abstract |
A substituted alanine derivative as a neprilysin inhibitor. The present invention provides a compound of formula I', or a pharmaceutically acceptable salt thereof, wherein R 1 , R 2 , R 3 , R 5 , B 1 , X and n are as defined herein. The invention also relates to processes for the preparation of the compounds of the invention and their therapeutic use. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition. |