| abstract |
Novel thymidylate analogs having the following formula are synthesized in the present invention, which are found active against human immunodeficiency virus type 1 (HIV-1): <IMAGE> wherein R1 is hydrogen, cyano (-CN), halogen or azido (-N3); R2 is hydroxyl or an amino ester radical having a formula of -NHR4COOR5, wherein R4 is a bivalent C1-C4 saturated hydrocarbon and R5 is C1-C4 alkyl; Me is methyl; and R3 is hydroxyl or thymidinyl having a formula as follows: <IMAGE> |