abstract |
The present invention, formula (I) [wherein, R 1 is hydroxy or hydrogen; R 2 is hydroxy, methoxy or hydrogen, provided that at least one of R 1 and R 2 is hydroxy; R 3 is Selected from hydrogen, halogen, cyano, optionally substituted C 1-5 hydrocarbyl and optionally substituted C 1-5 hydrocarbyloxy; R 4 is hydrogen; a group — (O) n—R 7 ( Here, n is 0 or 1, and R 7 is an optionally substituted acyclic C 1-5 hydrocarbyl group or a monocyclic carbocyclic group or heterocyclic group having 3 to 7 ring members. there), halogen, cyano, hydroxy, amino; and optionally substituted mono- - or di -C 1-5 hydrocarbyl - is selected from amino; or R 3 and R 4 taken together To 7 forms a monocyclic carbocyclic or heterocyclic ring of ring members; and NR 5 R 6 has from 8 to 12 ring members, optionally substituted bicyclic heterocyclic Wherein up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulfur], or a salt, tautomer, solvate and N-oxide thereof. . These compounds have activity as Hsp90 inhibitors. |