| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_2a819eda0adf22936a52362eeebb9fb4 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-426 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-426
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D293-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-50 |
| filingDate |
2005-02-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b9c56e773de7f3daf97eb8dad3fcc74e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_937e628f282e26b044441a8ef5030402
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fd134d36217bb9e7c4916901c2012e16
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b116d76221cb23dae04d126679435ded
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_214b2cb9242de34519d3a0322f094fcb |
| publicationDate |
2010-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7718684-B2 |
| titleOfInvention |
Methods and materials for assessing prostate cancer therapies and compounds |
| abstract |
A modest (2-5 fold) increase in androgen receptor (AR) mRNA is the only expression change consistently associated with developing resistance to antiandrogen therapy. Increased levels of AR confer resistance to anti-androgens by amplifying signal output from low levels of residual ligand and altering the normal response to antagonists. This invention provides cell based assays for use in the examination of new therapeutic modalities and provides for the design of novel antiandrogen compounds. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007254933-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8680291-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9126941-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2008139634-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8183274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010210665-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8648105-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2013034501-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9896437-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2010172975-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-8110594-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009111864-A1 |
| priorityDate |
2004-02-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |