abstract |
The present invention relates to methods of treating contrast-induced nephropathy. The present invention provides the use of neutral endopeptidase inhibitors in the preparation of medicines for treating, improving and/or preventing nephropathy induced by contrast medium. The present invention also relates to the use of the compound of formula (I) in the treatment, improvement and/or prevention of contrast agent-induced nephropathy, wherein R 1 , R 2 , R 3 , R 5 , X, A 3 , B 1 , s and n as defined herein. The present invention further provides combinations of pharmacologically active agents for use in the treatment, amelioration and/or prevention of contrast-induced nephropathy. |