| abstract |
Novel glutarylamino acid derivative dual inhibitors of neutral endopeptidase and angiotensin converting enzyme of the formula ##STR1## wherein: R 1 and R 3 are independently hydroxy, lower alkoxy, aryllower alkoxy, amino, lower alkylamino and di-(lower alkyl)amino; n R 2 is H or hydroxy; n R 4 is aryl, substituted aryl, heteroaryl or substituted heteroaryl; n R 6 is H or R 7 --(CH 2 ) 3 --, wherein R 7 is amino or (aryllower alkoxy)carbonylamino; n Q is --C(O)-- or --SO 2 --; n Y is lower alkyl, lower alkoxy, aryllower alkoxy, amino, lower alkylamino, di-(lower alkyl)amino, or a group of the formula ##STR2## wherein A is a bond, --N(R 5 )--, or --O--; and R 5 is H or lower alkyl; n B is H or Z--(CH 2 ) m -- n Z is amino, lower alkylamino, di-(lower alkyl)amino, (aryllower alkoxy)carbonylamino, 1-pyrrolidino or 1-piperidino; n m=1,2,3,4 or 5; and n=1,2 or 3; or n or a pharmaceutically acceptable addition salt thereof; useful in the treatment of cardiovascular disorders, are disclosed. |