abstract |
The present invention provides siRNAs with modified bases in the antisense strand, e.g., 5-Iodo-Uridine (U(5I)), 5-Bromo-uridine (U(5Br)), or DAP, and methods for using the modified siRNAs to selectively down-regulate the expression of a mutant allele, even when the mutant mRNA differs from wild-type by only a single nucleotide. |