China. College of Chemistry and Materials Science Sichuan Normal University Chengdu 610068 China; Beijing National Laboratory for Molecular Sciences (BNLMS) CAS Key Laboratory of Molecular Nanostructure and Nanotechnology Institute of Chemistry Chinese Academy of Sciences (CAS) Beijing 100190 China Shanxi YunQuan Geotechnical Engineering Technology Co. Ltd, Yangquan 045000, China Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.; Zhejiang Provincial Key Laboratory of Pancreatic Disease, Hangzhou, Zhejiang, China.; Innovation Center for the Study of Pancreatic Disease, Hangzhou, Zhejiang, China. Key Laboratory of Cardiovascular Remodeling and Function Research, Qilu Hospital,Shandong University; State Key Laboratory of Biocontrol School of Life Science Sun Yat‐sen University Guangzhou China Fruit Crops Center of Guizhou Engineering Research, College of Agricultural, Guizhou University, Guiyang 550025, China State Key Laboratory of Power Transmission Equipment & System Security and New Technology; College of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400044, China; Beijing National Laboratory for Molecular Sciences William R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory Richland Washington Dow Division of Urologic Health Services Research University of Michigan Health System Ann Arbor Michigan Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology Beijing National Laboratory for Molecular Sciences, Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, University of Chinese Academy of Sciences, Beijing 100190, China; State Key Laboratory of Power Transmission Equipment and System Security and New Technology, College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, China Department of Endocrinology, Zhejiang Hospital, Hangzhou School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 China Institute of Pharmaceutics, School of Pharmacy, Lanzhou University, Lanzhou 730000, China Department of Radiation Oncology, Jiangxi Cancer Hospital , 519 East Beijing Road, Qingshanhu District, Nanchang 330029, China Department of Epidemiology, Medical Institute of Nanjing Army, Nanjing 210002, China Guanganmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China. bingqian0711@sina.com Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo , Tokyo , Japan Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology QiLu Hospital Shandong University , Jinan 250012, China College of Life and Environmental Sciences, Minzu University of China, Beijing 100081, China School of Information Science and Technology, Xi’an Jiaotong University, Xi’an 710049, China College of Chemistry and Molecular Sciences, Key Laboratory of Biomedical Polymers of Ministry of Education, Institute of Molecular Medicine, Renmin Hospital of Wuhan University, School of Microelectronics, Wuhan University, Wuhan 430072, P. R. China Department of Immunology, Fourth Military Medical University, Xi'an 710032, China. Guangdong Provincial Key Laboratory of Proteomics, State Key Laboratory of Organ Failured Research, Department of Pathophysiology, School of Basic Medical Science, Southern Medical University, Guangzhou, China. State Key Laboratory of Microbial Resource, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Department of Biomedical Engineering, Key Laboratory for Biomedical Engineering of Ministry of Education of China, Zhejiang University Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Jinan 250012, China; Department of Cardiology, QiLu Hospital, Shandong University, Jinan 250012, China Center for Neurological and Psychiatric Research and Drug Discovery Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai China; School of Chinese Materia Medica Nanjing University of Chinese Medicine Nanjing China Department of Organismic and Evolutionary Biology Center for Brain Science, Harvard University Cambridge MA 02138 U.S.A. Department of Organismic and Evolutionary Biology and Center for Brain Science, Harvard University, Cambridge, MA 02138; and Institute for Advanced Study, Shenzhen University , Shenzhen 518060 , China Department of Chemistry; Zhejiang University; Hangzhou Zhejiang China Department of Advanced Energy Materials College of Materials Science and Engineering Sichuan University Chengdu Sichuan 610064 P. R. China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University, Ji’nan, P.R. China Department of Neurosurgery and neuro‐oncology, Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital Key Laboratory of Animal Models and Human Disease Mechanisms Kunming China; Key Laboratory of Bioactive Peptides of Yunnan ProvinceKunming Institute of Zoology Kunming China; Center for Excellence in Animal Evolution and GeneticsChinese Academy of Sciences Kunming China School of Electronics and Information Engineering, Xi'an Jiaotong University, Xi'an 710049, P.R.China. School of Life Sciences Zhengzhou University Zhengzhou 450001 China Department of Human Anatomy and Neurobiology, School of Basic Medical Sciences, Central