abstract |
An imidazole derivative represented by formula (I): n nwherein Q is:n n nA is hydrogen, halogen, or a substituted or unsubstituted C 1-4 alkyl group; E is independently selected from a C 1-6 alkyl group; R 2 and R 3 are independently selected from C 1-6 alkyls; X 1 and X 2 are independently selected from O and S; Y is selected from a substituted or unsubstituted arylene group and a substituted or unsubstituted divalent 5- or 6-membered monocyclic or 8- to 10-membered condensed heterocyclic group; Z is —CON(—Ra)—, —CO—, —OOO—, —NRa—C(═NH)NRb—, —NRa—C(═N—CN)NRb—, —N(—Ra)COO—, —C(═NH)—, —SO 2 —, —SO 2 N(—Ra)—, —SO 2 NR 1 —, —N(—Ra)CO—, —N(—Ra)CON(—Rb)—, —N(COR 1 )CO—, —N(—Ra)SO 2 —, —N(SO 2 R 1 )SO 2 —, —N(—Ra)— or —N(—Ra)SO 2 N(—Rb)—; R 1 is independently a hydrogen atom, a hydroxyl group, or substituted or unsubstituted group selected from C 1-6 alkyl group, heterocyclic group, aryl group, C 3-8 cycloalkyl group and C 3-8 cycloalkenyl group; or salt or prodrug thereof. |