| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_03f5823745ff8472f0fcb3fcf25d27e9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_4a8a1cb36c35065d98f072e3cf942055
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59f299a84228e97f93b9940f8f518485
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_fcb809008f7f17362cc1e12d601eb8de |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate |
2005-11-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3341f735bfe421e46db6a868a4c3012a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c8b6b129cde41f1b023b4a7431336c8b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fe694a8ea3b2a8094a0f523bc9d89d51
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_92e096424b88d969d75d404c1b2fa3bb |
| publicationDate |
2007-05-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-2007123702-A1 |
| titleOfInvention |
Oligonucleotdies having A-DNA form and B-DNA form conformational geometry |
| abstract |
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance. By utilizing C2′ endo sugars or O4′ endo sugars, the B-form characteristics are imparted to a portion of the oligonucleotide. The A-form characteristics are imparted via use of either 2′-O-modified nucleotides that have 3′ endo geometries or use of end caps having particular nuclease stability or by use of both of these in conjunction with each other. |
| priorityDate |
1992-03-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |