| abstract |
The present invention relates to one or more auxiliary compounds and a compound of formula (I) Wherein R 1 is hydroxy or hydrogen; R 2 is hydroxy, methoxy or hydrogen; provided that at least one of R 1 and R 2 is hydroxy; R 3 is hydrogen, halogen, cyano, optionally Selected from substituted C 1-5 hydrocarbyl and optionally substituted C 1-5 hydrocarbyloxy; R 4 is hydrogen; group — (O) n—R 7 wherein n is 0 or 1 And R 7 is an optionally substituted acyclic C 1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3-7 ring members); halogen; cyano; hydroxy ; amino; and optionally substituted mono- - or di -C 1-5 hydrocarbyl - or is selected from amino; or R 3 and R 4 are 5-7 ring members together Forms a monocyclic carbocyclic or heterocyclic ring; and NR 5 R 6 has from 8 to 12 ring members, optionally bicyclic heterocyclic group substituted, the Of which a maximum of 5 ring members is a heteroatom selected from oxygen, nitrogen and sulfur] or a salt, tautomer, solvate and N-oxide thereof (or consisting essentially of them) ) Provide a combination. Said combination has activity as an Hsp90 inhibitor. |