http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1529784-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_50bb50bd8f32cd17475ae244ec215e2b |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P1-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-38 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-325 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-201 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K33-02 |
| filingDate | 2004-11-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b537259b7070bf641cb1fdfe2099dcd1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2d33c02eaf74615620ce1e44fda92064 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cd81ce4ebb176c8473a7a6ab3b2e01fe |
| publicationDate | 2005-05-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | EP-1529784-A1 |
| titleOfInvention | Polymeric anhydride of magnesium and proteic ammonium phospholinoleate-palmitoleate. |
| abstract | Protein Aggregate Magnesium-AmmoniumnPhospholinoleate-Palmitoleate Anhydride Immunomodulator, itsnProduction Process and Formulation characterized in that annimmunomodulator consisting of a protein aggregate of ammoniumnand magnesium phospholinoleate-palmitoleate anhydride,ncontaining 11.6 ± 4.0% of total lipids, (22.7 ± 5.0% ofnpalmitoleic acid, 42.9 ± 2.0% of linoleic acid, and 32.0 ± 3.0%nof oxidated linoleic acid), 20.1 ± 0.9% of magnesium ions, 10.0n± 3.3% of ammonium ions, 45.2 ± 2.7% of phosphate, and 0.49 ±n0.01% of protein (Asp 7.19%, Thr 3.56%, Ser 7.56%, Glu 8.53%,nPro 0.5%, Gly 9.69%, Ala 7.46%, Val 1.0%, Met 4.38%, Isoleun2.54%, Leu 3.03%, Tyr 0.5%, Phe 1.0%, His 2.83%, Lys 3.56%, Trpn1.3%, and Arg 35.2%). This compound is produced by means of then Aspergillus oryzae fungus, cultured in a culture mediumnconsisting of an aqueous solution of oat and gelatin in thenproportion of 10:1 oat:gelatin in weight for a period of 5 daysnin a bioreactor kept between 20° and 35° C, with pH stabilizednin the range of 2 to 4, under low aeration (-2 liters/min) andnslow agitation (5 rotations per hour), followed by mechanicalnfiltration of the culture medium; extraction of the compoundnwith ethyl acetate; precipitation of the compound under pH 11 byna 20% aqueous solution of sodium carbonate; washing of thencrystals in ethyl acetate and ether; and drying. For use innbiological systems, the compound is formulated in injectablenform or in the form of polymeric microspheres. The injectablenform is obtained by dissolving the compound in anphosphate-saline buffer solution (PBS) 0.1 M, and is stable forn30 days when kept between 5°C and 8°C. The form of polymericnmicrospheres is achieved by preparing an emulsion containing thencompound, obtained by solvent evaporation, using a biodegradablenpolymer, e.g. poly(epsilon-caprolactone), and poly(vinylnalcohol) (PVA) as a surfactant agent. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7951913-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2011028385-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/CN-101503831-B http://rdf.ncbi.nlm.nih.gov/pubchem/patent/DE-102011103882-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009097670-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8889153-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9295682-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2011082458-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8119371-B2 |
| priorityDate | 2003-11-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 249.