| abstract |
Compounds of the formula (I): ##STR1## wherein: Y is --CH 2 CH 2 --, --CH═CH-- or --C═C-- n n is 1 to 5; n R 1 is hydrogen, or CO 2 R 1 represents an ester group in which the R 1 moiety contains from 1 to 12 carbon atoms; n R 2 is hydrogen, C 1-4 alkyl, trifluoromethyl, or phenyl; n R 3 is hydroxy or protected hydroxy; n R 5 is hydrogen, C 1-6 alkyl, phenyl or phenyl C 1-6 alkyl, any of which phenyl moieties may be substituted by one or more halogen, trifluoromethyl, C 1-6 alkyl, C 1-6 alkoxy or nitro groups; and n X is CH 2 and n R 4 is C 1-9 alkyl, C 3-8 cycloalkyl--C 1-6 alkyl, phenyl--C 1-6 alkyl or naphthyl--C 1-6 alkyl, any of which groups may have one acyclic carbon-carbon bond interrupted by an oxygen atom; hydrogen, C 3-8 cycloalky, phenyl or naphthyl, any of which phenyl of naphthyl moieties in R 4 may be substituted by one or more halogen, trifluoromethyl, C 1-6 alkyl, hydroxy, C 1-6 alkoxy or nitro groups; or R 2 and R 4 taken with the carbon atom to which they are joined represent a C 5-8 cycloalkyl group; or n X is CS and n R 4 is C 1-9 alkyl, C 3-8 cycloalkyl--C 1-6 alkyl, phenyl--C 1-6 alkyl or naphthyl--C 1-6 alkyl, having one acyclic carbon-carbon bond interrupted by an oxygen atom, and in which any phenyl or naphthyl moieties may be substituted by one or more halogen, trifluoromethyl, C 1-6 alkyl, hydroxy C 1-6 alkoxy or nitro groups; and salts thereof; having similar pharmacological activity to natural prostaglandins, processes for their preparation, intermediates useful in those processes and pharmaceutical compositions containing compounds of the formula (I). |