| abstract |
The subject of the invention is the products of formula (I): <IMAGE> in which: R1 represents cyano, nitro or halogen, R2 represents trifluoromethyl or halogen; the group -A-B- is chosen from the <IMAGE> radicals in which X represents oxygen or sulfur and R3 is chosen from: a hydrogen, alkyl, alkenyl, alkynyl, aryl or aryl-alkyl, these radicals being optionally substituted; trialkylsilyl, acyl or acyloxy Y represents oxygen or sulfur or NH, with the exception of the products in which: the group -AB- represents the radical <IMAGE> in which X represents oxygen, R3 represents hydrogen, Y represents oxygen or NH, R2 represents halogen or trifluoromethyl and R1 represents nitro or halogen; the preparation, their application as drugs and in particular anti-androgens. |