| abstract |
NEW MATERIAL:An imidazolidine derivative shown by formula I [R 1 is H or (lower) alkyl; R 2 is lower alkyl, lower alkylthio (lower) alkyl or tri-(lower) alkoxyaryl; R 3 is benzyl; R 4 is lower alkyl or ar-(lower) alkyl; or R 3 is H, phenyl (2C-6C) alkyl, naphthyl (lower) alkyl, aryl, diphenyl (lower) alkyl, etc.; R 4 is H or lower alkyl; with the proviso that when R 3 and R 4 are H, R 1 is lower alkyl] and a salt thereof. n EXAMPLE: 3-Butyl-5-(1-phenylethyl)imidazolidine-2,4-dione. n USE: Useful as an antagonist of platelet activating factor. A preventive and remedy for diseases such as allergic symptoms and thrombosis. n PREPARATION: For example, as shown the reaction formula, a compound shown by formula II is reacted with a compound shown by formula III to give a compound shown by formula Ia among compounds shown by formula I. n COPYRIGHT: (C)1990,JPO&Japio |