Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_ff81a650b70e913d3b2524b45e4c7320 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S530-858 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-43518 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
filingDate |
2005-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8117d34c278cd06d91953ddb0348ddd8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f1eb892ee2fd61c457a3a78e14e8cc68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b3402ddbb3d164191563ee65a091239 |
publicationDate |
2007-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
US-7259145-B2 |
titleOfInvention |
Mechanically activated channel blocker |
abstract |
The present invention discloses a peptide of SEQ ID NO:1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata . The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alterations in mechanical stress. |
isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9796766-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10344060-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9211313-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2012184491-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9340590-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-9636418-B2 |
priorityDate |
2004-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |