| abstract |
PCT No. PCT/US92/04305 Sec. 371 Date Apr. 25, 1994 Sec. 102(e) Date Apr. 25, 1994 PCT Filed May 21, 1992 PCT Pub. No. WO92/20823 PCT Pub. Date Nov. 26, 1992Oligonucleotide analogs are provided wherein phosphodiester inter-sugar linkages are replaced with four atom linking groups. Such linking groups include NR-C(O)-CH2-CH2, NR-C(S)-CH2-CH2, CH2-NR-C(O)-CH2, CH2-NR-C(S)-CH2, CH2-CH2-NR-C(O)-R-CH2, and CH2-C(S)-NR-CH2. Methods for preparing and using these oligonucleotide analogs are also provided. |