| abstract |
The present invention relates to biaryl-substituted 4-aminobutyric acid derivatives, their preparation method and application. Specifically, the present invention relates to a biaryl-substituted 4-aminobutyric acid derivative as shown in formula (I) and its preparation method and use. The biaryl-substituted 4-aminobutyric acid derivative is prepared by ring closure reaction Intermediates of compounds and pharmaceutical compositions containing biaryl-substituted 4-aminobutyric acid derivatives. These biaryl-substituted 4-aminobutyric acid derivatives have NEP inhibitory activity and can be used as NEP inhibitors. |