South University, Changsha 410013, China CAS Key Laboratory of Design and Assembly of Functional Nanostructures, and Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou 350002, China; Xiamen Institute of Rare Earth Materials, Haixi Institute, Chinese Academy of Sciences, Xiamen 361021, China School of Chemistry and Chemical Engineering University of Jinan Jinan 250024 P. R. China Department of Emergency Medicine, Suqian Hospital of Nanjing Drum Tower Hospital Group , Suqian , China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, P.R. China Department of Radiology Xi'an Jiaotong University Medical College First Affiliated Hospital Xi'an Shaanxi Province China From the Key Laboratory of Cardiovascular Remodeling and Function Research (P.L., C.Z., J.B.F., Y.X.Z., X.P.W., J.M.Y., M.X.Z., Y.Z.), Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong, China; the Second Hospital of Shandong University (P.L.), Jinan, Shandong, China; and the Texas Heart Institute at St Luke’s Episcopal Hospital (X.L.W.), Division of Cardiothoracic Surgery, Michael DeBakey Department of Surgery, Baylor College of Medicine... Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, China; Inflammation & Allergic Diseases Research Unit, Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, China; First Department of Respiratory Disease, Affiliated Hospital of Southwest Medical University, Luzhou, 646000 Sichuan, China Department of Oncology, Linyi Peopales' Hospital, Linyi, China - linsong_lyrm@126.com. Department of Experimental Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX 77030, USA. yzhang@ciit.org School of Information Shanghai Ocean University Shanghai China; Key Laboratory of Fishery Information Ministry of Agriculture Shanghai China Department of Neurology, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China. From The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Shandong University Qilu Hospital, Jinan, Shandong, People’s Republic of China (K.Z., X.L., L.W., C.G., X.L., J.S., Y.Z., M.Z.); The Key Laboratory of Atherosclerosis in Universities of Shandong, Institute of Atherosclerosis, Taishan Medical University, Taian, Shandong, People’s Republic of China (Y.Y., T.L., S.Q.); and Department of Cell Biology, State... Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou, China; School of Pharmacy, Lanzhou University, Lanzhou, China The Institute of Chemical Physics, Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing 100081, People’s Republic of China Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health Department of Cardiology Shandong University Qilu Hospital Jinan Shandong China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University College of Management, Sichuan Agricultural University, Chengdu, P. R. China The Fifth Ward of Neurology Department, Kaifeng Central Hospital, Kaifeng 475000, Henan Province, China Department of Immunology, Fourth Military Medical University National Clinical Research Center for Geriatric Disorders Xuanwu Hospital, Capital Medical University Beijing China Department of General Internal Medicine Department of Chemistry, Washington University in St. Louis, St. Louis, Missouri 63130, and Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701 State Key Laboratory of Polymer Physics and Chemistry Beijing National Laboratory for Molecular Sciences CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 P. R. China Department of Cardiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. College of Chemistry and Materials Science Sichuan Normal University Chengdu 610068 China Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Science, 2 North 1st Street, Zhongguancun, Beijing 100190, China 1Department of Gastrointestinal Oncology, Affiliated Hospital Cancer Center, Academy of Military Medical Sciences, Beijing, China. Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford, UK; These authors contributed equally to this work Key Laboratory of Animal Models and Human Disease Mechanisms, The Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan 650223, China; and *Department of Pathology and Pathophysiology, Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou, China 310058; and Department of Emergency Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China Department of Immunology, The Fourth Military Medical University, Xi'an, China. Shanghai Hengrui Pharmaceutical Co., Ltd., 279 Wenjing Road, Shanghai 200245, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital; Chongqing Key Laboratory of Natural Product Synthesis and Drug Research; School of Pharmaceutical Sciences; Chongqing University; Chongqing; P. R. China Department of Geriatrics, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China (mainland) State Key Laboratory of Veterinary Etiological Biology and National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, People’s Republic of China Beijing Key Laboratory of Cardiopulmonary Cerebral Resuscitation, Beijing Tong‐Ren Hospital Capital Medical University Beijing China Department of Neurology, General Hospital of Chinese People's Armed Police Forces, Beijing, China Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials Science Northwest University Xi'an People's Republic of China; Chemical Research Institute, School of Chemical Engineering Northwest University Xi'an People's Republic of China Department of Emergency, Wuxi People’s Hospital Affiliated to Nanjing Medical University, Wuxi, 214023, China The Institute of Chemical Physics, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China CAS Key Laboratory of Microbial Physiological and Metabolic Engineering, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China School of Electronics and Information, Northwestern Polytechnical University, Xi’an, Shaanxi 710072, People’s Republic of China Authors' Affiliations: 1Department of Genetics, School of School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China Institute of Chemical Physics; Beijing Institute of Technology; Beijing 100081; People's Republic of China Changzhou Key Laboratory of Functional Film Materials, Pan Asian Microvent Tech (Jiangsu) Corporation, Changzhou213164, China Dendrite Differentiation Group, Department of Molecular Neurobiology, MPI of Neurobiology, 82152 Munich-Martinsried, Germany. Department of Pharmacy, The Affiliated Lianyungang Hospital of Xuzhou Medical University/The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, China Agriculture and Agri-Food Canada, London, Ontario, Canada Plant Germplasm and Genomics Center Germplasm Bank of Wild Species in Southwestern China Kunming Institute of Botany Chinese Academy of Sciences Kunming China Department of Chemistry and Center for Chemical Methodology and Library Development, Metcalf Center for Science and Engineering, Boston University, 590 Commonwealth Avenue, Boston, Massachusetts 02215 Department of Critical Care Medicine, Zibo Central Hospital, Zibo, China. Key Laboratory of Cardiovascular Remodeling and Function Research affiliated to Chinese Ministry of Education and Chinese Ministry of Public Health; Department of Cardiology, Qilu Hospital of Shandong University Institute of Chemical Physics, Key Laboratory of Cluster Science, School of Chemistry, Beijing Institute of Technology, Beijing 100081, China Hospital of Stomatology Lanzhou University, Lanzhou 730031, China Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science & Peking Union Medical College, Beijing, P.R. China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Shandong University Qilu Hospital, Jinan, Shandong, China National Engineering Research Center for Colloidal Materials and School of Chemistry and Chemical Engineering Shandong University Ji'Nan 250100 P. R. China School of Pharmacy, Lanzhou University, 222 South Tianshui Road, Lanzhou 730000, P. R. China Department of Rehabilitation Medicine, Fifth Hospital of Xiamen, Xiamen 361101, China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China (J.J., Y.Z., Z.Z., Z.T., X.W., C.Z., Q.Z.). From the Key Laboratory of Cardiovascular Remodeling and Function Research (D.G., J.L., X.W., Y.Z., Q.Z., F.J.), Department of Cardiology (J.L., P.B.), Qilu Hospital, Shandong University, Jinan, Shandong Province, China; Department of Neurology, Liaocheng People’s Hospital, Medical School of Liaocheng, Taishan Medical University, Liaocheng, Shandong Province, China (D.G., W.W., F.H., Y.L., F.L.); and Division of Neurology, Shandong Provincial Hospital, Jinan, Shandong Province, China (X.S.). State Key Laboratory of Molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R. China State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, P.R. China General Surgery Department, Affiliated Yixing Hospital of Jiangsu University, Jiangsu Province, China. College of Land and Environment, Shenyang Agriculture University, China Program in Public Health, Stony Brook University, New York CAS Key Laboratory of Molecular Nanostructure and Nanotechnology and CAS Research/Education Center for Excellence in Molecular Sciences Institute of Chemistry Chinese Academy of Sciences 2 North first Street Zhongguancun Beijing 100190 China; College of Chemistry and Materials Science Sichuan Normal University Chengdu 610068 China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences; Lanzhou University; Lanzhou 730000 China; School of Pharmacy; Lanzhou University; Lanzhou 730000 China Organ Transplant Center, Hospital of University of Electronic Science and Technology of China and Sichuan Provincial People's Hospital, Chengdu 610072, Sichuan, P.R.China Institute of Physics and Optoelectronics Technology Baoji University of Arts and Sciences Baoji 721016 Shaanxi P. R. China Guang'anmen Hospital, China Academy of Chinese Medical Science Beijing 100053, China. Departments of Experimental Radiation Oncology Key Laboratory of Cardiovascular Remodeling and Function Research Affiliated to Ministry of Education of the P. R. China and Ministry of Health of the