| abstract |
N-substituted derivatives of staurosporin of the general formula [Jam] -N (CH₃) -R (I), where [jam] the rest of the sub-formula wherein R is a hydrocarbyl R⁰ or an acyl Ac, which preferably have at most 30 carbon atoms, and salts of compounds of formula I with salt-forming properties, are characterized as selective inhibitors of protein kinase C. They are produced by conventional alkylation or acylation of staurosporine. |