| abstract |
The present invention provides a series of compounds that have potent antagonistic activity and minimal agonist activity against the androgen receptor (AR). These compounds inhibit the growth of hormone refractory prostate cancer. The present invention provides that R 3 is selected from the group consisting of hydrogen, cyano, formyl, R 1 and R 2 together contain up to 8 carbon atoms, together with alkyl-substituted alkyl and the carbon to which they are attached. And diarylhydantoin compounds selected from the group consisting of cycloalkyl or substituted cycloalkyl groups, methods of synthesizing them, and methods of using them in the treatment of hormone refractory prostate cancer. |