| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_785ac2b35073f5a6d251678e6fb31b6f |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-20
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-04 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H19-20 |
| filingDate |
2001-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2006-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1455b043e78b40e1afb0ed264136d299
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0792f0d22dfe7322a82bc3251e8e626d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4de16ca7c6a4b3a20a567be701d7e12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_407e9a2628cbfc032dc6a7b23f4186fa |
| publicationDate |
2006-10-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7119184-B2 |
| titleOfInvention |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry |
| abstract |
Modified oligonucleotides containing both A-form conformation geometry and B-from conformation geometry nucleotides are disclosed. The B-form geometry allows the oligonucleotide to serve as substrates for RNase H when bound to a target nucleic acid strand. The A-form geometry imparts properties to the oligonucleotide that modulate binding affinity and nuclease resistance. By utilizing C2′ endo sugars or O4′ endo sugars, the B-form characteristics are imparted to a portion of the oligonucleotide. The A-form characteristics are imparted via use of either 2′-O-modified nucleotides that have 3′ endo geometries or use of end caps having particular nuclease stability or by use of both of these in conjunction with each other. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9394333-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11142763-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10238682-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10167309-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9896689-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9617547-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10329318-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9598458-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9605019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9381208-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10160969-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9399658-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10322173-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9695211-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10590413-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10280192-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10149905-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10428019-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10072262-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9738680-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10307434-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10036021-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9982257-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10144933-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9744183-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10059943-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009069263-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10196638-B2 |
| priorityDate |
1991-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |