| abstract |
2ʹ3,ʹ-dideoxynucleosides which are effective in inhibiting the infectivity of the human immunodeficiency virus and which are stable in an acidic environment are disclosed, which compounds conform to the formula:n wherein nX is selected from the group consisting of hydrogen, F, CN, N₃ and NO₂; nY is either H or F; with the proviso that Y is F only when X=H. n Also disclosed is a compound of the formula:n n Also disclosed are compounds conforming to the formula:n wherein nR may be either OH or NH₂; and L is NH₂. n Also disclosed are compounds conforming to the formula:n wherein nA is selected from the group consisting of OH and NH₂ nB is selected from the group consisting of H, CH₃, CF₃, CH=CHBr, and halogen. |