| abstract |
N-substituted derivatives of staurosporine of the general formula [Stau]-N(CH3)-R(I) in which [Stau] represents a residue of the partial formula <IMAGE> and R represents a hydrocarbyl radical Ro or an acyl radical Ac, which radicals preferably have a maximum of 30 carbon atoms, and salts of compounds of the formula I having salt-forming properties, are distinguished as selective inhibitors of proteinkinase C. They are manufactured by conventional alkylation or acylation, respectively, of staurosporine. |