| abstract |
A therapeutic agent for cancers having resistance to protease inhibitors which contains, as a heat shock protein 90 (Hsp90) family protein inhibitor, either a benzoyl compound represented by the formula (I) [wherein n is an integer of 1-5; R1 represents (un)substituted lower alkyl, CONR7R8 (wherein R7 and R8 are the same or different and each represents hydrogen, (un)substituted lower alkyl, etc.), etc.; R2 represents (un)substituted aryl, etc.; R3 and R5 are the same or different and each represents hydrogen, (un)substituted lower alkyl, etc.; R4 represents hydrogen, etc.; and R6 represents hydrogen, halogeno, (un)substituted lower alkyl, etc.] or a pharmaceutically acceptable salt of the compound. |