| abstract |
An improved method and tools for quantifying the effect of an influence on cellular response is described. In particular, an improved method is described for detecting intracellular translocation or redistribution of biologically active polypeptides. The invention also describes several ways of contacting the cells with a substance influencing a cellular response and extracting quantitative information relating to the response in a highly parallel fashion. The method may be used as a very efficient procedure for testing or discovering the influence of a substance on a physiological process using commercially available parallel, high volume assay techniques, for example in connection with screening for new drugs, testing of substances for toxicity, and identifying drug targets for known or novel drugs. |