P. R. China, Shandong University; Department of Cardiology, Qilu Hospital of Shandong University Department of Hepatobiliary and Pancreatic Surgery; Zhejiang Provincial Key Laboratory of Pancreatic Disease, The First Affiliated Hospital, Zhejiang University School of Medicine; The Innovation Center for the Study of Pancreatic Diseases of Zhejiang Province, Hangzhou Immunology Department, the Fourth Military Medical University, Xi'an City 710032, Shannxi Province, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University, Jinan, Shandong 250012, China Department of Cardiology, The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China; Cardiovascular Disease Research Center of Shandong First Medical University, Central Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250013, China Biology Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan 28789 P. R. China Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois 60115, and Department of Chemistry, California State Polytechnic University, 3801 West Temple Avenue, Pomona, California 91768 Department of Emergency Ward, Hai'an People's Hospital Affiliated to Nantong University, Nantong 226699, China. luohui607438884@163.com. Center for Intelligent Chemical Instrumentation, Department of Chemistry and Biochemistry, Ohio University, Athens, Ohio 45701, United States Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Departments of Experimental Radiation Oncology, and Molecular Genetics, University of Texas M. D. Anderson Cancer Center, Houston, TX 77030-4095; and Department of Physiology, Southern Illinois University, School of Medicine, Carbondale, IL 62901 Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, P.R. China School of Pharmaceutical Sciences; Zhengzhou University; Zhengzhou; P. R. China Department of Geriatrics Tianjin Geriatric Institute Tianjin China Department of Fetal Medicine & Prenatal Diagnosis Center Shanghai Key Laboratory of Maternal Fetal Medicine Shanghai First Maternity and Infant Hospital Tongji University School of Medicine Shanghai China Department of Radiology, Shijiazhuang No. 4 Hospital, Shijiazhuang, Hebei 050000, China Division of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN, USA; Department of Biostatistics & Computational Biology, University of Rochester, Rochester, NY, USA Jiangsu Center of Drug Screening China Pharmaceutical University 24 Tong Jia Xiang Nanjing 210009 China Institute of Reproductive Immunology, Jinan University, Guangzhou, Guangdong 510632, China. Department of Emergency, Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, Jiangsu, China. Corresponding author: Shi Jing, Email: wxshijing@163.com. From the Department of Medicine, University of California at Los Angeles School of Medicine. State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China Institute for Energy Research Jiangsu University Zhenjiang 212013 P. R. China Department of Medicine, UCLA School of Medicine, Los Angeles, California Department of Civil Engineering, Peter Kiewit Institute, University of Nebraska-Lincoln, Omaha, Nebraska 68182-0178, United States The Institute of Chemical Physics, Key Laboratory of Cluster Science, School of Science, Beijing Institute of Technology, Beijing 100081, China Biology Institute Qilu University of Technology (Shandong Academy of Sciences) Jinan China; Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening of Shandong Province Jinan China; Shandong Provincial Engineering Laboratory for Biological Testing Technology Jinan China Department of Endocrinology, Henan Province People’s Hospital and Zhengzhou University People’s Hospital, 7 Weiwu Road, Zhengzhou, Henan 470003, China Howard Hughes Medical Institute, The Rockefeller University, 1230 York Avenue, New York, NY 10021; and College of Science; Beijing University of Chemical Technology; Beijing 100029 China Department of Chemistry and Biochemistry, Northern Illinois University, DeKalb, Illinois, 60115, and Department of Chemistry, California State Polytechnic University, 3801 West Temple Avenue, Pomona, California 91768 dklumpp@niu.edu Institute of Organic and Biomolecular Chemistry, Georg-August University Göttingen, Tammannstrasse 2, 37077 Göttingen, Germany Qilu Hospital, Shandong University, Jinan, Shandong, China. College of Chemistry and Bioengineering, Guilin University of Technology, Guilin 541004, China Cardiology Department Qilu Hospital of Shandong University 107 Wen Hua Xi Lu Jinan 250012 Shandong Province China; Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health China Institute for Superconducting and Electronic Materials, University of Wollongong, Northfields Ave., Wollongong, NSW 2522, Australia. ArmaGen Technologies, Incorporated, 914 Colorado Avenue, Santa Monica, California, and Department of Medicine, University of California at Los Angeles, Los Angeles, California The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, Shandong; and State Key Laboratories of Medicinal Chemical Biology, College of Life Sciences, Nankai University , Tianjin, China Department of Chemistry, Emory University, 1515 Dickey Drive, Atlanta, Georgia 30322, United States Department of Pediatrics, Qilu Hospital of Shandong University, No. 107, West Wenhua Road, Jinan City 250012, Shandong Province, China Department of Dermatology and Venerology Foshan Hospital of Traditional Chinese Medicine Foshan Guangdong China Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials; College of Chemistry and Bioengineering; Guilin University of Technology; Guilin 541004; P. R. China Institute of Arthritis Research; Shanghai Academy of Chinese Medical Sciences and Guanghua Integrative Medicine Hospital; Shanghai PR China Qilu Hospital of Shandong University, Jinan, China. