| abstract |
PCT No. PCT/JP95/02236 Sec. 371 Date Jul. 15, 1996 Sec. 102(e) Date Jul. 15, 1996 PCT Filed Nov. 1, 1995 PCT Pub. No. WO96/14293 PCT Pub. Date May 17, 1996The present invention related to compounds represented by the following formula (I) and salts thereof, <IMAGE> (I) wherein R1 and R4 each represents a carboxyl or a carboxyl which is converted into an ester, an amide or hydroxamic acid; R2 represents a lower alkyl or a phenyl-lower alkyl; R3 represents a hydrogen atom, a lower alkyl, an amino-lower alkyl, a lower alkylamino-lower alkyl, a hydroxy-lower alkyl, a mercapto-lower alkyl, a carboxy-lower alkyl, a lower alkoxycarbonyl-lower alkyl, an imidazolyl-lower alkyl, an indolyl-lower alkyl, a (substituted) phenyl group, a (substituted) phenyl-lower alkyl group, a (substituted) naphthyl group, or a (substituted) naphtyl-lower group. The compounds of the present invention have inhibitory effects on endopeptidase 24.11 and are useful as therapeutic agents for cardiovascular disease such as heart failure and hypertension, renal disease such as renal failure, gastroenteric disorder, such as diarrhea and hyperchlorhydria, endocrine and metabolic disease such as obesity, and autoimmune disease such as rheumatism, and as an analgesics for myosalgia and migraine. |