| abstract |
The invention relates to biaryl substituted 4-amino-butyric acid derivatives of formula In wherein COX and COX' independently represent carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester or amide; R 1 represents hydrogen, lower alkyl, C 3 -C 7 -cycloalkyl-lower alkyl, aryl-lower alkyl, biaryl-lower alkyl, lower alkoxy, aryl-lower alkoxy, aryloxy, N-lower alkylamino, N,N-di-lower alkylamino, N-aryl-lower alkylamino, N,N-di-aryl-lower alkylamino, N-arylamino, N,N-diarylamino, lower alkanoylamino, aryl-lower alkanoylamino or aroylamino; R 2 represents hydrogen, hydroxy, lower alkoxy, lower alkyl, aryl-lower alkyl, C 3 -C 7 -cycloalkyl-lower alkyl, amino-lower alkyl, hydroxy-lower alkyl, lower alkylthio-lower alkyl, lower alkoxy-lower alkyl, aryl-lower alkylthio-lower alkyl or aryl-lower alkoxy-lower alkyl ; biaryl represents phenyl substituted by carbocyclic or heterocyclic aryl ; A represents a direct bond, lower alkylene, phenylene or cyclohexylene ; m represents 1 or zero, provided that m represents 1 when A is a direct bond ; or pharmaceutically acceptable salts thereof ; pharmaceutical compositions comprising said compounds ; methods for the preparation of said compounds and for the preparation of intermediates; and methods of treating disorders in mammals which are responsive to the inhibition of neutral endopeptidases by administration of said compounds to mammals in need of such treatment. |