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Shandong University Qilu Hospital, Jinan, Shandong 250012, People’s Republic of China; Department of General Practice (General Internal Medicine), Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Science (CAMS) and Peking Union Medical College (PUMC), Beijing Key Laboratory of Cardiovascular Remodeling and Function Research Affiliated to Ministry of Education of the P.R.China and Ministry of Health of the P.R.China, Shandong University; Department of Cardiology, Qilu Hospital affiliated Shandong University Center for Emerging Infectious Diseases Key Laboratory of Special Pathogens and Biosafety Wuhan Institute of Virology Chinese Academy of Sciences Wuhan 430071 China Guangdong Key Laboratory of Environmental Pollution and Health, School of Environment, Jinan University, Guangzhou 511443, China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Jinan University, Guangzhou 511443, China Agriculture and Agri-Food Canada, 1391 Sandford Street, London, ON N5V 4T3, Canada.; Biotechnology Research Institute, National Research Council of Canada, 6100 Royalmount Avenue, Montreal, QC H4P 2R2, Canada.; Pacific Agri-Food Research Centre, Agriculture and Agri-Food Canada, Agassiz, BC V0M 1A0, Canada. Institute of Chemical Physics, School of Chemistry, Beijing Institute of Technology, Beijing 100081, China Department of Physiology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu 610041, China. Children's Nutrition Research Center Children's Hospital of Chongqing Medical University Chongqing China; Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing China; Chongqing Stem Cell Therapy Engineering Technical Center Children's Hospital of Chongqing Medical University Chongqing China Department of Immunology, The Fourth Military Medical University, 169 Changle West Road, Xi'an 710032, China The Key Laboratory of Cardiovascular Remodeling and Function Research Chinese Ministry of Education and Chinese Ministry of Health The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine Department of Cardiology Qilu Hospital of Shandong University Jinan Shandong China Department of General Surgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China From the School of Cardiovascular Medicine & Sciences, King’s College London BHF Centre, United Kingdom (E.K., B.Y., C.M.F.P., M.M.W., R.M.L.S., Z.Z., X.W., Y.H., Q.X.); The Key Laboratory of Cardiovascular Remodelling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Jinan, China (C. Zhai, L.Q., Y.Z., C. Zhang); State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Bioactive Materials of Ministry of Education... The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese Ministry of Health and Chinese Academy of Medical Sciences, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China Department of Pathology, Hunan Cancer Hospital and The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410013, P.R. China Diabetes Research Laboratories, University of Oxford Oxford, U.K. Agriculture and Agri-Food Canada, London, Ontario N5V 4T3, Canada 12BeiGene (Beijing) Co, Ltd, Beijing, China, BeiGene (Shanghai) Co, Ltd, Shanghai, China, and BeiGene USA, Inc., San Mateo, California. The First Clinical Medical College, Lanzhou, Lanzhou 730000, P.R. China The Key Laboratory of Cardiovascular Remodelling and Function Research Chinese Ministry of Education and Chinese Ministry of Public Health Jinan Shandong China Department of Cardiology, The First Affiliated Hospital of Harbin Medical University, Harbin Medical University, Harbin, P.R. China College of Chemistry and Chemical Engineering, Research Center for Advanced Mirco- and Nano-Fabrication Materials, Shanghai University of Engineering Sciences, Shanghai 201620, PR China Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China. zhangy@mail.kiz.ac.cn. Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China College of Chemistry and Materials Science, Sichuan Normal University, Chengdu 610068, China; CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, 2 North First Street, Zhongguancun, Beijing 100190, China Janssen Research and Development, San Diego, California, USA Department of Respiratory Medicine, Affiliated Hospital of School of Medicine, Ningbo University, Ningbo 315020, China. Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu, China; Research Laboratory of Macular Disease, West China Hospital, Sichuan University, Chengdu, China Analytical Development, Novavax, Inc. 20 Firstfield Road, Gaithersburg, MD 20878, USA Department of Business, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China Department of Radiation Oncology, Jiangxi Cancer Hospital , 519 East Beijing Road, Qingshanhu District, Nanchang, Jiangxi 330029 , PR China; Department of Radiation Oncology, The Second Affiliated Hospital of Nanchang , Nanchang, Jiangxi 330029 , PR China Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Key Laboratory of Molecular Nanostructure and Nanotechnology, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Department of Retina Center Affiliated Eye Hospital of Wenzhou Medical University Hangzhou, Zhejiang China Department of Pathology and PathophysiologyZhejiang University School of MedicineHangzhouChina; Program in Molecular Cell BiologyZhejiang University School of MedicineHangzhouChina Department of General Internal Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, China Department of Metabolism and EndocrinologyMetabolic Syndrome Research CenterKey Laboratory of Diabetes ImmunologyMinistry of EducationNational Clinical Research Center for Metabolic DiseaseSecond Xiangya HospitalCentral South UniversityChangshaChina Department of Pathology and Pathophysiology, and Program in Molecular Cell Biology, Zhejiang University School of Medicine, Hangzhou, China; Department of Cardiology the First Affiliated Hospital Harbin Medical University Harbin China Biology Institute of Shandong Academy of Sciences 19 Keyuan Road, Lixia District Jinan 250014 Shandong Province People's Republic of China; Key Laboratory for Drug Screening Technology of Shandong Academy of Sciences 19 Keyuan Road, Lixia District Jinan 250014 Shandong Province People's Republic of China School of Pharmacy, Lanzhou University, Lan Zhou, Gansu Province, China Biology Institute, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250000, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Shandong 250012, P.R. China; The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital, Shandong University, Shandong 250012, P.R. China Department of Geriatric Cardiology, The Second Medical Center and National Clinical Research Center for Geriatric Diseases, Chinese PLA General Hospital, Beijing, China Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Department of Cardiology, Shandong University Qilu Hospital, Jinan, Shandong, China From the Department of Neurology (Dr. Schlachetzki), University of Regensburg, Germany; and Department of Medicine (Drs. Zhang, Boado, and Pardridge), University of California Los Angeles. Institute of Pharmaceutics, School of Pharmacy Lanzhou University Lanzhou China State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China Department of Cardiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China; Acornmed Biotechnology Co., Ltd., Beijing, People's Republic of China Institute of Biology, Qilu University of Technology, Jinan 250103, China Department of Epidemiology and Health Statistics, School of Public Health Anhui Medical University Hefei Anhui China State Key Laboratory of Veterinary Etiological Biology and National Foot and Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, 730046 Gansu, People’s Republic of China. Cell Biology Group, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, USA; Baltimore Veterans Affairs Medical Center, Baltimore, Maryland, USA State Key Laboratory of Biocontrol, Life Sciences School, Sun Yat-sen University , Guangzhou , China CAS Key Laboratory of Microbial Physiological and Metabolic Engineering at Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou, China Department of Neurology, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Division of Innate Immunity, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Minato-ku, Tokyo, Japan The National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100080, China, Graduate School of Chinese Academy of Sciences, Beijing 100080, China, School of Life Science and Technology, Xi‘an Jiaotong University, Xi‘an 710049, China, and Department of Biochemistry and Molecular Biology, Beijing Normal University, Beijing Keb Laboratory, Beijing 100875, China Department of Genetics University of Texas MD Anderson Cancer Center Houston TX USA Key Laboratory of Biocatalysis & Chiral Drug Synthesis of Guizhou Province, Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnomedicine of Ministry of Education, School of Pharmacy, Zunyi Medical University, Zunyi 563003, P. R. China Physics Department and Institute for Nanoscience and Engineering University of Arkansas Fayetteville AR 72701 USA; Department of Physics and Information Technology Baoji University of Arts and Sciences Baoji 721016 China Department of Biostatistics and Computation Biology, University of Rochester, Rochester, NY, USA; Informatics Department, J. Craig Venter Institute (JCVI), City, La Jolla, CA, USA Infectious Disease Department, Jiangsu Taizhou People's Hospital, Taizhou, Jiangsu 225300, P.R. China College of Plant Protection, Yangzhou University, Yangzhou, China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, and The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, China Department of Informatics, J. Craig Venter Institute , La Jolla , CA 92037, USA Department of Obstetrics and Gynecology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong, China 1Department of Basic Medicine, School of Medicine, Tsinghua University, Beijing, China.; 2Department of Pharmacology, School of Basic Medicine, Nanjing Medical University, Nanjing, Jiangsu Province, China. 1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China; Institute of Epidemiology and Microbiology, Eastern Theater Command Centers for Disease Control and Prevention, Nanjing, China CAS Key Laboratory of Tropical Marine Bio-Resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China Medical Center of Hematology, The Xinqiao Hospital of Army Medical University, Chongqing, China; Department of Clinical Laboratory, Children’s Hospital of Chongqing Medical University, Chongqing, China Engineering Research Center of Zebrafish Models for Human Diseases and Drug Screening, Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China Department of Opto-Electronics and Information Engineering; School of Precision Instruments and Opto-Electronics Engineering, and Key Laboratory of Optoelectronic Information Science & Technology (Ministry of Education); Tianjin University; Tianjin 300072; China University of Michigan, Ann Arbor, MI, USA Henan University of Technology Zhengzhou China State Key Laboratory and Institute of Elemento-Organic Chemistry; College of Chemistry; Nankai University; Tianjin 300071; China Department of Psychological Medicine, Mianyang Central Hospital, Mianyang Sichuan, 621000, P.R.China. Department of Radiology, The Sixth Medical Center of Chinese PLA General Hospital, Beijing, China; Department of Radiology, Chinese PLA General Hospital, Beijing, China College of Chemistry and Materials Science Sichuan Normal University Chengdu 610068 P.R. China Plant Germplasm and Genomics Center Germplasm Bank of Wild Species in Southwestern China, Kunming Inst. of Botany, Chinese Acad. of Sciences Kunming 650204 China College of Food Science & Technology, Shanghai Ocean University, Shanghai 201306, People’s Republic of China Department of Organismic and Evolutionary Biology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA Institute of Hydrogeology and Environmental Geology; Shi Jiazhuang; China Department of Gastrointestinal Surgery, The Affiliated Shanghai Shuguang Hospital of Shanghai University of Traditional Chinese Medicine Shanghai 201203, China. Vascular Biology and Hypertension Program, Division of Cardiovascular Disease, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China; Graduate University of the Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, People's Republic of China Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China Lyda Hill Department of Bioinformatics, University of Texas Southwestern , Dallas, TX 75390, USA School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong 250012, P. R. China The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Qilu Hospital of Shandong University, Jinan, Shandong, China Department of Orthopedics People's Hospital of Ningxia Hui Autonomous Region Ningxia China College of Chemistry and Bioengineering; Guilin University of Technology; Guilin 541004, China State Key Laboratory of Environmental Aquatic Chemistry, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, P.O. Box 2871, Beijing, 100085, PR China Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 2 Nanwei Rd, Beijing 100050, P. R. China State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou 510006, China Department of Chemistry and Green Emulsions, Micelles, & Surfactants (GEMS) Center University of Connecticut 55 N. Eagleville Rd Storrs CT 06269-3060 USA Department of Medical Oncology, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, China; Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Provincial Key Laboratory of Nanomaterials, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, China; Department of Translational Medicine, Xiamen Institute of Rare Earth Materials, Chinese Academy of Sciences, Xiamen, China College of Science Beijing University of Chemical Technology Beijing China Guangxi Key Laboratory of Electrochemical and Magnetochemical Function Materials; College of Chemistry and Bioengineering; Guilin University of Technology; Guilin 541004; China Dept. of Stomatology, The Second Hospital, Lanzhou University, Lanzhou 730030, China. Department of Renal Medicine, The Second Affiliated Hospital of Fujian Medical University Quanzhou, Fujian, China. |
Incoming Links
Total number of triples: 4357.