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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00
filingDate 2007-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2011-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8fd537e96fde5fcbfc704eced4f00e5a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2cfe99aa6d5ff4755bb510b6ce80040c
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publicationDate 2011-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber US-7951913-B2
titleOfInvention Method of polymyxin B recovery from fermentation broth
abstract The invention is related to the method of polymyxine B recovery from fermentation broth for the purpose of pure substance recovery. The invention mentioned above is obtained by using the method of polymyxine B recovery from fermentation broth according invention, which abstract is characterized by, that the filtrate is obtained from fermentation broth, its pH and color is adjusted and purified on non-ionogenic synthetic adsorbents of polystyrene type with specific surface 500 till 1000 m 2 ·g −1 and fabric size 3 till 30 nm. The polymyxine B is eluated from adsorbent by aqueous solution of organic solvent. The polymyxine B base is coagulated from eluate after adjustment of pH to alcaline area. The polymyxine B base is converted by mineral acid to polymyxine B salt solution, from which is obtained crystal substance by drying.
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