| abstract |
A compound of formula ##STR1## where R 1 is hydrogen or a protecting group Q; n R 2 is hydrogen, a C 1 -C 8 aliphatic radical, a C 6 -C 15 aromatic radical, a C 3 -C 8 cycloaliphatic radical, a C 7 -C 13 araliphatic radical, an alkali metal ion or an ammonium ion; n R 3 and R 4 are independently hydrogen, halogen or hydroxy; n R 5 is C 6 -C 10 aryloxythiocarbonyloxy, the C 6 -C 10 aryl group being unsubstituted or substituted, or R 5 a ; n R 5 a is hydrogen, fluorine, chlorine, hydroxy, --OR 8 , --OCOR 8 or silyloxy substituted by three C 1 -C 15 hydrocarbyl groups; n R 6 is hydrogen, a C 1 -C 10 aliphatic radical, a C 6 -C 15 aromatic radical, a C 7 -C 16 araliphatic radical, --COR 9 , --SO 2 R 9 or silyl substituted by three C 1 -C 15 hydrocarbyl groups; n R 7 is a monovalent nucleoside base radical, hydroxyl, --OR 8 or --OCOR 8 , and n R 9 are independently a C 1 -C 10 aliphatic radical, a C 3 -C 8 cycloaliphatic radical, a C 6 -C 15 aromatic radical or a C 7 -C 16 araliphatic radical; or n R 5 and the indicated R 6 O-together denote an isopropylidenedioxy group or R 5 and R 7 together denote an isopropylidenedioxy group, provided that when R 5 and R 7 together denote isopropylidenedioxy, R 1 R 2 , R 3 R 4 and R 6 are not all hydrogen. The disclosure further relates to a method of preparing the compounds of formula I by reacting a olefinic acetonide with a phosphinate compound and to the use of the compounds of formula I as pharmaceutical agents. |