| abstract |
An oligo- or polynucleotide analogue having one or more structures of the general formula n where B is a pyrimidine or purine nucleic acid base, or an analogue thereof, n is disclosed. The use of this analogue provides an oligonucleotide analogue antisense molecule, which is minimally hydrolyzable with an enzyme in vivo, has a high sense strand binding ability, and is easily synthesized. |