| abstract |
A modified polynucleotide containing at least one cleavable or abasic site as shown below. ##STR1## DNA 1 is a first segment of DNA; DNA 2 is a second segment of DNA; and R m is C 1 to C 16 alkylene or an oxytheylene oligomer --(CH 2 CH 2 O) z -- where z is an interger in the range of 1 to 16 inclusive, and R n is selected from the group consisting of ##STR2## Such polynucleotides are useful in solid phase hybridizations because they permit the release of a label from the solid support after the hybridization reaction. |