| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8268e39ce70ff2ad19742e2a21d5a90c |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2320-31
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-0089
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y115-01001
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-111
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-11
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-02 |
| filingDate |
2008-07-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate |
2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_65cefc0d0a67e538febf19a3bee28257
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d227ab76de7f13532c57a61e060a53a8 |
| publicationDate |
2011-08-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
US-8008271-B2 |
| titleOfInvention |
Methods and compositions for treating gain-of-function disorders using RNA interference |
| abstract |
The present invention relates to novel methods for treating dominant gain-of-function diseases. The invention provides methods for targeting regions of the copper zinc superoxide dismutase (SOD1), which causes inherited amyotrophic lateral sclerosis (ALS), with RNAi agent. The invention further provides RNAi resistant replacement genes containing mismatches with their respective RNAi agents. The invention also provides for vectors that express RNAi agent and RNAi resistant replacement gene of the present invention. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10954518-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11739330-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542506-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10851375-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11760999-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10280418-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11542525-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11578340-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11603542-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2017161043-A1
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10711274-B2
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11434502-B2 |
| priorityDate |
2004-04-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |