| abstract |
(57) [Summary] [Structure] The (thio) urea derivative of the formula (I) (in the formula, X Is O, S; R 1 is alkyl (R), alkenyl (Re), alkynyl, (substituted) carbocycle (R c), a heterocycle (Rh), when A is ar (alkylene, kenylene), halo, OH, OR, Oφ, SR, amino, C OOR 6 , Rc, Rh; R 2 is H, R, when B is a bond. When Re, Rc, Rh, and B are (substituted) alkylene, O H, OR, SR, COOR 9 , Rc, Rh; R 3 is H, R, R 2 -B-R 3 and C with a cycloalkyl, a lactone ring; R 4 is H, COOR 10, CH 2 OR 13, CONR 15 R 16 , CO- (heterocycle) -R 17 , R 5 are COOR 18 , phenyl, tetrazolyl (phenyl), m is 0 to 4, n is 1 ~ 4). [Chemical 1] [Effect] It has angiotensin II antagonism and is useful for prevention and / or treatment of hypertension and the like. |