| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8268e39ce70ff2ad19742e2a21d5a90c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y115-01001 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 |
| filingDate |
2005-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2009-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d227ab76de7f13532c57a61e060a53a8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65cefc0d0a67e538febf19a3bee28257 |
| publicationDate |
2009-03-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-7498316-B2 |
| titleOfInvention |
Methods and compositions for treating gain-of-function disorders using RNA interference |
| abstract |
The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the copper zinc superoxide dismutase (SOD1), which causes inherited amyotrophic lateral sclerosis (ALS), with RNAi agent. The invention further provides RNAi resistant replacement genes containing mismatches with their respective RNAi agent s. The invention also provides for vectors that express RNAi agent and RNAi resistant replacement gene of the present invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954518-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11434502-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10851375-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11760999-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739330-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2020010042-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11603542-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019079240-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2019079242-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2015161184-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11505807-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10793861-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542506-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10513710-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10280418-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-4124658-A2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11649459-B2 |
| priorityDate |
2004-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |