| abstract |
The present invention relates to diarylhydantoin compounds, including diarylthiohydantoins, and methods for synthesizing them, and methods for using them in the treatment of hormone refractory prostate cancer. A method for treating a hyperproliferative disorder comprising administering a composition of the invention to a subject in need of such treatment, thereby treating the hyperproliferative disorder. Method. The present invention provides a series of compounds with potent antagonist activity with minimal agonist activity against AR. |