| abstract |
The invention relates to tetra-substituted heteroarylic compounds of the formula (I) wherein X 1 , X 3 and X 4 are independently C or N, Y is C-H, N-H or N, wherein the total number of nitrogen atoms represented by X 1 , X 3 , X 4 and Y is 1 or 2; rings A and B are independently selected from phenyl or pyridyl; R1, R4, R', R", n and m are as defined herein. Such compounds are suitable for the treatment of a disorder or disease which is mediated by the activity of MDM2 and/or MDM4, or variants thereof. |