abstract |
The present invention relates to an iRNA duplex agent comprising a first and a second sequence, having at a selected or constrained sequence, a first monomer in the first sequence, and a second monomer in the second sequence, wherein the monomers are selected such that the stability of the pairing of the monomers contribute to a duplex between the first and second sequence will differ from the stability of the pairing between the first or second sequence with a target sequence. |