| abstract |
A dinucleotide analogue of formula <IMAGE> I where B1and B2 are each independently a monovalent nucleoside base radical; R1 is R1a or Z; R1a, R2, R3 and R4 are each independently hydrogen, halogen or hydroxy; R5 is R5a or Z; R6 is hydrogen or R6a; R7 is hydrogen, alkyl-N,N-dialkylphosphoramidyl or R7a, R8 is R8a or Z, or the indicated R7O and R8 together denote an isopropylidenedioxy group; R5a and R8a are each independently hydrogen, halogen, hydroxy, -OR10, -OCOR10 or silyloxy substituted by three C1-C15 hydrocarbyl groups; R6a and R7a are each independently a C1-C10 aliphatic radical, a C6-C15 aromatic radical, a C7-C30 araliphatic radical, -COR11, -SO2R11 or silyl substituted by three C1-C15 hydrocarbyl groups; R9 is hydrogen, a C1-C8 aliphatic radical, a C3-C8 cycloaliphatic radical, a C6-C15 aromatic radical, a C7-C13 araliphatic radical, an alkali metal ion or an ammonium ion; R10 and R11 are each independently a C1-C10 aliphatic radical, a C3-C8 cycloaliphatic radical, a C6-C15 aromatic radical or a C7-C16 araliphatic radical; Rx and Ry are independently hydrogen, halogen, hydroxy, a C1-C10 alkyl, C2-C10 alkenyl, C3-C8 cycloalkyl, C6-C15 aryl, C7-C16 aralkyl, C1-C10alkoxy, C2-C10 alkenoxy, C6-C10 aryloxy or C7-C16 aralkyloxy group, which is substituted or unsubstituted, or -OCORz; Rz is a substituted or unsubstituted C1-C10 alkyl, C2-C10 alkenyl, C3-C8 cycloalkyl, C6-C15 aryl or C7-C16 aralkyl group; and Z is C6-C10 aryloxythiocarbonyloxy, the C6-C10 aryl group being substituted or unsubstituted. |