| abstract |
New nucleic acid sequences are provided which encode 3' untranslated regions of human protein kinase Cα. Compositions and methods are provided for the treatment and diagnosis of diseases associated with protein kinase Cα. Oligonucleotides are provided which are specifically hybridizable with nucleic acid encoding PKCα. Methods of treating animals suffering from disease amenable to therapeutic intervention by modulating protein kinase C expression with an oligonucleotide specifically hybridizable with RNA or DNA corresponding to PKC are disclosed. Polynucleotide probes for PKCα are also disclosed. |