http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7045653-B2
Outgoing Links
Predicate | Object |
---|---|
assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D295-185 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C229-00 |
filingDate | 2003-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2006-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8a993e8149c41e4477bfd1d1c37482d9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4a35676ba2634e1d449ef9f00f5a6738 |
publicationDate | 2006-05-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | US-7045653-B2 |
titleOfInvention | Pharmaceuticals |
abstract | The invention relates to NEP inhibitors for treating cardiovascular disorders. Preferred NEP inhibitors are compounds of formula (I) wherein R 1 is C 1 –C 6 alkyl, C 1 –C 6 alkoxyC 1 –C 3 alkyl or C 1 –C 6 alkoxyC 1 –C 6 alkoxyC 1 –C 3 alkyl; R 2 is hydrogen or C 1 –C 6 alkyl; L is a three atom linkage selected from —CH 2 —X—CH 2 — and —CH 2 —CH 2 —X— where the right hand side of the linkage is attached to R 3 and where X is oxygen, sulfur or methylene; R 3 is phenyl or aromatic heterocyclyl, either of which may be independently substituted by one or more groups selected from: C 1 –C 6 alkyl, halo, haloC 1 –C 6 alkyl, C 1 –C 6 alkoxy, haloC 1 –C 6 alkoxy, C 1 –C 6 alkylthio, haloC 1 –C 6 alkylthio and nitrile; and R 4 and R 5 are either both hydrogen, or one of R 4 and R 5 is hydrogen and the other is a biolabile ester-forming group that in the body of a patient is replaced by hydrogen. |
isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2006189595-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7816347-B2 |
priorityDate | 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 1458.