Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785ac2b35073f5a6d251678e6fb31b6f |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 |
filingDate |
2002-03-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2004-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4de16ca7c6a4b3a20a567be701d7e12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0792f0d22dfe7322a82bc3251e8e626d |
publicationDate |
2004-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-6737520-B2 |
titleOfInvention |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
abstract |
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance. By utilizing C2' endo sugars or O4' endo sugars, the B-form characteristics are imparted to a portion of the oligonucleotide. The A-form characteristics are imparted via use of either 2'-O-modified nucleotides that have 3' endo geometries or use of end caps having particular nuclease stability or by use of both of these in conjunction with each other. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9982257-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2007066551-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9068219-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9896689-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394333-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10196638-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9381208-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015011001-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10322173-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2014348907-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10072262-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10280192-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10149905-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10144933-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10590413-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10329318-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9506061-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9447414-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9598458-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10059943-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10167309-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10238682-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2015005366-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11142763-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9399658-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9695211-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9617547-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307434-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9605019-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738680-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160969-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428019-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9382537-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9744183-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10036021-B2 |
priorityDate |
1999-05-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |