| abstract |
Compounds of the structure ##STR1## R and R 1 are each, independently, hydrogen, or ##STR2## R 2 and R 3 are each, independently, alkyl, arylalkyl, or may be taken together to form a cycloalkyl ring; n R 4 and R 5 are each, independently, hydrogen, alkyl, arylalkyl, or may be taken together to form a saturated heterocycle wherein the heterocyclic ring may be optionally mono-, di-, or tri-substituted; n m=0-1; and n n=0-6; n with the proviso that R and R 1 are not both hydrogen, or a pharmaceutically acceptable salt thereof, and ##STR3## R 1 is ##STR4## R 2 and R 3 are each, independently, hydrogen, alkyl, arylalkyl, or may be taken together to form a cycloalkyl ring; n R 4 and R 5 are each, independently, hydrogen, alkyl, arylalkyl, or may be taken together to form a saturated heterocycle wherein the heterocyclic ring may be optionally mono-, di-, or tri-substituted; n m=0-1; and n n=0-6; n or a pharmaceutically acceptable salt thereof which are useful as immunosuppressive, antiinflammatory, antifungal, antiproliferative, and antitumor agents. |