| abstract |
Hsp90 family protein inhibitors containing as the active ingredient benzoyl compounds represented by the general formula (I), prodrugs thereof, or pharmacologically acceptable salts of both: (I) wherein n is an integer of 1 to 10; R1 is substituted or unsubstituted lower alkoxy, substituted or unsubstituted lower alkoxycarbonyl, CONR7R8, or the like; R2 is substituted or unsubstituted aryl, a substituted or unsubstituted aromatic heterocyclic group, or the like; R3 and R5 are each independently hydrogen, substituted or unsubstituted lower alkyl, substituted or unsubstituted lower alkenyl, or the like; and R4 and R6 are each independently hydrogen, halogeno, substituted or unsubstituted lower alkyl, substituted or unsubstituted aryl, or the like. |