http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-5432186-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_79751aeaa9923745648e5ae7d9c35782 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06078 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K5-06139 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C327-38 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-065 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K5-078 |
| filingDate | 1993-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 1995-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_785a44928aea0f1aa33a6944879bf2ab |
| publicationDate | 1995-07-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | US-5432186-A |
| titleOfInvention | Cyclic amino acid derivatives |
| abstract | Disclosed are the compounds of formula I <IMAGE> (I) wherein R represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl-lower alkyl or cycloalkyl-lower alkyl; R1 represents hydrogen, lower alkyl, cycloalkyl, carbocyclic aryl or heterocyclic aryl, or biaryl; R3 represents hydrogen or acyl; R4 represents hydrogen, lower alkyl, carbocyclic or heterocyclic aryl, carbocyclic or heterocyclic aryl-lower alkyl, cycloalkyl, cycloalkyl-lower alkyl, biaryl or biaryl-lower alkyl; R5 represents hydrogen or lower alkyl; A together with the carbon atom to which it is attached represents 3 to 10 membered cycloalkylidene or 5 to 10 membered cycloalkenylidene radical which may be substituted by lower alkyl or aryl-lower alkyl or may be fused to a saturated or unsaturated carbocyclic 5-7-membered ring; or A together with the carbon to which it is attached represents 5 or 6 membered oxacycloalkylidene, thiacycloalkylidene or azacycloalkylidene optionally substituted by lower alkyl or aryl-lower alkyl; m is 0, 1, 2 or 3; and COOR2 represents carboxyl or carboxyl derivatized in form of a pharmaceutically acceptable ester; disulfide derivatives of said compounds wherein R3 is hydrogen; and pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising said compounds; methods for preparation of said compounds; intermediates; and methods of treating disorders in mammals which are responsive to ACE and NEP inhibition by administration of said compounds to mammals in need of such treatment. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-7595399-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2009325962-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-11426375-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-10668035-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6689801-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-1392720-A2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-2239268-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009135526-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2009138122-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6613782-B2 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004110753-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-2004158076-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6426354-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/US-6423727-B1 |
| priorityDate | 1993-11-16-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 831.