| abstract |
N-alkanoyl derivatives of staurospodne represented by the formula I <IMAGE> wherein Ra and Rb are each H or <IMAGE> A <IMAGE> B wherein R1 and R2 are independently H or -OH or -OCH3 and R3 is OH, NHCH3, NCH COCH3 or NHCOCH3 and R4 is OH or H and, stereochemical isomers thereof with the provisos that (1) when Ra and Rb=A, and R1=H2 or OH R3 is not NHCH3; (2) when Ra and Rb=B, then R1=R4=OH or R1=R4=H; (3) when Ra=Rb=H R1=-OCH3, and (4) when Ra and Rb=A, and R1=H and R2=OCH3, then R3 is not and <IMAGE> pharmaceutical compositions thereof useful for inhibiting myosin light chain kinase, protein kinase C or tumor cell proliferation as well as producing an antihypertensive effect and an anti-inflammatory effect in warm-blood animals such as man are disclosed. |