| abstract |
The present invention relates to diarylthiohydantoin compounds and methods for their synthesis and their use in the treatment of hormone refractory prostate cancer. The dosage of these compounds is about 0.001 mg / kg body weight per day to about 100 mg / kg body weight per day, about 0.01 mg / kg body weight per day to about 100 mg / kg body weight per day, It may be in the range of about 0.1 mg / kg body weight to about 10 mg / kg body weight per day, or about 1 mg / kg body weight per day. |