| abstract |
Compounds of Formula I ##STR1## wherein X is oxygen or CH 2 ; n A is CH 2 --CH 2 , trans-CH═CH or C.tbd.C; n W is free or functionally modified hydroxymethylene or free or functionally modified ##STR2## and the OH groups may be in the α- or the β-position; D is straight chain or branched, saturated or unsaturated hydrocarbon aliphatic of from 1 to 10 carbon atoms, which may be substituted by fluorine; n E is C.tbd.C or CR 3 ═CR 4 , R 3 and R 4 being different and being hydrogen or alkyl of 1 to 5 carbon atoms; n R 1 is free or functionally modified hydroxy; and n R 2 is alkyl, cycloalkyl, optionally substituted aryl or heterocyclic, n have valuable pharmacological properties, e.g., hypotensive and bronchodilatory characteristics. They can furthermore be used for prophylaxis and therapy of coronary infarct and as a treatment for stroke. They are produced by means of reduction of the corresponding 1-carbonic acid derivatives. |